With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors...With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors determining consumers purchasing decisions.However,due to the high moisture content,active endogenous enzymes,and rich nutrients in aquatic products,both fresh and processed products are highly susceptible to quality deterioration during procurement,distribution,and storage,which leads to a significant decline in sensory quality and nutritional value,while also compromising safety.Today,the consumption of high-quality aquatic products has become a prevailing trend.This paper reviewed the methods for freshness evaluation and quality grading of aquatic products in terms of sensory and nutritional aspects,aiming to support the market circulation principle of"higher price for better quality"and"price based on quality",and better meeting consumer demands.Therefore,it is imperative to enhance the analysis and evaluation of aquatic product quality and to continuously refine assessment systems and methods,which is crucial for promoting industry transformation and fostering a healthy market-consumer economic cycle.展开更多
Objective:To evaluate the cost-effectiveness of annual trivalent inactivated influenza vaccine(IIV3)under the context of Zhejiang province.Methods:A state transition simulation model was constructed to estimate the he...Objective:To evaluate the cost-effectiveness of annual trivalent inactivated influenza vaccine(IIV3)under the context of Zhejiang province.Methods:A state transition simulation model was constructed to estimate the health and economic outcomes of IIV3 vaccination program compared to no vaccination for hypothetical cohorts of Zhejiang province stratified by age and risk status.Model input parameters were chosen based on published literatures and expert advices.The analysis used societal perspectives and a one-year time horizon,and permanent outcomes were also included.The primary outcome was the incremental cost-effectiveness ratio(ICER),with expression of US dollars per quality adjusted life years(QALYs)gained.Results:In subgroups not at high risk for influenza-related complications(non-high risk subgroup),ICER ranged from $6268/QALY(for adults aged 50-64 years)to $11260/QALY(for children aged from 6 months to 4 years).In subgroups at high risk for influenza-related complications(high risk subgroup),ICER ranged from cost-saving(adults aged≥65 years)to $5260/QALY(for children aged from 6 months to 4 years).ICER were most sensitive to changes in probability of influenza illness,cost of hospitalization,and probability of death for adults aged 18-49 years with non-high risk status.Conclusions:ICERs of annual influenza vaccination varied by age and risk status but were less than the Gross Domestic Product(GDP)per capita of Zhejiang province($17745 in 2023),which remained cost-effective for all-age and different risk status groups from a societal perspective.展开更多
It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typica...It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typically transfer the Non-Destructive Testing/Evaluation(NDT/E)reliability metrics to SHM without a systematic analysis of where these metrics originated.Seldom attentions are paid to the evaluation conditions which are very important to apply these metrics.Aimed at this issue,a new condition control-based Dual-Reliability Evaluation(Dual-RE)method for SHM is proposed.This new method is proposed based on a systematic analysis of the whole framework of reliability evaluation from instrument to NDT,and emphasis is paid to the evaluation condition control.Based on these analyses,considering the special online application scenario of SHM,the proposed Dual-RE method contains two key components:Integrated Sensor-based SHM-RE(IS-SHM-RE)and Critical Service Condition-based SHM-RE(CSC-SHM-RE).ISSHM-RE evaluates the reliability of integrated SHM sensor and system themselves under approximate repeatability conditions,while CSC-SHM-RE assesses SHM reliability under the dominant uncertainties during service,namely intermediate conditions.To demonstrate the Dual-RE,crack monitoring by using the Guided Wave-based-SHM(GW-SHM)on aircraft lug structures is taken as a case study.Both the crack detection and sizing performance are evaluated from accuracy and uncertainty.展开更多
Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces ...Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces a visual evaluation index named confidence centroid skewing quadrilateral,which is based on a classification confidence-based confusion matrix,offering a quantitative and visual comparison of the adversarial robustness among different classification algorithms,and enhances intuitiveness and interpretability of attack impacts.We first conduct a validity test and sensitive analysis of the method.Then,prove its effectiveness through the experiments of five classification algorithms including artificial neural network(ANN),logistic regression(LR),support vector machine(SVM),convolutional neural network(CNN)and transformer against three adversarial attacks such as fast gradient sign method(FGSM),DeepFool,and projected gradient descent(PGD)attack.展开更多
BACKGROUND Robotic assistance is increasingly used for donor and recipient hepatectomy in liver transplantation,yet existing evidence is fragmented and variably indirect.AIM To evaluate clinical outcomes,surgical perf...BACKGROUND Robotic assistance is increasingly used for donor and recipient hepatectomy in liver transplantation,yet existing evidence is fragmented and variably indirect.AIM To evaluate clinical outcomes,surgical performance,and economic effects of robotic-assisted donor and recipient hepatectomy in the transplant pathway.METHODS Following Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 and a priori registration,systematic reviews were included with or without meta-analysis.Four databases were searched through July 2025.Methodological quality was appraised with a measurement tool to assess systematic reviews(AMSTAR 2),and certainty was graded with grading of recommendations assessment,development and evaluation(GRADE).Evidence overlap was calculated via a citation-matrix-based corrected covered area(CCA).Effect sizes were prespecified as risk ratios(RR)for dichotomous outcomes and mean differences for continuous outcomes.RESULTS Five reviews met the inclusion criteria,four with meta-analyses and one