The mechanical balance process is the key process to eliminate the quadrature error and improve the performance of the cupped wave gyro. The conventional mechanical balance method for cupped wave gyro based on cup-wal...The mechanical balance process is the key process to eliminate the quadrature error and improve the performance of the cupped wave gyro. The conventional mechanical balance method for cupped wave gyro based on cup-wall trimming requires high control accuracy of trimming quantity, which increases the production cost and decreases the fabrication efficiency in large extent. However, it is hard to reach the high balance accuracy with the natural frequency split of mHz grade by using the conventional method. In this paper, the lumped mass dynamic model of the cupped wave gyro is built by discretization method, and the effects of different position trimming on the natural frequency are analyzed. It is pointed out that trimming off a tiny quantity of material from cup-wall causes large variation of the natural frequency is the main reason for the low accuracy of the conventional mechanical balance method. Then, a precision balance method for cupped wave gyro based on cup-bottom trimming is presented and the entire procedures of this method are given. The static balance process and dynamic balance process of the precision balance method are simulated by the finite element software. The simulation result shows that the precision balance method based on cup-bottom trimming brings less additional natural frequency split in the static balance process, minimizes the natural frequency split to mHz grade and rectify the angle of mode offset to 0.1° grade in the dynamic balance process, furthermore, the method decreases the requirement for control accuracy of trimming quantity evidently. The research work provides references for structure optimization design and balance process plan of the cupped wave gyro.展开更多
During a dive peregrine falcons can reach velocities of more than 320 km/h and makes themselves the fastest animals in the world. The aerodynamic mechanisms involved are not fully understood yet and the search for a c...During a dive peregrine falcons can reach velocities of more than 320 km/h and makes themselves the fastest animals in the world. The aerodynamic mechanisms involved are not fully understood yet and the search for a conclusive answer to this fact motivates the three-dimensional (3-D) flow study. Especially the cupped wing configuration which is a unique feature of the wing shape in falcon peregrine dive is our focus herein. In particular, the flow in the gap between the main body and the cupped wing is studied to understand how this flow interacts with the body and to what extend it affects the integral forces of lift and drag. Characteristic shapes of the wings while diving are studied with regard to their aerodynamics using computational fluid dynamics (CFD). The results of the numerical simulations via ICEM CFD and OpenFOAM show predominant flow structures around the body surface and in the wake of the falcon model such as a pair of body vortices and tip vortices. The drag for the cupped wing profile is reduced in relation to the configuration of opened wings (without cupped-like profile) while lift is increased. The purpose of this study is primarily the basic research of the aerodynamic mechanisms during the falcon’s diving flight. The results could be important for maintaining good maneuverability at high speeds in the aviation sector.展开更多
Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,con...Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.展开更多
In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not o...In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not only a sporting event but also a well-planned“economic feast.”展开更多
I never thought much about earthquakes until that morning.I was making coffee in my kitchen,still half asleep.My dog Max was acting strangely,whining(哀鸣)and running around in circles.Then my coffee cup started shaki...I never thought much about earthquakes until that morning.I was making coffee in my kitchen,still half asleep.My dog Max was acting strangely,whining(哀鸣)and running around in circles.Then my coffee cup started shaking.At first I thought I was just tired,but soon the whole kitchen was moving.The floor felt like jelly under my feet.展开更多
