Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analys...Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analysis was performed using data and urine samples from 70 pregnant women in their third trimester recruited at Qujing Central Hospital.Urinary BPA was measured by HPLC-MS/MS.Participants were stratified into high and low BPA exposure groups based on the median concentration.Results:BPA was detected in all samples(100%)with a median concentration of 2.41μg/L(IQR:0.68-4.96).The high BPA exposure group(≥2.41μg/L)had a significantly higher proportion of gestational diabetes mellitus(GDM)(42.9%vs.17.1%,p=0.021)and a lower median fetal birth weight(3250 g vs.3450 g,p=0.048)compared to the low exposure group.Conclusion:This pilot study reveals ubiquitous BPA exposure in pregnant women from Northeastern Yunnan.The observed preliminary associations with GDM and reduced fetal birth weight warrant further investigation in larger,longitudinal studies.展开更多
Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentrat...Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.展开更多
Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Fa...Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.展开更多
We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In...We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In two complementary experiments,the use of photographs to estimate cross-sectional areas was first validated,then the use of a caliper and diameter tape was computer-simulated.The results indicated that the photographic method offers high precision,with mean relative errors below 0.1%,minimal deviation,and no significant bias,and the traditional methods led to substantial and systematic errors,with deviations from circularity and convexity significantly increasing the errors in area estimation.展开更多
With the increasing and refined applications of silicone rubber devices in the biomedical field,it is of great significance to accurately describe and predict the mechanical behavior of them under large deformation.Th...With the increasing and refined applications of silicone rubber devices in the biomedical field,it is of great significance to accurately describe and predict the mechanical behavior of them under large deformation.This paper finds that after con-sidering the influence of higher-order shear strain on the normal stress,the Poynting effect in ribbed silicone rubber tubes with certain cross-sectional shapes exhibits a new phenomenon―a non-monotonic trend between axial deformation and twist angle.This paper develops a nonlinear finite element program for simulating large deformations of hyperelastic materials,and studies the Poynting effect in ribbed circular tubes of twisted silicone rubber.The results show that in the ribbed circular tubes with a porosity between 12% and 40%(with the number of ribs ranging from 12 to 26),there appears a normal to reverse conversion of the Poynting effect,that is,the axial extension ratio first decreases and then increases during a monotonic loading process,indicating that the influence of higher-order shear strain on normal stress cannot be ignored when the cross-sectional shape is complex.Especially in ribbed circular tubes with about 20% porosity,a substantial change of axial normal strain from−0.035% to 0.035% can be achieved within a twist angle range of 180°.Based on this,the quantitative influence of higher-order shear strain on normal stress is studied.These research results provide a theoretical basis for accurately controlling the axial expansion and contraction of twisted parts and indicate that a normal to reverse conversion of the Poynting effect can be implemented by designing the cross-sectional shape under certain conditions.展开更多
Chronic kidney disease(CKD)is a recognized global public health burden affecting over 15%of the general population[1].By 2040,CKD is expected to become the fifth-leading cause of death in the world[2].The neutrophil-t...Chronic kidney disease(CKD)is a recognized global public health burden affecting over 15%of the general population[1].By 2040,CKD is expected to become the fifth-leading cause of death in the world[2].The neutrophil-to-lymphocyte ratio(NLR)indicates local or systemic inflammation status.The NLR has been demonstrated to exhibit predictive value in various pathological conditions,including—but not limited to—pancreatic cancer,as well as macrovascular and microvascular diseases,and sepsis[3,4].展开更多
Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between ...Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.展开更多
