Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative deb...Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative debilitation syndrome.This study aimed to evaluate the clinical efficacy and mechanism of Shenqi Hexue Decoction on early postoperative recovery of such patients.Methods:36 Patients were randomly divided into an experimental group(Shenqi Hexue Decoction+conventional treatment)and a control group(conventional treatment).The changes of hemoglobin(HB),Karnofsky functional status(KPS)score,and TCM syndrome score on the 1st,4th,and 7th day after operation were observed.Results:The HB value of the experimental group was significantly higher than that of the control group on the 4th and 7th days after operation(p<0.01),and the maximum decline value of HB decreased by 42.1%(p<0.001);The improvement rate of KPS score in the experimental group was 94.4%on the 7th day after operation,which was significantly better than 66.7%in the control group(p<0.05).The total effective rate of TCM syndrome efficacy was 94.4%in the experimental group and 72.2%in the control group(p<0.05);No drug-related serious adverse reactions were found.Conclusion:Shenqi Hexue decoction can effectively improve the anemia state and activity ability of patients with Qi blood deficiency syndrome in the early stage after PKP,and its possible mechanism involves multi-target regulation such as hematopoietic regulation,microcirculation improvement and inflammation inhibition,with good safety.展开更多
Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequa...Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.展开更多
BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the...BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE： This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN： A self-control experiment. SETTING： Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS： A total of 125 amblyopic children （250 amblyopic eyes）, 73 males, 52 females, averaging （6±2） years of age, received treatment at the Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child＇s parent. The protocol received approval from the Hospital＇s Ethics Committee. METHODS： Visual function was tested with a perceptual learning system （Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement） for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures （each training procedure lasted for ten minutes）. There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES： Visual function change; relationship of curative effects and curative time. RESULTS： A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment （P 〈 0.05）. Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment （P 〈 0.05）. The mean time to reach improved levels with curative effects was （2.82 ± 1.30） months, and to reach a basically cured level was （2.87 ±1.40） months. Percentage of improved visual acuity was the highest [98% （39/40）] in children that received 3 months of treatment and the lowest [55% （31/56）] in children that received 1 month of treatment （P 〈 0.05）. The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% （31/46）, P 〈 0.05]. CONCLUSION： Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.展开更多
The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of t...The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of the complexes against Candida using proportionally-diluted test-tube medium and examined the evolution of the morphology and structures of Candida albicans using scanning electronic microscopy(SEM) and transmission elec tronic microscopy(TEM).We found that the aver age MIC values of the complexes against the fung were 0.064 mg/mL(cinnamon oil),0.032 mg/mL(pogostemon oil) for Candida albicans,0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil for Candida tropicalis,and 0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil),for Candida krusei.SEM examination over a 24-48 h period showed that the morphology of Candida albicans cells changed significantly.Irregular hollows ap peared on the surfaces,inside organelles were destroyed and the cells burst after treatment.TEM examination over a 48-72 h period indicated that the cell walls were damaged,organelles were destroyed and most cytoplasms became empty bubbles.Sixty intestinal Candida-infected patients were treated with a capsule containing cinnamon and pogostemon oil.The curative ratio was 71.67%(43/60),and the improvement ratio was 28.33%(17/60),giving a to talratio of 100%.Thus,the cinnamonoil and pogostemon oil complexes had strong anti-funguseffectsag ainst Candida albicans,Candidatropicalis,and Candidakrusei.They impacted the morphology and sub-micro structures of the fungus within48-72h,and eventually denatured and killed the cells.The complexes have also shown considerable curative effects to intestinal Candida infections.展开更多
Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific ...Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.展开更多
Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as ...Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.展开更多
Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness...Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness. Methods: 60 patients with angina pectoris from January 2019 to June 2020 were included in this study. After the patients were judged to meet the inclusion criteria, they were treated in groups and studied simultaneously. The study aimed at Danhong injection combined with trimetazidine treatment (30 cases in the observation group) and trimetazidine treatment alone (30 cases in the control group), and observed the treatment efficiency and angina pectoris status of each group after group treatment, and compared the two groups after statistical analysis. Results: the score of angina related progress in the observation group showed a very prominent advantage over that in the control group. Therefore, the treatment method in the observation group had higher clinical feasibility. The statistical method of data packet processing showed P < 0.05, and the test results were significant. Conclusion: Danhong injection combined with trimetazidine is more effective in the treatment of angina pectoris, which can better control the patient's disease development and is worthy of clinical promotion.展开更多
Objective: this study will carry out surgical treatment for patients with hysterectomy for uterine fibroids. Combined with laparoscopic surgical treatment and traditional surgical treatment, the operative results will...Objective: this study will carry out surgical treatment for patients with hysterectomy for uterine fibroids. Combined with laparoscopic surgical treatment and traditional surgical treatment, the operative results will be compared and investigated, and the operative application quality will be analyzed. Methods: 76 patients with uterine fibroids admitted to our department of gynecology from January 2014 to December 2020 were selected, and all of them met the requirements of the experimental investigation. Patients in the control group received conventional abdominal hysterectomy, and patients in the observation group received laparoscopic hysterectomy. Compare the surgery. Results: the hospital stay of the observation group was shorter than that of the control group, and the amount of surgical bleeding was less, and the comparison was statistically significant (P < 0.05). In addition, in terms of adverse events, patients in the observation group had better surgical safety. Conclusion: the application of laparoscopy in gynecological clinical operations, especially in hysteromyomectomy, can help to control the amount of intraoperative bleeding, shorten the length of hospital stay of patients, whcih has clinical application value.展开更多
Objective: this paper mainly discusses the role of closed thoracic drainage with traditional silicone tube and central venous tube in the diagnosis and treatment of pneumothorax. Methods: 60 patients were selected, al...Objective: this paper mainly discusses the role of closed thoracic drainage with traditional silicone tube and central venous tube in the diagnosis and treatment of pneumothorax. Methods: 60 patients were selected, all from pneumothorax patients treated in our hospital from January 2015 to December 2019. The application measures are different, and the patient's group is also different. 30 pneumothorax patients in the observation group were treated with central venous catheter, and 30 pneumothorax patients in the reference group were treated with traditional silicone tube. With the help of statistical tools, the treatment effect was determined. Results: the treatment mode of the observation group showed outstanding advantages, and the curative effect of the patients was more satisfactory, compared with the control group (P < 0.05). Conclusion: closed thoracic drainage through central venous catheter is more effective in the treatment of pneumothorax.展开更多
This paper discusses the novelty search report on the efficacy and mechanism of Gukangling liquid, and analyzes the project basis and research content of Gukangling liquid project. Research objectives and novelty sear...This paper discusses the novelty search report on the efficacy and mechanism of Gukangling liquid, and analyzes the project basis and research content of Gukangling liquid project. Research objectives and novelty search conclusions. We have developed and produced a valuable drug for patients, and provided experimental basis for future clinical application of Gukangling Liquid.展开更多
Objective: to deeply analyze and study the treatment methods and forms of "conventional treatment" compared with "oral implant" in the repair of "dentition defect". Methods: In order to i...Objective: to deeply analyze and study the treatment methods and forms of "conventional treatment" compared with "oral implant" in the repair of "dentition defect". Methods: In order to improve the therapeutic effect of oral cavity repair, a total of 70 patients with "dentition defect" who were treated in our hospital from February 2018 to February 2020 were selected and divided into conventional group (conventional repair treatment) and implant group (dental implant restoration technology), 35 cases in each group. The satisfaction and total effective rate of chewing and pronunciation function, stability and aesthetic function of patients in two groups were analyzed. Results: the total effective rate of "Implant group" was obviously superior to that of the conventional group in pronunciation, chewing, aesthetic function, stability enhancement and satisfaction (P < 0.05). Conclusion: compared with the conventional treatment, the "oral implant" repair technique in our hospital has a significant effect on the dentition defect patients, with good stability and better recovery of chewing, pronunciation and other functions.展开更多
