Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various phy...Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.展开更多
Compatibilities of reactive dyes were conventionally shown by exhausting curves. But the change of proportion of dyes in padding dyebath was difficult for pad dyeing to be described by these curves. In this paper, a k...Compatibilities of reactive dyes were conventionally shown by exhausting curves. But the change of proportion of dyes in padding dyebath was difficult for pad dyeing to be described by these curves. In this paper, a kind of simulation of pad dyeing process was used to determine dyestuff compatibility in pad dyeing for ramie and linen fabrics. Seven reactive dyes were divided into three groups and tested., The group with Cibacron Yellow C - 2R, Red C - R, and Blue C - R showed very good compatibility both for ramie and linen,and the other two groups of dyes gave out correspondingly low compatibilities in the pad dyeing tests. The results of the method for determining the compatibility of dyes displayed good consistency with the actul pad dyeing process.展开更多
Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR clo...Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration limitations.Here,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption layer.The top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass through.Meanwhile,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric synergy.Through theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ranges.Specifically,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of 0.35.Additionally,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.展开更多
Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening ...Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening weapon safety.Therefore,a stealth material compatible with radar and infrared was designed based on the photonic bandgap characteristics of photonic crystals.The radar stealth lay-er(bottom layer)is a composite of carbonyl iron/silicon dioxide/epoxy resin,and the infrared stealth layer(top layer)is a 1D photonic crystal with alternately and periodically stacked germanium and silicon nitride.Through composition optimization and structural adjust-ment,the effective absorption bandwidth of the compatible stealth material with a reflection loss of less than-10 dB has reached 4.95 GHz.The average infrared emissivity of the proposed design is 0.1063,indicating good stealth performance.The theoretical analysis proves that photonic crystals with this structural design can produce infrared waves within the photonic bandgap,achieving high radar wave transmittance and low infrared emissivity.Infrared stealth is achieved without affecting the absorption performance of the radar stealth layer,and the conflict between radar and infrared stealth performance is resolved.This work aims to promote the application of photonic crystals in compatible stealth materials and the development of stealth technology and to provide a design and theoretical found-ation for related experiments and research.展开更多
Objective This study aimed to study the effects of different crystalline states of Sheng Shigao(raw gypsum,RG)and its inorganic elements on the antipyretic efficacy of Baihu Decoction(BHT).Methods RG samples calcined ...Objective This study aimed to study the effects of different crystalline states of Sheng Shigao(raw gypsum,RG)and its inorganic elements on the antipyretic efficacy of Baihu Decoction(BHT).Methods RG samples calcined at different temperatures were prepared.The phase composition of RG and Duan Shigao(calcination of gypsum,CG)as well as the changes in phase composition before and after adding water to RG calcined at specific temperatures,were determined using X-ray diffraction(XRD).A fever model was established by subcutaneously injecting 20%yeast suspension(10 mL·kg~(-1))into the backs of rats.The effects of BHT containing RG in different crystalline states on rat body temperature were measured.Serum levels of IL-1β,IL-6,and hypothalamic prostaglandin E2(PGE_2)were detected using ELISA.Serum Ca~(2+)levels were measured using a microplate method.The content of trace elements in RG and CG and the corresponding freeze-dried BHT powder was determined using inductively coupled plasma mass spectrometry(ICP-MS).The complexation of representative inorganic elements with mangiferin,a major active component in BHT,was investigated using UV-Vis spectroscopy and fluorescence spectroscopy.A validation model was established using RAW264.7 mouse macrophages.Drug-containing serum of BHT with different inorganic elements was prepared,and the nitric oxide(NO)levels in the cell supernatant of different treatment groups were measured using the Griess method.The mRNA levels of IL-6,TNF-α,and PGE2in each group were detected using qPCR(real-time fluorescent quantitative PCR).Results After calcination,the phase composition of RG changed,and the content of inorganic elements in RG,CG170(RG calcined at 170°C),and CG350(RG calcined at 350°C)showed similar trends.Compared with RG,the content of Ca,Sr,Al,and Na in CG changed significantly.Compared with BHT,the content of Ca,Sr,Si,and Na in CG changed significantly when incorporated into the formula.Intermolecular interactions confirmed strong binding between mangiferin and Cu~(2+)and Al~(3+).Cu~(2+)and Fe~(3+)exhibited fluorescence quenching effects on mangiferin solution,while Al~(3+)and Zn~(2+)showed strong fluorescence enhancement,with fluorescence intensity increasing by 120-fold and 30-fold,respectively.In vitro evaluation of synergistic anti-inflammatory effects confirmed that Ca,Fe,Cr,Al,and Si exhibited synergistic anti-inflammatory effects.Conclusion The crystalline state of RG has little effect on its antipyretic properties,while Ca,Sr,Na,Fe,and Al are likely the key material bases influencing its efficacy.展开更多
Grafting is widely used in cucumbers to enhance their tolerance to environmental stress.Compatibility is a key factor for successful grafting,however,the physiological mechanisms that affect grafting compatibility are...Grafting is widely used in cucumbers to enhance their tolerance to environmental stress.Compatibility is a key factor for successful grafting,however,the physiological mechanisms that affect grafting compatibility are not clear.This study aimed to investigate the physiological mechanism underlying cucumber/pumpkin grafting compatibility.Two pumpkin cultivars with significant differences in compatibility,Figleaf gourd(compatible rootstock,Cf)and Dongyangshenli(incompatible rootstock,Cmo),were used as rootstocks.Three cucumber cultivars with different growth rates were used as scions,including cucumber‘Shenluchunsi’(strong growth,V1),‘Cuilü’(weak growth,V2),and‘Liangyoulüjian 102’(medium growth,V3).Six grafting combinations(V1/Cf,V2/Cf,V3/Cf,V1/Cmo,V2/Cmo,and V3/Cmo)were used to analyze the effect of scion and rootstock varieties,as well as the chemical composition of the exudate from the stem cutting surface,on the compatibility of grafted plants.Here,we found that rootstock was closely correlated with the compatibility of cucumber/pumpkin grafted plants.The sucrose content in the exudate of the stem,enzyme activity,and the expression of genes related to sucrose biosynthesis in Cmo were significantly higher than those in Cf.Correlation analysis showed that the sucrose content difference between the exudate of rootstock and scion stems was negatively correlated with graft compatibility.Exogenous treatment with a 0.5%sucrose solution on the scions significantly reduced the difference in sucrose content between rootstock and scion and enhanced graft survival rate in the incompatible combination.The stem segment grafting experiment in vitro found that the high difference in sucrose concentration between the rootstock and scion decreased the grafting compatibility of cucumber/pumpkin by reducing the adhesion of the cutting surface.Taken together,the higher sucrose concentration difference between rootstock and scion decreased the adhesion of the cutting surface,resulting in the incompatibility of cucumber/pumpkin grafted plants.展开更多
Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”co...Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”compatibilities theory provides a systematic framework for drug compatibility and has guided the formation of a large number of classic formulas.However,due to the complex compositions and diverse mechanisms of action of TCM,it is difficult to comprehensively reveal its potential synergistic patterns using traditional methods.Synergistic prediction based on molecular compatibility theory provides new ideas for identifying combinations of active compounds in TCM.Compared to resource-intensive traditional experimental methods,artificial intelligence possesses the ability to mine synergistic patterns from multi-omics and structural data,providing an efficient means for modeling and optimizing TCM combinations.This paper systematically reviews the application progress of AI in the synergistic prediction of TCM active compounds and explores the challenges and prospects of its application in modeling combination relationships,thereby contributing to the modernization of TCM theory and methodological innovation.展开更多
A personalized outfit recommendation has emerged as a hot research topic in the fashion domain.However,existing recommendations do not fully exploit user style preferences.Typically,users prefer particular styles such...A personalized outfit recommendation has emerged as a hot research topic in the fashion domain.However,existing recommendations do not fully exploit user style preferences.Typically,users prefer particular styles such as casual and athletic styles,and consider attributes like color and texture when selecting outfits.To achieve personalized outfit recommendations in line with user style preferences,this paper proposes a personal style guided outfit recommendation with multi-modal fashion compatibility modeling,termed as PSGNet.Firstly,a style classifier is designed to categorize fashion images of various clothing types and attributes into distinct style categories.Secondly,a personal style prediction module extracts user style preferences by analyzing historical data.Then,to address the limitations of single-modal representations and enhance fashion compatibility,both fashion images and text data are leveraged to extract multi-modal features.Finally,PSGNet integrates these components through Bayesian personalized ranking(BPR)to unify the personal style and fashion compatibility,where the former is used as personal style features and guides the output of the personalized outfit recommendation tailored to the target user.Extensive experiments on large-scale datasets demonstrate that the proposed model is efficient on the personalized outfit recommendation.展开更多
Turbojet engines played significant roles in the aviation industry and still have important applications in small engines for missiles to reduce weight.In this paper,we concentrate on the simulation of the centrifugal...Turbojet engines played significant roles in the aviation industry and still have important applications in small engines for missiles to reduce weight.In this paper,we concentrate on the simulation of the centrifugal turbine impeller and introduce the advanced Isogeometric analysis(IGA)method.IGA,which bypasses the mesh generation process in finite element analysis(FEA),has the potential for seamless integration between computer-aided design(CAD)and computer-aided engineering(CAE).To overcome the problem of only applying the spline basis function in IGA,we propose a parametric modeling approach and construct a centrifugal impeller library.The proposed modeling method generates a compatible hub by rotating the customized shaped blades,avoids the trimmed curves and surfaces,and provides suitable analysis models straight for IGA.The constructed library produces three distinct centrifugal impellers,which are represented by multiple nonuniform rational B-splines(NURBS)patches,including Reissner-Mindlin(RM)shell-to-RM shell,RM shell-to-solid,and solid-to-solid.To avoid the instability issues arising from weakly gluing algorithms in the analysis process on complex geometries,we propose an effective coupling method utilizing compatible patches to globally number the control points and assemble the stiffness matrix and load vector.The degree of freedom(DOF)of the solid is employed to dispose of the inconsistent DOF problem between the RM shell-to-solid model in this algorithm.We consider two kinds of operating environments,including centrifugal force and steady heat conduction to the functioning turboprop.Under the same accuracy,our MATLAB coding results demonstrate that IGA requires fewer elements,and achieves superior rendering effects to ABAQUS.Unlike FEA,the IGA method maintains the same geometry as the origin model after analysis.展开更多
A CMOS compatible RRAM device with TaN/Ta/TaOx/Ta N structure was proposed for nonvolatile memory applications.Excellent resistive switching characteristics,including low operation voltages(<1 V),low operation curr...A CMOS compatible RRAM device with TaN/Ta/TaOx/Ta N structure was proposed for nonvolatile memory applications.Excellent resistive switching characteristics,including low operation voltages(<1 V),low operation current(<100μA),good programming/erasing endurance(>10^(6) cycles),satisfactory uniformity,and reliable data retention,have been demonstrated.Furthermore,all of the elements in the fabricated Ta N/Ta/Ta Ox/Ta N devices are highly compatible with modern CMOS manufacturing process,showing promising application in the next generation of nonvolatile memory.展开更多
Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage...Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage-ment,which pose risks to human health and the environment.Consequently,there is a need for eco-friendly alterna-tives.This study evaluates the bio-efficacy of the entomopathogenic fungus Metarhizium anisopliae strain TMBMA1 against pink bollworm and assesses its compatibility with major insecticides.Additionally,to comprehend the dynam-ics of colonization and the infection processes of entomopathogenic fungi(EPF),scanning electron microscopy(SEM)of infected larvae was carried out.Result We challenged the second instar PBW larvae to eight different concentrations(1×10^(3) to 1×10^(10) conidia mL^(-1))of an M.anisopliae strain TMBMA1.The highest mortality(100%)occurred at the higher concentrations i.e.,1×109 and 1×10^(10) spores mL^(-1),while the lowest mortality rate(46.6%)was observed at 1×10^(3) spores mL^(-1) con-centration compared to control(3.33%).TMBMA1’s biocontrol efficacy was validated by Probit analysis,exhibiting an exceptionally low median lethal concentration(LC50)value of 7.1×10^(5).The comparative evaluation revealed that the M.anisopliae strain TMBMA1 performed excellently with insecticide[Cypermethrin 10%(volume fraction)emulsifiable concentrate(EC)at 1 mL·L^(-1) water]giving 100%mortality,both being superior to a commercial prod-uct of M.anisopliae(60%).According to SEM analysis,the EPF strain was profusely colonized on both the internal and external surfaces of PBW larvae.Compatibility studies with insecticides revealed>98%and>96%reduction in the sporulation of M.anisopliae due to the treatment of Emamectin Benzoate 1.5%(mass fraction)+Profenofos 35%(mass fraction)water dispersible granules(WDG)and Profenofos 50%EC,respectively.In contrast,Cypermethrin 10%EC,Emamectin Benzoate 5%(mass fraction)Soluble Granules and Neem Seed Kernel Extract(NSKE)0.15%(volume fraction)treatments reported lower reduction(11.45%,13.79%and 21.21%respectively)in spore production.Conclusion According to the current investigations,the M.anisopliae strain TMBMA1 exhibits high virulence against PBW and offers a promising eco-friendly solution for managing this pest.It shows significant potential to pro-liferate on both external and internal surfaces of PBW.This strain can be integrated into PBW management programs with chemical insecticides,improving pest control and lessening environmental impact.展开更多