consensus review used only for context.Donor(direct)findings were more favorable for robotics in terms of estimated blood loss(≈-117 mL)and length of stay(≈-0.6 days),although with longer operative time(≈+105 minutes).Absolute risks for donor complications were not estimable from ratio-only data.Recipient(indirect)meta-analysis indicated robotics to be favorable in terms of conversion(RR≈0.41)and severe morbidity(RR≈0.81),with a trend toward lower overall morbidity(RR≈0.92)and no difference in 30-day mortality.Differences in length of stay and operative time were small and heterogeneous.Economic evidence(indirect,network meta-analysis)suggested higher procedural costs for robotic vs laparoscopic intervention,but lower hospitalization costs vs open intervention,with laparoscopy the least expensive overall.AMSTAR 2 ratings were moderate-to-high across the reviews,GRADE certainty was low for key donor continuous outcomes,and low-to-moderate for recipient and economic outcomes.Overlap was slight(graded-corpus CCA=0.0%;including a contextual non-transplant review increased CCA to≈1.25%).CONCLUSION Robotic donor hepatectomy confers perioperative advantages at the cost of longer operative time.Recipient and economic findings are indirect and considered hypothesis-generating.Transplant-specific,prospective comparisons using a minimum standardized dataset and uniform outcome definitions are needed to resolve remaining uncertainties and to clarify the cost-utility correlation.展开更多
Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation...Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation-integrated multimodal photoacoustic/ultrasound(PA/US)imaging framework designed to quantify entheseal oxygen saturation(SO_(2))for assessing entheseal disease activity in PsA.In this cross-sectional study,25 PsA patients underwent bilateral PA/US imaging of 12 entheses,where ultrasound lesions were scored using the Outcome Measures in Rheumatology scoring system,and PA-derived SO_(2) levels,quantified via dual-wavelength PA imaging,were classified into hyperoxia or hypoxia groups using k-means clustering.This approach provides metabolic insights complementary to conventional ultrasonic assessment.A composite score integrating hypoxia with US parameters was validated against clinical disease activity indices(Disease Activity Score 28-C-reactive protein,DAS28-CRP;Disease Activity Index for Psoriatic Arthritis,DAPSA).Among 300 entheses,103(34.3%)exhibited PA positivity,with 40(38.8%)classified as hypoxia.Hypoxia scores independently predicted DAS28-CRP(β=0.618,p=0.001)and DAPSA(β=0.612,p<0:001).The hypoxia-optimized PAUS score demonstrated superior correlation with disease activity indices compared to conventional US(DAS28-CRP:r=0.615,p=0.001 versus r=0.474,p=0.017;DAPSA:r=0.743,p<0:001 versus r=0.567,p=0.003),alongside superior diagnostic accuracy for minimal disease activity(area under the curve,AUC 0.776 versus 0.614,p=0.008)and low disease activity(AUC 0.853 versus 0.772,p=0.009).This multimodal scoring system enhances the stratification of PsA disease activity by providing unique metabolic insights,offering a potential tool for therapeutic monitoring and guiding treat-to-target strategies.展开更多
Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluat...Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluate brittleness,many fail to comprehensively account for the impacts of microstructural changes,mineralogical characteristics,and stress conditions on energy evolution during failure.This study proposes a novel approach for brittleness evaluation based on the energy evolution throughout the post-peak failure process,integrating two micromechanical mechanisms:crack propagation and frictional sliding.A new brittleness index is defined as the ratio of generated surface energy to released elastic energy,providing a unified framework for assessing both Class I and Class II mechanical behaviors.The brittleness of cyan,white,and gray sandstones was investigated under various confining pressures and moisture conditions using X-ray diffraction(XRD),scanning electron microscopy(SEM),and conventional triaxial compression(CTC)tests.The results demonstrate that brittleness decreases with increasing confining pressure,due to suppressed crack propagation,and increases under saturated conditions,as moisture enhances crack propagation.By establishing connections between mineral composition,microstructural features,and stress-induced responses,the proposed method overcame limitations of previous approaches and offered a more precise tool for evaluating rock brittleness under diverse environmental scenarios.展开更多
Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characte...Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characteristics of C.gigas from different sources(ploidy,region,size,and culture mode),C.gigas from various ploidy(diploid and triploid),regions(Rushan,Off-site fattening,and Rongcheng),sizes(small,medium,and large)and culture modes(nearshore and offshore)were selected for comparative analyses.The nutritional components(moisture,protein,fat,and mineral),flavor substances(taste amino acids,nucleotides,and succinic acid),and functional indices(eicosapentaenoic acid(EPA),docosahexaenoic acid(DHA),and taurine)of C.gigas were determined.Principal component analysis(PCA)was used to comprehensively evaluate the oysters and investigate the variations in nutritional quality.The PCA results indicate that protein,essential fatty acids,selenium,zinc,taste amino acids,taurine,EPA,and DHA were core components contributing to 82.25%of the cumulative variance,providing a more comprehensive reflection of the nutrient composition of C.gigas.The extensive quality rankings for the C.gigas were as follows:diploid>triploid,Rushan>fattening>Rongcheng,medium>large>small,and offshore>nearshore.The score rank revealed that diploid oysters of medium-size from Rushan demonstrated superior nutritional quality compared to other tested samples.This is the first comprehensive and systematic investigation of C.gigas in northern China to reveal the feature of nutrients,flavor,and functional components.The study provided data support for the culture,consumption,processing,research,and nutritional quality improvement of oyster industry.展开更多
BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an e...BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.展开更多
Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core functi...Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core function is to characterize the complexity of the induced fracture network and the resulting effective stimulated volume.In this study,we quantified fracture area and geometric complexity using true triaxial fracturing experiments and computed tomography three-dimensional(3D)reconstruction technology,combined with the box-counting method to calculate the 3D fractal dimension of the fracture surfaces.The results revealed that the total fracture surface area per unit volume of the stimulated reservoir effectively characterized reservoir fracability;specifically,both a larger total fracture surface area and a higher fractal dimension corresponded to better reservoir fracability.Fracture complexity was enhanced by a decrease in the horizontal principal stress difference or an increase in the injection rate.Under optimal conditions of a 3 MPa stress difference and an injection rate of 60 mL/min,fracability improved by 27.6%.Furthermore,liquid carbon dioxide(CO_(2))improved fracability by 50.7%compared to using water as the fracturing fluid,a result attributed to its low viscosity and strong diffusion capacity,which activated a greater number of natural fractures.A fracability evaluation model integrating brittleness,fracture toughness,and dimensionless net pressure was developed using regression analysis,which demonstrated high reliability with a strong determination coefficient(R^(2))of 0.9019.This study clarifies the logical relationships among fracture area,complexity,and fractal dimension,providing a novel method for evaluating the fracability of coal reservoirs.展开更多
Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both g...Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.展开更多
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ...The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.展开更多
The comprehensive evaluation of six properties for equipment product is an important basis for their quality control,and their correlative relationship among six properties will affect their quality level.To understan...The comprehensive evaluation of six properties for equipment product is an important basis for their quality control,and their correlative relationship among six properties will affect their quality level.To understand their correlative relationship among six properties,this paper firstly combines group evaluation with decision-making trial and evaluation laboratory(DEMATEL)model,and develops the optimization model based on group consensus to form six influent relationship matrices.Secondly,group consensus matrix is used to design super network hierarchy matrix,and the weights of six properties with relevant environment is also proposed.Thirdly,the elimination and choice translating reality(ELECTRE)model is used to make comprehensive evaluation,and an example is used to compare the results under two kinds of conditions,and illustrate the effect of the weights of six properties on the priority of equipment products.展开更多
Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance to...Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke.展开更多
Carbonate gas reservoirs are often characterized by strong heterogeneity,complex inter-well connectivity,extensive edge or bottom water,and unbalanced production,challenges that are also common in many heterogeneous g...Carbonate gas reservoirs are often characterized by strong heterogeneity,complex inter-well connectivity,extensive edge or bottom water,and unbalanced production,challenges that are also common in many heterogeneous gas reservoirs with intricate storage and flow behavior.To address these issues within a unified,data-driven framework,this study develops a multi-block material balance model that accounts for inter-block flow and aquifer influx,and is applicable to a wide range of reservoir types.The model incorporates inter-well and well-group conductive connectivity together with pseudo–steady-state aquifer support.The governing equations are solved using a Newton–Raphson scheme,while particle swarm optimization is employed to estimate formation pressures,inter-well connectivity,and effective aquifer volumes.An unbalanced exploitation factor,UEF,is introduced to quantify production imbalance and to guide development optimization.Validation using a synthetic reservoir model demonstrates that the approach accurately reproduces pressure evolution,crossflow behavior,and water influx.Application to a representative case(the Longwangmiao)field further confirms its robustness under highly heterogeneous conditions,achieving a 12.9%reduction in UEF through optimized production allocation.展开更多
Clinical bladder evaluation is a cost-effective,non-invasive method for diagnosing and managing urinary dysfunction,particularly in patients with neurogenic bladder or other impairments.This process aims to assess bla...Clinical bladder evaluation is a cost-effective,non-invasive method for diagnosing and managing urinary dysfunction,particularly in patients with neurogenic bladder or other impairments.This process aims to assess bladder capacity,storage,and voiding functions through simple,realistic,and resource-friendly approaches.It involves a structured series of steps,from history-taking and physical examination to bladder-emptying procedures,monitoring urine leaks,assessing reflex voiding,measuring post-void residual(PVR),and calculating total bladder capacity.These evaluations help differentiate between upper motor neuron and lower motor neuron bladder dysfunction,providing critical insights for tailored management.The interpretation of findings focuses on identifying bladder type,assessing leak timing and volume,evaluating reflex voiding,and measuring PVR and total bladder capacity.The results guide interventions such as timing selfclean intermittent catheterization,adjusting fluid intake,and using bladder diaries to monitor patterns.Clinical bladder evaluation is particularly advantageous in low-resource settings,as it avoids the risks and costs associated with urodynamic studies while reflecting real-life patient conditions more effectively.Despite its benefits,no validation studies currently exist for clinical bladder assessment,and its parameters,like maximum voided volume,remain underexplored compared to urodynamic measures.Given the accessibility,affordability,and practicality of this approach,it holds promise for widespread application,especially in primary care settings and among economically disadvantaged populations.This editorial describes the process step-by-step and highlights its role in improving patient outcomes while minimizing complications.展开更多
Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods...Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods.The research adopts the method of combining theoretical analysis and practical application,and designs the evidence-based value-added evaluation framework,which includes the core elements of a multi-source heterogeneous data acquisition and processing system,a value-added evaluation agent based on a large model,and an evaluation implementation and application mechanism.Through empirical research verification,the evaluation system has remarkable effects in improving learning participation,promoting ability development,and supporting teaching decision-making,and provides a theoretical reference and practical path for educational evaluation reform in the new era.The research shows that the evidence-based value-added evaluation system based on data-driven can reflect students’actual progress more fairly and objectively by accurately measuring the difference in starting point and development range of students,and provide strong support for the realization of high-quality education development.展开更多
In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in...In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.展开更多
Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide ...Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide mononitrate sustained-release capsules(IMSRC)combined with conventional treatments,compared to isosorbide mononitrate tablets(IMT)combined with conventional treatments,for managing angina pectoris in patients with coronary heart diseases.A network meta-analysis(NMA)was conducted to assess the efficacy and safety of IMSRC and IMT.Relevant literature was sourced from databases,including PubMed,Embase,Cochrane Library,ScienceDirect,Web of Science,CNKI,Wanfang,and VIP,covering publications up to July 2023.The cost-effectiveness analysis(CEA)was performed from the perspective of China’s healthcare system,utilizing inputs derived from the NMA.The analysis included 15 studies.The NMA results revealed no significant difference in efficacy and safety between IMSRC plus conventional treatments and IMT plus conventional treatments.However,both combinations were more effective than conventional treatments without isosorbide mononitrate.No differences in safety were observed among the three groups.The surface under the cumulative ranking(SUCRA)of the NMA indicated that IMT had a slight edge over IMSRC in the total effective rate of angina pectoris,whereas IMSRC showed higher probabilities for markedly effective rate and ECG effective rate compared to IMT.The incidence of adverse events was ranked as IMT>conventional preparation>IMSRC.The CEA results highlighted that the incremental cost-effectiveness ratios(ICERs)for the markedly effective and total effective rates of angina pectoris were-133.41 and-260.20,respectively.The ICERs for ECG effective rates were-83.34 and-234.24,respectively.In conclusion,while IMSRC combined with conventional treatments and IMT combined with conventional treatments were similar in efficacy and safety,IMSRC proved to be more economical.展开更多
Guangdong’s carbon emissions have surpassed the world’s 11th largest emitter.It is indispensable for this province to find a robust cost-effective strategy for reducing carbon emissions.This study employed the Low E...Guangdong’s carbon emissions have surpassed the world’s 11th largest emitter.It is indispensable for this province to find a robust cost-effective strategy for reducing carbon emissions.This study employed the Low Emissions Analysis Platform model,marginal cost curves,and Monte Carlo methods to simulate the energy consumption,carbon emissions,and economic benefits of emission reduction in Guangdong Province from 2020 to 2030 under the application of various structural optimization policies and energy-saving technologies.The main findings are as follows:In 2030,Guangdong Province is projected to achieve a carbon emission reduction of 273.6 to 304.6million t CO_(2eq),with a total reduction cost ranging from 1030.9 to 1452.2 billion yuan.Increasing the share of renewable energy,which still has significant growth potential,can lead to a 1.4 times greater reduction in carbon emissions compared to the application of energy-saving technologies,despite the latter yielding 2.3 times more energy savings.The emission reduction measures with net-cost can contribute 71.4%to the total carbon reduction of the province,being much larger than those with net benefits.The power sector plays a critical role in carbon emission reduction within Guangdong Province,with its various measures exerting the most substantial impact on emission reduction quantity and cost,contributing cumulative variance contributions of 90.1%and 84.3%,respectively.It has relatively large potential for emission reduction and relatively low cost of structural adjustment.展开更多
基金Supported by Tangshan Talent Funding Project in 2025(B202304018).
文摘With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors determining consumers purchasing decisions.However,due to the high moisture content,active endogenous enzymes,and rich nutrients in aquatic products,both fresh and processed products are highly susceptible to quality deterioration during procurement,distribution,and storage,which leads to a significant decline in sensory quality and nutritional value,while also compromising safety.Today,the consumption of high-quality aquatic products has become a prevailing trend.This paper reviewed the methods for freshness evaluation and quality grading of aquatic products in terms of sensory and nutritional aspects,aiming to support the market circulation principle of"higher price for better quality"and"price based on quality",and better meeting consumer demands.Therefore,it is imperative to enhance the analysis and evaluation of aquatic product quality and to continuously refine assessment systems and methods,which is crucial for promoting industry transformation and fostering a healthy market-consumer economic cycle.
基金funded by Medical and Health Science and Technology Project of Zhejiang province(Grant number:2023KY633).
