To enhance the computational efficiency of spatio-temporally discretized phase-field models,we present a high-speed solver specifically designed for the Poisson equations,a component frequently used in the numerical c...To enhance the computational efficiency of spatio-temporally discretized phase-field models,we present a high-speed solver specifically designed for the Poisson equations,a component frequently used in the numerical computation of such models.This efficient solver employs algorithms based on discrete cosine transformations(DCT)or discrete sine transformations(DST)and is not restricted by any spatio-temporal schemes.Our proposed methodology is appropriate for a variety of phase-field models and is especially efficient when combined with flow field systems.Meanwhile,this study has conducted an extensive numerical comparison and found that employing DCT and DST techniques not only yields results comparable to those obtained via the Multigrid(MG)method,a conventional approach used in the resolution of the Poisson equations,but also enhances computational efficiency by over 90%.展开更多
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ...In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.展开更多
The purpose of this study is to evaluate the price and composition of blood glucose meters and blood glucose test papers in Hubei Province,so as to improve the affordability of blood glucose monitoring for diabetes pa...The purpose of this study is to evaluate the price and composition of blood glucose meters and blood glucose test papers in Hubei Province,so as to improve the affordability of blood glucose monitoring for diabetes patients.Using the standard survey method jointly developed by the World Health Organization(WHO)and Health Action International(HAI)for drug price composition analysis,central level data was collected through literature review,policy review,and interviews with key informants.Field research was conducted in Wuhan and Yichang to trace price data at various levels of the supply chain.At the central level,data shows that China has implemented multiple policies related to the management and pricing of blood glucose meters and test strips,but has not yet introduced price restrictions for blood glucose meters and test strips;At the supply chain level,data shows that the price composition of blood glucose meters and test strips in Hubei Province is mainly composed of manufacturer prices and retail markups,followed by supply chain taxes and wholesale markups.It can be seen from this that China has established a comprehensive medical device registration,sales,quality control and management standard system through a series of policies.At present,China has not issued price policies for blood glucose meters and blood glucose test papers.Therefore,we can reduce product prices by including medical insurance,government subsidies,competitive bidding,and reducing supply chain taxes,thus improving the affordability of blood glucose monitoring for diabetes patients.展开更多
This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SE...This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions.展开更多
Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of...Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process.展开更多
Thymus quinquecostatus Celak.,a traditional aromatic edible plant from Lamiaceae,is widely used as food additive,food condiment,spice,and herbal teas.Polyphenol-rich fraction of T.quinquecostatus(PRF)has been proven t...Thymus quinquecostatus Celak.,a traditional aromatic edible plant from Lamiaceae,is widely used as food additive,food condiment,spice,and herbal teas.Polyphenol-rich fraction of T.quinquecostatus(PRF)has been proven to be effective protective effect for cerebral ischemia reperfusion injury(CIRI)in our previous study.In this study,we developed a novel“Gut flora-Compound-Target-Pathway”(GCTP)network based on network pharmacology coupled with gastrointestinal metabolism for screening bio-active components,key targets and gut floras through the classical technique for order preference by similarity to ideal solution(TOPSIS).This compensates for the lack of gut floras and gastrointestinal metabolism in network pharmacology.Firstly,four incubation models covering simulated gastric juice,simulated intestinal juice,gut floras of normal and transient middle cerebral artery occlusion(tMCAO)rat in vitro were applied to PRF.The 109 proto-components and 64 metabolites were elucidated by ultra-high performance liquid chromatography Q exactive orbitrap-mass spectrometry(UPLC-QE-Orbitrap-MS).Then,the key targets of matrix metalloproteinase 9(MMP9),prostaglandin-endoperoxide synthase 2(PTGS2),tyrosine-protein kinase