[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and ...[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,were investigated using the hot plate test and the acetic acid writhing test.Observations were made regarding the reactions of mice,specifically the licking of their forepaws and hindpaws,both prior to and following drug administration.The duration of these reactions was recorded,and the pain threshold of the mice was assessed following drug administration.Additionally,the frequency of writhing responses was documented following the injection of acetic acid into the abdominal cavity of the mice for 20 min.[Results]The pain thresholds observed in the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group were significantly elevated compared to those of the blank control group following 14 d of drug administration(P<0.05).This finding indicates that the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group of B.malabaricum flowers and O.fragrans at a 1:1 ratio exhibited analgesic efficacy in mice.Furthermore,the pain thresholds of the B.malabaricum flowers and O.fragrans groups were significantly lower than that of the compatibility group(P<0.05),suggesting that the compatibility group demonstrated a significantly superior analgesic effect compared to the B.malabaricum flowers group in mice.A statistically significant difference was observed in the frequency of writhing responses among the five experimental groups:the normal saline group,the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group(P=0.01<0.05).Post hoc analyses revealed that the frequency of writhing responses in the O.fragrans group was significantly lower than that observed in both the normal saline group and the compatibility group.Additionally,the frequency of writhing responses in the positive control group was significantly lower than that in the normal saline group.[Conclusions]B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,exhibits analgesic effects,with the analgesic effect being more pronounced in the compatibility group compared to the B.malabaricum flowers group or the O.fragrans group.展开更多
EMC anechoic chamber is used for radiation emission and radiation immunity test,and the wireless performance of products needs to be tested in OTA anechoic chamber.With more and more electronic and electrical equipmen...EMC anechoic chamber is used for radiation emission and radiation immunity test,and the wireless performance of products needs to be tested in OTA anechoic chamber.With more and more electronic and electrical equipment with wireless communication function,the rapid construction of a compatible OTA test system in the existing EMC anechoic chamber can save the cost and space of enterprises and third-party laboratories that already have EMC anechoic chamber.In this paper,the OTA test system is built in the existing EMC anechoic room,the ripple calibration test is carried out according to the OTA standard,the TRP and TIS tests are carried out on two test samples with different wireless communication standards,and the test samples are taken to the OTA anechoic room for a comparison test.The comparison between the ripple calibration data and the OTA test data showed that the EMC anechoic chamber could perform OTA test without affecting the original test ability.The data results provide a basis for the implementation of EMC anechoic chamber compatibility upgrade OTA test,and provide reference for further optimization of the compatible test system,reduction of test differences,and the design of anechoic chamber integrating two test functions.展开更多
Block-flexure toppling constitutes the predominant form of toppling failure in rock slopes.Although it has been extensively studied,the current theoretical models are often oversimplified by treating rock layers as ri...Block-flexure toppling constitutes the predominant form of toppling failure in rock slopes.Although it has been extensively studied,the current theoretical models are often oversimplified by treating rock layers as rigid bodies that diverge from actual conditions.The proposed Equivalent Deformation Compatibility Method(EDCM)offers a fresh approach to assess the stability of rock slopes prone to block-flexure toppling.EDCM posits that blocky rock layers,with their inability to withstand significant bending and role in merely transferring forces,can be modeled as intact layers with a reduced modulus.The method simplifies the complex issue of analyzing discrete and continuous rock layers to the study of layered soft and hard rock,establishing deformation compatibility equations subsequently.Validation of the EDCM was achieved through numerical models,physical model testing,and application to an actual slope.The factor of safety(FS)for slopes corresponds with the results from both models and the actual slope,demonstrating the method's applicability for evaluating susceptibility to block-flexure toppling.When applying the EDCM,it is advised to set the elastic modulus reduction coefficient for blocky layers at a value below 0.1.展开更多
Li-rich Mn-based oxides(LRMO)are of great significance in achieving high energy density all-solid-state lithium batteries(ASSLBs),owing to their high theoretical capacity and high operation voltage.Unfortunately,their...Li-rich Mn-based oxides(LRMO)are of great significance in achieving high energy density all-solid-state lithium batteries(ASSLBs),owing to their high theoretical capacity and high operation voltage.Unfortunately,their practical application is hindered by severe interface degradation due to the chemical oxidation and electrochemical decomposition of solid electrolytes(SEs),driven by high-active oxygen and electron sources from LRMO.Herein,an interfacial modification strategy is proposed to stabilize the surface lattice oxygen of LRMO and reduce electronic conduction between LRMO and SEs,synergistically.Accordingly,the byproducts from chemical oxidation(InO^(-))and electrochemical decomposition(LiCl^(-))are largely suppressed,leading to superior interfacial transport with the lowest resistance.Consequently,the ASSLB achieves a high reversible capacity of 227.9 mA h g^(-1)at 0.1 C,a cycling stability of 90.1%capacity retention after 200 cycles at 0.1 C,and a superior rate capability with a capacity of81.7 m A h g^(-1)at 3.0 C.This study enriches the fundamental understanding of LRMO/SEs interfacial evolution during the electrochemical cycling and the proposed interfacial modification strategy benefits the future design of Li-rich compounds for ASSLBs.展开更多
