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Direct data domain approach to space-time adaptive processing 被引量:2
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作者 Wen Xiaoqin Han Chongzhao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第1期59-64,共6页
In non-homogeneous environment, traditional space-time adaptive processing doesn't effectively suppress interference and detect target, because the secondary data don' t exactly reflect the statistical characteristi... In non-homogeneous environment, traditional space-time adaptive processing doesn't effectively suppress interference and detect target, because the secondary data don' t exactly reflect the statistical characteristic of the range cell under test. A ravel methodology utilizing the direct data domain approach to space-time adaptive processing ( STAP ) in airbome radar non-homogeneous environments is presented. The deterministic least squares adaptive signal processing technique operates on a "snapshot-by-snapshot" basis to dethrone the adaptive adaptive weights for nulling interferences and estimating signal of interest (SOI). Furthermore, this approach eliminates the requirement for estimating the covariance through the data of neighboring range cell, which eliminates calculating the inverse of covariance, and can be implemented to operate in real-time. Simulation results illustrate the efficiency of interference suppression in non-homogeneous environment. 展开更多
关键词 space-time adaptive processing direct data domain interference suppression.
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A Novel Receiving Method for Baseband DSSS Signal based on Phase Domain Processing
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作者 Sha Xuejun Zhan Zongchao Tang Xun 《China Communications》 SCIE CSCD 2010年第1期57-64,共8页
In this paper, the phase characteristic disturbance model for baseband direct sequence spread spectrum (DSSS) signal in additive white Gaussian noise (AWGN) environment is established, and the probability density func... In this paper, the phase characteristic disturbance model for baseband direct sequence spread spectrum (DSSS) signal in additive white Gaussian noise (AWGN) environment is established, and the probability density function (PDF) of phase characteristic disturbance is obtained. Then a novel receiver model for baseband DSSS signal based on maximum likelihood (ML) criterion is proposed. The simulation results show that, comparing with correlation scheme, the performance of the proposed method for baseband DSSS signal is 1dB worse in AWGN environment. However, if there is narrow interference in the AWGN environment, the proposed method will show better performance up to 2.5dB, and it has good adaptive resistance to narrowband interference located in different frequency points. This method could be used as an alterative communication scheme for military circumstance when existing strong narrowband interference of various frequencies. 展开更多
关键词 PHASE domain processing PHASE characteristic DISTURBANCE ML criterion anti-narrow-band interference
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TIME DOMAIN PROCESSING MODE SPREAD SPECTRUM SYSTEM
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作者 何世平 《Journal of Electronics(China)》 1995年第3期276-283,共8页
The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this sy... The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this system is provided. The formula for calculating the probability of error of the system is given. The experimental results agree with the theoretical analysis. 展开更多
关键词 Time domain processing SPREAD SPECTRUM system STORAGE CORRELATOR
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Human Brain Microwave Imaging Signal Processing: Frequency Domain (S-parameters) to Time Domain Conversion
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作者 Kim Mey Chew Rubita Sudirman +2 位作者 Nasrul Humaimi Mahmood Norhudah Seman Ching Yee Yong 《Engineering(科研)》 2013年第5期31-36,共6页
