Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multip...Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.展开更多
Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu...Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yuan et al demonstrated that CPD4,an ATP-binding pocket inhibitor of MLKL,significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling,suggesting its use as a potential therapeutic candidate for alcoholic liver disease.However,the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.Moreover,a single therapeutic strategy targeting MLKL may not be sufficient.Future studies should focus on the precise regulation of MLKL and develop combination therapies to achieve dual intervention of inflammatory and cell death pathways.This paper provides an important theoretical foundation for translational research on MLKL-targeted therapy.However,its clinical translation requires overcoming existing limitations and further elucidating the regulatory network of MLKL in complex microenvironments.展开更多
Additive engineering significantly enhances the photovoltaic performance of perovskite solar cells(PSCs).The atomistic and mechanistic origins of these jfurther investigation to fully understand the physicochemical in...Additive engineering significantly enhances the photovoltaic performance of perovskite solar cells(PSCs).The atomistic and mechanistic origins of these jfurther investigation to fully understand the physicochemical interactions of additives with the perovskite lattice,band structure,and charge carriers.Herein,how additives of cellulose triacetate(CTA)improve the photovoltaic performance and stability of perovskite solar cells(PSCs)is shown.These improvements are found to stem from the formation of hydrogen bonds between CTA molecules and organic cations.The Kelvin probe force microscopy results show that contact potential difference variation under dark and light conditions increases from 79.68 to 141.24 mV by doping CTA,indicating enhanced separation of electron-hole pairs in perovskite.The piezoresponse force microscopy(PFM)tests indicate that CTA additives reduce the PFM amplitude by approximately 50 pm under dark and light conditions and inhibit flipping from antiferroelectric domains to ferroelectric domains.Moreover,the CTA additives regulate the charge distribution within the PbI6 octahedron and bind organic ions through hydrogen bonding,forming a compact film structure.These findings not only improve the long-term stability of organic-inorganic hybrid perovskites(OIHPs),but also pave the way for developing novel strategies for large-scale PSCs.展开更多
基金supported by the National Natural Science Foundation of China under grants 62072229,U1936201,62071220,61976113joint project of China Mobile Research Institute&X-NET。
文摘Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.
文摘Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yuan et al demonstrated that CPD4,an ATP-binding pocket inhibitor of MLKL,significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling,suggesting its use as a potential therapeutic candidate for alcoholic liver disease.However,the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.Moreover,a single therapeutic strategy targeting MLKL may not be sufficient.Future studies should focus on the precise regulation of MLKL and develop combination therapies to achieve dual intervention of inflammatory and cell death pathways.This paper provides an important theoretical foundation for translational research on MLKL-targeted therapy.However,its clinical translation requires overcoming existing limitations and further elucidating the regulatory network of MLKL in complex microenvironments.
基金supported by the National Natural Science Foundation of China(No.U2130128)Yanzhao Young Scientist Project from Natural Science Foundation of Hebei Province(Nos.B2023205040)+4 种基金Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region(Nos.H2022205047,22JCZXJC00060 and E3B33911DF)Hebei Administration for Market Supervision Science and Technology Project List(No.2023ZC03)the Innovation Capability Improvement Plan Project of Hebei Province(No.22567604H)Ph.D.Scientific Research Start-up Fund of Hebei Normal University(No.L2023B18)College Student’s Innovation and Entrepreneurship Training Plan Program(No.S202410094046).
文摘Additive engineering significantly enhances the photovoltaic performance of perovskite solar cells(PSCs).The atomistic and mechanistic origins of these jfurther investigation to fully understand the physicochemical interactions of additives with the perovskite lattice,band structure,and charge carriers.Herein,how additives of cellulose triacetate(CTA)improve the photovoltaic performance and stability of perovskite solar cells(PSCs)is shown.These improvements are found to stem from the formation of hydrogen bonds between CTA molecules and organic cations.The Kelvin probe force microscopy results show that contact potential difference variation under dark and light conditions increases from 79.68 to 141.24 mV by doping CTA,indicating enhanced separation of electron-hole pairs in perovskite.The piezoresponse force microscopy(PFM)tests indicate that CTA additives reduce the PFM amplitude by approximately 50 pm under dark and light conditions and inhibit flipping from antiferroelectric domains to ferroelectric domains.Moreover,the CTA additives regulate the charge distribution within the PbI6 octahedron and bind organic ions through hydrogen bonding,forming a compact film structure.These findings not only improve the long-term stability of organic-inorganic hybrid perovskites(OIHPs),but also pave the way for developing novel strategies for large-scale PSCs.