[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patie...[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patients diagnosed with CSR who received treatment at the International Mongolian Hospital of Inner Mongolia between October 2021 and October 2022 were selected and randomly divided into two groups:A test group and a control group,with 60 patients in each group.The patients in the test group received Mongolian medicine silver needle combined with cupping and bloodletting therapy,following the principles of syndrome differentiation in Mongolian medicine.In contrast,the patients in the control group received only the Mongolian medicine silver needle therapy.After treatment,the Mongolian medicine syndrome scores,visual analogue scale(VAS)scores,and total clinical therapeutic effects in the two groups of patients were compared both prior to and following the treatment.[Results]The improvement in VAS and Mongolian medicine syndrome scores in the test group was greater than that in the control group,with a statistically significant difference(P<0.05).The scores of the test group surpassed those of the control group,and this difference was also statistically significant(P<0.05).Furthermore,the overall therapeutic effect in the test group was 93.33%,which was markedly higher than 76.67%observed in the control group(P<0.05).[Conclusions]The therapeutic effect of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of CSR is remarkable.This approach has demonstrated efficacy in alleviating patient pain and improving the functionality of the cervical vertebrae,thereby warranting clinical promotion and application.展开更多
OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated ...OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated literature searching in 7 databases was conducted from January 2014 to January 2023.Two authors extracted data and assessed the risk of bias independently.Statistical analysis was performed using RevMan 5.4.1 software(Cochrane Collaboration,London,UK).Meta-analysis with a random effect model was conducted when there was no serious statistical heterogeneity among trials(I^(2) ≤ 75%).Grading of Recommendations Assessment,Development,and Evaluation was also conducted to assess the quality of evidence.RESULTS:Seventy-two trials with 5720 participants were included.All included trials were assessed as having high risk of bias.The majority of the included trials reported the benefit of cupping plus other therapy or cupping alone on improving cure rate(average risk ratio more than 1.15) and reducing visual analogue scale [average mean difference(MD) reduction 0.16 to 7.0 cm],improving quality of life,quality of sleep or other symptoms related to pain condition.And there was low/very low quality evidence that the incidence of adverse events in the cupping groups were lower than that in the control groups.Although the heterogeneity between studies and the methodological quality of the study itself lead to the low evidence strength of the current conclusions,the results of this study are a valuable supplement to the founding of previous review.CONCLUSION:Cupping therapy alone or combined with other therapy was considered benefit in relieving pain,improving the quality of life,and increasing the cure rate of patients with pain conditions,though supported by the low quality of evidence.According to the limited evidence,cupping therapy seems to have less harm than drugs when treating pain conditions.展开更多
As the sun rises over Mtego wa Simba,a quiet village nestled in the heart of Tanzania’s Morogoro Region,the aroma of sizzling mandazi,a deep-fried dough snack popular in East African countries,floats through the scho...As the sun rises over Mtego wa Simba,a quiet village nestled in the heart of Tanzania’s Morogoro Region,the aroma of sizzling mandazi,a deep-fried dough snack popular in East African countries,floats through the school compound.At Juhudi Primary School,the air is filled with cheerful voices as children eagerly line up for a warm,unfamiliar treat-a steaming cup of soy milk.展开更多
BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegra...BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegration and enhances implant stability.However,there is a lack of evidence in the literature on the use of this material in patients with femoral neck fracture.AIM To evaluate the short-term clinical-functional and radiographic outcomes in patients with femoral neck fractures undergoing total hip arthroplasty(THA)with Trabecular Titanium™acetabular cup implants.METHODS The study included 104 patients with medial femoral neck fractures who underwent THA between January 2020 and December 2020 with the Delta TT acetabular cup(Lima Corporate,Villanova di San Daniele del Friuli,Italy).The mean age of the patients was 69.57±10.16 years(range:36-85 years).The followup period ranged from a minimum of 3 to a maximum of 4 years.Three questionnaires(Harris Hip Score,Oxford Hip Score,and EQ5D)were administered along with radiographic evaluations.Statistical