The paper presents the microwave signal processing method using MATLAB based on the result of microwave imaging system simulation developed using Computer Simulation Technology (CST). The simulation system contains a ... The paper presents the microwave signal processing method using MATLAB based on the result of microwave imaging system simulation developed using Computer Simulation Technology (CST). The simulation system contains a transmitting/receiving antenna, human brain and a tumor inside the brain model. The source signal, microwave signal operates from 1 to 10 GHz. The generated scattering parameters (S-parameters) are in frequency domain form. This paper describes in detail regarding the signal conversion from frequency domain to time domain through proposed Inverse Fast Fourier Transform (IFFT) method as well as the noise filtering process. Peaks detection process was performed in order to identify the time delay of the reflection points at different Y-axis 展开更多
关键词 Microwave SIGNAL SIGNAL processing SCATTERING Parameters Time domain IFFT
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Building a Productive Domain-Specific Cloud for Big Data Processing and Analytics Service
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作者 Yuzhong Yan Mahsa Hanifi +1 位作者 Liqi Yi Lei Huang 《Journal of Computer and Communications》 2015年第5期107-117,共11页
Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open sour... Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open source frameworks in Cloud Computing for storing and processing big data in the scalable fashion. Spark is the latest parallel computing engine working together with Hadoop that exceeds MapReduce performance via its in-memory computing and high level programming features. In this paper, we present our design and implementation of a productive, domain-specific big data analytics cloud platform on top of Hadoop and Spark. To increase user’s productivity, we created a variety of data processing templates to simplify the programming efforts. We have conducted experiments for its productivity and performance with a few basic but representative data processing algorithms in the petroleum industry. Geophysicists can use the platform to productively design and implement scalable seismic data processing algorithms without handling the details of data management and the complexity of parallelism. The Cloud platform generates a complete data processing application based on user’s kernel program and simple configurations, allocates resources and executes it in parallel on top of Spark and Hadoop. 展开更多
关键词 BUILDING a Productive domain-Specific CLOUD for BIG Data processing and ANALYTICS SERVICE
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CPS Modeling of CNC Machine Tool Work Processes Using an Instruction-Domain Based Approach 被引量:19
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作者 Jihong Chen Jianzhong Yang +5 位作者 Huicheng Zhou Hua Xiang Zhihong Zhu Yesong Li Chen-Han Lee Guangda Xu 《Engineering》 SCIE EI 2015年第2期247-260,共14页
Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a C... Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a CNC machine tool is the main source of the big data on which a CPS model is established. In this work-process model, a method based on instruction domain is applied to analyze the electronic big data, and a quantitative description of the numerical control(NC) processes is built according to the G code of the processes. Utilizing the instruction domain, a work-process CPS model is established on the basis of the accurate, real-time mapping of the manufacturing tasks, resources, and status of the CNC machine tool. Using such models, case studies are conducted on intelligent-machining applications, such as the optimization of NC processing parameters and the health assurance of CNC machine tools. 展开更多
关键词 cyber-physical system (CPS) big data computer numerical control (CNC) machine tool electronic data of work processes instruction domain intelligent machining
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Infrared Image Target Segmentation Processing Based On Space-Time Combination 被引量:3
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作者 Chuanwen Liu 《通讯和计算机(中英文版)》 2006年第3期102-108,共7页
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Physiological signal processing in heart rate variability measurement:A focus on spectral analysis
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作者 Amin Gasmi 《Life Research》 2022年第4期36-45,共10页