Two new size factors of cross-section hollow coefficient and bending degree are introduced to reveal the size effect of bending forming of bimetallic composite tube.Hollow coefficient and bending degree can limit the ...Two new size factors of cross-section hollow coefficient and bending degree are introduced to reveal the size effect of bending forming of bimetallic composite tube.Hollow coefficient and bending degree can limit the commonly used bent tube to the size description range of(0,2.00).The evolution laws of the cross-section distortion forms in the hollow coefficient-bending degree interval are revealed as well as the action of the mandrel-cores on the size effect.Results show the mandrel-cores filling can expand the forming limit of the bent tube,but also bring two other forming defects of wrinkle and rupture.The identification factor(hollow coefficient multiply bending degree)provides a method for querying the cross-section distortion forms of all composite bending tubes.In the identification factor interval(0,1.00),the distribution area of bending forming defects of the composite tube is continuous.The thin-walled composite bending tube collapses when identification factor in(0,0.39),wrinkles when identification factor in[0.39,0.50),and ruptures when identification factor in[0.50,1.00).The mathematical model of size effect is derived,by which the average cross-section distortion rate is found to distribute like a radial leaf in the hollow coefficient-bending degree qualified forming space.The best forming zone is hollow coefficient 0.46-0.68,and bending degree 0.25-0.47.展开更多
The umbilical,a key component in offshore energy extraction,plays a vital role in ensuring the stable operation of the entire production system.The extensive variety of cross-sectional components creates highly comple...The umbilical,a key component in offshore energy extraction,plays a vital role in ensuring the stable operation of the entire production system.The extensive variety of cross-sectional components creates highly complex layout combinations.Furthermore,due to constraints in component quantity and geometry within the cross-sectional layout,filler bodies must be incorporated to maintain cross-section performance.Conventional design approaches based on manual experience suffer from inefficiency,high variability,and difficulties in quantification.This paper presents a multi-level automatic filling optimization design method for umbilical cross-sectional layouts to address these limitations.Initially,the research establishes a multi-objective optimization model that considers compactness,balance,and wear resistance of the cross-section,employing an enhanced genetic algorithm to achieve a near-optimal layout.Subsequently,the study implements an image processing-based vacancy detection technique to accurately identify cross-sectional gaps.To manage the variability and diversity of these vacant regions,the research introduces a multi-level filling method that strategically selects and places filler bodies of varying dimensions,overcoming the constraints of uniform-size fillers.Additionally,the method incorporates a hierarchical strategy that subdivides the complex cross-section into multiple layers,enabling layer-by-layer optimization and filling.This approach reduces manufac-turing equipment requirements while ensuring practical production process feasibility.The methodology is validated through a specific umbilical case study.The results demonstrate improvements in compactness,balance,and wear resistance compared with the initial cross-section,offering novel insights and valuable references for filler design in umbilical cross-sections.展开更多
OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which...OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.展开更多
Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess...Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.展开更多
In this companion paper, flow patterns in the upstream and downstream tubes of a sudden-expansion cross-section (SECS) in a vertical straight pipe were presented. The effect of SECS on flow patterns upstream and down...In this companion paper, flow patterns in the upstream and downstream tubes of a sudden-expansion cross-section (SECS) in a vertical straight pipe were presented. The effect of SECS on flow patterns upstream and downstream was analyzed by comparing with flow patterns in uniform cross-section vertical tubes. It is found the effect is great. There exist great instabilities of two-phase flow in the neighboring areas of the SECS both downstream and upstream.展开更多
To investigate the effects of the maximum principal stress direction(θ)and cross-section shape on the failure characteristics of sandstone,true-triaxial compression experiments were conducted using cubic samples with...To investigate the effects of the maximum principal stress direction(θ)and cross-section shape on the failure characteristics of sandstone,true-triaxial compression experiments were conducted using cubic samples with rectangular,circular,and D-shaped holes.Asθincreases from 0°to 60°in the rectangular hole,the left failure location shifts from the left corner to the left sidewall,the left corner,and then the floor,while the right failure location shifts from the right corner to the right sidewall,right roof corner,and then the roof.Furthermore,the initial failure vertical stress first decreases and then increases.In comparison,the failure severity in the rectangular hole decreases for variousθvalues as 30°>45°>60°>0°.With increasingθ,the fractal dimension(D)of rock slices first increases and then decreases.For the rectangular and D-shaped holes,whenθ=0°,30°,and 90°,D for the rectangular hole is less than that of the D-shaped hole.Whenθ=45°and 60°,D for the rectangular hole is greater than that of the D-shaped hole.Theoretical analysis indicates that the stress concentration at the rectangular and D-shaped corners is greater than the other areas.The failure location rotates with the rotation ofθ,and the failure occurs on the side with a high concentration of compressive stress,while the side with the tensile and compressive stresses remains relatively stable.Therefore,the fundamental reason for the rotation of failure location is the rotation of stress concentration,and the external influencing factor is the rotation ofθ.展开更多