methods included the Student's t-test and one-way analysis of variance for comparisons(with significance set at 0.05),and the Kaplan-Meier curve for prosthetic implant survival.RESULTS The mean follow-up was 41.5 months.The Harris Hip Score(HHS)showed a mean increase of 2.74 points(mean HHS 88.52 at 6 months postoperatively and mean HHS 91.26 at the last follow-up)with statistical significance.Similarly,the Oxford Hip Score demonstrated a statistically significant difference between follow-up groups.However,the EQ5D did not show statistically significant differences among the three groups(preoperative,6-month follow-up,and last follow-up).Revision surgery was required in 6 patients.According to Moore's criteria,96%of the acetabular components were radiographically stable and well-integrated at the last follow-up.The Kaplan-Meier curve showed a 96%survival rate.CONCLUSION The clinical and radiographic results obtained in the short to medium term confirm the excellent performance of the Delta TT acetabular cup in terms of osseointegration,providing an optimal solution both for young patients with high functional recovery demands and for fragile patients requiring optimal stability of the acetabular component to reduce the risk of implant failure.展开更多
Traditional Mongolian Medicine(TMM)therapies have emerged as a prominent therapeutic option for Cervical Spondylotic Radiculopathy(CSR),owing to their demonstrated efficacy,cost-effectiveness,and high clinical accessi...Traditional Mongolian Medicine(TMM)therapies have emerged as a prominent therapeutic option for Cervical Spondylotic Radiculopathy(CSR),owing to their demonstrated efficacy,cost-effectiveness,and high clinical accessibility.This study systematically reviews classical Mongolian medical texts to synthesize CSR-related knowledge,including disease profiles,pathogenesis,and therapeutic strategies—through dual analytical perspectives from modern medicine and TMM theory.Furthermore,it critically evaluates recent clinical research on TMM interventions for CSR,encompassing manual therapies,herbal formulations,and holistic regimens.The integrated analysis aims to provide references for optimizing TMM clinical practices in CSR treatment.展开更多
AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were i...AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were isolated from optic cups of rats on embryonic day 12.5,and high-purity OC-RSCs were obtained by conditioned culture and passage.Differentiation of OC-RSCs into RGCs under different serum concentrations was examined using flow cytometry,and the serum concentration with high interference with differentiation ratio was selected.Furthermore,the effect of blocking IGF-1Rαon the differentiation of OC-RSCs into RGCs was analyzed through immunocytochemistry and Western blotting.RESULTS:Immunohistochemical analysis revealed IGF-1Rαwas highly expressed in rat embryos at day 12.5.OC-RSCs were isolated and purified,and high-purity OCRSCs were obtained.When 2.5%serum was administered,the ratio of differentiated RGCs(Thy-1.1 positive)decreased significantly,and the results of immunoblotting also confirmed the blockade of IGF-1Rαreduced Thy-1.1 protein expression.CONCLUSION:IGF-1Rαblocking can reduce the differentiation of OC-RSCs into RGCs.展开更多
Nanogrinding of SiC wafers with high flatness and low subsurface damage was proposed and nanogrinding experiments were carried out on an ultra precision grinding machine with fine diamond wheels. Experimental results ...Nanogrinding of SiC wafers with high flatness and low subsurface damage was proposed and nanogrinding experiments were carried out on an ultra precision grinding machine with fine diamond wheels. Experimental results show that nanogrinding can produce flatness less than 1.0μm and a surface roughness Ra of 0.42nm. It is found that nanogrinding is capable of producing much flatter SiC wafers with a lower damage than double side lapping and mechanical polishing in much less time and it can replace double side lapping and mechanical polishing and reduce the removal amount of chemical mechanical polishing.展开更多
High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the diffe...High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the difference in grinding style between the cup wheel and the conventional external wheel. So the grit grinding process of the cup wheel is studied, and a new concept of the effective grinding width of the cup wheel is presented. Then the grinding force in grinding WC-Co coating materials by cup wheel is analyzed and a theoretical formula is deduced. Finally, experimental results of the grinding force verify the correctness and the precision of the theoretical formula.展开更多