Human physiological(biological)systems function in such a way that their complexity requires mathematical analysis.The functioning of the brain,heart and other parts are so complex to be easily comprehended.Under cond... Human physiological(biological)systems function in such a way that their complexity requires mathematical analysis.The functioning of the brain,heart and other parts are so complex to be easily comprehended.Under conditions of rest or work,the temporal distances of successive heartbeats are subject to fluctuations,thereby forming the basis of Heart Rate Variability(HRV).In normal conditions,the human is persistently exposed to highly changing and dynamic situational demands.With these demands in mind,HRV can,therefore,be considered as the human organism’s ability to cope with and adapt to continuous situational requirements,both physiologically and emotionally.Fast Fourier Transform(FFT)is used in various physiological signal processing,such as heart rate variability.FFT allows a spectral analysis of HRV and is great help in HRV analysis and interpretation. 展开更多
关键词 Fast Fourier Transform heart rate variability spectral analysis frequency domain physiological signals processing
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The Role of Combined OSR and SDF Method for Pre-Processing of Microarray Data that Accounts for Effective Denoising and Quantification
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作者 Jayakishan Meher Mukesh Kumar Raval +1 位作者 Pramod Kumar Meher Gananath Dash 《Journal of Signal and Information Processing》 2011年第3期190-195,共6页
Microarray data is inherently noisy due to the noise contaminated from various sources during the preparation of microarray slide and thus it greatly affects the accuracy of the gene expression. How to eliminate the e... Microarray data is inherently noisy due to the noise contaminated from various sources during the preparation of microarray slide and thus it greatly affects the accuracy of the gene expression. How to eliminate the effect of the noise constitutes a challenging problem in microarray analysis. Efficient denoising is often a necessary and the first step to be taken before the image data is analyzed to compensate for data corruption and for effective utilization for these data. Hence preprocessing of microarray image is an essential to eliminate the background noise in order to enhance the image quality and effective quantification. Existing denoising techniques based on transformed domain have been utilized for microarray noise reduction with their own limitations. The objective of this paper is to introduce novel preprocessing techniques such as optimized spatial resolution (OSR) and spatial domain filtering (SDF) for reduction of noise from microarray data and reduction of error during quantification process for estimating the microarray spots accurately to determine expression level of genes. Besides combined optimized spatial resolution and spatial filtering is proposed and found improved denoising of microarray data with effective quantification of spots. The proposed method has been validated in microarray images of gene expression profiles of Myeloid Leukemia using Stanford Microarray Database with various quality measures such as signal to noise ratio, peak signal to noise ratio, image fidelity, structural content, absolute average difference and correlation quality. It was observed by quantitative analysis that the proposed technique is more efficient for denoising the microarray image which enables to make it suitable for effective quantification. 展开更多
关键词 DENOISING MICROARRAY PRE-processing Quantification SPATIAL domain Filtering Optimized SPATIAL Resolution Quality Measures
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Domain adaptation method inspired by quantum convolutional neural network
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作者 Chunhui Wu Junhao Pei +2 位作者 Yihua Wu Anqi Zhang Shengmei Zhao 《Chinese Physics B》 2025年第7期185-195,共11页