fyn(FYN),estrogen receptor 1(ESR1),amyloid precursor protein(APP),and epidermal growth factor receptor(EGFR),and gut floras of Enterococcus avium LY1 were selected.Moreover,the selected key proto components were rosmarinic acid,daidzein,quercetin,luteolin,apigenin,methyl rosmarinate,kaempferol,luteoloside,and caffeic acid,and the key metabolites were isokaempferide,isorhamnetin,isoquercetin,and mangiferin.Binding of compounds to the key proteins was analyzed by molecular docking,and also verified though an 2,2'-azobis(2-amidinopropane)dihydrochloride(AAPH)induced oxidative stress zebrafish model and real-time quantitative polymerase chain reaction(RT-qPCR)assays.This study provides a new idea and a better understanding of PRF for its protective effects on CIRI and its underlying mechanisms.展开更多
In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical m...In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing.展开更多
A new quadrilateral edge element method is proposed and analyzed for Maxwell equations.This proposed method is based on Duan-Liang quadrilateral element(Math.Comp.73(2004),pp.1–18).When applied to the eigenvalue prob...A new quadrilateral edge element method is proposed and analyzed for Maxwell equations.This proposed method is based on Duan-Liang quadrilateral element(Math.Comp.73(2004),pp.1–18).When applied to the eigenvalue problem,the method is spectral-correct and spurious-free.Stability and error estimates are obtained,including the interpolation error estimates and the error estimates between the finite element solution and the exact solution.The method is suitable for singular solution as well as smooth solution,and consequently,the method is valid for nonconvex domains which may have a number of reentrant corners.Of course,the method is suitable for arbitrary quadrilaterals(under the usual shape-regular condition).展开更多
Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision...Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.展开更多
The application of nitrogen fertilizers in agricultural fields can lead to the release of nitrogen-containing gases(NCGs),such as NO_(x),NH_(3) and N_(2)O,which can significantly impact regional atmospheric environmen...The application of nitrogen fertilizers in agricultural fields can lead to the release of nitrogen-containing gases(NCGs),such as NO_(x),NH_(3) and N_(2)O,which can significantly impact regional atmospheric environment and con-tribute to global climate change.However,there remain considerable research gaps in the accurate measurement of NCGs emissions from agricultural fields,hindering the development of effective emission reduction strategies.We improved an open-top dynamic chambers(OTDCs)system and evaluated the performance by comparing the measured and given fluxes of the NCGs.The results showed that the measured fluxes of NO,N_(2)O and NH_(3)were 1%,2%and 7%lower than the given fluxes,respectively.For the determination of NH_(3) concentration,we employed a stripping coil-ion chromatograph(SC-IC)analytical technique,which demonstrated an absorption efficiency for atmospheric NH_(3) exceeding 96.1%across sampling durations of 6 to 60 min.In the summer maize season,we utilized the OTDCs system to measure the exchange fluxes of NO,NH_(3),and N_(2)O from the soil in the North China Plain.Substantial emissions of NO,NH_(3) and N_(2)O were recorded following fertilization,with peaks of 107,309,1239 ng N/(m^(2)·s),respectively.Notably,significant NCGs emissions were observed following sus-tained heavy rainfall one month after fertilization,particularly with NH_(3) peak being 4.5 times higher than that observed immediately after fertilization.Our results demonstrate that the OTDCs system accurately reflects the emission characteristics of soil NCGs and meets the requirements for long-term and continuous flux observation.展开更多
Convex feasibility problems are widely used in image reconstruction, sparse signal recovery, and other areas. This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recov...Convex feasibility problems are widely used in image reconstruction, sparse signal recovery, and other areas. This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery. We first derive the projection formulas for a vector onto the feasible sets. The centralized circumcentered-reflection method is designed to solve the convex feasibility problem. Some numerical experiments demonstrate the feasibility and effectiveness of the proposed algorithm, showing superior performance compared to conventional alternating projection methods.展开更多
Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The t...Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The traditional thermal elastic-plastic finite element method(TEP-FEM)can accurately predict welding deformation.However,its efficiency is low because of the complex nonlinear transient computation,making it difficult to meet the needs of rapid engineering evaluation.To address this challenge,this study proposes an efficient prediction method for welding deformation in marine thin plate butt welds.This method is based on the coupled temperature gradient-thermal strain method(TG-TSM)that integrates inherent strain theory with a shell element finite element model.The proposed method first extracts the distribution pattern and characteristic value of welding-induced inherent strain through TEP-FEM analysis.This strain is then converted into the equivalent thermal load applied to the shell element model for rapid computation.The proposed method-particularly,the gradual temperature gradient-thermal strain method(GTG-TSM)-achieved improved computational efficiency and consistent precision.Furthermore,the proposed method required much less computation time than the traditional TEP-FEM.Thus,this study lays the foundation for future prediction of welding deformation in more complex marine thin plates.展开更多
Advanced intensity measures(IMs)based on an inelastic deformation spectrum improved the evaluation of the median engineering demand parameters(EDPs)and reduced dispersion.In this regard,an optimized two-degreefreedom(...Advanced intensity measures(IMs)based on an inelastic deformation spectrum improved the evaluation of the median engineering demand parameters(EDPs)and reduced dispersion.In this regard,an optimized two-degreefreedom(2DOF)modal pushover-based scaling procedure(2DMPS)has been developed for a nonlinear dynamic analysis of asymmetric in-plan buildings.The 2DMPS procedure scales ground motions to approach close enough to a target value of the inelastic displacement of the first-mode inelastic 2DOF modal stick,extended for structures with significant contributions of higher modes.Further,4-,6-and 13-story RC SMRF buildings were selected for analyses using ground motion records scaled by the 2DMPS procedure,the modal pushover-based scaling method(MPS),and ASCE/SEI 7-16 scaling procedures.The median values of EDPs on scaled records closely matched the benchmark results.The bias in the EDP values due to the scaled records in every group regarding their median value was lower than the dispersion of the 21 unscaled records.These results generally demonstrate the accuracy and efficiency of the 2DMPS method.Additionally,the 2DOF modal stick’s inelastic response spectra are better suited for calculating seismic demands for one-way asymmetric-plan structures than the SDOF inelastic response spectra.展开更多
At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systema...At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.展开更多
The stochastic extended finite-fault simulation method(EXSIM)is a widely used tool in seismological research,with applications in ground motion prediction and simulation,seismic hazard analysis,and engineering studies...The stochastic extended finite-fault simulation method(EXSIM)is a widely used tool in seismological research,with applications in ground motion prediction and simulation,seismic hazard analysis,and engineering studies.However,recent studies have revealed a significant limitation:EXSIM tends to overpredict ground motions in the low-to-intermediate frequency range,particularly for large thrust earthquakes that are often characterized by a double-corner-frequency source model.To address this issue and enhance simulation accuracy,this study introduces two key improvements:(1)a novel asperity-distributed stress-drop composite fault model and(2)a hybrid application of EXSIM with the composite fault model.The proposed method is validated through its application to the 2013 M_(w)6.7 Lushan earthquake that occurred in China and six thrust earthquakes with an M_(w)≥6.5 in Japan.By comparing the simulated ground motions with recorded data,the results demonstrate that the improved method achieves consistent accuracy across the high-and low-frequency spectrum(combined goodness-of-fit:CGOF<0.35).This study significantly broadens the applicability of stochastic finite-fault simulations,enabling more reliable predictions for a wider range of seismic scenarios,including complex thrust faulting events.展开更多