文摘Objective:To evaluate the cost-effectiveness of annual trivalent inactivated influenza vaccine(IIV3)under the context of Zhejiang province.Methods:A state transition simulation model was constructed to estimate the health and economic outcomes of IIV3 vaccination program compared to no vaccination for hypothetical cohorts of Zhejiang province stratified by age and risk status.Model input parameters were chosen based on published literatures and expert advices.The analysis used societal perspectives and a one-year time horizon,and permanent outcomes were also included.The primary outcome was the incremental cost-effectiveness ratio(ICER),with expression of US dollars per quality adjusted life years(QALYs)gained.Results:In subgroups not at high risk for influenza-related complications(non-high risk subgroup),ICER ranged from $6268/QALY(for adults aged 50-64 years)to $11260/QALY(for children aged from 6 months to 4 years).In subgroups at high risk for influenza-related complications(high risk subgroup),ICER ranged from cost-saving(adults aged≥65 years)to $5260/QALY(for children aged from 6 months to 4 years).ICER were most sensitive to changes in probability of influenza illness,cost of hospitalization,and probability of death for adults aged 18-49 years with non-high risk status.Conclusions:ICERs of annual influenza vaccination varied by age and risk status but were less than the Gross Domestic Product(GDP)per capita of Zhejiang province($17745 in 2023),which remained cost-effective for all-age and different risk status groups from a societal perspective.
基金the support from National Natural Science Foundation of China(No.52275153)the Frontier Technologies R&D Program of Jiangsu,China(No.BF2024068)+1 种基金The Fund of Prospective Layout of Scientific Research for Nanjing University of Aeronautics and Astronautics,ChinaResearch Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(Nanjing University of Aeronautics and Astronautics),China(Nos.MCAS-I-0425K01,MCAS-I-0423G01)。
文摘It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typically transfer the Non-Destructive Testing/Evaluation(NDT/E)reliability metrics to SHM without a systematic analysis of where these metrics originated.Seldom attentions are paid to the evaluation conditions which are very important to apply these metrics.Aimed at this issue,a new condition control-based Dual-Reliability Evaluation(Dual-RE)method for SHM is proposed.This new method is proposed based on a systematic analysis of the whole framework of reliability evaluation from instrument to NDT,and emphasis is paid to the evaluation condition control.Based on these analyses,considering the special online application scenario of SHM,the proposed Dual-RE method contains two key components:Integrated Sensor-based SHM-RE(IS-SHM-RE)and Critical Service Condition-based SHM-RE(CSC-SHM-RE).ISSHM-RE evaluates the reliability of integrated SHM sensor and system themselves under approximate repeatability conditions,while CSC-SHM-RE assesses SHM reliability under the dominant uncertainties during service,namely intermediate conditions.To demonstrate the Dual-RE,crack monitoring by using the Guided Wave-based-SHM(GW-SHM)on aircraft lug structures is taken as a case study.Both the crack detection and sizing performance are evaluated from accuracy and uncertainty.
文摘Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces a visual evaluation index named confidence centroid skewing quadrilateral,which is based on a classification confidence-based confusion matrix,offering a quantitative and visual comparison of the adversarial robustness among different classification algorithms,and enhances intuitiveness and interpretability of attack impacts.We first conduct a validity test and sensitive analysis of the method.Then,prove its effectiveness through the experiments of five classification algorithms including artificial neural network(ANN),logistic regression(LR),support vector machine(SVM),convolutional neural network(CNN)and transformer against three adversarial attacks such as fast gradient sign method(FGSM),DeepFool,and projected gradient descent(PGD)attack.
文摘BACKGROUND Robotic assistance is increasingly used for donor and recipient hepatectomy in liver transplantation,yet existing evidence is fragmented and variably indirect.AIM To evaluate clinical outcomes,surgical performance,and economic effects of robotic-assisted donor and recipient hepatectomy in the transplant pathway.METHODS Following Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 and a priori registration,systematic reviews were included with or without meta-analysis.Four databases were searched through July 2025.Methodological quality was appraised with a measurement tool to assess systematic reviews(AMSTAR 2),and certainty was graded with grading of recommendations assessment,development and evaluation(GRADE).Evidence overlap was calculated via a citation-matrix-based corrected covered area(CCA).Effect sizes were prespecified as risk ratios(RR)for dichotomous outcomes and mean differences for continuous outcomes.RESULTS Five reviews met the inclusion criteria,four with meta-analyses and one consensus review used only for context.Donor(direct)findings were more favorable for robotics in terms of estimated blood loss(≈-117 mL)and length of stay(≈-0.6 days),although with longer operative time(≈+105 minutes).Absolute risks for donor complications were not estimable from ratio-only data.Recipient(indirect)meta-analysis indicated robotics to be favorable in terms of conversion(RR≈0.41)and severe morbidity(RR≈0.81),with a trend toward lower overall morbidity(RR≈0.92)and no difference in 30-day mortality.Differences in length of stay and operative time were small and heterogeneous.Economic evidence(indirect,network meta-analysis)suggested higher procedural costs for robotic vs laparoscopic intervention,but lower hospitalization costs vs open intervention,with laparoscopy the least expensive overall.AMSTAR 2 ratings were moderate-to-high across the reviews,GRADE certainty was low for key donor continuous outcomes,and low-to-moderate for recipient and economic outcomes.Overlap was slight(graded-corpus CCA=0.0%;including a contextual non-transplant review increased CCA to≈1.25%).CONCLUSION Robotic donor hepatectomy confers perioperative advantages at the cost of longer operative time.Recipient and economic findings are indirect and considered hypothesis-generating.Transplant-specific,prospective comparisons using a minimum standardized dataset and uniform outcome definitions are needed to resolve remaining uncertainties and to clarify the cost-utility correlation.