In order to study the influence of die combination on continuous variable cross-section direct extrusion （CVCDE） in the extrusion process, the accumulative strain formula is derived, and it can be known that the ext...In order to study the influence of die combination on continuous variable cross-section direct extrusion （CVCDE） in the extrusion process, the accumulative strain formula is derived, and it can be known that the extrusion ratio of various stages directly determines the size of corresponding stage strain by formula. In this paper, as an example of the two interim dies, three die combinations of different angles and extrusion ratio are designed. Aviation magnesium alloy ZM6 is studied, and the results show that dynamic recrystallization is even more complete when continuous shear deformation occurs, so that the refinement and homogenization of microstructure are obtained. By the use of different die combinations, the accumulative strain increases under the conditions of same total extrusion ratio. Thus, the refined crystalline strengthening effect of extrusion deformation can be further analyzed. Due to the dead-zone defects, the actual accumulative strain decreases significantly and the effect of microstructure and performance improvements also decreases with it. Therefore, the optimal design of die combination is the key to the process and product of CVCDE, which provides a scientific basis for the development of severe plastic deformation.展开更多
Flow patterns upstream and downstream of a sudden-contraction cross-section in a vertical straight pipe were presented. By comparing with flow patterns in uniform cross-section vertical tubes, the effect of the sudde...Flow patterns upstream and downstream of a sudden-contraction cross-section in a vertical straight pipe were presented. By comparing with flow patterns in uniform cross-section vertical tubes, the effect of the sudden change in pipe diameter on flow patterns was analyzed. Flow pattern transition mechanisms were discussed and transition criteria for flow pattern transitions were deduced accordingly using the dimensional analysis.展开更多
The coconut structure exhibits inherent impact resistance,with the macroscopically ordered distribution of variable crosssection fibers in its husk playing a crucial role in stress wave propagation and scaling.Inspire...The coconut structure exhibits inherent impact resistance,with the macroscopically ordered distribution of variable crosssection fibers in its husk playing a crucial role in stress wave propagation and scaling.Inspired by the natural structure and fibers,this study proposes a stress wave propagation model for a variable cross-section bar considering viscous effects.A theoretical model for stress wave propagation in a fusiform-shaped bar with variable cross-section is established,elucidating the stress wave scaling effect observed in coconut fibers.Additionally,a quasi-one-dimensional method for analyzing and measuring stress wave propagation is introduced,and an experimental setup is assembled.Experimental validation of the stress wave scaling effect confirms the theory’s accuracy for stress wave scaling in variable cross-section bars.This research provides theoretical guidance and measurement methods for the design of space landers,automobile anti-collision beams,stress wave collectors,and scalers,as well as for impact testing of macro and micro materials and the design of sustainable plant-based materials for impact protection.展开更多
This paper presents the fully differential cross sections （FDCS） for 102eV electron impact single ionization of helium for both the coplanar and perpendicular plane asymmetric geometries within the framework of dyna...This paper presents the fully differential cross sections （FDCS） for 102eV electron impact single ionization of helium for both the coplanar and perpendicular plane asymmetric geometries within the framework of dynamically screened three-Coulomb-wave theory. Comparisons are made with the experimental data and those of the three-Coulomb wave function model and second-order distorted-wave Born method. The angular distribution and relative heights of the present FDCS is found to be in very good agreement with the experimental data in the perpendicular plane geometry. It is shown that dynamical screening effects are significant in this geometry. Three-body coupling is expected to be weak in the coplanar geometry, although the precise absolute value of the cross section is still sensitive to the interaction details.展开更多
