Herein we report a nickel-catalyzed asymmetric two-component reductive aryl-acylation and arylcarbamoylation of aryl-iodide-tethered unactivated alkenes,which utilize ortho-pyridinyl esters and isocyanates as the elec...Herein we report a nickel-catalyzed asymmetric two-component reductive aryl-acylation and arylcarbamoylation of aryl-iodide-tethered unactivated alkenes,which utilize ortho-pyridinyl esters and isocyanates as the electrophilic acyl sources,respectively.Under the catalysis of a nickel–pyrox complex with zinc powder as the reductant,a variety of chiral indanes,indolines,and dihydrobenzofurans bearing a quaternary stereogenic center were prepared in moderate to high efficiency and good to excellent enantioselectivities.The utility of this method is demonstrated by various simple derivatizations of the attached carbonyl group,particularly the sequential benzylic oxidation and pinacol coupling,which provide a concise entry to the benzene-fused bicyclic bridged ring framework containing three challenging tetrasubstituted stereocenters in high stereocontrol.展开更多
The photocatalytic C–P bond formation reaction involving phosphoryl radicals provides a powerful strategy in phosphorus chemistry.However,the engagement of the phosphoryl radical-forming reaction without stoichiometr...The photocatalytic C–P bond formation reaction involving phosphoryl radicals provides a powerful strategy in phosphorus chemistry.However,the engagement of the phosphoryl radical-forming reaction without stoichiometric oxidants or radical initiators has proven difficult.展开更多
基金supported by start-up funds from the Young Scholar 1000 Talents Planthe National Natural Science Foundation of China(21772183 and 22071230)+2 种基金the Fundamental Research Funds for the Central Universities(WK2060190086)the Project Funded by China Postdoctoral Science Foundation(2020M682006)the University of Science and Technology of China.
文摘Herein we report a nickel-catalyzed asymmetric two-component reductive aryl-acylation and arylcarbamoylation of aryl-iodide-tethered unactivated alkenes,which utilize ortho-pyridinyl esters and isocyanates as the electrophilic acyl sources,respectively.Under the catalysis of a nickel–pyrox complex with zinc powder as the reductant,a variety of chiral indanes,indolines,and dihydrobenzofurans bearing a quaternary stereogenic center were prepared in moderate to high efficiency and good to excellent enantioselectivities.The utility of this method is demonstrated by various simple derivatizations of the attached carbonyl group,particularly the sequential benzylic oxidation and pinacol coupling,which provide a concise entry to the benzene-fused bicyclic bridged ring framework containing three challenging tetrasubstituted stereocenters in high stereocontrol.
基金support from the National Natural Science Foundation of China(nos.22088102,21933007,and 22193013)the Ministry of Science and Technology of China(nos.2017YFA0206903,2021YFA1500102,and 2021YFA1500802)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Science(no.XDB17000000)the Key Research Program of Frontier Sciences of the Chinese Academy of Science(no.QYZDY-SSW-JSC029).
文摘The photocatalytic C–P bond formation reaction involving phosphoryl radicals provides a powerful strategy in phosphorus chemistry.However,the engagement of the phosphoryl radical-forming reaction without stoichiometric oxidants or radical initiators has proven difficult.