采用超高效液相色谱-串联质谱仪分析了辽宁典型海域表层海水中14种在用化学农药(current use pesticides,CUPs)浓度水平,探讨了CUPs的可能来源,并评估其潜在生态风险.结果表明,辽宁典型海域表层海水中共检出7种CUPs,总浓度水平范围为16....采用超高效液相色谱-串联质谱仪分析了辽宁典型海域表层海水中14种在用化学农药(current use pesticides,CUPs)浓度水平,探讨了CUPs的可能来源,并评估其潜在生态风险.结果表明,辽宁典型海域表层海水中共检出7种CUPs,总浓度水平范围为16.7~176.1 ng·L^(-1),高值区域主要位于河流入海口,辽东湾西部海域CUPs检出浓度普遍高于黄海东北部海域.除草剂阿特拉津(atrazine)和杀菌剂三唑醇(triadimenol)在检出7种CUPs中占比最高,贡献率分别为56.0%和34.5%.源解析表明,6种CUPs可能来源于农田退水等径流输入和生产化学农药的工厂废水排放等,水果种植业则可能是单一组分乙草胺(acetochlor)的重要贡献源.除草剂阿特拉津和乙草胺对研究海域微藻存在中等-高风险,7种CUPs对无脊椎动物和鱼类的风险均处于较低水平.展开更多
在基于人工免疫的入侵检测研究领域,一般都是应用随机产生字符串的方法来生成检测器。这种方法生成检测器的速度较慢,而且生成的检测器集的检测率低。由于非我样本中存在着关于非我空间的信息,提出通过应用非我样本来初始化基因库并应...在基于人工免疫的入侵检测研究领域,一般都是应用随机产生字符串的方法来生成检测器。这种方法生成检测器的速度较慢,而且生成的检测器集的检测率低。由于非我样本中存在着关于非我空间的信息,提出通过应用非我样本来初始化基因库并应用基因库来生成检测器的方法来检测入侵。应用KDD Cup 1999入侵检测数据集,通过实验证明该方法是有效的,能更快地生成检测率更高的检测器集。展开更多
Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at D...Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at Dhzhui （大椎 GV 14） and bilateral Dazhu （大杼 BL 11） for 10 min in healthy subject. Blood flow monitoring video system of laser speckle was used to record blood flow of GV 14, Shenzhu （身柱 GV 12）, bilateral Feishu （肺俞 BL 13） and Xinshu （心俞 BL 15） before cupping therapy, immediate time of cupping removal and 5 min, 10 rain, 15 min, 20 min, 25 rain and 30 rain after cupping removal. Results Compared before cupping therapy, the blood flow of GV 14, GV 12 and bilateral BL 13 was obviously increased at immediate time of cupping removal （all P〈0.05）. Compared with immediate time of cupping removal, the blood flow of GV 14 at each time point after 20 rain of cupping removal, GV 12 at 10 min and 15 min after cupping removal, bilateral BL 13 at each time point after cupping removal was all obviously decreased （all P〈0.05）. The difference of blood flow of Shendao （神道 GV 11） and bilateral BL 15 before and after cupping therapy was not significantly different （all P〉0.05）. Conclusion The cupping therapy could adjust skin blood flow, which is more obvious near the cupping area.展开更多
Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation g...Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation group （45 cases） and a control group （45 cases）. Basic treatments selected according to corresponding stroke units were applied to both groups. Besides, scalp acupuncture at Dingnie Qianxiexian （MS 6, 顶颞前斜线）, Dingnie Houxiexian （MS 6, 顶颞前斜线） and Dingzhongxian （NS 5, 顶中线）, was applied in the treatment group. In the observation group, active and passive movement was carried out during the process of scalp acupuncture, and then needling plus bloodletting puncturing and cupping was applied. In the control group, only needling plus blood-letting puncturing and cupping was given. Therapeutic effects, pain scoring obtained by visual analogue scales （VAS）, FugI-Meyer and FugI-Meyer＇s scoring reflecting moving functions of upper limbs were made after 4 courses of treatments in both groups. Results The total effective rate was 95.5% and 91.1% in the observation group and control group, respectively, showing superiority of the former to the latter （P〈0.05）. After treatment, VAS scores were all obviously reduced in both groups （P〈0.01）, and the reduction in the former was significantly more than that in the latter （P〈0.01）. Moving functions of upper limbs shown by Fugl-Meyer＇s scoring were improved after 2 courses of treatment in both groups （P〈0.01）. The improvement was more obvious after 4 courses of treatment than that after 2 courses of treatment in both groups （P〈0.05）. After 4 courses of treatment, moving functions shown by FugI-Meyer＇s scoring were more remarkably improved in the observation group than those in the control group（t=3.9, P〈0.01）. Conclusion Both kinetic needling combined with needling plus blood-letting puncturing and cupping and simple needling plus blood-letting puncturing and cupping are effective in treating shoulder-hand syndrome after apoplexy, and the former is better than the latter.展开更多
Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with mediu...Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with medium-sized cups with a volume of 260 mL The randomly selected Xinshu（心俞 BL 15）on one side（37 cases） was given cupping treatment while that on the other side as the control.And Shenshu（肾俞 BL 23）（6 cases） was treated in the same way.The thermal infrared imager was used to record the changes in localized skin temperature before and after cupping（for 10 minutes）,and then comparison was made with that of the control side.Results After cupping,the localized skin temperature fell and then rose.When the cup was removed after retaining for 10 minutes,the localized skin temperature was（0.4±0.9） ℃（P=0.004） lower than that before cupping;10 minutes after cupping off,the localized skin temperature was（0.4±1.1） ℃（P=0.016） higher than that before cupping while（0.8±0.9） ℃ higher than that when cupping off.The skin surface temperature on the control side declined steadily.Conclusion After cupping treatment,the localized skin temperature fell and then rose while that of the control side declined steadily.It might be related to therapeutic effects.展开更多
