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A Higher Order BEM for Wave-Current Action on Structures—Direct Computation of Free-Term Coefficient and CPV Integrals 被引量:9
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作者 滕斌 勾莹 宁德志 《China Ocean Engineering》 SCIE EI 2006年第3期395-410,共16页
A higher order boundary dement method (HOBEM) is implemented for wave-current action on structures. The freeterm coefficient and Cauchy principal value ( GPV) integrals are computed by direct methods. Numerical ex... A higher order boundary dement method (HOBEM) is implemented for wave-current action on structures. The freeterm coefficient and Cauchy principal value ( GPV) integrals are computed by direct methods. Numerical experiments are carried out to validate the computation of free-term coefficient and GPV integrals. The results show that the computation precision of free-term coefficient is very high for various bodies, even with edges and corners, and the convergence speed is fast for CPV integrals for different meshes. The comparison of the second order mean drift force due to wave-current action on a uniform cylinder is made with an analytic solution. It is found that good agreement exists between the present calculation and the analytic solutions. Finally, the numerical code is applied for computing wave-current action on Snorrc TLP. 展开更多
关键词 wave-current action boundary dement method singular imegral free-term coefficient
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Study on scour around vertical large-size cylinder base due to combined action of wave and current 被引量:1
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作者 姜萌 李林普 +1 位作者 韩丽华 张日向 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第4期45-50,共6页
Based on the mechanism of local scour around vertical large-sized cylinder due to combined action of wave and current,the sour morphology,scour process and the maximum scour depth around the cylinders are studied expe... Based on the mechanism of local scour around vertical large-sized cylinder due to combined action of wave and current,the sour morphology,scour process and the maximum scour depth around the cylinders are studied experimentally.The influence of various ocean environmental parameters on local scour around the cylinder is considered in physical model test.The experimental results indicate that the principal effect factors on the scour in fine-sand seabed are wave height,wavelength,current velocity,ratio of diameter to wavelength and ratio of depth to wavelength when the ratio of cylinder diameter to wavelength is from 0.2 to 0.8.In this paper,dimensional analysis theory is utilized to establish a theoretical equation for forecasting maximum scour depth around large-sized round cylinder base due to the combined action of wave and current.The results computed with the theoretical equation are compared with the experimental results,and found to be in good consistency.The results in this studies can be used to estimate the maximum sour depth around analogous structures. 展开更多
关键词 OFFSHORE combined action of wave and current large-sized cylinder local scour
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Damage Evolution of Concrete under the Actions of Stray Current and Sulphate 被引量:5
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作者 ZHANG Lu WEN Bo +1 位作者 NIU Ditao JI Zhiyuan 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2021年第4期578-587,共10页