Stand age plays a crucial role in forest biomass estimation and carbon cycle modeling.Assessing the uncertainty of stand age prediction models and identifying the key driving factors in the modeling process have becom...Stand age plays a crucial role in forest biomass estimation and carbon cycle modeling.Assessing the uncertainty of stand age prediction models and identifying the key driving factors in the modeling process have become major challenges in forestry research.In this study,we selected the Shaanxi-Gansu-Ningxia region of Northeast China as the research area and utilized multi-source datasets from the summer of 2019 to extract information on spectral,textural,climatic,water balance,and stand characteristics.By integrating the Random Forest(RF)model with Monte Carlo(MC)simulation,we constructed six regression models based on different combina-tions of features and evaluated the uncertainty of each model.Furthermore,we investigated the driving factors influencing stand age modeling by analyzing the effects of different types of features on age inversion.Model performance and accuracy were assessed using the root mean square error(RMSE),mean absolute error(MAE),and the coefficient of determination(R^(2)),while the relative root mean square error(rRMSE)was employed to quantify model uncertainty.The results indicate that the scenarios with more obvious improve-ment in accuracy and effective reduction in uncertainty were Scenario 3 with the inclusion of climate and water balance information(RMSE=25.54 yr,MAE=18.03 yr,R^(2)=0.51,rRMSE=19.17%)and Scenario 5 with the inclusion of stand characterization informa-tion(RMSE=18.47 yr,MAE=13.05 yr,R^(2)=0.74,rRMSE=16.99%).Scenario 6,incorporating all feature types,achieved the highest accuracy(RMSE=17.60 yr,MAE=12.06 yr,R^(2)=0.77,rRMSE=14.19%).In this study,elevation,minimum temperature,and diameter at breast height(DBH)emerged as the key drivers of stand-age modeling.The proposed method can be used to identify drivers and to quantify uncertainty in stand-age estimation,providing a useful reference for improving model accuracy and uncertainty assessment.展开更多
Cost-effectiveness analysis（CEA） is increasingly important in health care decision making.Cost-effectiveness threshold is a critical parameter in the cost-effectiveness analysis.This review introduces the concept of...Cost-effectiveness analysis（CEA） is increasingly important in health care decision making.Cost-effectiveness threshold is a critical parameter in the cost-effectiveness analysis.This review introduces the concept of cost-effectiveness threshold, summarizes its determining methods,and classifies the existing methods into two kinds according to budget constraints,then analyzes the merit and demerit of every methods.When there is a flexible budget,the methods for determining the cost-effectiveness threshold include inferring the threshold from previous decisions,comparison with other health care technology or transfer from elsewhere in the public sector,social willingness-to-pay approach,GDP per capita criteria,and rule of thumb.When there is a fixed budget,the methods for determining the cost-effectiveness threshold include shadow price approach,opportunity cost approach,and ICER threshold-searcher model.Each approach to determining threshold has its strength and weakness.The aim of this article is to introduce the existing methods and discuss the features of each method.The background information,such as the definition of threshold,is also described.The basic theory of cost-effectiveness threshold is elaborated,and we recommend the establishment of a cost-effectiveness threshold in the Chinese health care.展开更多
Since the introduction of the concept, studies on valuation of ecosystem services have been overwhelming, in cognizance of its great significance. In this article, the authors took Northeast China as the study area an...Since the introduction of the concept, studies on valuation of ecosystem services have been overwhelming, in cognizance of its great significance. In this article, the authors took Northeast China as the study area and applied the published coefficients for the world by Costanza to calculate the ecosystem services values through a spatial convolution method. The convolution analysis was done with a square processor with 5×5 neighborhood cells. The results showed that the ecosystem services value for the study area in the year 2003 was US$44 990 million which is US$89 million less than the value without operation, and the main contributions for that decrease were from water bodies, wetlands and estuaries. It is expected that this article can attract more interest to explore this field adopting geographic methods.展开更多