基金supported by National Natural Science Foundation of China (Grant No. 51005239)
文摘The mechanical balance process is the key process to eliminate the quadrature error and improve the performance of the cupped wave gyro. The conventional mechanical balance method for cupped wave gyro based on cup-wall trimming requires high control accuracy of trimming quantity, which increases the production cost and decreases the fabrication efficiency in large extent. However, it is hard to reach the high balance accuracy with the natural frequency split of mHz grade by using the conventional method. In this paper, the lumped mass dynamic model of the cupped wave gyro is built by discretization method, and the effects of different position trimming on the natural frequency are analyzed. It is pointed out that trimming off a tiny quantity of material from cup-wall causes large variation of the natural frequency is the main reason for the low accuracy of the conventional mechanical balance method. Then, a precision balance method for cupped wave gyro based on cup-bottom trimming is presented and the entire procedures of this method are given. The static balance process and dynamic balance process of the precision balance method are simulated by the finite element software. The simulation result shows that the precision balance method based on cup-bottom trimming brings less additional natural frequency split in the static balance process, minimizes the natural frequency split to mHz grade and rectify the angle of mode offset to 0.1° grade in the dynamic balance process, furthermore, the method decreases the requirement for control accuracy of trimming quantity evidently. The research work provides references for structure optimization design and balance process plan of the cupped wave gyro.
文摘During a dive peregrine falcons can reach velocities of more than 320 km/h and makes themselves the fastest animals in the world. The aerodynamic mechanisms involved are not fully understood yet and the search for a conclusive answer to this fact motivates the three-dimensional (3-D) flow study. Especially the cupped wing configuration which is a unique feature of the wing shape in falcon peregrine dive is our focus herein. In particular, the flow in the gap between the main body and the cupped wing is studied to understand how this flow interacts with the body and to what extend it affects the integral forces of lift and drag. Characteristic shapes of the wings while diving are studied with regard to their aerodynamics using computational fluid dynamics (CFD). The results of the numerical simulations via ICEM CFD and OpenFOAM show predominant flow structures around the body surface and in the wake of the falcon model such as a pair of body vortices and tip vortices. The drag for the cupped wing profile is reduced in relation to the configuration of opened wings (without cupped-like profile) while lift is increased. The purpose of this study is primarily the basic research of the aerodynamic mechanisms during the falcon’s diving flight. The results could be important for maintaining good maneuverability at high speeds in the aviation sector.
基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(No.RS-2023-00256265,RS-2024-00352352,RS-2024-00405818)the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare).(No.25A0102L1)support from the Market-led K-sensor technology program(RS-2022-00154781,Development of large-area wafer-level flexible/stretchable hybrid sensor platform technology for form factor-free highly integrated convergence sensor),funded By the Ministry of Trade,Industry&Energy(MOTIE,Korea).
文摘Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.
文摘In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not only a sporting event but also a well-planned“economic feast.”
文摘I never thought much about earthquakes until that morning.I was making coffee in my kitchen,still half asleep.My dog Max was acting strangely,whining(哀鸣)and running around in circles.Then my coffee cup started shaking.At first I thought I was just tired,but soon the whole kitchen was moving.The floor felt like jelly under my feet.
基金Supported by Project of Science and Technology Department of Inner Mongolia Autonomous Region(2019GG125).