Based on the mechanism of stray current generation in underground structures,the concrete durability test device for stray current and sulphate in typical soil environment was designed to study the damage of concrete ... Based on the mechanism of stray current generation in underground structures,the concrete durability test device for stray current and sulphate in typical soil environment was designed to study the damage of concrete under the action of stray current and sulphate.The deterioration law of concrete under the action of stray current and sulphate was studied by microscopic techniques such as scanning electron microscopy (SEM) and X-ray diffraction (XRD).The microstructure of corroded concrete was observed to determine the phase composition of erosion products.The damage performances such as quality,strength,and dynamic elastic mode of corroded concrete were performed.The experimental results show that,under the action of stray current,the products of sulfate-eroded concrete are mainly gypsum,ettringite,and thaumasite;the stray current accelerates the hydration process of cement and the erosion of concrete by sulfate;when the concrete pores are filled with the erosion product,there is an increase of approximately 10% in the concrete compressive strength and dynamic elastic modulus;and the concrete compressive strength is more sensitive to the stray current electrification period than the current intensity. 展开更多
关键词 Damage Evolution of Concrete under the actions of Stray current and Sulphate
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Research on Characteristics of Density Current Under the Action of Waves
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作者 Li, DS Shen, Y +1 位作者 Ren, RS Chen, Y 《China Ocean Engineering》 SCIE EI 1997年第1期69-78,共10页
In this paper, the characteristics of density current under the action of waves are described with the help of flume experiment and theoretical analysis. The study shows that turbid water under the action of the waves... In this paper, the characteristics of density current under the action of waves are described with the help of flume experiment and theoretical analysis. The study shows that turbid water under the action of the waves can present three types of motion, i. e. significant stratification, fragile stratification and strong mixing. The motion gf turbid;,ater presents significant stratification when (H/D)/root Delta rho/rho less than or equal to 4.5, generally this state is known as density current. The formulas of motion velocity, thickness, and discharge of density current moving on horizontal bottom are derived by use of basic equations such as momemtum equation, equation of energy conservation and continuity equation of fluid. The time-average velocity and the thickness of density current under the action of waves have a relationship with such parameters as relative density (Delta rho/rho), wave height (H), and water depth (D). When these parameters are determined, the time-average thickness and motion velocity of density current are also determined. The relative thickness of density current (D-t/D) decreases with the increase of Delta rho/rho and increases with the increase of H/D. On the other hand, the motion velocity of density current increases with the increase of Delta rho/rho and decreases with the increase of the relative thickness (D-t/D) of density current. It is shown that the calculated results are in agreement with those of the flume experiment. 展开更多
关键词 turbid current density current gravity current wave action motion velocity thickness
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Numerical Simulation for Refraction-Diffraction of Waves in Water of Slowly Varying Current and Topography 被引量:5
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作者 Hong, GW Feng, WB +1 位作者 Xia, QY Pan, SH 《China Ocean Engineering》 SCIE EI 1997年第4期373-386,共14页
