The published article titled“CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line”has been retracted from Oncology Research,Vol.24,No.6,2016,pp....The published article titled“CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line”has been retracted from Oncology Research,Vol.24,No.6,2016,pp.487–494.展开更多
Background Unverricht-Lundborg disease(ULD)is a rare autosomal recessive neurodegenerative disorder,often caused by biallelic promoter expansions of CSTB gene or,more rarely by point/indel variants.The best-known area...Background Unverricht-Lundborg disease(ULD)is a rare autosomal recessive neurodegenerative disorder,often caused by biallelic promoter expansions of CSTB gene or,more rarely by point/indel variants.The best-known area for ULD are the shores of the Baltic and Mediterranean Sea and few cases have been recorded from Asia.Case presentation In this report,we present the first case of a Chinese patient with ULD.The patient was a 21-yearold female with normal cognitive function.She developed nocturnal bilateral tonic–clonic seizures(BTCS)at age 8,with subsequent onset of myoclonic jerks along with ataxia at age 12.Myoclonic jerks were triggered by flashing lights and during menstrual periods.EEG recording showed multifocal spikes and sharp-waves,predominantly in bilateral occipital regions.Genetic testing revealed heterozygous compound variants for a novel indel variant(c.116-117 delAG)and the repeat expansion of CSTB gene.The refractory BTCS and myoclonic jerks showed remarkable response to low-dose(2 mg/day)perampanel treatment.After 24 months of follow-up,the patient remained seizurefree,but her myoclonic jerks recurred,which could be reduced by increasing the dosage of perampanel.Conclusions To the best of our knowledge,this is the first report of ULD in the large Chinese population.By comparison with homozygous promoter expansions,we found an earlier age of first symptom onset and more refractory BTCS of ULD patients with compound or homozygous point/indel variants.展开更多
目的:研究Cystatin B(CSTB)在肝癌组织中的表达及其与肝癌患者预后的相关性。方法:利用Realtime PCR和Wester n blot分别检测肝癌病人癌与癌旁组织中CSTB m R NA水平和蛋白的表达,进一步通过免疫组织化学法检测组织芯片中CSTB表达并分...目的:研究Cystatin B(CSTB)在肝癌组织中的表达及其与肝癌患者预后的相关性。方法:利用Realtime PCR和Wester n blot分别检测肝癌病人癌与癌旁组织中CSTB m R NA水平和蛋白的表达,进一步通过免疫组织化学法检测组织芯片中CSTB表达并分析其与肝癌临床特征的关系。采用KaplanMeier生存分析法分析CSTB与肝癌预后的关系。结果:在肝癌组织中CSTB m RNA水平和蛋白水平的表达明显高于癌旁(P<0.05);生存分析发现CSTB高表达肝癌患者比低表达的患者更易复发且总体生存期短(P值均小于0.05);CSTB的表达与年龄、性别、BCLC分级以及肿瘤大小差异均无统计学意义(P值均大于0.05),CSTB高表达的患者更容易形成门脉癌栓(P<0.05)。结论:CSTB在肝细胞癌组织中高表达,其表达水平与肝癌病人预后有关,有望成为肝癌预后指标。展开更多
文摘The published article titled“CSTB Downregulation Promotes Cell Proliferation and Migration and Suppresses Apoptosis in Gastric Cancer SGC-7901 Cell Line”has been retracted from Oncology Research,Vol.24,No.6,2016,pp.487–494.
基金supported by the grants from the National Natural Science Foundation of China 82101515.
文摘Background Unverricht-Lundborg disease(ULD)is a rare autosomal recessive neurodegenerative disorder,often caused by biallelic promoter expansions of CSTB gene or,more rarely by point/indel variants.The best-known area for ULD are the shores of the Baltic and Mediterranean Sea and few cases have been recorded from Asia.Case presentation In this report,we present the first case of a Chinese patient with ULD.The patient was a 21-yearold female with normal cognitive function.She developed nocturnal bilateral tonic–clonic seizures(BTCS)at age 8,with subsequent onset of myoclonic jerks along with ataxia at age 12.Myoclonic jerks were triggered by flashing lights and during menstrual periods.EEG recording showed multifocal spikes and sharp-waves,predominantly in bilateral occipital regions.Genetic testing revealed heterozygous compound variants for a novel indel variant(c.116-117 delAG)and the repeat expansion of CSTB gene.The refractory BTCS and myoclonic jerks showed remarkable response to low-dose(2 mg/day)perampanel treatment.After 24 months of follow-up,the patient remained seizurefree,but her myoclonic jerks recurred,which could be reduced by increasing the dosage of perampanel.Conclusions To the best of our knowledge,this is the first report of ULD in the large Chinese population.By comparison with homozygous promoter expansions,we found an earlier age of first symptom onset and more refractory BTCS of ULD patients with compound or homozygous point/indel variants.
文摘目的:研究Cystatin B(CSTB)在肝癌组织中的表达及其与肝癌患者预后的相关性。方法:利用Realtime PCR和Wester n blot分别检测肝癌病人癌与癌旁组织中CSTB m R NA水平和蛋白的表达,进一步通过免疫组织化学法检测组织芯片中CSTB表达并分析其与肝癌临床特征的关系。采用KaplanMeier生存分析法分析CSTB与肝癌预后的关系。结果:在肝癌组织中CSTB m RNA水平和蛋白水平的表达明显高于癌旁(P<0.05);生存分析发现CSTB高表达肝癌患者比低表达的患者更易复发且总体生存期短(P值均小于0.05);CSTB的表达与年龄、性别、BCLC分级以及肿瘤大小差异均无统计学意义(P值均大于0.05),CSTB高表达的患者更容易形成门脉癌栓(P<0.05)。结论:CSTB在肝细胞癌组织中高表达,其表达水平与肝癌病人预后有关,有望成为肝癌预后指标。