基金supported by the National Natural Science Foundation of China(62325112)the National Key Research and Development Program of China(2023YFC2411700,2023YFC2411705)+2 种基金the National Natural Science Foundation of China(U22A2023)the National High-Level Hospital Clinical Research Funding(2022-PUMCH-C-009,2022-PUMCH-B-064,2022-PUMCH-D-002)the National Basic Research Program of China(973 Program,2014CB541801).
文摘Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation-integrated multimodal photoacoustic/ultrasound(PA/US)imaging framework designed to quantify entheseal oxygen saturation(SO_(2))for assessing entheseal disease activity in PsA.In this cross-sectional study,25 PsA patients underwent bilateral PA/US imaging of 12 entheses,where ultrasound lesions were scored using the Outcome Measures in Rheumatology scoring system,and PA-derived SO_(2) levels,quantified via dual-wavelength PA imaging,were classified into hyperoxia or hypoxia groups using k-means clustering.This approach provides metabolic insights complementary to conventional ultrasonic assessment.A composite score integrating hypoxia with US parameters was validated against clinical disease activity indices(Disease Activity Score 28-C-reactive protein,DAS28-CRP;Disease Activity Index for Psoriatic Arthritis,DAPSA).Among 300 entheses,103(34.3%)exhibited PA positivity,with 40(38.8%)classified as hypoxia.Hypoxia scores independently predicted DAS28-CRP(β=0.618,p=0.001)and DAPSA(β=0.612,p<0:001).The hypoxia-optimized PAUS score demonstrated superior correlation with disease activity indices compared to conventional US(DAS28-CRP:r=0.615,p=0.001 versus r=0.474,p=0.017;DAPSA:r=0.743,p<0:001 versus r=0.567,p=0.003),alongside superior diagnostic accuracy for minimal disease activity(area under the curve,AUC 0.776 versus 0.614,p=0.008)and low disease activity(AUC 0.853 versus 0.772,p=0.009).This multimodal scoring system enhances the stratification of PsA disease activity by providing unique metabolic insights,offering a potential tool for therapeutic monitoring and guiding treat-to-target strategies.
基金supported by the National Natural Science Foundation of China(Grant No.42277147)Ningbo Public Welfare Research Program(Grant No.2024S081)Ningbo Natural Science Foundation(Grant No.2024J186).
文摘Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluate brittleness,many fail to comprehensively account for the impacts of microstructural changes,mineralogical characteristics,and stress conditions on energy evolution during failure.This study proposes a novel approach for brittleness evaluation based on the energy evolution throughout the post-peak failure process,integrating two micromechanical mechanisms:crack propagation and frictional sliding.A new brittleness index is defined as the ratio of generated surface energy to released elastic energy,providing a unified framework for assessing both Class I and Class II mechanical behaviors.The brittleness of cyan,white,and gray sandstones was investigated under various confining pressures and moisture conditions using X-ray diffraction(XRD),scanning electron microscopy(SEM),and conventional triaxial compression(CTC)tests.The results demonstrate that brittleness decreases with increasing confining pressure,due to suppressed crack propagation,and increases under saturated conditions,as moisture enhances crack propagation.By establishing connections between mineral composition,microstructural features,and stress-induced responses,the proposed method overcame limitations of previous approaches and offered a more precise tool for evaluating rock brittleness under diverse environmental scenarios.
基金Supported by the Central Public-interest Scientific Institution Basal Research Fund,YSFRI,CAFS(No.20603022024016)the Central Public-interest Scientific Institution Basal Research Fund,CAFS(Nos.2023TD52,2023TD76)the earmarked fund for CARS(No.CARS-49)。
文摘Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characteristics of C.gigas from different sources(ploidy,region,size,and culture mode),C.gigas from various ploidy(diploid and triploid),regions(Rushan,Off-site fattening,and Rongcheng),sizes(small,medium,and large)and culture modes(nearshore and offshore)were selected for comparative analyses.The nutritional components(moisture,protein,fat,and mineral),flavor substances(taste amino acids,nucleotides,and succinic acid),and functional indices(eicosapentaenoic acid(EPA),docosahexaenoic acid(DHA),and taurine)of C.gigas were determined.Principal component analysis(PCA)was used to comprehensively evaluate the oysters and investigate the variations in nutritional quality.The PCA results indicate that protein,essential fatty acids,selenium,zinc,taste amino acids,taurine,EPA,and DHA were core components contributing to 82.25%of the cumulative variance,providing a more comprehensive reflection of the nutrient composition of C.gigas.The extensive quality rankings for the C.gigas were as follows:diploid>triploid,Rushan>fattening>Rongcheng,medium>large>small,and offshore>nearshore.The score rank revealed that diploid oysters of medium-size from Rushan demonstrated superior nutritional quality compared to other tested samples.This is the first comprehensive and systematic investigation of C.gigas in northern China to reveal the feature of nutrients,flavor,and functional components.The study provided data support for the culture,consumption,processing,research,and nutritional quality improvement of oyster industry.
基金Supported by Inter Disciplinary Direction Cultivation Project of Hunan University of Chinese Medicine,No.2025JC01032025 Hunan Province Science and Technology Innovation Plan Project,No.2025RC9012+2 种基金2022"Unveiling and Leading"Project of Discipline Construction at Hunan University of Chinese Medicine,No.22JBZ044Changsha Municipal Natural Science Foundation,No.kq2402174Hunan Provincial Science Popularization Fund Project,No.2025ZK4223.