A new numerical finite difference iteration method for refraction-diffraction of waves ia water of slowly varying current and topography is developed in this paper. And corresponding theoretical model including the di... A new numerical finite difference iteration method for refraction-diffraction of waves ia water of slowly varying current and topography is developed in this paper. And corresponding theoretical model including the dissipation term is briefly described, together with some analysis and comparison of computational results of the model with measurements in a hydraulic scale model (Berkhoff et al., 1982). An example of practical use of the method is given, showing that the present model is useful to engineering practice. 展开更多
关键词 refraction-diffraction of waves on current wave number conservation wave action conservation Eikonal equation time dependent mild slope equation on current energy dissipation
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CHARACTERISTICS OF ACTIONPOTENTIAL AND THEIR UNDERLYING OUTWARD CURRENTS IN MAMMALIAN TASTE RECEPTOR CELLS
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作者 陈玉社 《Journal of Pharmaceutical Analysis》 CAS 1995年第2期189-189,共1页
Many rat taste receptor cells conduct action potentials(APs).APs had a mean threshold of -35 mV(n=95 cells)and a spike height of 52mV above threshold in current clamp(hold= -80mV).Aps could be classified into two sign... Many rat taste receptor cells conduct action potentials(APs).APs had a mean threshold of -35 mV(n=95 cells)and a spike height of 52mV above threshold in current clamp(hold= -80mV).Aps could be classified into two significantly different (P<0.001) groups-fast,with short half-time durations and large outward currents (mean1.3 ms and 2.7nA),and slow,with long duration and small outward currents(mean9.2ms and 0. 29nA).AP upstrokes were conducted by TTX-sensitive sodium currents whereas the downstroke by TEA-blockable outward currents. Voltage dependent analysis of outward current separated transient and sustained components.The transient component was specifically blocked by 4-AP(1mmol/L).A calcium-dependent outward component was also revealed modulating voltage and external calcium concentration.The fast recovery phase of the AP appears related the sustained outward current whereas the after hyperpolarization(AHP) was blocked by 4AP suggesting a significant contribution of the transient component.Forskolin (FSK),which elevates cAMP,reversibly blocked the majority of the sustained current without influencing the transient. FSK greatly exaggerated the AHP without changing the spike height or duration. These data suggest that several components of the outward current contribute specifically to the gustatory AP and that the AP may be modulated by cyclic nucleotides. 展开更多
关键词 TASTE patch-clamps action potential potassium currents FORSKOLIN
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Generalized Mean-Flow Theory of Wave-Current-BottomInteractions 被引量:1
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作者 黄虎 《China Ocean Engineering》 SCIE EI 2006年第1期165-172,共8页
The interaction between waves, currents and bottoms in estuarine and coastal regions is ubiquitious, in particular the dynamic mechanism of waves on large-scale slowly varying currents. The wave action concept may be ... The interaction between waves, currents and bottoms in estuarine and coastal regions is ubiquitious, in particular the dynamic mechanism of waves on large-scale slowly varying currents. The wave action concept may be extended and applicated to the study of the mechanism. Considering the effects of moving bottoms and starting from the Navier-Stokes equation of motion of a vinous fluid including the Coriolis force, a generalized mean-flow medel theory for the nearshore region, that is, a set of mean-flow equations and their generalized wave action equation involving the three new kinds of actions termed respectively as the current wave action, the bottom wave action and the dissipative wave action which can be applied to arbitrary depth over moving bottoms and ambient currents with a typical vertical structure, is developed by vertical integration and time-averaglng over a wave peried, thus extending the classical concept, wave action, from the ideal averaged flow conservative system to the real averaged flow dissipative dynamical system, and having a large range of application. 展开更多