In this article,we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame,taking into account the Aharonov–Bohm(AB)effect and a uniform magnetic field.Our analysis entails the de...In this article,we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame,taking into account the Aharonov–Bohm(AB)effect and a uniform magnetic field.Our analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the system.Solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions,providing a clear expression for the energy levels.Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties.Specifically,we evaluate the photoionization cross-section with and without the effects of rotation.To elucidate the impact of rotation on the photoionization process of the system,we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.展开更多
Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a kno...Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issues/topics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.展开更多
A train body's cross-sectional shape has a significant impact on aerodynamic drag and operational safety in high-speed trains(HSTs).This study extracts five design variables from a real-world HST body:height,width...A train body's cross-sectional shape has a significant impact on aerodynamic drag and operational safety in high-speed trains(HSTs).This study extracts five design variables from a real-world HST body:height,width,side arc radius,arc radius at the connection between the side and the roof,and arc radius at the connection between the side and the train's bottom.The cross-validated Kriging surrogate model and the genetic algorithm are used to perform two types of aerodynamic optimization,with the cross-sectional area as a constraint.Cross-sectional shapes are optimized in both windless and windy conditions.Numerical results indicate that in a windless environment,the aerodynamic drag coefficient of the whole train is reduced by 2.4%;in a windy condition,the aerodynamic drag coefficient of the entire vehicle is reduced by 2.4%,and the aerodynamic lateral force of the leading car is reduced by 37.8%.These suggest that a flat and wide shape helps to reduce not only overall aerodynamic drag in a windless environment but also aerodynamic load in a windy environment,which can be accomplished by reducing the area of the side wall and top region,lowering the train body's height,increasing its width,and lowering the radius of the side and top arcs.展开更多
文摘Objective:To assess prenatal Bisphenol A(BPA)exposure levels and explore their preliminary associations with maternal and fetal characteristics in a population from Northeastern Yunnan.Methods:A cross-sectional analysis was performed using data and urine samples from 70 pregnant women in their third trimester recruited at Qujing Central Hospital.Urinary BPA was measured by HPLC-MS/MS.Participants were stratified into high and low BPA exposure groups based on the median concentration.Results:BPA was detected in all samples(100%)with a median concentration of 2.41μg/L(IQR:0.68-4.96).The high BPA exposure group(≥2.41μg/L)had a significantly higher proportion of gestational diabetes mellitus(GDM)(42.9%vs.17.1%,p=0.021)and a lower median fetal birth weight(3250 g vs.3450 g,p=0.048)compared to the low exposure group.Conclusion:This pilot study reveals ubiquitous BPA exposure in pregnant women from Northeastern Yunnan.The observed preliminary associations with GDM and reduced fetal birth weight warrant further investigation in larger,longitudinal studies.
基金supported by the National Key Research and Development Program of China(Grant No.2023YFB3710805).
文摘Ultra-high-strength aluminumalloy profile is an ideal choice for aerospace structuralmaterials due to its excellent specific strength and corrosion resistance.However,issues such as uneven metal flow,stress concentration,and forming defects are prone to occur during their extrusion.This study focuses on an Al-Zn-Mg-Cu ultra-high-strength aluminum alloy profile with a double-U,multi-cavity thin-walled structure.Firstly,hot compression experiments were conducted at temperatures of 350○C,400○C,and 450○C,with strain rates of 0.01 and 1.0 s^(−1),to investigate the plastic deformation behavior of the material.Subsequently,a 3D coupled thermo-mechanical extrusion simulation model was established using Deform-3D to systematically analyze the influence of die structure and process parameters on metal flow velocity,effective stress/strain,and temperature distribution.The simulation revealed significant velocity differences,stress concentration,and uneven temperature distribution.Key parameters,including mesh density,extrusion ratio,die fillet,and bearing length,were optimized through full-factorial experiments.This optimization,combined with a stepped flow-guiding die design,effectively improved the metal flow pattern during extrusion.Trial production based on both the initial and optimized parameters were carried out.A comparative analysis demonstrates that the optimized scheme results in a final profile whose cross-section matches the target design closely,with complete filling of complex features and no obvious forming defects.This research provides a valuable reference for the extrusion process optimization and die design of complex-section profiles made from ultra-high-strength aluminum alloys.