Objective: to investigate the curative effect of control surgery with external fixation for traumatic fracture. Methods: 90 patients with traumatic fracture admitted to our hospital from June 2019 to June 2020 were se...Objective: to investigate the curative effect of control surgery with external fixation for traumatic fracture. Methods: 90 patients with traumatic fracture admitted to our hospital from June 2019 to June 2020 were selected and randomization. 45 patients in the control group underwent open reduction and internal fixation, 45 patients in the observation group underwent control surgery with external fixation. Treatment outcomes were compared. Results: the incidence of complications, operative time and intraoperative blood loss in the observation group were significantly lower than those in the control group, and the comparison was statistically significant (P < 0.05). Conclusion: for patients with traumatic fracture, control surgery with external fixation has better effect, shorter operation time, less injury to the body, less incidence of postoperative complications and high safety, which is worthy of clinical promotion.展开更多
Objective: the experiment will apply Mongolian medicine triple therapy for patients with ulcerative colitis, the ultimate goal is improving the clinical efficacy and controlling the development of the disease. Methods...Objective: the experiment will apply Mongolian medicine triple therapy for patients with ulcerative colitis, the ultimate goal is improving the clinical efficacy and controlling the development of the disease. Methods: to analyze the therapeutic effect. Results: In terms of treatment, the recurrence rate was 5% (3/60) in the observation group and 11.7% (7/60) in the control group, with statistical significance (P < 0.05). At the same time, in terms of therapeutic effect, the total curative effect of the observation group was 90.0%, the control group was 80.0%, and the difference was statistically significant (P < 0.05). Conclusion: Mongolian medicine triple therapy has a relatively ideal effect on the improvement of patients with ulcerative colitis and can reduce the recurrence rate. Therefore, it can be popularized and applied.展开更多
Objective: to analyze the effect of Buyang Huanwu Decoction combined with Chinese acupuncture on limb dysfunction after apoplexy. Methods: a total of 80 patients with limb dysfunction after stroke in our hospital from...Objective: to analyze the effect of Buyang Huanwu Decoction combined with Chinese acupuncture on limb dysfunction after apoplexy. Methods: a total of 80 patients with limb dysfunction after stroke in our hospital from January 2018 to January 2021 were selected, and the digital table randomly divided into 2 groups with 40 patients in each group. Patients in the acupuncture group were treated with acupuncture and moxibustion, and patients in the acupuncture and medicine group were additionally treated with Buyang Huanwu Decoction. The walking time, BI index, FMA score and total effective rate before and after treatment were compared between the two groups. Results: after treatment, BI index and FMA points of patients in acupuncture and medicine group were higher than those in acupuncture and medicine group, and the total effective rate was higher than that in acupuncture and medicine group, P < 0.05. Conclusion: acupuncture and moxibustion combined with Buyang Huanwu Decoction has a definite effect on the treatment of limb dysfunction after stroke, and can promote the improvement of limb motor ability and self-care ability, which is worthy of promotion and application.展开更多
Objective: to comprehensively explore the curative effect on gout and analyze the effect by Modified Simiao Powder. Methods: by exploring the pharmacological effects of traditional Chinese medicine, 80 stroke patients...Objective: to comprehensively explore the curative effect on gout and analyze the effect by Modified Simiao Powder. Methods: by exploring the pharmacological effects of traditional Chinese medicine, 80 stroke patients who were hospitalized in our hospital were selected, and the patients who came to our hospital for treatment from January 2019 to December 2019 were divided into the control group/observation group. The patients in the control group received the related routine treatments, mainly "Febuxostat Tablets". On the basis of the control group, the observation group was treated with