关键词 mean-flow equations wave action large-scale slowly varying currents wave-current-bottom interactions dissipative dynamical system
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A Study of Compound Action Potentials in Current-Coupled Tracts: the General Case
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作者 Aman Chawla Salvatore Domenic Morgera 《Journal of Applied Mathematics and Physics》 2023年第11期3345-3353,共9页
In this paper, the authors investigate compound action potentials formed when the underlying tract's axons have current-mediated coupling amongst themselves, and no field-mediated coupling. The key finding of the ... In this paper, the authors investigate compound action potentials formed when the underlying tract's axons have current-mediated coupling amongst themselves, and no field-mediated coupling. The key finding of the paper is that, for the case of biophysically inhomogeneous axon tracts, the compound action potential is governed by a Hodgkin-Huxley like equation itself in certain cases. The paper extends an earlier result for the identical axon case. 展开更多
关键词 Compound action Potentials current-Mediated Coupling Biophysically Inhomogeneous Axon Tracts Hodgkin-Huxley Equation Identical Axon Case
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Refraction-Diffraction Model for Irregular Wave and Directional Spectrum Considering Current
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作者 Li Yucheng and Zhang Yonggang Professor, Department of Civil Engineering, Dalian University of Technology, Dalian 116023 Ph. D. Candidate, Dalian University of Technology, Dalian 116023 《China Ocean Engineering》 SCIE EI 1996年第2期193-202,共10页
A mild-slope equation for combined refraction and diffraction of random waves in the independent time current is derived using Kirby equation(1984). In the derivation, the frequency of random waves is represented base... A mild-slope equation for combined refraction and diffraction of random waves in the independent time current is derived using Kirby equation(1984). In the derivation, the frequency of random waves is represented based on the time series concept, by a typical frequency and its deviation part. Numerical results, compared with those of laboratory experiments, demonstrate that new set of irregular mild slope equation with current is of good adaptability. 展开更多
关键词 wave rejraction-diff action irregular wave directional spectrum wave-current interaction SIMULATION
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Hydrodynamic Characteristics of Submarine Composite Pipeline in a Wave-Current Coexisting Field 被引量:2
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作者 Li Yucheng and Zhang Ningchuan Professor, Dalian University of Technology, Dalian 116024 . Lecturer, Dalian University of Technology, Dalian 116024 《China Ocean Engineering》 SCIE EI 1994年第3期331-342,共12页