Cancer therapy continues to face major challenges,including drug resistance,toxicity,and tumor heterogeneity,which highlight the need for multitarget strategies.This review examines the molecular compatibility theory ...Cancer therapy continues to face major challenges,including drug resistance,toxicity,and tumor heterogeneity,which highlight the need for multitarget strategies.This review examines the molecular compatibility theory in integrative oncology,which combines traditional Chinese medicine(TCM)with systems biology to address these limitations.TCM formulas,such as Banxia Xiexin decoction and Qiqin Huchang formula,contain bioactive compounds(e.g.,quercetin and berberine)that modulate interconnected pathways(phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase)and the tumor microenvironment,thereby promoting apoptosis,inhibiting angiogenesis,and regulating immune responses.The theory modernizes TCM’s“Jun-Chen-Zuo-Shi”principle by optimizing herb combinations through network pharmacology and omics technologies.For instance,Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao(Huang Qi)-Curcuma phaeocaulis Val.(E Zhu)pairs co-target hypoxia-inducible factor 1-alpha to suppress metastasis,while artificial intelligence-driven models predict synergistic interactions such as quercetin-cyclin-dependent kinase 1 inhibition.Clinical studies have shown improved outcomes;for instance,modified Banxia Xiexin decoction reduces chemotherapy-induced toxicity in gastric cancer,and Xihuang pill enhances immunotherapy via signal transducer and activator of transcription 3-programmed death-ligand 1 modulation.Despite these advances,challenges remain in standardization and mechanistic validation.Future research should prioritize single-cell sequencing,organoid models,and international collaboration to refine personalized therapies and translate TCM into evidence-based oncology.By integrating empirical knowledge with modern science,molecular compatibility theory provides a robust framework for multitarget drug development and the advancement of integrative cancer therapies.展开更多
All-solid-state batteries(ASSBs)assembled with sulfide solid electrolytes(SSEs)and nickel(Ni)-rich oxide cathode materials are expected to achieve high energy density and safety,representing potential candidates for t...All-solid-state batteries(ASSBs)assembled with sulfide solid electrolytes(SSEs)and nickel(Ni)-rich oxide cathode materials are expected to achieve high energy density and safety,representing potential candidates for the next-generation energy storage systems.However,interfacial issues between SSEs and Nirich oxide cathode materials,attributed to space charge layer,interfacial side reactions,and mechanical contact failure,significantly restrict the performances of ASSBs.The interface degradation is closely related to the components of the composite cathode and the process of electrode fabrication.Focusing on the influencing factors of interface compatibility between SSEs and Ni-rich oxide cathode,this article systematically discusses how cathode active materials(CAMs),electrolytes,conductive additives,binders,and electrode fabrication impact the interface compatibility.In addition,the strategies for the compatibility modification are reviewed.Furthermore,the challenges and prospects of intensive research on the degradation and modification of the SSE/Ni-rich cathode material interface are discussed.This review is intended to inspire the development of high-energy-density and high-safety all-solid-state batteries.展开更多
Enhancing rubber-bitumen compatibility is crucial to improve pavement performance and durability.To investigate the compatibility improvement between H2O2-activated waste crumb rubber(AWCR)and bitumen,coarse and fine ...Enhancing rubber-bitumen compatibility is crucial to improve pavement performance and durability.To investigate the compatibility improvement between H2O2-activated waste crumb rubber(AWCR)and bitumen,coarse and fine waste crumb rubber(WCR)were treated and analyzed through multi-scale characterization and molecular simulation.Microstructure and chemical changes of WCR and AWCR were analyzed with scanning electron microscope(SEM),contact angle tests and Fourier transform infrared spectroscopy(FTIR).Compatibility was also indirectly evaluated through modified boiling tests and storage stability tests.Besides,molecular dynamics was used to explore the interaction between WCR/AWCR and bitumen.SEM,contact angle,and FTIR results showed bond breakage of C=C and C–C and increased polar groups like–OH and–COOH in AWCR,resulting in a rougher texture and higher surface energy.Compared with WCR,AWCR showed a lower bitumen stripping rate after boiling,and the binder with AWCR also had a lower softening point difference and segregation rate after storage.Molecular dynamics simulations further confirmed that AWCR has a closer solubility parameter and higher binding energy to bitumen than WCR,reflected in a relatively slower diffusion rate.This study provides comprehensive evidence for an eco-friendly method of WCR surface treatment for more efficient recycling of tire rubber in asphalt pavements.展开更多
The initial stresses widely exist in elastic materials.While achieving a continuum stress-free configuration through compatible unloading is desirable,mechanical unloading alone frequently proves insufficient,posing c...The initial stresses widely exist in elastic materials.While achieving a continuum stress-free configuration through compatible unloading is desirable,mechanical unloading alone frequently proves insufficient,posing challenges in avoiding virtual stress-free configurations.In this paper,we introduce a novel concept of equivalent temperature variation to counteract the incompatible initial strain.Our focus is on initially stressed cylindrical and spherical elastomers,where we first derive the Saint-Venant,Beltrami-Michell,and Volterra integral conditions in orthogonal curvilinear coordinates using the exterior differential form theory.It is shown that for any given axially or spherically distributed initial stress,an equivalent temperature variation always exists.Furthermore,we propose two innovative initial stress forms based on the steady-state heat conduction.By introducing an equivalent temperature variation,the initial stress can be released through a compatible thermo-mechanical unloading process,offering valuable insights into the constitutive theory of initially stressed elastic materials.展开更多
基金funded by the Entrusted service project of Shaanxi Administration of Traditional Chinese Medicine(ZYJXG-L23001)2023 Sanqin Talent Special Support Program Innovation and Entrepreneurship Team Project,and Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine(2023).
文摘Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.
文摘Compatibilities of reactive dyes were conventionally shown by exhausting curves. But the change of proportion of dyes in padding dyebath was difficult for pad dyeing to be described by these curves. In this paper, a kind of simulation of pad dyeing process was used to determine dyestuff compatibility in pad dyeing for ramie and linen fabrics. Seven reactive dyes were divided into three groups and tested., The group with Cibacron Yellow C - 2R, Red C - R, and Blue C - R showed very good compatibility both for ramie and linen,and the other two groups of dyes gave out correspondingly low compatibilities in the pad dyeing tests. The results of the method for determining the compatibility of dyes displayed good consistency with the actul pad dyeing process.