Modified Simiao Powder. Comprehensive analysis of the two groups of patients after the implementation of treatment related to the treatment of gout effect and monitoring the level of uric acid joint function score and upper model simulation score and related safety. Results: through the analysis, related gout treatment effect in the observation group was significantly better than the control group, two groups of patients after treatment of related indicators were scored significantly better than the control group, two groups of patients in the clinical treatment of related indicators, the difference was statistically significant (P < 0.05). Conclusion: through careful analysis of patients with gout in the treatment process, and then using the conventional effect of traditional treatment, combined with the modified Simiao Powder treatment, the resulting clinical effect of improving the condition of patients can better promote the relief of pain in patients with gout, and reduce the level of related clinical detection of uric acid, which effectively enhances the function of patients in improving related joints and promotes the clinical effect of safety treatment at the same time, reducing side effects, worthy of clinical application.展开更多
Objective: to explore the significance of combined guided bone regeneration technique on the basis of jaw cyst curettage in the treatment of patients with odontogenic jaw cyst to improve the treatment quality of patie...Objective: to explore the significance of combined guided bone regeneration technique on the basis of jaw cyst curettage in the treatment of patients with odontogenic jaw cyst to improve the treatment quality of patients. Methods: the project started in October 2020 and the project ended in January 2022. The data composition of the project were all confirmed patients in our hospital, with a total of 54 cases. The project was divided into the general group and the study group, with 27 cases in each group. The treatment parameters, changes in jaw height and width after surgery, treatment efficiency and surgical treatment indexes of the two groups were compared. Results: compared with other groups, the volume and area of cysts in the study group changed more significantly, and the bone mineral density of the patients increased more than that in the general group. Comparing the changes of jaw height and width, the parameters of the study group were higher than those of the conventional group. The number of patients in the study group who showed significant improvement in treatment was larger, and the total effective rate was significantly higher than that in the general group. Compared with the surgical treatment, although the treatment time and blood loss of the study group were more, the incidence of postoperative complications and recurrence rate were lower than those of the general group (P≤0.05). Conclusion: for the patients with odontogenic jaw cyst, the application of combined therapy is of positive significance in improving the disease pathological changes of the patients, improving the overall recovery quality, and reducing the influence of disease complications and recurrence rate.展开更多
基金the Guo Wei Expert Work station,Yunnan Province(202305AF-150151).
文摘Objective:After percutaneous kyphoplasty(PKP),patients with pathological vertebral fractures of thoracolumbar metastases often have Qi and blood deficiency syndrome and hidden blood loss,resulting in postoperative debilitation syndrome.This study aimed to evaluate the clinical efficacy and mechanism of Shenqi Hexue Decoction on early postoperative recovery of such patients.Methods:36 Patients were randomly divided into an experimental group(Shenqi Hexue Decoction+conventional treatment)and a control group(conventional treatment).The changes of hemoglobin(HB),Karnofsky functional status(KPS)score,and TCM syndrome score on the 1st,4th,and 7th day after operation were observed.Results:The HB value of the experimental group was significantly higher than that of the control group on the 4th and 7th days after operation(p<0.01),and the maximum decline value of HB decreased by 42.1%(p<0.001);The improvement rate of KPS score in the experimental group was 94.4%on the 7th day after operation,which was significantly better than 66.7%in the control group(p<0.05).The total effective rate of TCM syndrome efficacy was 94.4%in the experimental group and 72.2%in the control group(p<0.05);No drug-related serious adverse reactions were found.Conclusion:Shenqi Hexue decoction can effectively improve the anemia state and activity ability of patients with Qi blood deficiency syndrome in the early stage after PKP,and its possible mechanism involves multi-target regulation such as hematopoietic regulation,microcirculation improvement and inflammation inhibition,with good safety.
基金supported by the Natural Science Foundation of Hunan Province,China(No.2021JJ40505/No.2021JJ30619/No.2020JJ8002)the Scientific Research Project of Hunan Provincial Health Commission(No.202210004450)。
文摘Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.