-A composite pipeline is defined as a pipeline system composed of one big pipe and one or several small pipes. Based on the theory of wave- current interaction and physical model test, the hydrodynamic characteristics... -A composite pipeline is defined as a pipeline system composed of one big pipe and one or several small pipes. Based on the theory of wave- current interaction and physical model test, the hydrodynamic characteristics of the submarine composite pipeline in wave-current coexisting field (both regular and irregular waves) are investigated. The so-called 'modified diameter method' is used for analyzing the in-fine hydrodynamic coefficients of the composite pipeline, which are well related to KC number. The comparison of test data for regular and irregular waves shows that in the region of 90 > KC> 20, the results in these two cases can be unified. The effect of water depth is analyzed in details. The relationships between CD, CM and KC , which are based on the results of present research, may be used as a reference in engineering design. 展开更多
关键词 submarine pipeline hydrodynamic coefficient wave-current action model test composite pipeline
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Numerical Simulation of Local Scour Around A Large Circular Cylinder Under Wave Action 被引量:2
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作者 赵明 滕斌 《China Ocean Engineering》 SCIE EI 2001年第3期371-382,共12页
A horizontal two-dimensional numerical model is developed for estimation of sediment transport and sea bed change around it large circular cylinder tinder wave action, The wave model is based on an elliptic mild slope... A horizontal two-dimensional numerical model is developed for estimation of sediment transport and sea bed change around it large circular cylinder tinder wave action, The wave model is based on an elliptic mild slope equation. The wave-induced current by the gradient of radiation stress is considered and a depth integrated shallow water equation is applied to the calculation of the current. The mass transport velocity and the bed shear stress due to streaming are considered, which are important factors affecting the sediment transport around a structure due to waves, especially in reflective areas. Wave-current interaction is taken into account in the model for computing the bed shear stress. The model is implemented by it finite element method, The results of this model are compared with those from other methods and agree well with experimental data. 展开更多
关键词 local scour sediment transport wave action current numerical simulation circular cylinder
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Distributions of sediments of the tidal flats in response to dynamic actions,Yangtze (Changjiang) Estuary 被引量:3
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作者 YAN Hong DAI Zhijun +3 位作者 LI Jiufa ZHAO Jianchun ZHANG Xiaoling ZHAO Junkai 《Journal of Geographical Sciences》 SCIE CSCD 2011年第4期719-732,共14页
Sediment samples with high spatial resolution (432 samples in total) and flow data were collected on the tidal flats in the mouth-bar region of the Yangtze Estuary. The data was collected in July 2005, July 2006 and... Sediment samples with high spatial resolution (432 samples in total) and flow data were collected on the tidal flats in the mouth-bar region of the Yangtze Estuary. The data was collected in July 2005, July 2006 and May 2007. The samples were analyzed with a particle sizer, resulting in the sediment distribution. The grain sizes and related parameters were analyzed. The results were presented in a ternary diagram. The sediment mainly consisted of sand, silty sand, sandy silt, sand-silt-clay, silt and clayey silt. And sand skeletons and clay matrices were found. At Nanhui Shoal, silt skeletons could be identified as well. Furthermore, the results were discussed per shoal. Although some depth dependencies were found per shoal, no general relation was found. The results are as follows: sediment located at these tidal flats of the Yangtze Estuary was mainly composed of sand, silty sand and silt. The median grain size in sediment was relatively