基金financial support from the National Nature Science Foundation of China(No.52273247)the National Science and Technology Major Project of China(J2019-VI-0017-0132).
文摘Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration limitations.Here,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption layer.The top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass through.Meanwhile,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric synergy.Through theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ranges.Specifically,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of 0.35.Additionally,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.
基金supported by the National Natural Science Foundation of China(Nos.52071053,U1704253,and 52103334).
文摘Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening weapon safety.Therefore,a stealth material compatible with radar and infrared was designed based on the photonic bandgap characteristics of photonic crystals.The radar stealth lay-er(bottom layer)is a composite of carbonyl iron/silicon dioxide/epoxy resin,and the infrared stealth layer(top layer)is a 1D photonic crystal with alternately and periodically stacked germanium and silicon nitride.Through composition optimization and structural adjust-ment,the effective absorption bandwidth of the compatible stealth material with a reflection loss of less than-10 dB has reached 4.95 GHz.The average infrared emissivity of the proposed design is 0.1063,indicating good stealth performance.The theoretical analysis proves that photonic crystals with this structural design can produce infrared waves within the photonic bandgap,achieving high radar wave transmittance and low infrared emissivity.Infrared stealth is achieved without affecting the absorption performance of the radar stealth layer,and the conflict between radar and infrared stealth performance is resolved.This work aims to promote the application of photonic crystals in compatible stealth materials and the development of stealth technology and to provide a design and theoretical found-ation for related experiments and research.
基金Joint Fund Project of the Henan Provincial Science and Technology Research and Development Plan(222301420060)。
文摘Objective This study aimed to study the effects of different crystalline states of Sheng Shigao(raw gypsum,RG)and its inorganic elements on the antipyretic efficacy of Baihu Decoction(BHT).Methods RG samples calcined at different temperatures were prepared.The phase composition of RG and Duan Shigao(calcination of gypsum,CG)as well as the changes in phase composition before and after adding water to RG calcined at specific temperatures,were determined using X-ray diffraction(XRD).A fever model was established by subcutaneously injecting 20%yeast suspension(10 mL·kg~(-1))into the backs of rats.The effects of BHT containing RG in different crystalline states on rat body temperature were measured.Serum levels of IL-1β,IL-6,and hypothalamic prostaglandin E2(PGE_2)were detected using ELISA.Serum Ca~(2+)levels were measured using a microplate method.The content of trace elements in RG and CG and the corresponding freeze-dried BHT powder was determined using inductively coupled plasma mass spectrometry(ICP-MS).The complexation of representative inorganic elements with mangiferin,a major active component in BHT,was investigated using UV-Vis spectroscopy and fluorescence spectroscopy.A validation model was established using RAW264.7 mouse macrophages.Drug-containing serum of BHT with different inorganic elements was prepared,and the nitric oxide(NO)levels in the cell supernatant of different treatment groups were measured using the Griess method.The mRNA levels of IL-6,TNF-α,and PGE2in each group were detected using qPCR(real-time fluorescent quantitative PCR).Results After calcination,the phase composition of RG changed,and the content of inorganic elements in RG,CG170(RG calcined at 170°C),and CG350(RG calcined at 350°C)showed similar trends.Compared with RG,the content of Ca,Sr,Al,and Na in CG changed significantly.Compared with BHT,the content of Ca,Sr,Si,and Na in CG changed significantly when incorporated into the formula.Intermolecular interactions confirmed strong binding between mangiferin and Cu~(2+)and Al~(3+).Cu~(2+)and Fe~(3+)exhibited fluorescence quenching effects on mangiferin solution,while Al~(3+)and Zn~(2+)showed strong fluorescence enhancement,with fluorescence intensity increasing by 120-fold and 30-fold,respectively.In vitro evaluation of synergistic anti-inflammatory effects confirmed that Ca,Fe,Cr,Al,and Si exhibited synergistic anti-inflammatory effects.Conclusion The crystalline state of RG has little effect on its antipyretic properties,while Ca,Sr,Na,Fe,and Al are likely the key material bases influencing its efficacy.
基金supported by grants from the Gansu Provincial Science and Technology Plan Project(Grant No.22CX8NA030)the National Natural Science Foundation of China(Grant No.32272793)the China Agriculture Research System(Grant No.CARS-23).
文摘Grafting is widely used in cucumbers to enhance their tolerance to environmental stress.Compatibility is a key factor for successful grafting,however,the physiological mechanisms that affect grafting compatibility are not clear.This study aimed to investigate the physiological mechanism underlying cucumber/pumpkin grafting compatibility.Two pumpkin cultivars with significant differences in compatibility,Figleaf gourd(compatible rootstock,Cf)and Dongyangshenli(incompatible rootstock,Cmo),were used as rootstocks.Three cucumber cultivars with different growth rates were used as scions,including cucumber‘Shenluchunsi’(strong growth,V1),‘Cuilü’(weak growth,V2),and‘Liangyoulüjian 102’(medium growth,V3).Six grafting combinations(V1/Cf,V2/Cf,V3/Cf,V1/Cmo,V2/Cmo,and V3/Cmo)were used to analyze the effect of scion and rootstock varieties,as well as the chemical composition of the exudate from the stem cutting surface,on the compatibility of grafted plants.Here,we found that rootstock was closely correlated with the compatibility of cucumber/pumpkin grafted plants.The sucrose content in the exudate of the stem,enzyme activity,and the expression of genes related to sucrose biosynthesis in Cmo were significantly higher than those in Cf.Correlation analysis showed that the sucrose content difference between the exudate of rootstock and scion stems was negatively correlated with graft compatibility.Exogenous treatment with a 0.5%sucrose solution on the scions significantly reduced the difference in sucrose content between rootstock and scion and enhanced graft survival rate in the incompatible combination.The stem segment grafting experiment in vitro found that the high difference in sucrose concentration between the rootstock and scion decreased the grafting compatibility of cucumber/pumpkin by reducing the adhesion of the cutting surface.Taken together,the higher sucrose concentration difference between rootstock and scion decreased the adhesion of the cutting surface,resulting in the incompatibility of cucumber/pumpkin grafted plants.
