Non-small cell lung cancer(NSCLC)is a leading cause of cancer-related mortality worldwide1-3.While radioimmuno-therapy shows promise in boosting antitumor immunity,the clinical outcomes have been inconsistent4 and are...Non-small cell lung cancer(NSCLC)is a leading cause of cancer-related mortality worldwide1-3.While radioimmuno-therapy shows promise in boosting antitumor immunity,the clinical outcomes have been inconsistent4 and are often lim-ited by the immunosuppressive tumor microenvironment(TME).Cyclooxygenase(COX)-2 and the COX-2 downstream product,prostaglandin E2(PGE2),are increasingly implicated in immune escape5,6 but the impact on radioimmunother-apy efficacy has not been explored.TCF1-expressing CD8+T cells demonstrate defining functional properties of progeni-tor-exhausted T cells,including clonal expansion through self-renewal capacity and multipotent differentiation toward terminal effector phenotypes,while maintaining long-term persistence critical for sustaining antitumor immunity7-9.Given the central role in anti-tumor immune maintenance,TCF1+CD8+T cells are likely critical to radioimmunotherapy efficacy10.The role of COX-2 inhibition in enhancing the effi-cacy of radioimmunotherapy efficacy in NSCLC was investi-gated in the current study.展开更多
目的探讨基于Cox健康行为互动模式(interaction model of client health behavior,IMCHB)的心理护理联合疼痛护理小组模式应用于带状疱疹患者中的效果。方法方便选取2021年9月—2023年9月山东省泰安市中心医院收治的82例带状疱疹患者为...目的探讨基于Cox健康行为互动模式(interaction model of client health behavior,IMCHB)的心理护理联合疼痛护理小组模式应用于带状疱疹患者中的效果。方法方便选取2021年9月—2023年9月山东省泰安市中心医院收治的82例带状疱疹患者为研究对象,依据不同护理方法分为两组,各41例。对照组采取常规护理,观察组实施基于IMCHB的心理护理联合疼痛护理小组模式护理,两组均连续护理1周。比较两组患者心理状态、疼痛程度、舒适度以及生活质量。结果护理后,观察组患者健康问卷、广泛性焦虑障碍量表评分分别为(12.33±1.84)分、(9.19±1.44)分,均低于对照组的(15.51±1.96)分、(12.76±1.52)分,差异均有统计学意义(t=7.574,10.918;P均<0.05)。护理后,观察组两项疼痛评分及生活质量评分低于对照组,舒适度评分高于对照组,差异均有统计学意义(P均<0.05)。结论基于IMCHB的心理护理联合疼痛护理小组模式可缓解带状疱疹患者负面情绪,改善其疼痛程度和舒适度,促进患者生活质量提升。展开更多
基金funded by the National Natural Science Foundation of China(Grant Nos.82030082 and 82272845)the Natural Science Foundation of Shandong Province(Grant No.ZR2023LZL001).
文摘Non-small cell lung cancer(NSCLC)is a leading cause of cancer-related mortality worldwide1-3.While radioimmuno-therapy shows promise in boosting antitumor immunity,the clinical outcomes have been inconsistent4 and are often lim-ited by the immunosuppressive tumor microenvironment(TME).Cyclooxygenase(COX)-2 and the COX-2 downstream product,prostaglandin E2(PGE2),are increasingly implicated in immune escape5,6 but the impact on radioimmunother-apy efficacy has not been explored.TCF1-expressing CD8+T cells demonstrate defining functional properties of progeni-tor-exhausted T cells,including clonal expansion through self-renewal capacity and multipotent differentiation toward terminal effector phenotypes,while maintaining long-term persistence critical for sustaining antitumor immunity7-9.Given the central role in anti-tumor immune maintenance,TCF1+CD8+T cells are likely critical to radioimmunotherapy efficacy10.The role of COX-2 inhibition in enhancing the effi-cacy of radioimmunotherapy efficacy in NSCLC was investi-gated in the current study.
文摘目的探讨基于Cox健康行为互动模式(interaction model of client health behavior,IMCHB)的心理护理联合疼痛护理小组模式应用于带状疱疹患者中的效果。方法方便选取2021年9月—2023年9月山东省泰安市中心医院收治的82例带状疱疹患者为研究对象,依据不同护理方法分为两组,各41例。对照组采取常规护理,观察组实施基于IMCHB的心理护理联合疼痛护理小组模式护理,两组均连续护理1周。比较两组患者心理状态、疼痛程度、舒适度以及生活质量。结果护理后,观察组患者健康问卷、广泛性焦虑障碍量表评分分别为(12.33±1.84)分、(9.19±1.44)分,均低于对照组的(15.51±1.96)分、(12.76±1.52)分,差异均有统计学意义(t=7.574,10.918;P均<0.05)。护理后,观察组两项疼痛评分及生活质量评分低于对照组,舒适度评分高于对照组,差异均有统计学意义(P均<0.05)。结论基于IMCHB的心理护理联合疼痛护理小组模式可缓解带状疱疹患者负面情绪,改善其疼痛程度和舒适度,促进患者生活质量提升。