基金supported by the National Natural Science Foundation of China(82341245,82371491)the Chinese Central Government(Key Project of Public Health Program)the National Key Research and Development Program of China(2018YFC1311706,2018YFC1311702)。
文摘Objective This study aimed to determine the temporal trends in sleep duration among Chinese adults.Methods In this series of repeated nationally representative cross-sectional surveys(China Chronic Disease and Risk Factors Surveillance)conducted between 2010 and 2018,a total of 645,420 adult participants(97,741 in 2010;175,749 in 2013;187,777 in 2015;and 184,153 in 2018)were included in the trend analysis.Linear and logistic regression models were utilized to assess trends in sleep duration.Results In 2018,the estimated overall mean sleep duration among the Chinese adult population was7.58(SD,1.45)hours per day,with no significant trend from 2010.A significant increase in short sleep duration(≤6 hours)was observed in the total population,from 15.3%(95%CI:14.1%–16.5%)in 2010 to18.5%(95%CI:17.7%–19.3%)in 2018(P<0.001).Similarly,the trend in long sleep duration(>9 hours)was also significant,increasing in weighted prevalence from 7.2%(95%CI:6.3%–8.1%)in 2010 to 9.0%(95%CI:8.2%–9.9%)in 2018(P<0.001).Conclusion The prevalence of both short and long sleep durations significantly increased among Chinese adults from 2010 to 2018,highlighting the urgency of health initiatives to promote optimal sleep duration in China.
文摘We investigated the impact of convexity and isoperimetric deficits on the accuracy of sectional area estimates of tree stems using traditional methods(caliper,tape,formulas based on stem diameter and circumference).In two complementary experiments,the use of photographs to estimate cross-sectional areas was first validated,then the use of a caliper and diameter tape was computer-simulated.The results indicated that the photographic method offers high precision,with mean relative errors below 0.1%,minimal deviation,and no significant bias,and the traditional methods led to substantial and systematic errors,with deviations from circularity and convexity significantly increasing the errors in area estimation.
基金supported by the National Natural Science Foundation of China(Grant Nos.52009107 and 11972285)the Youth Innovation Team Project of Shaanxi Provincial Department of Education(Grant No.21JP079).
文摘With the increasing and refined applications of silicone rubber devices in the biomedical field,it is of great significance to accurately describe and predict the mechanical behavior of them under large deformation.This paper finds that after con-sidering the influence of higher-order shear strain on the normal stress,the Poynting effect in ribbed silicone rubber tubes with certain cross-sectional shapes exhibits a new phenomenon―a non-monotonic trend between axial deformation and twist angle.This paper develops a nonlinear finite element program for simulating large deformations of hyperelastic materials,and studies the Poynting effect in ribbed circular tubes of twisted silicone rubber.The results show that in the ribbed circular tubes with a porosity between 12% and 40%(with the number of ribs ranging from 12 to 26),there appears a normal to reverse conversion of the Poynting effect,that is,the axial extension ratio first decreases and then increases during a monotonic loading process,indicating that the influence of higher-order shear strain on normal stress cannot be ignored when the cross-sectional shape is complex.Especially in ribbed circular tubes with about 20% porosity,a substantial change of axial normal strain from−0.035% to 0.035% can be achieved within a twist angle range of 180°.Based on this,the quantitative influence of higher-order shear strain on normal stress is studied.These research results provide a theoretical basis for accurately controlling the axial expansion and contraction of twisted parts and indicate that a normal to reverse conversion of the Poynting effect can be implemented by designing the cross-sectional shape under certain conditions.
基金supported by the Hunan Province Key Field R&D Program(Grant no.2020SK2097)Key Research and Development Project of Hunan Province(Grant no.2020SK2089)+1 种基金the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(Grant no.YX202212)Fundamental Research Funds for the Central Universities of Central South University(Grant No.2023ZZTS0839).