基金supported by the National Key Research and Development Program of China(No.2024YFC3506900)Science and Technology Program of Tianjin(No.24ZXZSSS00460)Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines(No.24ZXZKSY00010)。
文摘Due to its synergistic effects and reduced side effects,combination therapy has become an important strategy for treating complex diseases.In traditional Chinese medicine(TCM),the“monarch,minister,assistant,envoy”compatibilities theory provides a systematic framework for drug compatibility and has guided the formation of a large number of classic formulas.However,due to the complex compositions and diverse mechanisms of action of TCM,it is difficult to comprehensively reveal its potential synergistic patterns using traditional methods.Synergistic prediction based on molecular compatibility theory provides new ideas for identifying combinations of active compounds in TCM.Compared to resource-intensive traditional experimental methods,artificial intelligence possesses the ability to mine synergistic patterns from multi-omics and structural data,providing an efficient means for modeling and optimizing TCM combinations.This paper systematically reviews the application progress of AI in the synergistic prediction of TCM active compounds and explores the challenges and prospects of its application in modeling combination relationships,thereby contributing to the modernization of TCM theory and methodological innovation.
基金Shanghai Frontier Science Research Center for Modern Textiles,Donghua University,ChinaOpen Project of Henan Key Laboratory of Intelligent Manufacturing of Mechanical Equipment,Zhengzhou University of Light Industry,China(No.IM202303)National Key Research and Development Program of China(No.2019YFB1706300)。
文摘A personalized outfit recommendation has emerged as a hot research topic in the fashion domain.However,existing recommendations do not fully exploit user style preferences.Typically,users prefer particular styles such as casual and athletic styles,and consider attributes like color and texture when selecting outfits.To achieve personalized outfit recommendations in line with user style preferences,this paper proposes a personal style guided outfit recommendation with multi-modal fashion compatibility modeling,termed as PSGNet.Firstly,a style classifier is designed to categorize fashion images of various clothing types and attributes into distinct style categories.Secondly,a personal style prediction module extracts user style preferences by analyzing historical data.Then,to address the limitations of single-modal representations and enhance fashion compatibility,both fashion images and text data are leveraged to extract multi-modal features.Finally,PSGNet integrates these components through Bayesian personalized ranking(BPR)to unify the personal style and fashion compatibility,where the former is used as personal style features and guides the output of the personalized outfit recommendation tailored to the target user.Extensive experiments on large-scale datasets demonstrate that the proposed model is efficient on the personalized outfit recommendation.
基金supported by the Aeronautical Science Foundation of China(2023Z068051002)2021 Special Scientific Research on Civil Aircraft Projectthe Natural Science Foundation of China(52175213)。
文摘Turbojet engines played significant roles in the aviation industry and still have important applications in small engines for missiles to reduce weight.In this paper,we concentrate on the simulation of the centrifugal turbine impeller and introduce the advanced Isogeometric analysis(IGA)method.IGA,which bypasses the mesh generation process in finite element analysis(FEA),has the potential for seamless integration between computer-aided design(CAD)and computer-aided engineering(CAE).To overcome the problem of only applying the spline basis function in IGA,we propose a parametric modeling approach and construct a centrifugal impeller library.The proposed modeling method generates a compatible hub by rotating the customized shaped blades,avoids the trimmed curves and surfaces,and provides suitable analysis models straight for IGA.The constructed library produces three distinct centrifugal impellers,which are represented by multiple nonuniform rational B-splines(NURBS)patches,including Reissner-Mindlin(RM)shell-to-RM shell,RM shell-to-solid,and solid-to-solid.To avoid the instability issues arising from weakly gluing algorithms in the analysis process on complex geometries,we propose an effective coupling method utilizing compatible patches to globally number the control points and assemble the stiffness matrix and load vector.The degree of freedom(DOF)of the solid is employed to dispose of the inconsistent DOF problem between the RM shell-to-solid model in this algorithm.We consider two kinds of operating environments,including centrifugal force and steady heat conduction to the functioning turboprop.Under the same accuracy,our MATLAB coding results demonstrate that IGA requires fewer elements,and achieves superior rendering effects to ABAQUS.Unlike FEA,the IGA method maintains the same geometry as the origin model after analysis.
基金Project supported by the Key Research and Development Program of Gansu Province-Industrial Project(Grant No.25YFGA005)。
文摘A CMOS compatible RRAM device with TaN/Ta/TaOx/Ta N structure was proposed for nonvolatile memory applications.Excellent resistive switching characteristics,including low operation voltages(<1 V),low operation current(<100μA),good programming/erasing endurance(>10^(6) cycles),satisfactory uniformity,and reliable data retention,have been demonstrated.Furthermore,all of the elements in the fabricated Ta N/Ta/Ta Ox/Ta N devices are highly compatible with modern CMOS manufacturing process,showing promising application in the next generation of nonvolatile memory.
文摘Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage-ment,which pose risks to human health and the environment.Consequently,there is a need for eco-friendly alterna-tives.This study evaluates the bio-efficacy of the entomopathogenic fungus Metarhizium anisopliae strain TMBMA1 against pink bollworm and assesses its compatibility with major insecticides.Additionally,to comprehend the dynam-ics of colonization and the infection processes of entomopathogenic fungi(EPF),scanning electron microscopy(SEM)of infected larvae was carried out.Result We challenged the second instar PBW larvae to eight different concentrations(1×10^(3) to 1×10^(10) conidia mL^(-1))of an M.anisopliae strain TMBMA1.The highest mortality(100%)occurred at the higher concentrations i.e.,1×109 and 1×10^(10) spores mL^(-1),while the lowest mortality rate(46.6%)was observed at 1×10^(3) spores mL^(-1) con-centration compared to control(3.33%).TMBMA1’s biocontrol efficacy was validated by Probit analysis,exhibiting an exceptionally low median lethal concentration(LC50)value of 7.1×10^(5).The comparative evaluation revealed that the M.anisopliae strain TMBMA1 performed excellently with insecticide[Cypermethrin 10%(volume fraction)emulsifiable concentrate(EC)at 1 mL·L^(-1) water]giving 100%mortality,both being superior to a commercial prod-uct of M.anisopliae(60%).According to SEM analysis,the EPF strain was profusely colonized on both the internal and external surfaces of PBW larvae.Compatibility studies with insecticides revealed>98%and>96%reduction in the sporulation of M.anisopliae due to the treatment of Emamectin Benzoate 1.5%(mass fraction)+Profenofos 35%(mass fraction)water dispersible granules(WDG)and Profenofos 50%EC,respectively.In contrast,Cypermethrin 10%EC,Emamectin Benzoate 5%(mass fraction)Soluble Granules and Neem Seed Kernel Extract(NSKE)0.15%(volume fraction)treatments reported lower reduction(11.45%,13.79%and 21.21%respectively)in spore production.Conclusion According to the current investigations,the M.anisopliae strain TMBMA1 exhibits high virulence against PBW and offers a promising eco-friendly solution for managing this pest.It shows significant potential to pro-liferate on both external and internal surfaces of PBW.This strain can be integrated into PBW management programs with chemical insecticides,improving pest control and lessening environmental impact.