文摘[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patients diagnosed with CSR who received treatment at the International Mongolian Hospital of Inner Mongolia between October 2021 and October 2022 were selected and randomly divided into two groups:A test group and a control group,with 60 patients in each group.The patients in the test group received Mongolian medicine silver needle combined with cupping and bloodletting therapy,following the principles of syndrome differentiation in Mongolian medicine.In contrast,the patients in the control group received only the Mongolian medicine silver needle therapy.After treatment,the Mongolian medicine syndrome scores,visual analogue scale(VAS)scores,and total clinical therapeutic effects in the two groups of patients were compared both prior to and following the treatment.[Results]The improvement in VAS and Mongolian medicine syndrome scores in the test group was greater than that in the control group,with a statistically significant difference(P<0.05).The scores of the test group surpassed those of the control group,and this difference was also statistically significant(P<0.05).Furthermore,the overall therapeutic effect in the test group was 93.33%,which was markedly higher than 76.67%observed in the control group(P<0.05).[Conclusions]The therapeutic effect of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of CSR is remarkable.This approach has demonstrated efficacy in alleviating patient pain and improving the functionality of the cervical vertebrae,thereby warranting clinical promotion and application.
基金National Natural Science Foundation of China Project:Research on the Correlation between Traditional Chinese Medicine Constitution,Cupping Marks Color,and Clinical Efficacy Based on Regression Models (No.81804000)。
文摘OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated literature searching in 7 databases was conducted from January 2014 to January 2023.Two authors extracted data and assessed the risk of bias independently.Statistical analysis was performed using RevMan 5.4.1 software(Cochrane Collaboration,London,UK).Meta-analysis with a random effect model was conducted when there was no serious statistical heterogeneity among trials(I^(2) ≤ 75%).Grading of Recommendations Assessment,Development,and Evaluation was also conducted to assess the quality of evidence.RESULTS:Seventy-two trials with 5720 participants were included.All included trials were assessed as having high risk of bias.The majority of the included trials reported the benefit of cupping plus other therapy or cupping alone on improving cure rate(average risk ratio more than 1.15) and reducing visual analogue scale [average mean difference(MD) reduction 0.16 to 7.0 cm],improving quality of life,quality of sleep or other symptoms related to pain condition.And there was low/very low quality evidence that the incidence of adverse events in the cupping groups were lower than that in the control groups.Although the heterogeneity between studies and the methodological quality of the study itself lead to the low evidence strength of the current conclusions,the results of this study are a valuable supplement to the founding of previous review.CONCLUSION:Cupping therapy alone or combined with other therapy was considered benefit in relieving pain,improving the quality of life,and increasing the cure rate of patients with pain conditions,though supported by the low quality of evidence.According to the limited evidence,cupping therapy seems to have less harm than drugs when treating pain conditions.
文摘As the sun rises over Mtego wa Simba,a quiet village nestled in the heart of Tanzania’s Morogoro Region,the aroma of sizzling mandazi,a deep-fried dough snack popular in East African countries,floats through the school compound.At Juhudi Primary School,the air is filled with cheerful voices as children eagerly line up for a warm,unfamiliar treat-a steaming cup of soy milk.
文摘BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegration and enhances implant stability.However,there is a lack of evidence in the literature on the use of this material in patients with femoral neck fracture.AIM To evaluate the short-term clinical-functional and radiographic outcomes in patients with femoral neck fractures undergoing total hip arthroplasty(THA)with Trabecular Titanium™acetabular cup implants.METHODS The study included 104 patients with medial femoral neck fractures who underwent THA between January 2020 and December 2020 with the Delta TT acetabular cup(Lima Corporate,Villanova di San Daniele del Friuli,Italy).The mean age of the patients was 69.57±10.16 years(range:36-85 years).The followup period ranged from a minimum of 3 to a maximum of 4 years.Three questionnaires(Harris Hip Score,Oxford Hip Score,and EQ5D)were administered along with radiographic evaluations.Statistical methods included the Student's t-test and one-way analysis of variance for comparisons(with significance set at 0.05),and the Kaplan-Meier curve for prosthetic implant survival.RESULTS The mean follow-up was 41.5 months.The Harris Hip Score(HHS)showed a mean increase of 2.74 points(mean HHS 88.52 at 6 months postoperatively and mean HHS 91.26 at the last follow-up)with statistical significance.Similarly,the Oxford Hip Score demonstrated a statistically significant difference between follow-up groups.However,the EQ5D did not show statistically significant differences among the three groups(preoperative,6-month follow-up,and last follow-up).Revision surgery was required in 6 patients.According to Moore's criteria,96%of the acetabular components were radiographically stable and well-integrated at the last follow-up.The Kaplan-Meier curve showed a 96%survival rate.CONCLUSION The clinical and radiographic results obtained in the short to medium term confirm the excellent performance of the Delta TT acetabular cup in terms of osseointegration,providing an optimal solution both for young patients with high functional recovery demands and for fragile patients requiring optimal stability of the acetabular component to reduce the risk of implant failure.