文摘Chronic kidney disease(CKD)is a recognized global public health burden affecting over 15%of the general population[1].By 2040,CKD is expected to become the fifth-leading cause of death in the world[2].The neutrophil-to-lymphocyte ratio(NLR)indicates local or systemic inflammation status.The NLR has been demonstrated to exhibit predictive value in various pathological conditions,including—but not limited to—pancreatic cancer,as well as macrovascular and microvascular diseases,and sepsis[3,4].
文摘Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains unknown.This study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to 2018.Subgroup and sensitivity analyses were conducted to test the robustness of the results.Results This study included 29,928 adult participants,of which 1,165 participants had a history of stroke.Logistic regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup analyses.Further investigation of the NHHR may enhance our understanding of stroke prevention and treatment.Conclusion Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for stroke.Timely intervention and management of the NHHR may effectively mitigate stroke occurrence.Prospective studies are required to validate this association and further explore the underlying biological mechanisms.
基金co-supported by the National Natural Science Foundation of China(Nos.51601070 and 51875263)the Open Project of Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology,China(No.PEMT202102)the Natural Science Foundation of Jiangsu Province,China(No.BK20181447)。
文摘Two new size factors of cross-section hollow coefficient and bending degree are introduced to reveal the size effect of bending forming of bimetallic composite tube.Hollow coefficient and bending degree can limit the commonly used bent tube to the size description range of(0,2.00).The evolution laws of the cross-section distortion forms in the hollow coefficient-bending degree interval are revealed as well as the action of the mandrel-cores on the size effect.Results show the mandrel-cores filling can expand the forming limit of the bent tube,but also bring two other forming defects of wrinkle and rupture.The identification factor(hollow coefficient multiply bending degree)provides a method for querying the cross-section distortion forms of all composite bending tubes.In the identification factor interval(0,1.00),the distribution area of bending forming defects of the composite tube is continuous.The thin-walled composite bending tube collapses when identification factor in(0,0.39),wrinkles when identification factor in[0.39,0.50),and ruptures when identification factor in[0.50,1.00).The mathematical model of size effect is derived,by which the average cross-section distortion rate is found to distribute like a radial leaf in the hollow coefficient-bending degree qualified forming space.The best forming zone is hollow coefficient 0.46-0.68,and bending degree 0.25-0.47.
基金financially supported by Guangdong Province Basic and Applied Basic Research Fund Project(Grant No.2022B1515250009)Liaoning Provincial Natural Science Foundation-Doctoral Research Start-up Fund Project(Grant No.2024-BSBA-05)+1 种基金Major Science and Technology Innovation Project in Shandong Province(Grant No.2024CXGC010803)the National Natural Science Foundation of China(Grant Nos.52271269 and 12302147).
文摘The umbilical,a key component in offshore energy extraction,plays a vital role in ensuring the stable operation of the entire production system.The extensive variety of cross-sectional components creates highly complex layout combinations.Furthermore,due to constraints in component quantity and geometry within the cross-sectional layout,filler bodies must be incorporated to maintain cross-section performance.Conventional design approaches based on manual experience suffer from inefficiency,high variability,and difficulties in quantification.This paper presents a multi-level automatic filling optimization design method for umbilical cross-sectional layouts to address these limitations.Initially,the research establishes a multi-objective optimization model that considers compactness,balance,and wear resistance of the cross-section,employing an enhanced genetic algorithm to achieve a near-optimal layout.Subsequently,the study implements an image processing-based vacancy detection technique to accurately identify cross-sectional gaps.To manage the variability and diversity of these vacant regions,the research introduces a multi-level filling method that strategically selects and places filler bodies of varying dimensions,overcoming the constraints of uniform-size fillers.Additionally,the method incorporates a hierarchical strategy that subdivides the complex cross-section into multiple layers,enabling layer-by-layer optimization and filling.This approach reduces manufac-turing equipment requirements while ensuring practical production process feasibility.The methodology is validated through a specific umbilical case study.The results demonstrate improvements in compactness,balance,and wear resistance compared with the initial cross-section,offering novel insights and valuable references for filler design in umbilical cross-sections.