complex with a range from 2.5 φ to 8 φ. The distributions of sorting coefficients ranging from 1 to 2 were in agreement with median sizes. It was suggested that sediment of the tidal flats was coarser and better sorted or finer and worse sorted. The skewness in sediment distribution varied from 0.1 to 0.8. In addition, the distributions of sorting coefficient and skewness in sediment at Chongming Eastern Shoal, Hengsha Eastern Shoal and Jiuduan Shoal were of similar characteristics because there were closely positive correlated relationships among these parameters. However, due to the location difference between Nanhui Southern Shoal and Eastern Shoal, the values of sorting coefficient and skewness had relatively large distinctions. The tracks of sediment transport could be described based on the distributions of sediment, which might reveal sediment transport controlled by two dominant hydrodynamic factors of current and wave. It was appreciable that coarser sediment with lower sorted coefficient was affected by dominant ebb current action and intense wave action resulted from rapidly dissipated wave energy. Moreover, due to the effects of obstructed branches, guided current and broken wave actions of the Deep Water Channel Project, grain-size in sediment located at two sides of the groyne was of uneven distribution characteristics. 展开更多
关键词 SEDIMENT tidal flat deposition wave action tidal current Yangtze (Changjiang) Estuary
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波流作用下半潜式养殖平台水动力特性物理模型试验
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作者 宋峥嵘 唐鸣夫 +4 位作者 胡性涛 刘俊斐 梅华东 郑振钧 杨传东 《渔业现代化》 北大核心 2025年第3期53-61,共9页
半潜式平台在无遮蔽海况下面临波流联合作用引发的系泊失效与运动失稳风险。针对可升降式养殖平台设计方案,通过物理模型试验校核其在维修、漂浮、坐底三类典型工况下的水动力性能。试验采用1∶75缩尺模型,测量平台6自由度运动响应及系... 半潜式平台在无遮蔽海况下面临波流联合作用引发的系泊失效与运动失稳风险。针对可升降式养殖平台设计方案,通过物理模型试验校核其在维修、漂浮、坐底三类典型工况下的水动力性能。试验采用1∶75缩尺模型,测量平台6自由度运动响应及系泊链张力动态特征。结果显示:维修和漂浮工况下,波流联合作用导致锚泊力达到最大,且不同荷载组合对平台运动的影响很小。波浪周期对锚泊力及纵摇影响显著,但对线位移影响较小。波流联合作用下,锚泊力和线位移随波周期增大而增加,而在纯浪作用下,这一趋势则相反。坐底工况下,平台具有富裕重力,抗滑和抗倾覆性能较强,运动量和锚泊力可忽略。对比了维修状态和漂浮状态的平台动力响应,在海流或波流联合作用下,增加吃水会增大锚泊力并加剧纵摇,同时限制线位移,而在纯浪作用下,增加吃水深度会减小运动响应和锚泊力。研究结果验证了6点系泊方案的稳定性和锚链强度均满足设计要求,为平台建设提供了依据。 展开更多
关键词 半潜式平台 规则波 物理模型试验 浪流联合作用
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系泊点高度对半潜式养殖平台水动力和结构应力的影响
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作者 张艳芳 郑振钧 +4 位作者 梅华东 胡性涛 王衍鑫 唐鸣夫 杨传东 《渔业现代化》 北大核心 2025年第3期12-20,共9页
系泊点高度的不同会显著影响养殖平台的水动力特性和结构应力,从而影响平台的稳定性。采用ANSYS研究了半潜式养殖平台在不同系泊点高度下的水动力和结构应力特征。结果显示:系泊点越高,平台运动响应越大,尤其是倾斜角度增大,对平台运维... 系泊点高度的不同会显著影响养殖平台的水动力特性和结构应力,从而影响平台的稳定性。采用ANSYS研究了半潜式养殖平台在不同系泊点高度下的水动力和结构应力特征。结果显示:系泊点越高,平台运动响应越大,尤其是倾斜角度增大,对平台运维及极端海况下的稳定性不利。最低系泊点P1的锚泊力和应力较大,但未超过限制值,且运动响应最小,有利于平台运营,被推荐为理想系泊点。进一步研究了不同波浪周期和荷载方向对平台运动与受力的影响。仅波浪作用时,锚泊力与应力对波浪周期敏感性低,线位移和纵摇与波浪周期呈正相关关系。波流联合作用时变化趋势与纯浪作用相反。荷载方向0°时锚泊力最大,平台线位移最小。荷载方向15°和30°时,有2根锚链共同承力,锚泊力、纵摇和应力减小,线位移增大。研究结果可为半潜式养殖平台系泊高度的设计和优化提供依据。 展开更多
关键词 半潜式养殖平台 系泊点 浪流联合作用 锚泊力 结构应力
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波流共同作用下砂质海床液化分析
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作者 薛莹莹 张杰 +2 位作者 陈炜昀 张璟哲 蔡飞 《哈尔滨工程大学学报》 北大核心 2025年第7期1317-1324,共8页
针对潮流对海床液化前和液化后海床位移特征的影响规律尚不明确问题,本文建立了一个波流共同作用下多孔弹塑性海床有限元模型,采用Biot控制方程描述海床动力响应,采用状态相关的边界面模型模拟海床液化行为。计算结果表明:潮流不仅影响... 针对潮流对海床液化前和液化后海床位移特征的影响规律尚不明确问题,本文建立了一个波流共同作用下多孔弹塑性海床有限元模型,采用Biot控制方程描述海床动力响应,采用状态相关的边界面模型模拟海床液化行为。计算结果表明:潮流不仅影响海床内部的累积孔压,对海床内振荡孔压也有较大影响;波流对砂质海床的密实作用在海床液化后尤为显著。当海床液化后,同向波流总体能够增大海床的位移,尤其是水平位移,而逆向波流显著降低海床水平位移。砂质海床竖向位移随着波流的持续作用,经历了3个典型阶段,即弹性响应阶段、逐渐压密阶段、严重液化阶段。 展开更多
关键词 波流共同作用 海床液化 饱和多孔弹塑性海床 u-p形式Biot理论 海床位移轨迹 海床孔压累积 有限元分析 边界面模型
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波流作用下裙式吸力锚基础的冲刷特征研究
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作者 刘红军 郭子贤 +1 位作者 于雅琼 朱成浩 《中国海洋大学学报(自然科学版)》 北大核心 2025年第9期80-90,共11页