基金Supported by Science and Technology Program of Inner Mongolia Autonomous Region"Clinical Observation of Warm Needling Acupuncture of Mongolian Medicine in the Treatment of Lumbar Disc Herniation"(2019GG125).
文摘Traditional Mongolian Medicine(TMM)therapies have emerged as a prominent therapeutic option for Cervical Spondylotic Radiculopathy(CSR),owing to their demonstrated efficacy,cost-effectiveness,and high clinical accessibility.This study systematically reviews classical Mongolian medical texts to synthesize CSR-related knowledge,including disease profiles,pathogenesis,and therapeutic strategies—through dual analytical perspectives from modern medicine and TMM theory.Furthermore,it critically evaluates recent clinical research on TMM interventions for CSR,encompassing manual therapies,herbal formulations,and holistic regimens.The integrated analysis aims to provide references for optimizing TMM clinical practices in CSR treatment.
文摘AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were isolated from optic cups of rats on embryonic day 12.5,and high-purity OC-RSCs were obtained by conditioned culture and passage.Differentiation of OC-RSCs into RGCs under different serum concentrations was examined using flow cytometry,and the serum concentration with high interference with differentiation ratio was selected.Furthermore,the effect of blocking IGF-1Rαon the differentiation of OC-RSCs into RGCs was analyzed through immunocytochemistry and Western blotting.RESULTS:Immunohistochemical analysis revealed IGF-1Rαwas highly expressed in rat embryos at day 12.5.OC-RSCs were isolated and purified,and high-purity OCRSCs were obtained.When 2.5%serum was administered,the ratio of differentiated RGCs(Thy-1.1 positive)decreased significantly,and the results of immunoblotting also confirmed the blockade of IGF-1Rαreduced Thy-1.1 protein expression.CONCLUSION:IGF-1Rαblocking can reduce the differentiation of OC-RSCs into RGCs.
基金Project (50975040) supported by the National Natural Science Foundation of China
文摘Nanogrinding of SiC wafers with high flatness and low subsurface damage was proposed and nanogrinding experiments were carried out on an ultra precision grinding machine with fine diamond wheels. Experimental results show that nanogrinding can produce flatness less than 1.0μm and a surface roughness Ra of 0.42nm. It is found that nanogrinding is capable of producing much flatter SiC wafers with a lower damage than double side lapping and mechanical polishing in much less time and it can replace double side lapping and mechanical polishing and reduce the removal amount of chemical mechanical polishing.
文摘High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the difference in grinding style between the cup wheel and the conventional external wheel. So the grit grinding process of the cup wheel is studied, and a new concept of the effective grinding width of the cup wheel is presented. Then the grinding force in grinding WC-Co coating materials by cup wheel is analyzed and a theoretical formula is deduced. Finally, experimental results of the grinding force verify the correctness and the precision of the theoretical formula.
文摘采用超高效液相色谱-串联质谱仪分析了辽宁典型海域表层海水中14种在用化学农药(current use pesticides,CUPs)浓度水平,探讨了CUPs的可能来源,并评估其潜在生态风险.结果表明,辽宁典型海域表层海水中共检出7种CUPs,总浓度水平范围为16.7~176.1 ng·L^(-1),高值区域主要位于河流入海口,辽东湾西部海域CUPs检出浓度普遍高于黄海东北部海域.除草剂阿特拉津(atrazine)和杀菌剂三唑醇(triadimenol)在检出7种CUPs中占比最高,贡献率分别为56.0%和34.5%.源解析表明,6种CUPs可能来源于农田退水等径流输入和生产化学农药的工厂废水排放等,水果种植业则可能是单一组分乙草胺(acetochlor)的重要贡献源.除草剂阿特拉津和乙草胺对研究海域微藻存在中等-高风险,7种CUPs对无脊椎动物和鱼类的风险均处于较低水平.