基金Grant from Major Scientific Research Program of Medical Treatment and Public Health of Guangxi Zhuang Autonomous Region, No.200730
文摘BACKGROUND： Conventional methods （such as occlusion therapy, fine manipulation, complementary, and alternative medicine） take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE： This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN： A self-control experiment. SETTING： Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS： A total of 125 amblyopic children （250 amblyopic eyes）, 73 males, 52 females, averaging （6±2） years of age, received treatment at the Visual Science and Optometry Center, People＇s Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child＇s parent. The protocol received approval from the Hospital＇s Ethics Committee. METHODS： Visual function was tested with a perceptual learning system （Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement） for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures （each training procedure lasted for ten minutes）. There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES： Visual function change; relationship of curative effects and curative time. RESULTS： A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment （P 〈 0.05）. Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment （P 〈 0.05）. The mean time to reach improved levels with curative effects was （2.82 ± 1.30） months, and to reach a basically cured level was （2.87 ±1.40） months. Percentage of improved visual acuity was the highest [98% （39/40）] in children that received 3 months of treatment and the lowest [55% （31/56）] in children that received 1 month of treatment （P 〈 0.05）. The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% （31/46）, P 〈 0.05]. CONCLUSION： Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.
文摘The anti-fungus mechanisms and curative effects of cinnamon oil and pogostemon oil complexes to wards intestinal Candida infections were investigat ed.We measured the minimal inhibitory concentra tion(MIC) values of the complexes against Candida using proportionally-diluted test-tube medium and examined the evolution of the morphology and structures of Candida albicans using scanning electronic microscopy(SEM) and transmission elec tronic microscopy(TEM).We found that the aver age MIC values of the complexes against the fung were 0.064 mg/mL(cinnamon oil),0.032 mg/mL(pogostemon oil) for Candida albicans,0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil for Candida tropicalis,and 0.129 mg/mL(cinnamon oil),0.064 mg/mL(pogostemon oil),for Candida krusei.SEM examination over a 24-48 h period showed that the morphology of Candida albicans cells changed significantly.Irregular hollows ap peared on the surfaces,inside organelles were destroyed and the cells burst after treatment.TEM examination over a 48-72 h period indicated that the cell walls were damaged,organelles were destroyed and most cytoplasms became empty bubbles.Sixty intestinal Candida-infected patients were treated with a capsule containing cinnamon and pogostemon oil.The curative ratio was 71.67%(43/60),and the improvement ratio was 28.33%(17/60),giving a to talratio of 100%.Thus,the cinnamonoil and pogostemon oil complexes had strong anti-funguseffectsag ainst Candida albicans,Candidatropicalis,and Candidakrusei.They impacted the morphology and sub-micro structures of the fungus within48-72h,and eventually denatured and killed the cells.The complexes have also shown considerable curative effects to intestinal Candida infections.
基金The National Key Research and Development Plan"Public Safety Risk Prevention and Control and Emergency Technical Equipment"Key Project"Clinical Evaluation Research on Chinese Medicine Intervention in COVID-19 Recovery Period"(2020YFC0845000)。
文摘Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.
基金National Natural Science Foundation of China(No.81660010,31660329,8191101552)。
文摘Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.
文摘Objective: to investigate the clinical application value of trimetazidine and Danhong injection, observe its application in the treatment of patients with angina pectoris, and analyze its feasibility and effectiveness. Methods: 60 patients with angina pectoris from January 2019 to June 2020 were included in this study. After the patients were judged to meet the inclusion criteria, they were treated in groups and studied simultaneously. The study aimed at Danhong injection combined with trimetazidine treatment (30 cases in the observation group) and trimetazidine treatment alone (30 cases in the control group), and observed the treatment efficiency and angina pectoris status of each group after group treatment, and compared the two groups after statistical analysis. Results: the score of angina related progress in the observation group showed a very prominent advantage over that in the control group. Therefore, the treatment method in the observation group had higher clinical feasibility. The statistical method of data packet processing showed P < 0.05, and the test results were significant. Conclusion: Danhong injection combined with trimetazidine is more effective in the treatment of angina pectoris, which can better control the patient's disease development and is worthy of clinical promotion.
