Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China.Interestingly,our previous work has found that R.crenulate extract(RCE)could significantly improve the pathology as...Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China.Interestingly,our previous work has found that R.crenulate extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced colitis.Thus,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against colitis.The chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were identified.Meanwhile,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds.The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis.The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid metabolism.Correspondingly,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.展开更多
The MohroCoulomb criterion has been widely used to explain formation of fractures. However, it fails to explain large strain deformation that widely occurs in nature. There is presently a new theory, the MEMC, which i...The MohroCoulomb criterion has been widely used to explain formation of fractures. However, it fails to explain large strain deformation that widely occurs in nature. There is presently a new theory, the MEMC, which is mathematically expressed as Meff = （（σ1-σ3） L.sin 2α sin α）/2, where σ1-σ3 represents the yield strength of the related rock, L is a unit length and a is the angle between σ1 and deformation bands. This criterion demonstrates that the maximum value appears at angles of ±54.7° to σ1 and there is a slight difference in the moment in the range of 55°±10°. The range covers the whole observations available from nature and experiments. Its major implications include： （1） it can be used to determine the stress state when the related deformation features formed; （2） it provides a new approach to determine the Wk of the related ductile shear zone if only the ratio of the vorticity and strain rate remains fixed; （3） It can be used to explain （a） the obtuse angle in the contraction direction of conjugate kink-bands and extensional crenulation cleavages, （b） formation of low-angle normal faults and high-angle reverse faults, （c） lozenge ductile shear zones in basement terranes, （d） some crocodile structures in seismic profiles and （e） detachment folds in foreland basins.展开更多
A local-scale phase-resolving wave transformation model with CGWAVE is established in connection with a regional-scale coupled STWAVE-ADCIRC wave-current model for its application in the Half Moon Bay, Grays Harbor.Wa...A local-scale phase-resolving wave transformation model with CGWAVE is established in connection with a regional-scale coupled STWAVE-ADCIRC wave-current model for its application in the Half Moon Bay, Grays Harbor.Wave transformation from offshore to the harbor entrance is simulated by the STWAVE model which includes wave-current interaction.The STWAVE results provide incident wave conditions for the local-scale CGWAVE model at its outer boundary. A simple method is developed to take into account the lateral variation of wave height in constructing the model’s wave boundary conditions.The model was validated for three wave condition cases which yielded good agreement with field data.The validated model was applied to predicting nearshore waves in the Half Moon Bay and longshore transport parameters along the wave breaking line for the existing condition and three engineering alternatives. A comparative analysis indicated that storm waves that have a combination of long period and large height are the most destructive to the crenulate shoreline in the Half Moon Bay; both 152 m jetty extension (Alt. 2) and diffraction mound enlargement (Alt. 3) would significantly reduce breaking wave height and longshore transport potential in the southwest corner of Half Moon Bay.展开更多
基金supported by China Postdoctoral Science Foundation(2021M701759)Nanjing Medical University Science and Technology Development Fund(NMUB20210012)+4 种基金Jiangsu Provincial Outstanding Postdoctoral Programme(2022ZB430)National Natural Science Foundation of China(grant No.81873654,82201579)Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM2022020)Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology(kjzr220009)Zhejiang Province Key Laboratory of Medical Electronics and Digital Health(MEDH2022016)。
文摘Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China.Interestingly,our previous work has found that R.crenulate extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced colitis.Thus,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against colitis.The chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were identified.Meanwhile,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds.The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis.The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid metabolism.Correspondingly,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.
基金This work is financed by the grants of the National Natural Science Foundation of China （Grant No 40272084, 40472101 and 40572123）.
文摘The MohroCoulomb criterion has been widely used to explain formation of fractures. However, it fails to explain large strain deformation that widely occurs in nature. There is presently a new theory, the MEMC, which is mathematically expressed as Meff = （（σ1-σ3） L.sin 2α sin α）/2, where σ1-σ3 represents the yield strength of the related rock, L is a unit length and a is the angle between σ1 and deformation bands. This criterion demonstrates that the maximum value appears at angles of ±54.7° to σ1 and there is a slight difference in the moment in the range of 55°±10°. The range covers the whole observations available from nature and experiments. Its major implications include： （1） it can be used to determine the stress state when the related deformation features formed; （2） it provides a new approach to determine the Wk of the related ductile shear zone if only the ratio of the vorticity and strain rate remains fixed; （3） It can be used to explain （a） the obtuse angle in the contraction direction of conjugate kink-bands and extensional crenulation cleavages, （b） formation of low-angle normal faults and high-angle reverse faults, （c） lozenge ductile shear zones in basement terranes, （d） some crocodile structures in seismic profiles and （e） detachment folds in foreland basins.
基金US Army Research and Development Center (EROC), Coastal Inlet Research Program (CIRP),Vicksbarg, MS, USA.
文摘A local-scale phase-resolving wave transformation model with CGWAVE is established in connection with a regional-scale coupled STWAVE-ADCIRC wave-current model for its application in the Half Moon Bay, Grays Harbor.Wave transformation from offshore to the harbor entrance is simulated by the STWAVE model which includes wave-current interaction.The STWAVE results provide incident wave conditions for the local-scale CGWAVE model at its outer boundary. A simple method is developed to take into account the lateral variation of wave height in constructing the model’s wave boundary conditions.The model was validated for three wave condition cases which yielded good agreement with field data.The validated model was applied to predicting nearshore waves in the Half Moon Bay and longshore transport parameters along the wave breaking line for the existing condition and three engineering alternatives. A comparative analysis indicated that storm waves that have a combination of long period and large height are the most destructive to the crenulate shoreline in the Half Moon Bay; both 152 m jetty extension (Alt. 2) and diffraction mound enlargement (Alt. 3) would significantly reduce breaking wave height and longshore transport potential in the southwest corner of Half Moon Bay.