Quantum machine learning is an important application of quantum computing in the era of noisy intermediate-scale quantum devices.Domain adaptation(DA)is an effective method for addressing the distribution discrepancy ... Quantum machine learning is an important application of quantum computing in the era of noisy intermediate-scale quantum devices.Domain adaptation(DA)is an effective method for addressing the distribution discrepancy problem between the training data and the real data when the neural network model is deployed.In this paper,we propose a variational quantum domain adaptation method inspired by the quantum convolutional neural network,named variational quantum domain adaptation(VQDA).The data are first uploaded by a‘quantum coding module',then the feature information is extracted by several‘quantum convolution layers'and‘quantum pooling layers',which is named‘Feature Extractor'.Subsequently,the labels and the domains of the samples are obtained by the‘quantum fully connected layer'.With a gradient reversal module,the trained‘Feature Extractor'can extract the features that cannot be distinguished from the source and target domains.The simulations on the local computer and IBM Quantum Experience(IBM Q)platform by Qiskit show the effectiveness of the proposed method.The results show that VQDA(with 8 quantum bits)has 91.46%average classification accuracy for DA task between MNIST→USPS(USPS→MNIST),achieves 91.16%average classification accuracy for gray-scale and color images(with 10 quantum bits),and has 69.25%average classification accuracy on the DA task for color images(also with 10 quantum bits).VQDA achieves a 9.14%improvement in average classification accuracy compared to its corresponding classical domain adaptation method with the same parameter scale for different DA tasks.Simultaneously,the parameters scale is reduced to 43%by using VQDA when both quantum and classical DA methods have similar classification accuracies. 展开更多
关键词 quantum image processing domain adaptation quantum convolutional neural network IBM quantum experience
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DNEFNET: Denoising and Frequency Domain Feature Enhancement Event Fusion Network for Image Deblurring
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作者 Kangkang Zhao Yaojie Chen Jianbo Li 《Computers, Materials & Continua》 2025年第7期745-762,共18页
Traditional cameras inevitably suffer from motion blur when facing high-speed moving objects.Event cameras,as high temporal resolution bionic cameras,record intensity changes in an asynchronous manner,and their record... Traditional cameras inevitably suffer from motion blur when facing high-speed moving objects.Event cameras,as high temporal resolution bionic cameras,record intensity changes in an asynchronous manner,and their recorded high temporal resolution information can effectively solve the problem of time information loss in motion blur.Existing event-based deblurring methods still face challenges when facing high-speed moving objects.We conducted an in-depth study of the imaging principle of event cameras.We found that the event stream contains excessive noise.The valid information is sparse.Invalid event features hinder the expression of valid features due to the uncertainty of the global threshold.To address this problem,a denoising-based long and short-term memory module(DTM)is designed in this paper.The DTM suppressed the original event information by noise reduction process.Invalid features in the event stream and solves the problem of sparse valid information in the event stream,and it also combines with the long short-term memory module(LSTM),which further enhances the event feature information in the time scale.In addition,through the in-depth understanding of the unique characteristics of event features,it is found that the high-frequency information recorded by event features does not effectively guide the fusion feature deblurring process in the spatial-domain-based feature processing,and for this reason,we introduce the residual fast fourier transform module(RES-FFT)to further enhance the high-frequency characteristics of the fusion features by performing the feature extraction of the fusion features from the perspective of the frequency domain.Ultimately,our proposed event image fusion network based on event denoising and frequency domain feature enhancement(DNEFNET)achieved Peak Signal-to-Noise Ratio(PSNR)/Structural Similarity Index Measure(SSIM)scores of 35.55/0.972 on the GoPro dataset and 38.27/0.975 on the REBlur dataset,achieving the state of the art(SOTA)effect. 展开更多
关键词 Image deblurring event camera DENOISING frequency domain Algorithm 1:DNEFNET image processing
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Simulation of pavement roughness based on time domain model 被引量:2
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作者 钮凯健 李昶 《Journal of Southeast University(English Edition)》 EI CAS 2010年第3期475-479,共5页