基金Supported by Undergraduate Innovation and Entrepreneurship Training Program of Guangxi Zhuang Autonomous Region(S202310599060).
文摘[Objectives]To investigate the impact of the compatibility of Bombax malabaricum flowers and Osmanthus fragrans on the analgesic therapeutic effects in mice.[Methods]The analgesic effects of B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,were investigated using the hot plate test and the acetic acid writhing test.Observations were made regarding the reactions of mice,specifically the licking of their forepaws and hindpaws,both prior to and following drug administration.The duration of these reactions was recorded,and the pain threshold of the mice was assessed following drug administration.Additionally,the frequency of writhing responses was documented following the injection of acetic acid into the abdominal cavity of the mice for 20 min.[Results]The pain thresholds observed in the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group were significantly elevated compared to those of the blank control group following 14 d of drug administration(P<0.05).This finding indicates that the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group of B.malabaricum flowers and O.fragrans at a 1:1 ratio exhibited analgesic efficacy in mice.Furthermore,the pain thresholds of the B.malabaricum flowers and O.fragrans groups were significantly lower than that of the compatibility group(P<0.05),suggesting that the compatibility group demonstrated a significantly superior analgesic effect compared to the B.malabaricum flowers group in mice.A statistically significant difference was observed in the frequency of writhing responses among the five experimental groups:the normal saline group,the positive control group,the B.malabaricum flowers group,the O.fragrans group,and the compatibility group(P=0.01<0.05).Post hoc analyses revealed that the frequency of writhing responses in the O.fragrans group was significantly lower than that observed in both the normal saline group and the compatibility group.Additionally,the frequency of writhing responses in the positive control group was significantly lower than that in the normal saline group.[Conclusions]B.malabaricum flowers and O.fragrans,as well as their compatibility at a 1:1 ratio,exhibits analgesic effects,with the analgesic effect being more pronounced in the compatibility group compared to the B.malabaricum flowers group or the O.fragrans group.
基金Yancheng Science and Technology Bureau(YCBK2023027)。
文摘EMC anechoic chamber is used for radiation emission and radiation immunity test,and the wireless performance of products needs to be tested in OTA anechoic chamber.With more and more electronic and electrical equipment with wireless communication function,the rapid construction of a compatible OTA test system in the existing EMC anechoic chamber can save the cost and space of enterprises and third-party laboratories that already have EMC anechoic chamber.In this paper,the OTA test system is built in the existing EMC anechoic room,the ripple calibration test is carried out according to the OTA standard,the TRP and TIS tests are carried out on two test samples with different wireless communication standards,and the test samples are taken to the OTA anechoic room for a comparison test.The comparison between the ripple calibration data and the OTA test data showed that the EMC anechoic chamber could perform OTA test without affecting the original test ability.The data results provide a basis for the implementation of EMC anechoic chamber compatibility upgrade OTA test,and provide reference for further optimization of the compatible test system,reduction of test differences,and the design of anechoic chamber integrating two test functions.
基金financially supported by Youth Innovation Promotion Association,CAS(Grant No.2022333)Knowledge Innovation Program of Wuhan e Basic Research(Grant No.2022010801010161)Natural Science Foundation of Hubei Province,China(Grant No.2023AFD219).
文摘Block-flexure toppling constitutes the predominant form of toppling failure in rock slopes.Although it has been extensively studied,the current theoretical models are often oversimplified by treating rock layers as rigid bodies that diverge from actual conditions.The proposed Equivalent Deformation Compatibility Method(EDCM)offers a fresh approach to assess the stability of rock slopes prone to block-flexure toppling.EDCM posits that blocky rock layers,with their inability to withstand significant bending and role in merely transferring forces,can be modeled as intact layers with a reduced modulus.The method simplifies the complex issue of analyzing discrete and continuous rock layers to the study of layered soft and hard rock,establishing deformation compatibility equations subsequently.Validation of the EDCM was achieved through numerical models,physical model testing,and application to an actual slope.The factor of safety(FS)for slopes corresponds with the results from both models and the actual slope,demonstrating the method's applicability for evaluating susceptibility to block-flexure toppling.When applying the EDCM,it is advised to set the elastic modulus reduction coefficient for blocky layers at a value below 0.1.
基金supported by the National Natural Science Foundation of China with Grant No.12274176 and No.12474210supported by the relevant national program+1 种基金support from Department of Science and Technology of Jilin Province with Grant No.20210301021GXthe Fundamental Research Funds for the Center Universities with Grant No.2023-JCXK-03。
文摘Li-rich Mn-based oxides(LRMO)are of great significance in achieving high energy density all-solid-state lithium batteries(ASSLBs),owing to their high theoretical capacity and high operation voltage.Unfortunately,their practical application is hindered by severe interface degradation due to the chemical oxidation and electrochemical decomposition of solid electrolytes(SEs),driven by high-active oxygen and electron sources from LRMO.Herein,an interfacial modification strategy is proposed to stabilize the surface lattice oxygen of LRMO and reduce electronic conduction between LRMO and SEs,synergistically.Accordingly,the byproducts from chemical oxidation(InO^(-))and electrochemical decomposition(LiCl^(-))are largely suppressed,leading to superior interfacial transport with the lowest resistance.Consequently,the ASSLB achieves a high reversible capacity of 227.9 mA h g^(-1)at 0.1 C,a cycling stability of 90.1%capacity retention after 200 cycles at 0.1 C,and a superior rate capability with a capacity of81.7 m A h g^(-1)at 3.0 C.This study enriches the fundamental understanding of LRMO/SEs interfacial evolution during the electrochemical cycling and the proposed interfacial modification strategy benefits the future design of Li-rich compounds for ASSLBs.