基金National Nonprofit Institute Research Grant for the Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences:Mechanism of Regulating Phlegm-Dampness Constitution to Prevent Metabolic Diseases based on Gut Microbiota-host DNA Methylation(No.YZ-202151)。
文摘OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.
基金supported by an Innovation Fund for Medical Sciences of the Chinese Academy of Medical Sciences (Grant No.2019-I2M-2-007).
文摘Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.
基金the National Natural Science Foundation of China (No. 59236130).
文摘In this companion paper, flow patterns in the upstream and downstream tubes of a sudden-expansion cross-section (SECS) in a vertical straight pipe were presented. The effect of SECS on flow patterns upstream and downstream was analyzed by comparing with flow patterns in uniform cross-section vertical tubes. It is found the effect is great. There exist great instabilities of two-phase flow in the neighboring areas of the SECS both downstream and upstream.
基金supported by the National Natural Science Foundation of China (Grant Nos.52304227 and 52104133)Scientific and Technological Research Platform for Disaster Prevention and Control of Deep Coal Mining (Anhui University of Science and Technology) (Grant No.DPDCM2208).
文摘To investigate the effects of the maximum principal stress direction(θ)and cross-section shape on the failure characteristics of sandstone,true-triaxial compression experiments were conducted using cubic samples with rectangular,circular,and D-shaped holes.Asθincreases from 0°to 60°in the rectangular hole,the left failure location shifts from the left corner to the left sidewall,the left corner,and then the floor,while the right failure location shifts from the right corner to the right sidewall,right roof corner,and then the roof.Furthermore,the initial failure vertical stress first decreases and then increases.In comparison,the failure severity in the rectangular hole decreases for variousθvalues as 30°>45°>60°>0°.With increasingθ,the fractal dimension(D)of rock slices first increases and then decreases.For the rectangular and D-shaped holes,whenθ=0°,30°,and 90°,D for the rectangular hole is less than that of the D-shaped hole.Whenθ=45°and 60°,D for the rectangular hole is greater than that of the D-shaped hole.Theoretical analysis indicates that the stress concentration at the rectangular and D-shaped corners is greater than the other areas.The failure location rotates with the rotation ofθ,and the failure occurs on the side with a high concentration of compressive stress,while the side with the tensile and compressive stresses remains relatively stable.Therefore,the fundamental reason for the rotation of failure location is the rotation of stress concentration,and the external influencing factor is the rotation ofθ.
基金financially supported by the National Natural Science Foundation of China(No.51205094)
文摘In order to study the influence of die combination on continuous variable cross-section direct extrusion （CVCDE） in the extrusion process, the accumulative strain formula is derived, and it can be known that the extrusion ratio of various stages directly determines the size of corresponding stage strain by formula. In this paper, as an example of the two interim dies, three die combinations of different angles and extrusion ratio are designed. Aviation magnesium alloy ZM6 is studied, and the results show that dynamic recrystallization is even more complete when continuous shear deformation occurs, so that the refinement and homogenization of microstructure are obtained. By the use of different die combinations, the accumulative strain increases under the conditions of same total extrusion ratio. Thus, the refined crystalline strengthening effect of extrusion deformation can be further analyzed. Due to the dead-zone defects, the actual accumulative strain decreases significantly and the effect of microstructure and performance improvements also decreases with it. Therefore, the optimal design of die combination is the key to the process and product of CVCDE, which provides a scientific basis for the development of severe plastic deformation.
基金the National Natrual Science Foundation of China (No. 59236130).
文摘Flow patterns upstream and downstream of a sudden-contraction cross-section in a vertical straight pipe were presented. By comparing with flow patterns in uniform cross-section vertical tubes, the effect of the sudden change in pipe diameter on flow patterns was analyzed. Flow pattern transition mechanisms were discussed and transition criteria for flow pattern transitions were deduced accordingly using the dimensional analysis.