裙式吸力锚是一种有着施工方便,抗冲刷性能强等优点的新型海上风机基础型式。本文通过室内波流水槽冲刷试验,将裙式吸力锚模型安装在平底砂床中,改变波流条件,记录冲刷发展的过程与冲刷坑的形态特征,并就冲刷发展规律受到不同波流因素... 裙式吸力锚是一种有着施工方便,抗冲刷性能强等优点的新型海上风机基础型式。本文通过室内波流水槽冲刷试验,将裙式吸力锚模型安装在平底砂床中,改变波流条件,记录冲刷发展的过程与冲刷坑的形态特征,并就冲刷发展规律受到不同波流因素的影响进行分析。研究成果如下:当流速增加或淹没率减小时,冲刷范围增大,冲刷发展加快,准平衡阶段冲刷深度与淤积高度增加。得到了预测不同的基础高度(淹没率)下基础周围冲刷深度历时发展规律。波高增大时,随着试验从清水冲刷阶段发展到动床冲刷阶段,最大冲刷深度先增加后减小,最大淤积高度始终增加。增加相对流速会使冲刷加剧,增加速率先提升再降低。基础前方冲刷坑为“倒勺状”,基础两侧对称出现沙丘,基础后方有马蹄状淤积沙丘。流速增加或淹没率减小时,基础前方冲刷坑,后方淤积沙丘的尺度都会增大。筒裙结构能较好地发挥抗冲刷作用。 展开更多
关键词 海上风机 裙式吸力锚 波流作用 冲刷深度 冲刷坑形态
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基于CFD-FEM的弹性楔形体入水砰击特性分析
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作者 崔杰 胡翔宇 +1 位作者 李季阳 韩鸿阳 《振动与冲击》 北大核心 2025年第13期22-31,共10页
在舰船的结构强度设计中,耦合入水砰击荷载受到很大的重视。采用计算流体动力学-有限元法(computational fluid dynamics-finite element method,CFD-FEM)双向耦合数值方法,研究重力作用下弹性楔形体于不同流场环境下入水时的流固耦合... 在舰船的结构强度设计中,耦合入水砰击荷载受到很大的重视。采用计算流体动力学-有限元法(computational fluid dynamics-finite element method,CFD-FEM)双向耦合数值方法,研究重力作用下弹性楔形体于不同流场环境下入水时的流固耦合问题。首先,以静水中楔形体砰击为例,将其仿真结果与试验进行对比验证该耦合方法的准确性;而后,分析了不同入水速度和底部斜升角的弹性楔形体在静水、流和波浪等不同流场环境中入水时所受砰击荷载以及结构响应和流场的变化。结果表明:静水中楔形体入水砰击与模型试验结果相吻合,证明该数值模拟具有可靠性和可行性;均匀流作用下楔形体入水时由于结构物对来流产生壁面反射,导致楔形体附近在靠近来流侧与远离来流侧流速不同从而产生压力差,楔形体底部向来流方向偏移,不同波浪位置下入水时,模型在波浪速度向上的平衡位置,因波浪与楔形体的相对冲击速度增加,所产生的砰击荷载比静水中大,高应力区主要集中在楔形体底部及焊缝位置。研究结果对舰船结构设计以及入水砰击研究提供了指导依据。 展开更多
关键词 入水砰击 弹性楔形体 流固耦合 波流作用
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芪冬颐心颗粒通过抑制Nav1.5和Kv4.3电流改善心肌缺血再灌注心律失常的电生理机制
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作者 高原 吴莹 +7 位作者 李彬 于瑞 谢世阳 王建茹 周璐烨 孙雨蝶 王选阳 朱明军 《中华中医药杂志》 北大核心 2025年第4期1883-1891,共9页
目的:研究芪冬颐心颗粒(QDYX)通过抑制Nav1.5钠电流和Kv4.3钾电流保护缺血再灌注(I/R)心肌并抗室性心律失常的电生理机制。方法;采用冠状动脉左前降支结扎术建立心肌I/R大鼠模型,进行心律失常评分,评估心肌损伤程度及心功能改变。体外... 目的:研究芪冬颐心颗粒(QDYX)通过抑制Nav1.5钠电流和Kv4.3钾电流保护缺血再灌注(I/R)心肌并抗室性心律失常的电生理机制。方法;采用冠状动脉左前降支结扎术建立心肌I/R大鼠模型,进行心律失常评分,评估心肌损伤程度及心功能改变。体外分离豚鼠单个心室肌细胞,采用膜片钳技术检测其动作电位;在培养细胞株上记录Navl.5钠电流和Kv4.3钾电流变化,并研究其离子通道动力学。结果:与I/R组比较,QDYX中、高剂量组可显著减少室性期前收缩发生次数及持续时间(P<0.01),减低心律失常评分(P<0.01),改善心肌I/R损伤(P<0.01),提高心功能。QDYX可使心肌细胞静息膜电位去极化,降低动作电位幅值(APA);QDYX可抑制Navl.5钠电流静息态和失活态,还可抑制Kv4.3钾电流;根据QDYX抑制Nav1.5钠电流和Kv4.3钾电流的IC_(50)数值,进行离子通道动力学检测,发现QDYX使Nav1.5激活电流明显减小,激活曲线右移,还可使Nav1.5失活电流明显减小,失活曲线左移;QDYX对Kv4.3钾通道的影响同Nav1.5钠通道。结论:QDYX可通过抑制Nav1.5钠电流和Kv4.3钾电流改善I/R室性心律失常,从而起到保护心脏和提高心功能作用。 展开更多
关键词 芪冬颐心颗粒 膜片钳技术 心肌细胞动作电位 Nav1.5钠电流 Kv4.3钾电流 缺血再灌注室性心律失常
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基于数值水池的风浪流联合作用下半潜式海洋平台动力响应分析
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作者 刘晖 朱兆琛 +1 位作者 巴宁 吉柏锋 《振动与冲击》 北大核心 2025年第18期217-225,共9页
为分析半潜式海洋平台在复杂深海环境荷载作用下的动力响应,建立了能综合考虑风浪流等海洋环境荷载的三维数值水池,以南海工作水深为1100 m的某半潜式海洋平台为研究对象,研究了该平台在不同海况下的动力响应。先基于N-S(Navier-Stokes... 为分析半潜式海洋平台在复杂深海环境荷载作用下的动力响应,建立了能综合考虑风浪流等海洋环境荷载的三维数值水池,以南海工作水深为1100 m的某半潜式海洋平台为研究对象,研究了该平台在不同海况下的动力响应。先基于N-S(Navier-Stokes)方程和VOF(volume of fluid)多相流模型构建了数值水池,利用动网格技术实现流场与海洋平台网格的实时更新;再根据系泊缆刚度计算获得系泊力时程,在平台相应位置施加系泊力而实现系泊系统作用;最后将分析得到的海洋平台动力响应与基于ANSYS的AWQA软件建立数值模型分析得到的结果进行对比。研究结果表明:基于数值水池分析得到的平台纵荡和垂荡响应与基于AWQA软件分析结果较为接近;此外,数值水池的分析结果还展现了流场湍流特性的影响,得到了平台的横荡响应;而且,在百年一遇的海况下,数值水池计算的平台纵荡、垂荡和横荡响应最大位移幅值分别为26.0000 m、3.5553 m和0.3897 m。因此,采用数值水池方法能较好模拟海洋环境,可得到精度较高的动力响应,为半潜式海洋平台的结构设计奠定可靠基础。 展开更多
关键词 结构工程 半潜式海洋平台 数值水池 风浪流联合作用 动力响应分析
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中医药治疗肝硬化腹水的作用机制及临床应用概述 被引量:6
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作者 梅梦如 李雨 +7 位作者 陈炳东 刘美燕 卢昌林 刘志芳 黄小桃 林镛 颜耿杰 龙富立 《辽宁中医杂志》 北大核心 2025年第1期195-199,共5页
腹水的产生是肝硬化从代偿期进入失代偿期的标志,是肝硬化失代偿期最主要的并发症之一,其发病机制尚未完全明晰。中医学认为其病病位在肝、脾、肾三脏,基本病机为水停、气结、血瘀相互夹杂致病。近年来,国内学者运用中医药防治肝硬化腹... 腹水的产生是肝硬化从代偿期进入失代偿期的标志,是肝硬化失代偿期最主要的并发症之一,其发病机制尚未完全明晰。中医学认为其病病位在肝、脾、肾三脏,基本病机为水停、气结、血瘀相互夹杂致病。近年来,国内学者运用中医药防治肝硬化腹水取得了一定的临床疗效,在缩小腹围、减轻腹胀、增加尿量及改善肝功能等方面展现出独特优势;其作用机制主要集中在降低门静脉高压、利尿、改善炎症介质水平、调节肠道菌群、调控水通道蛋白表达等方面。文章就近年来中医药防治肝硬化腹水相关作用机制及临床应用进行综述,旨在为该病的临床防治提供思路与参考。 展开更多
关键词 肝硬化腹水 中医药治疗 作用机制 临床应用
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