文摘在基于人工免疫的入侵检测研究领域,一般都是应用随机产生字符串的方法来生成检测器。这种方法生成检测器的速度较慢,而且生成的检测器集的检测率低。由于非我样本中存在着关于非我空间的信息,提出通过应用非我样本来初始化基因库并应用基因库来生成检测器的方法来检测入侵。应用KDD Cup 1999入侵检测数据集,通过实验证明该方法是有效的,能更快地生成检测率更高的检测器集。
基金Supported by Natural Science Foundaion of China in 2012(No.81273673)
文摘Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at Dhzhui （大椎 GV 14） and bilateral Dazhu （大杼 BL 11） for 10 min in healthy subject. Blood flow monitoring video system of laser speckle was used to record blood flow of GV 14, Shenzhu （身柱 GV 12）, bilateral Feishu （肺俞 BL 13） and Xinshu （心俞 BL 15） before cupping therapy, immediate time of cupping removal and 5 min, 10 rain, 15 min, 20 min, 25 rain and 30 rain after cupping removal. Results Compared before cupping therapy, the blood flow of GV 14, GV 12 and bilateral BL 13 was obviously increased at immediate time of cupping removal （all P〈0.05）. Compared with immediate time of cupping removal, the blood flow of GV 14 at each time point after 20 rain of cupping removal, GV 12 at 10 min and 15 min after cupping removal, bilateral BL 13 at each time point after cupping removal was all obviously decreased （all P〈0.05）. The difference of blood flow of Shendao （神道 GV 11） and bilateral BL 15 before and after cupping therapy was not significantly different （all P〉0.05）. Conclusion The cupping therapy could adjust skin blood flow, which is more obvious near the cupping area.
文摘Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation group （45 cases） and a control group （45 cases）. Basic treatments selected according to corresponding stroke units were applied to both groups. Besides, scalp acupuncture at Dingnie Qianxiexian （MS 6, 顶颞前斜线）, Dingnie Houxiexian （MS 6, 顶颞前斜线） and Dingzhongxian （NS 5, 顶中线）, was applied in the treatment group. In the observation group, active and passive movement was carried out during the process of scalp acupuncture, and then needling plus bloodletting puncturing and cupping was applied. In the control group, only needling plus blood-letting puncturing and cupping was given. Therapeutic effects, pain scoring obtained by visual analogue scales （VAS）, FugI-Meyer and FugI-Meyer＇s scoring reflecting moving functions of upper limbs were made after 4 courses of treatments in both groups. Results The total effective rate was 95.5% and 91.1% in the observation group and control group, respectively, showing superiority of the former to the latter （P〈0.05）. After treatment, VAS scores were all obviously reduced in both groups （P〈0.01）, and the reduction in the former was significantly more than that in the latter （P〈0.01）. Moving functions of upper limbs shown by Fugl-Meyer＇s scoring were improved after 2 courses of treatment in both groups （P〈0.01）. The improvement was more obvious after 4 courses of treatment than that after 2 courses of treatment in both groups （P〈0.05）. After 4 courses of treatment, moving functions shown by FugI-Meyer＇s scoring were more remarkably improved in the observation group than those in the control group（t=3.9, P〈0.01）. Conclusion Both kinetic needling combined with needling plus blood-letting puncturing and cupping and simple needling plus blood-letting puncturing and cupping are effective in treating shoulder-hand syndrome after apoplexy, and the former is better than the latter.
文摘Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with medium-sized cups with a volume of 260 mL The randomly selected Xinshu（心俞 BL 15）on one side（37 cases） was given cupping treatment while that on the other side as the control.And Shenshu（肾俞 BL 23）（6 cases） was treated in the same way.The thermal infrared imager was used to record the changes in localized skin temperature before and after cupping（for 10 minutes）,and then comparison was made with that of the control side.Results After cupping,the localized skin temperature fell and then rose.When the cup was removed after retaining for 10 minutes,the localized skin temperature was（0.4±0.9） ℃（P=0.004） lower than that before cupping;10 minutes after cupping off,the localized skin temperature was（0.4±1.1） ℃（P=0.016） higher than that before cupping while（0.8±0.9） ℃ higher than that when cupping off.The skin surface temperature on the control side declined steadily.Conclusion After cupping treatment,the localized skin temperature fell and then rose while that of the control side declined steadily.It might be related to therapeutic effects.