In order to describe pavement roughness more intuitively and effectively, a method of pavement roughness simulation, i.e., the stochastic sinusoidal wave, is introduced. The method is based on the primary idea that pa... In order to describe pavement roughness more intuitively and effectively, a method of pavement roughness simulation, i.e., the stochastic sinusoidal wave, is introduced. The method is based on the primary idea that pavement roughness is denoted as the sum of numerous sines or cosines with stochastic phases, and uses the discrete spectrum to approach the target stochastic process. It is a discrete numerical method used to simulate pavement roughness. According to a given pavement power spectral density (PSD) coefficient, under the condition that the character of displacement frequency based on the time domain model is in accordance with the given pavement surface spectrum, the pavement roughness is optimized to stochastic equivalent vibrations by computer simulation, and the curves that describe pavement roughness under each grade are obtained. The results show that the stochastic sinusoidal wave is suitable for simulation of measured pavement surface spectra based on the time domain model. The method of the stochastic sinusoidal wave is important to the research on vehicle ride comfort due to its rigorous mathematical derivation, extensive application range and intuitive simulation curve. Finally, a roughness index defined as the nominal roughness index (NRI) is introduced, and it has correlation with the PSD coefficient. 展开更多
关键词 pavement roughness stochastic sinusoidal wave stochastic process power spectral density (PSD) coefficient time domain nominal roughness index (NRI)
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基于深度学习的双域信息CT金属伪影抑制方法
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作者 海潮 田鑫 +4 位作者 张宏 谭大龙 何一新 孟凡勇 杨民 《北京航空航天大学学报》 北大核心 2026年第1期232-243,共12页
当CT扫描视野中出现金属时,重建图像不可避免地会产生金属伪影,严重影响图像质量。为了抑制金属伪影,提出一种新的深度学习CT金属伪影抑制(MAR)方法,结合正弦图域和图像域的双域信息,采用自适应最优阈值分割方法分割CT图像中的金属,并... 当CT扫描视野中出现金属时,重建图像不可避免地会产生金属伪影,严重影响图像质量。为了抑制金属伪影,提出一种新的深度学习CT金属伪影抑制(MAR)方法,结合正弦图域和图像域的双域信息,采用自适应最优阈值分割方法分割CT图像中的金属,并在正弦图中去除金属污染区域,使用线性插值(LI)初步修复缺失的金属区域,采用正弦图修补网络修复受金属污染的正弦图,利用编码器-解码器网络结构恢复缺失的图像信息。网络输出的正弦图经过滤波反投影(FBP)算法生成CT重建图像。对于初步校正后存在的正弦图信息不一致性问题,使用非局部细化网络在图像域进行修复,减少二次伪影产生。模拟和真实数据实验结果表明:所提方法能有效减少金属伪影,同时保留图像细节信息,显著提高重建图像质量。 展开更多
关键词 图像处理 深度学习 金属伪影抑制 双域信息 Pix2Pix 非局部细化网络
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图计算为科学计算加速
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作者 金海 《计算》 2026年第1期44-51,96,共9页
科学计算数据通常能够直接或间接表示为图结构且具有较强的稀疏性。图计算作为分析事物之间复杂关联关系的重要工具,能够有效支持科学计算领域中数据间稀疏关联关系分析,实现科学计算领域中海量稀疏数据的高效处理。然而,由于科学计算... 科学计算数据通常能够直接或间接表示为图结构且具有较强的稀疏性。图计算作为分析事物之间复杂关联关系的重要工具,能够有效支持科学计算领域中数据间稀疏关联关系分析,实现科学计算领域中海量稀疏数据的高效处理。然而,由于科学计算应用的复杂性,图计算驱动的科学计算面临着数据形态纷繁芜杂、处理手段多样和计算模式难适配等挑战。为此,本研究针对多个科学计算领域研究了面向科学计算的构图方法以及相应的图计算方法,通过图计算技术来高效支持各种科学计算应用的需求。通过在快速射电暴搜寻、RNA二级结构相似性分析以及高能物理实验径迹重建等多个科学计算领域进行了验证,探索了图计算为科学计算应用提供解决思路的新方法。 展开更多
关键词 稀疏数据处理 图计算 科学计算 构图方法 领域图算法 加速系统
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基于适配器技术的开放域问答及应用
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作者 宋才华 布力 +1 位作者 关兆雄 林钰杰 《华中师范大学学报(自然科学版)》 北大核心 2026年第1期10-17,共8页
开放域问答技术是自然语言处理领域的重要研究课题,通常采用编码器来学习自然语言问句和段落的密集表示,以进行语义匹配.现有的工作主要通过硬负例挖掘、知识蒸馏或预训练的方式来提高开放域问答系统的性能,但面临参数过多难以进行参数... 开放域问答技术是自然语言处理领域的重要研究课题,通常采用编码器来学习自然语言问句和段落的密集表示,以进行语义匹配.现有的工作主要通过硬负例挖掘、知识蒸馏或预训练的方式来提高开放域问答系统的性能,但面临参数过多难以进行参数高效学习以适应下游推理任务的需求.为了解决此问题,本文提出了一种基于适配器技术的参数高效学习的开放域问答算法(EPLA).首先,通过基于路由的令牌分配策略减少了编码候选片段的计算成本.其次,通过引入基于混合专家的适配器架构,在训练过程中冻结预训练模型的参数,只更新适配器、令牌分配器以及层归一化的参数.最后,通过强化学习的方式构建动态适配器模块,以获得最优的网络架构.验结果表明,EPLA在保持检索性能的同时,能够较大地提升开放域问答算法的效率. 展开更多
关键词 开放域问答 参数微调 预训练模型 自然语言处理
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多频激光通信网络信号谐振频率干扰检测方法
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作者 陈瑾瑾 李景景 刘利飞 《激光杂志》 北大核心 2026年第2期184-190,共7页
为实现对谐振频率干扰的准确检测,提出多频激光通信网络信号谐振频率干扰检测方法。采用提升小波变换算法去除多频激光通信网络信号中的干扰成分,提取对后续检测有用的信号,运用信道均衡技术的实时特性动态调整信号幅度和相位,使用时域... 为实现对谐振频率干扰的准确检测,提出多频激光通信网络信号谐振频率干扰检测方法。采用提升小波变换算法去除多频激光通信网络信号中的干扰成分,提取对后续检测有用的信号,运用信道均衡技术的实时特性动态调整信号幅度和相位,使用时域有限差分(FDTD)对信道均衡后的信号进行转换,经时域离散化和差分运算实现高保真转换,从前期处理信号中精准提取特征向量,再利用孪生网络识别模型的强大能力分析比对,准确识别出谐振频率干扰。实验结果表明,所提方法能够有效处理多频激光通信网络的信号无用数据并保证信道的均衡性,谐振频率干扰检测误差曲线整体保持在0.3以下,提高谐振频率干扰检测的精度和稳定性。 展开更多
关键词 多频激光通信网络 提升小波变换 信号处理 信道均衡 时域有限差分 频率干扰检测