文摘BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.
基金supported by the Natural Science Foundation of China(Grant No.52574047 and Grant No.52374045)Key Project of Sichuan Provincial Joint Fund for Science Technology and Education,China(Grant No.2025NSFSC2008).
文摘Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core function is to characterize the complexity of the induced fracture network and the resulting effective stimulated volume.In this study,we quantified fracture area and geometric complexity using true triaxial fracturing experiments and computed tomography three-dimensional(3D)reconstruction technology,combined with the box-counting method to calculate the 3D fractal dimension of the fracture surfaces.The results revealed that the total fracture surface area per unit volume of the stimulated reservoir effectively characterized reservoir fracability;specifically,both a larger total fracture surface area and a higher fractal dimension corresponded to better reservoir fracability.Fracture complexity was enhanced by a decrease in the horizontal principal stress difference or an increase in the injection rate.Under optimal conditions of a 3 MPa stress difference and an injection rate of 60 mL/min,fracability improved by 27.6%.Furthermore,liquid carbon dioxide(CO_(2))improved fracability by 50.7%compared to using water as the fracturing fluid,a result attributed to its low viscosity and strong diffusion capacity,which activated a greater number of natural fractures.A fracability evaluation model integrating brittleness,fracture toughness,and dimensionless net pressure was developed using regression analysis,which demonstrated high reliability with a strong determination coefficient(R^(2))of 0.9019.This study clarifies the logical relationships among fracture area,complexity,and fractal dimension,providing a novel method for evaluating the fracability of coal reservoirs.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2342210 and 42275043)the National Institute of Natural Hazards,Ministry of Emergency Management of China(Grant Nos.J2223806,ZDJ2024-25 and ZDJ2025-34)。
文摘Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.
基金supported by NARI Relays Electric Co.,Ltd.under the Project“Research on Evaluation of Clearing Results and Switching Criteria for Primary-Backup Systems in Electricity SpotMarkets”(Project No.CGSQ240800443).
文摘The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.
文摘The comprehensive evaluation of six properties for equipment product is an important basis for their quality control,and their correlative relationship among six properties will affect their quality level.To understand their correlative relationship among six properties,this paper firstly combines group evaluation with decision-making trial and evaluation laboratory(DEMATEL)model,and develops the optimization model based on group consensus to form six influent relationship matrices.Secondly,group consensus matrix is used to design super network hierarchy matrix,and the weights of six properties with relevant environment is also proposed.Thirdly,the elimination and choice translating reality(ELECTRE)model is used to make comprehensive evaluation,and an example is used to compare the results under two kinds of conditions,and illustrate the effect of the weights of six properties on the priority of equipment products.
基金supported by the Fundamental Research Funds for the Central Universities,Nos.G2021KY05107,G2021KY05101the National Natural Science Foundation of China,Nos.32071316,32211530049+1 种基金the Natural Science Foundation of Shaanxi Province,No.2022-JM482the Education and Teaching Reform Funds for the Central Universities,No.23GZ230102(all to LL and HH).
文摘Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke.
基金supported by the National Natural Science Foundation of China(No.52104018,52274030)China National Petroleum Corporation(CNPC)Innovation Foundation(No.2024DQ02-0303)China National Petroleum Corporation(CNPC)14th Five-Year Plan Major Strategic Scientific and Technological Project for Prospective and Fundamental Research(2024DJ86).
文摘Carbonate gas reservoirs are often characterized by strong heterogeneity,complex inter-well connectivity,extensive edge or bottom water,and unbalanced production,challenges that are also common in many heterogeneous gas reservoirs with intricate storage and flow behavior.To address these issues within a unified,data-driven framework,this study develops a multi-block material balance model that accounts for inter-block flow and aquifer influx,and is applicable to a wide range of reservoir types.The model incorporates inter-well and well-group conductive connectivity together with pseudo–steady-state aquifer support.The governing equations are solved using a Newton–Raphson scheme,while particle swarm optimization is employed to estimate formation pressures,inter-well connectivity,and effective aquifer volumes.An unbalanced exploitation factor,UEF,is introduced to quantify production imbalance and to guide development optimization.Validation using a synthetic reservoir model demonstrates that the approach accurately reproduces pressure evolution,crossflow behavior,and water influx.Application to a representative case(the Longwangmiao)field further confirms its robustness under highly heterogeneous conditions,achieving a 12.9%reduction in UEF through optimized production allocation.
文摘Clinical bladder evaluation is a cost-effective,non-invasive method for diagnosing and managing urinary dysfunction,particularly in patients with neurogenic bladder or other impairments.This process aims to assess bladder capacity,storage,and voiding functions through simple,realistic,and resource-friendly approaches.It involves a structured series of steps,from history-taking and physical examination to bladder-emptying procedures,monitoring urine leaks,assessing reflex voiding,measuring post-void residual(PVR),and calculating total bladder capacity.These evaluations help differentiate between upper motor neuron and lower motor neuron bladder dysfunction,providing critical insights for tailored management.The interpretation of findings focuses on identifying bladder type,assessing leak timing and volume,evaluating reflex voiding,and measuring PVR and total bladder capacity.The results guide interventions such as timing selfclean intermittent catheterization,adjusting fluid intake,and using bladder diaries to monitor patterns.Clinical bladder evaluation is particularly advantageous in low-resource settings,as it avoids the risks and costs associated with urodynamic studies while reflecting real-life patient conditions more effectively.Despite its benefits,no validation studies currently exist for clinical bladder assessment,and its parameters,like maximum voided volume,remain underexplored compared to urodynamic measures.Given the accessibility,affordability,and practicality of this approach,it holds promise for widespread application,especially in primary care settings and among economically disadvantaged populations.This editorial describes the process step-by-step and highlights its role in improving patient outcomes while minimizing complications.