基金supported by the National Natural Science Foundation of China(Grant Nos.11922206 and 11832011)theMajor Project of Science and Technology Innovation 2030(Grant No.2021ZD0113100)the 111 Project(Grant No.B16015).
文摘The coconut structure exhibits inherent impact resistance,with the macroscopically ordered distribution of variable crosssection fibers in its husk playing a crucial role in stress wave propagation and scaling.Inspired by the natural structure and fibers,this study proposes a stress wave propagation model for a variable cross-section bar considering viscous effects.A theoretical model for stress wave propagation in a fusiform-shaped bar with variable cross-section is established,elucidating the stress wave scaling effect observed in coconut fibers.Additionally,a quasi-one-dimensional method for analyzing and measuring stress wave propagation is introduced,and an experimental setup is assembled.Experimental validation of the stress wave scaling effect confirms the theory’s accuracy for stress wave scaling in variable cross-section bars.This research provides theoretical guidance and measurement methods for the design of space landers,automobile anti-collision beams,stress wave collectors,and scalers,as well as for impact testing of macro and micro materials and the design of sustainable plant-based materials for impact protection.
基金Project supported by the Natural Science Foundation of Shanxi Province,China (Grant No 20051008)the Science Foundation for Returnee of Shanxi Province of China (Grant No 02-16)
文摘This paper presents the fully differential cross sections （FDCS） for 102eV electron impact single ionization of helium for both the coplanar and perpendicular plane asymmetric geometries within the framework of dynamically screened three-Coulomb-wave theory. Comparisons are made with the experimental data and those of the three-Coulomb wave function model and second-order distorted-wave Born method. The angular distribution and relative heights of the present FDCS is found to be in very good agreement with the experimental data in the perpendicular plane geometry. It is shown that dynamical screening effects are significant in this geometry. Three-body coupling is expected to be weak in the coplanar geometry, although the precise absolute value of the cross section is still sensitive to the interaction details.
基金partially supported by the Brazilian agencies CAPES,CNPqthe support from the grants CNPq/306308/2022-3+3 种基金CNPq Grant No.153635/2024-0FAPEMAFAPEMA/UNIVERSAL-06395/22,FAPEMA/APP-12256/22financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nível Superior—Brasil(CAPES)—Finance Code 001。
文摘In this article,we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame,taking into account the Aharonov–Bohm(AB)effect and a uniform magnetic field.Our analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the system.Solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions,providing a clear expression for the energy levels.Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties.Specifically,we evaluate the photoionization cross-section with and without the effects of rotation.To elucidate the impact of rotation on the photoionization process of the system,we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202006)the High-level traditional Chinese medicine key subject construction project of National Administration of Traditional Chinese Medicine-Evidence-based Traditional Chinese Medicine(ZYYZDXK-2023249).
文摘Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issues/topics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.
基金Project(RE-KRIS/FF67/020)supported by the King Mongkut's Institute of Technology Ladkrabang(Fundamental Fund by National Science Research and Innovation Fund(NSRF)),Thailand。
文摘A train body's cross-sectional shape has a significant impact on aerodynamic drag and operational safety in high-speed trains(HSTs).This study extracts five design variables from a real-world HST body:height,width,side arc radius,arc radius at the connection between the side and the roof,and arc radius at the connection between the side and the train's bottom.The cross-validated Kriging surrogate model and the genetic algorithm are used to perform two types of aerodynamic optimization,with the cross-sectional area as a constraint.Cross-sectional shapes are optimized in both windless and windy conditions.Numerical results indicate that in a windless environment,the aerodynamic drag coefficient of the whole train is reduced by 2.4%;in a windy condition,the aerodynamic drag coefficient of the entire vehicle is reduced by 2.4%,and the aerodynamic lateral force of the leading car is reduced by 37.8%.These suggest that a flat and wide shape helps to reduce not only overall aerodynamic drag in a windless environment but also aerodynamic load in a windy environment,which can be accomplished by reducing the area of the side wall and top region,lowering the train body's height,increasing its width,and lowering the radius of the side and top arcs.