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基于频域特征和图像处理的轴承表面波纹状凹槽损伤检测算法
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作者 冯彦博 郑金志 王奔 《轨道交通材料》 2026年第1期34-38,46,共6页
针对轴承表面波纹状凹槽损伤提出一种基于频域特征和图像处理的检测算法。首先,利用局部灰度均衡和平滑滤波提高原始图像对比度,突出纹理特征;然后,计算得到傅里叶频谱图,通过基于3σ的阈值计算法筛选出离群值,并根据离群值数量判断波... 针对轴承表面波纹状凹槽损伤提出一种基于频域特征和图像处理的检测算法。首先,利用局部灰度均衡和平滑滤波提高原始图像对比度,突出纹理特征;然后,计算得到傅里叶频谱图,通过基于3σ的阈值计算法筛选出离群值,并根据离群值数量判断波纹状凹槽纹理的存在;最后,通过频域滤波和傅里叶逆变换筛选与波纹状凹槽纹理强相关的纵向波纹,使用基于最大类间方差法的图像二值化和形态学闭合操作实现波纹状凹槽纹理区域的定位,利用连通域分析完成区域外接方框绘制的最终定位。文章提出的波纹状凹槽损伤检测算法经过104张图像数据验证,取得良好的检测效果,精确率(Precision)为0.88、召回率(Recall)为0.897 9、F1分数(F1 Score)为0.888 8。此外,轴承表面图像分辨率为13 500×500像素,算法具有高运行效率和低运行资源要求,单张图片处理时长为1.25 s。该算法对于数据量要求低,检测精度高,运行实时性好,且计算资源消耗少,适合工业场景的自动检测,目前已应用于轴承表面损伤智能检测装备中。 展开更多
关键词 频域特征 图像处理 傅里叶变换 列车轴承 损伤 目标检测
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基于空时域联合匹配的水轮发电机故障声纹识别方法
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作者 罗明兴 毕光均 +3 位作者 龙世兴 刘敏 韩浩 胡飞 《机械制造与自动化》 2026年第1期271-276,282,共7页
水轮发电机故障发生时会产生复杂机械振动和噪声,且干扰信号来自不同方向,故障特征容易被噪声掩盖,影响故障识别的准确性与可靠性。因此,提出基于空时域联合匹配的水轮发电机故障声纹识别方法。通过空时域联合匹配方式从空间域和时间域... 水轮发电机故障发生时会产生复杂机械振动和噪声,且干扰信号来自不同方向,故障特征容易被噪声掩盖,影响故障识别的准确性与可靠性。因此,提出基于空时域联合匹配的水轮发电机故障声纹识别方法。通过空时域联合匹配方式从空间域和时间域两方面进行声音信号处理,并利用波束形成技术强化目标方向信号,减少噪声对故障特征的干扰和掩盖。采用梅尔频率倒谱系数对增强后的信号进行声纹特征提取,将得到的特征作为卷积神经网络的输入,通过卷积层和Softmax分类器自动学习并区分正常运行状态与故障状态下声纹差异。实验结果表明:所提方法在面对不同的水轮发电机故障时均能表现出有效的识别能力,且能够保持较低的损失函数值(约为0.04),这充分说明了该方法具有较高的准确性和鲁棒性,为水电站设备的智能维护提供了新的技术途径。 展开更多
关键词 水轮发电机 故障识别 空时域处理 声纹特征 卷积神经网络
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Argonaute protein as a linker to command center of physiological processes 被引量:2
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作者 Kaifa Wei Lingjuan Wu +4 位作者 Yanhui Chen Yina Lin Yanmei Wang Xiaoyao Liu Daoxin Xie 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第4期430-441,共12页
MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degrad... MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degradation or translational repression of the target mRNA. AGO proteins function as the Slicer enzyme in miRNA and small interfering RNA (siRNA) pathways involved in human physiological and pathophysiological processes, such as antiviral responses and disease formation. Although the past decade has witnessed rapid advancement in studies of AGO protein functions, to further elucidate the molecular mechanism of AGO proteins in cellular function and biochemical process is really a challenging area for researchers. In order to understand the molecular causes underlying the pathological processes, we mainly focus on five fundamental problems of AGO proteins, including evolution, functional domain, subcellular location, post-translational modification and protein-protein interactions. Our discussion highlight their roles in early diagnosis, disease prevention, drug target identification, drug response, etc. 展开更多
关键词 Small RNA Argonaute (AGO) protein functional domain subcellular location post-translational modification pathological process
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Hierarchical Domain Assignment BaseC on Word-Gloss 被引量:1
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作者 朱朝勇 黄河燕 史树敏 《China Communications》 SCIE CSCD 2012年第3期19-27,共9页
This paper proposes a hierarchical word domain assignment algorithm to automatically build domain dictionaries from Machine-Readable Dictionary(MRD).The process for word domain assignment can be divided into three ste... This paper proposes a hierarchical word domain assignment algorithm to automatically build domain dictionaries from Machine-Readable Dictionary(MRD).The process for word domain assignment can be divided into three steps:1) Hierarchical structure constructing;2) Classifier training;3) Word domain assigning.Compared with the traditional methods,the hierarchical word domain assignment algorithm enhances the accuracy of word domain assignment while reducing human efforts on collecting corpus.Experiments on WordNet 2.0 show that 62.53% of the first domain labels are matched with the WordNet Domains 3.0 by using gloss-based word domain assignment,and the performance can be further improved by utilizing the hierarchical relationships among the domain sets. 展开更多
关键词 natural language processing domaindictionary hierarchical classification domain as-sigrmaent WORDNET MRD
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