Programmable epigenetic editors(EEs)that achieve long-term gene expression modulation without altering the DNA sequence hold immense therapeutic potential.However,the clinical translation of current CRISPRbased epigen...Programmable epigenetic editors(EEs)that achieve long-term gene expression modulation without altering the DNA sequence hold immense therapeutic potential.However,the clinical translation of current CRISPRbased epigenome editors is impeded by substantial challenges,particularly their large molecular size,which limits efficient in vivo delivery.展开更多
基金supported by the Shenzhen Science and Technology Program(KJZD20240903102703005)the Guangdong S&T Program(2024B1111130001).
文摘Programmable epigenetic editors(EEs)that achieve long-term gene expression modulation without altering the DNA sequence hold immense therapeutic potential.However,the clinical translation of current CRISPRbased epigenome editors is impeded by substantial challenges,particularly their large molecular size,which limits efficient in vivo delivery.