基金supported from the Key R&D Program of Zhejiang(2025C02198)Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction Science and Technology Plan Project(GZY-ZJ-KJ-24083).
文摘Cancer therapy continues to face major challenges,including drug resistance,toxicity,and tumor heterogeneity,which highlight the need for multitarget strategies.This review examines the molecular compatibility theory in integrative oncology,which combines traditional Chinese medicine(TCM)with systems biology to address these limitations.TCM formulas,such as Banxia Xiexin decoction and Qiqin Huchang formula,contain bioactive compounds(e.g.,quercetin and berberine)that modulate interconnected pathways(phosphoinositide 3-kinase/protein kinase B and mitogen-activated protein kinase)and the tumor microenvironment,thereby promoting apoptosis,inhibiting angiogenesis,and regulating immune responses.The theory modernizes TCM’s“Jun-Chen-Zuo-Shi”principle by optimizing herb combinations through network pharmacology and omics technologies.For instance,Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao(Huang Qi)-Curcuma phaeocaulis Val.(E Zhu)pairs co-target hypoxia-inducible factor 1-alpha to suppress metastasis,while artificial intelligence-driven models predict synergistic interactions such as quercetin-cyclin-dependent kinase 1 inhibition.Clinical studies have shown improved outcomes;for instance,modified Banxia Xiexin decoction reduces chemotherapy-induced toxicity in gastric cancer,and Xihuang pill enhances immunotherapy via signal transducer and activator of transcription 3-programmed death-ligand 1 modulation.Despite these advances,challenges remain in standardization and mechanistic validation.Future research should prioritize single-cell sequencing,organoid models,and international collaboration to refine personalized therapies and translate TCM into evidence-based oncology.By integrating empirical knowledge with modern science,molecular compatibility theory provides a robust framework for multitarget drug development and the advancement of integrative cancer therapies.
基金financially supported by the National Natural Science Foundation of China(52072036,52272187)the China Petroleum&Chemical Corporation(SINOPEC)project(223128).
文摘All-solid-state batteries(ASSBs)assembled with sulfide solid electrolytes(SSEs)and nickel(Ni)-rich oxide cathode materials are expected to achieve high energy density and safety,representing potential candidates for the next-generation energy storage systems.However,interfacial issues between SSEs and Nirich oxide cathode materials,attributed to space charge layer,interfacial side reactions,and mechanical contact failure,significantly restrict the performances of ASSBs.The interface degradation is closely related to the components of the composite cathode and the process of electrode fabrication.Focusing on the influencing factors of interface compatibility between SSEs and Ni-rich oxide cathode,this article systematically discusses how cathode active materials(CAMs),electrolytes,conductive additives,binders,and electrode fabrication impact the interface compatibility.In addition,the strategies for the compatibility modification are reviewed.Furthermore,the challenges and prospects of intensive research on the degradation and modification of the SSE/Ni-rich cathode material interface are discussed.This review is intended to inspire the development of high-energy-density and high-safety all-solid-state batteries.
基金supported by the research project“Green-health-safety Nexus for New Urban Spaces-GreeNexUS”(HORIZON MSCA-2021 DN,Marie Sklodowska-Curie Actions)Grant Agreement No.101073437:research grant under the title"Impact Absorbing Pavements with Improved Accessibility Features(DC9-IAP)".
文摘Enhancing rubber-bitumen compatibility is crucial to improve pavement performance and durability.To investigate the compatibility improvement between H2O2-activated waste crumb rubber(AWCR)and bitumen,coarse and fine waste crumb rubber(WCR)were treated and analyzed through multi-scale characterization and molecular simulation.Microstructure and chemical changes of WCR and AWCR were analyzed with scanning electron microscope(SEM),contact angle tests and Fourier transform infrared spectroscopy(FTIR).Compatibility was also indirectly evaluated through modified boiling tests and storage stability tests.Besides,molecular dynamics was used to explore the interaction between WCR/AWCR and bitumen.SEM,contact angle,and FTIR results showed bond breakage of C=C and C–C and increased polar groups like–OH and–COOH in AWCR,resulting in a rougher texture and higher surface energy.Compared with WCR,AWCR showed a lower bitumen stripping rate after boiling,and the binder with AWCR also had a lower softening point difference and segregation rate after storage.Molecular dynamics simulations further confirmed that AWCR has a closer solubility parameter and higher binding energy to bitumen than WCR,reflected in a relatively slower diffusion rate.This study provides comprehensive evidence for an eco-friendly method of WCR surface treatment for more efficient recycling of tire rubber in asphalt pavements.
基金Project supported by the National Natural Science Foundation of China(Nos.12241205 and 12032019)the National Key Research and Development Program of China(No.2022YFA1203200)the Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB0620101 and XDB0620103)。
文摘The initial stresses widely exist in elastic materials.While achieving a continuum stress-free configuration through compatible unloading is desirable,mechanical unloading alone frequently proves insufficient,posing challenges in avoiding virtual stress-free configurations.In this paper,we introduce a novel concept of equivalent temperature variation to counteract the incompatible initial strain.Our focus is on initially stressed cylindrical and spherical elastomers,where we first derive the Saint-Venant,Beltrami-Michell,and Volterra integral conditions in orthogonal curvilinear coordinates using the exterior differential form theory.It is shown that for any given axially or spherically distributed initial stress,an equivalent temperature variation always exists.Furthermore,we propose two innovative initial stress forms based on the steady-state heat conduction.By introducing an equivalent temperature variation,the initial stress can be released through a compatible thermo-mechanical unloading process,offering valuable insights into the constitutive theory of initially stressed elastic materials.
