Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation.In the present study,naproxen sodium nanoparticles were prepared by desolvatio...Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation.In the present study,naproxen sodium nanoparticles were prepared by desolvation technique using various desolvating agents(butanol and combinations of acetonitrile and butanol),and two methods(continuous addition method and intermittent addition method)were adapted to decide the best desolvating agent.Obtained formulations were characterized and evaluated.The combination of acetonitrile and butanol as desolvating agent was giving good and promising results with good stability-40.7 mV and least mean particle diameter of 437.7 nm.From the results it was concluded that intermittent addition was the better method than continuous addition method for preparing naproxen sodium nanoparticles.The drug release was sustained till 12 h with 96.92%for nanoparticles prepared by intermittent addition method following zero order release with non-fickian diffusion mechanism.展开更多
To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average...To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average age at diagnosis of 7 years.Mutations in any of the 23 genes associated with the FA/BRCA pathway can lead to the onset of FA.The clinical manifestations of FA primar-ily include congenital abnormalities,progressive bone marrow failure,and heightened susceptibility to malignancies.展开更多
Cross-linking agents are frequently used to restore corneal properties after decellularization,and it is especially important to select an appropriate method to avoid excessive cross-linking.In addition,how to promote...Cross-linking agents are frequently used to restore corneal properties after decellularization,and it is especially important to select an appropriate method to avoid excessive cross-linking.In addition,how to promote wound healing and how to improve scar formation require further investigation.To ensure the safety and efficacy of animal-derived products,we designed bioartificial corneas(BACs)according to the criteria for Class III medical devices.Our BACs do not require crosslinking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid(AHA)and carboxymethyl chitosan(CMC)on the surface of decellularized porcine corneas(DPCs).The results showed that the BACs had good biocompatibility and transparency,and the modification enhanced their antibacterial and anti-inflammatory properties in vitro.Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month.After 3 months,the BACs were gradually filled with epithelial,stromal,and neuronal cells,and after 6 months,their transparency and histology were almost normal.In addition,side effects such as corneal neovascularization,conjunctival hyperemia,and ciliary body hyperemia rarely occur in vivo.Therefore,these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time.展开更多
文摘Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation.In the present study,naproxen sodium nanoparticles were prepared by desolvation technique using various desolvating agents(butanol and combinations of acetonitrile and butanol),and two methods(continuous addition method and intermittent addition method)were adapted to decide the best desolvating agent.Obtained formulations were characterized and evaluated.The combination of acetonitrile and butanol as desolvating agent was giving good and promising results with good stability-40.7 mV and least mean particle diameter of 437.7 nm.From the results it was concluded that intermittent addition was the better method than continuous addition method for preparing naproxen sodium nanoparticles.The drug release was sustained till 12 h with 96.92%for nanoparticles prepared by intermittent addition method following zero order release with non-fickian diffusion mechanism.
文摘To The Editor:1.INTRODUCTION Fanconi anemia(FA)is a hereditary disorder characterized by genomic instability and increased sensitivity to DNA cross-linking agents.FA is typically diagnosed in childhood,with an average age at diagnosis of 7 years.Mutations in any of the 23 genes associated with the FA/BRCA pathway can lead to the onset of FA.The clinical manifestations of FA primar-ily include congenital abnormalities,progressive bone marrow failure,and heightened susceptibility to malignancies.
基金supported by National Science Fund for Distinguished Young Scholars(No.31625011)the National Key Research and Development Program(No.2016YFC1101100).
文摘Cross-linking agents are frequently used to restore corneal properties after decellularization,and it is especially important to select an appropriate method to avoid excessive cross-linking.In addition,how to promote wound healing and how to improve scar formation require further investigation.To ensure the safety and efficacy of animal-derived products,we designed bioartificial corneas(BACs)according to the criteria for Class III medical devices.Our BACs do not require crosslinking agents and increase mechanical strength via self-cross-linking of aldehyde-modified hyaluronic acid(AHA)and carboxymethyl chitosan(CMC)on the surface of decellularized porcine corneas(DPCs).The results showed that the BACs had good biocompatibility and transparency,and the modification enhanced their antibacterial and anti-inflammatory properties in vitro.Preclinical animal studies showed that the BACs can rapidly regenerate the epithelium and restore vision within a month.After 3 months,the BACs were gradually filled with epithelial,stromal,and neuronal cells,and after 6 months,their transparency and histology were almost normal.In addition,side effects such as corneal neovascularization,conjunctival hyperemia,and ciliary body hyperemia rarely occur in vivo.Therefore,these BACs show promise for clinical application for the treatment of infectious corneal ulcers and as a temporary covering for corneal perforations to achieve the more time.