基金This paper is the research result of“Research on Innovation of Evidence-Based Teaching Paradigm in Vocational Education under the Background of New Quality Productivity”(2024JXQ176)the Shandong Province Artificial Intelligence Education Research Project(SDDJ202501035),which explores the application of artificial intelligence big models in student value-added evaluation from an evidence-based perspective。
文摘Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods.The research adopts the method of combining theoretical analysis and practical application,and designs the evidence-based value-added evaluation framework,which includes the core elements of a multi-source heterogeneous data acquisition and processing system,a value-added evaluation agent based on a large model,and an evaluation implementation and application mechanism.Through empirical research verification,the evaluation system has remarkable effects in improving learning participation,promoting ability development,and supporting teaching decision-making,and provides a theoretical reference and practical path for educational evaluation reform in the new era.The research shows that the evidence-based value-added evaluation system based on data-driven can reflect students’actual progress more fairly and objectively by accurately measuring the difference in starting point and development range of students,and provide strong support for the realization of high-quality education development.
文摘In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.
基金The 2022 Ministry of Education General Project for Humanities and Social Sciences Research(Grant No.22YJAZH147)the General Subject of Guangzhou Philosophy and Social Science Development“14th Five-Year Plan”in 2023(Grant No.2023GZYB68)+2 种基金China University Industry-Academia-Research Innovation Fund-Huatong Guokang Medical Research Special Project(Grant No.2023HT017)2024 Guangdong Province General Project for the Planning of Philosophy and Social Sciences(Grant No.GD24CGL29)the Innovation Team Project of Colleges and Universities in Guangdong Province(Grant No.2022WCXTD011).
文摘Different dosage forms can significantly impact pharmacokinetics in vivo,leading to varied effects and potential adverse reactions.This study aimed to evaluate the efficacy,safety,and cost-effectiveness of isosorbide mononitrate sustained-release capsules(IMSRC)combined with conventional treatments,compared to isosorbide mononitrate tablets(IMT)combined with conventional treatments,for managing angina pectoris in patients with coronary heart diseases.A network meta-analysis(NMA)was conducted to assess the efficacy and safety of IMSRC and IMT.Relevant literature was sourced from databases,including PubMed,Embase,Cochrane Library,ScienceDirect,Web of Science,CNKI,Wanfang,and VIP,covering publications up to July 2023.The cost-effectiveness analysis(CEA)was performed from the perspective of China’s healthcare system,utilizing inputs derived from the NMA.The analysis included 15 studies.The NMA results revealed no significant difference in efficacy and safety between IMSRC plus conventional treatments and IMT plus conventional treatments.However,both combinations were more effective than conventional treatments without isosorbide mononitrate.No differences in safety were observed among the three groups.The surface under the cumulative ranking(SUCRA)of the NMA indicated that IMT had a slight edge over IMSRC in the total effective rate of angina pectoris,whereas IMSRC showed higher probabilities for markedly effective rate and ECG effective rate compared to IMT.The incidence of adverse events was ranked as IMT>conventional preparation>IMSRC.The CEA results highlighted that the incremental cost-effectiveness ratios(ICERs)for the markedly effective and total effective rates of angina pectoris were-133.41 and-260.20,respectively.The ICERs for ECG effective rates were-83.34 and-234.24,respectively.In conclusion,while IMSRC combined with conventional treatments and IMT combined with conventional treatments were similar in efficacy and safety,IMSRC proved to be more economical.
基金supported by Hainan Provincial Natural Science Foundation of China(No.721RC525).
文摘Guangdong’s carbon emissions have surpassed the world’s 11th largest emitter.It is indispensable for this province to find a robust cost-effective strategy for reducing carbon emissions.This study employed the Low Emissions Analysis Platform model,marginal cost curves,and Monte Carlo methods to simulate the energy consumption,carbon emissions,and economic benefits of emission reduction in Guangdong Province from 2020 to 2030 under the application of various structural optimization policies and energy-saving technologies.The main findings are as follows:In 2030,Guangdong Province is projected to achieve a carbon emission reduction of 273.6 to 304.6million t CO_(2eq),with a total reduction cost ranging from 1030.9 to 1452.2 billion yuan.Increasing the share of renewable energy,which still has significant growth potential,can lead to a 1.4 times greater reduction in carbon emissions compared to the application of energy-saving technologies,despite the latter yielding 2.3 times more energy savings.The emission reduction measures with net-cost can contribute 71.4%to the total carbon reduction of the province,being much larger than those with net benefits.The power sector plays a critical role in carbon emission reduction within Guangdong Province,with its various measures exerting the most substantial impact on emission reduction quantity and cost,contributing cumulative variance contributions of 90.1%and 84.3%,respectively.It has relatively large potential for emission reduction and relatively low cost of structural adjustment.