文摘Objective: this study will carry out surgical treatment for patients with hysterectomy for uterine fibroids. Combined with laparoscopic surgical treatment and traditional surgical treatment, the operative results will be compared and investigated, and the operative application quality will be analyzed. Methods: 76 patients with uterine fibroids admitted to our department of gynecology from January 2014 to December 2020 were selected, and all of them met the requirements of the experimental investigation. Patients in the control group received conventional abdominal hysterectomy, and patients in the observation group received laparoscopic hysterectomy. Compare the surgery. Results: the hospital stay of the observation group was shorter than that of the control group, and the amount of surgical bleeding was less, and the comparison was statistically significant (P < 0.05). In addition, in terms of adverse events, patients in the observation group had better surgical safety. Conclusion: the application of laparoscopy in gynecological clinical operations, especially in hysteromyomectomy, can help to control the amount of intraoperative bleeding, shorten the length of hospital stay of patients, whcih has clinical application value.
文摘Objective: this paper mainly discusses the role of closed thoracic drainage with traditional silicone tube and central venous tube in the diagnosis and treatment of pneumothorax. Methods: 60 patients were selected, all from pneumothorax patients treated in our hospital from January 2015 to December 2019. The application measures are different, and the patient's group is also different. 30 pneumothorax patients in the observation group were treated with central venous catheter, and 30 pneumothorax patients in the reference group were treated with traditional silicone tube. With the help of statistical tools, the treatment effect was determined. Results: the treatment mode of the observation group showed outstanding advantages, and the curative effect of the patients was more satisfactory, compared with the control group (P < 0.05). Conclusion: closed thoracic drainage through central venous catheter is more effective in the treatment of pneumothorax.
文摘This paper discusses the novelty search report on the efficacy and mechanism of Gukangling liquid, and analyzes the project basis and research content of Gukangling liquid project. Research objectives and novelty search conclusions. We have developed and produced a valuable drug for patients, and provided experimental basis for future clinical application of Gukangling Liquid.
文摘Objective: to deeply analyze and study the treatment methods and forms of "conventional treatment" compared with "oral implant" in the repair of "dentition defect". Methods: In order to improve the therapeutic effect of oral cavity repair, a total of 70 patients with "dentition defect" who were treated in our hospital from February 2018 to February 2020 were selected and divided into conventional group (conventional repair treatment) and implant group (dental implant restoration technology), 35 cases in each group. The satisfaction and total effective rate of chewing and pronunciation function, stability and aesthetic function of patients in two groups were analyzed. Results: the total effective rate of "Implant group" was obviously superior to that of the conventional group in pronunciation, chewing, aesthetic function, stability enhancement and satisfaction (P < 0.05). Conclusion: compared with the conventional treatment, the "oral implant" repair technique in our hospital has a significant effect on the dentition defect patients, with good stability and better recovery of chewing, pronunciation and other functions.
文摘Objective: to investigate the curative effect of control surgery with external fixation for traumatic fracture. Methods: 90 patients with traumatic fracture admitted to our hospital from June 2019 to June 2020 were selected and randomization. 45 patients in the control group underwent open reduction and internal fixation, 45 patients in the observation group underwent control surgery with external fixation. Treatment outcomes were compared. Results: the incidence of complications, operative time and intraoperative blood loss in the observation group were significantly lower than those in the control group, and the comparison was statistically significant (P < 0.05). Conclusion: for patients with traumatic fracture, control surgery with external fixation has better effect, shorter operation time, less injury to the body, less incidence of postoperative complications and high safety, which is worthy of clinical promotion.
文摘Objective: the experiment will apply Mongolian medicine triple therapy for patients with ulcerative colitis, the ultimate goal is improving the clinical efficacy and controlling the development of the disease. Methods: to analyze the therapeutic effect. Results: In terms of treatment, the recurrence rate was 5% (3/60) in the observation group and 11.7% (7/60) in the control group, with statistical significance (P < 0.05). At the same time, in terms of therapeutic effect, the total curative effect of the observation group was 90.0%, the control group was 80.0%, and the difference was statistically significant (P < 0.05). Conclusion: Mongolian medicine triple therapy has a relatively ideal effect on the improvement of patients with ulcerative colitis and can reduce the recurrence rate. Therefore, it can be popularized and applied.
文摘Objective: to analyze the effect of Buyang Huanwu Decoction combined with Chinese acupuncture on limb dysfunction after apoplexy. Methods: a total of 80 patients with limb dysfunction after stroke in our hospital from January 2018 to January 2021 were selected, and the digital table randomly divided into 2 groups with 40 patients in each group. Patients in the acupuncture group were treated with acupuncture and moxibustion, and patients in the acupuncture and medicine group were additionally treated with Buyang Huanwu Decoction. The walking time, BI index, FMA score and total effective rate before and after treatment were compared between the two groups. Results: after treatment, BI index and FMA points of patients in acupuncture and medicine group were higher than those in acupuncture and medicine group, and the total effective rate was higher than that in acupuncture and medicine group, P < 0.05. Conclusion: acupuncture and moxibustion combined with Buyang Huanwu Decoction has a definite effect on the treatment of limb dysfunction after stroke, and can promote the improvement of limb motor ability and self-care ability, which is worthy of promotion and application.
文摘Objective: to comprehensively explore the curative effect on gout and analyze the effect by Modified Simiao Powder. Methods: by exploring the pharmacological effects of traditional Chinese medicine, 80 stroke patients who were hospitalized in our hospital were selected, and the patients who came to our hospital for treatment from January 2019 to December 2019 were divided into the control group/observation group. The patients in the control group received the related routine treatments, mainly "Febuxostat Tablets". On the basis of the control group, the observation group was treated with Modified Simiao Powder. Comprehensive analysis of the two groups of patients after the implementation of treatment related to the treatment of gout effect and monitoring the level of uric acid joint function score and upper model simulation score and related safety. Results: through the analysis, related gout treatment effect in the observation group was significantly better than the control group, two groups of patients after treatment of related indicators were scored significantly better than the control group, two groups of patients in the clinical treatment of related indicators, the difference was statistically significant (P < 0.05). Conclusion: through careful analysis of patients with gout in the treatment process, and then using the conventional effect of traditional treatment, combined with the modified Simiao Powder treatment, the resulting clinical effect of improving the condition of patients can better promote the relief of pain in patients with gout, and reduce the level of related clinical detection of uric acid, which effectively enhances the function of patients in improving related joints and promotes the clinical effect of safety treatment at the same time, reducing side effects, worthy of clinical application.
文摘Objective: to explore the significance of combined guided bone regeneration technique on the basis of jaw cyst curettage in the treatment of patients with odontogenic jaw cyst to improve the treatment quality of patients. Methods: the project started in October 2020 and the project ended in January 2022. The data composition of the project were all confirmed patients in our hospital, with a total of 54 cases. The project was divided into the general group and the study group, with 27 cases in each group. The treatment parameters, changes in jaw height and width after surgery, treatment efficiency and surgical treatment indexes of the two groups were compared. Results: compared with other groups, the volume and area of cysts in the study group changed more significantly, and the bone mineral density of the patients increased more than that in the general group. Comparing the changes of jaw height and width, the parameters of the study group were higher than those of the conventional group. The number of patients in the study group who showed significant improvement in treatment was larger, and the total effective rate was significantly higher than that in the general group. Compared with the surgical treatment, although the treatment time and blood loss of the study group were more, the incidence of postoperative complications and recurrence rate were lower than those of the general group (P≤0.05). Conclusion: for the patients with odontogenic jaw cyst, the application of combined therapy is of positive significance in improving the disease pathological changes of the patients, improving the overall recovery quality, and reducing the influence of disease complications and recurrence rate.