Indium tin oxide （ITO） nanoparticles with crystallite size of 12.6 nm and specific surface area of 45.7 m 2 ·g-1 were synthesized by co-precipitation method.The indium solution was obtained by dissolving metal ...Indium tin oxide （ITO） nanoparticles with crystallite size of 12.6 nm and specific surface area of 45.7 m 2 ·g-1 were synthesized by co-precipitation method.The indium solution was obtained by dissolving metal indium in HNO3.The tin solution was obtained by dissolving metal tin in HNO3 and followed by stabilizing with citric acid.The free of chlorine ions in the synthesis process brought several advantages：shortening the synthesis time,decreasing the particle agglomeration,decreasing the chlorine content in the ITO nanoparticles and improving the particle sinterability.This is the first time to report the synthesis of ITO nanoparticles free from chlorine contamination without using the expensive metal alkoxides as starting materials.展开更多
基金Supported by Shanxi Province Natural Science Research(202203021212249)Special/Youth Foundation of Taiyuan University of Technology(2022QN101)+3 种基金National Natural Science Foundation of China(12301556)Research Project Supported by Shanxi Scholarship Council of China(2021-029)International Cooperation Base and Platform Project of Shanxi Province(202104041101019)Basic Research Plan of Shanxi Province(202203021211129)。
文摘To enhance the computational efficiency of spatio-temporally discretized phase-field models,we present a high-speed solver specifically designed for the Poisson equations,a component frequently used in the numerical computation of such models.This efficient solver employs algorithms based on discrete cosine transformations(DCT)or discrete sine transformations(DST)and is not restricted by any spatio-temporal schemes.Our proposed methodology is appropriate for a variety of phase-field models and is especially efficient when combined with flow field systems.Meanwhile,this study has conducted an extensive numerical comparison and found that employing DCT and DST techniques not only yields results comparable to those obtained via the Multigrid(MG)method,a conventional approach used in the resolution of the Poisson equations,but also enhances computational efficiency by over 90%.
基金Supported in part by Natural Science Foundation of Guangxi(2023GXNSFAA026246)in part by the Central Government's Guide to Local Science and Technology Development Fund(GuikeZY23055044)in part by the National Natural Science Foundation of China(62363003)。
文摘In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.
基金Hubei Provincial Medical Institutions at all levels of basic drugs and drug bridging support policy projectsResearch on the Integrated Development of Disease Prevention and Control and Medical Services in the XPCC under the Background of Healthy China (Grant No. BTJKJ2024003)。
文摘The purpose of this study is to evaluate the price and composition of blood glucose meters and blood glucose test papers in Hubei Province,so as to improve the affordability of blood glucose monitoring for diabetes patients.Using the standard survey method jointly developed by the World Health Organization(WHO)and Health Action International(HAI)for drug price composition analysis,central level data was collected through literature review,policy review,and interviews with key informants.Field research was conducted in Wuhan and Yichang to trace price data at various levels of the supply chain.At the central level,data shows that China has implemented multiple policies related to the management and pricing of blood glucose meters and test strips,but has not yet introduced price restrictions for blood glucose meters and test strips;At the supply chain level,data shows that the price composition of blood glucose meters and test strips in Hubei Province is mainly composed of manufacturer prices and retail markups,followed by supply chain taxes and wholesale markups.It can be seen from this that China has established a comprehensive medical device registration,sales,quality control and management standard system through a series of policies.At present,China has not issued price policies for blood glucose meters and blood glucose test papers.Therefore,we can reduce product prices by including medical insurance,government subsidies,competitive bidding,and reducing supply chain taxes,thus improving the affordability of blood glucose monitoring for diabetes patients.
基金National Natural Science Foundation of China under Grant Nos.U2139208 and 52278516Key Laboratory of Earthquake Engineering and Engineering Vibration,China Earthquake Administration under Grant No.2024D15Key Laboratory of Soft Soil Characteristic and Engineering Environment,Tianjin Chengjian University under Grant No.2022SCEEKL003。
文摘This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions.
基金supported by the Fuxing Nursing Research Foundation of Fudan University[FNF202352].
文摘Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process.
基金supported by the Key Research and Development Project of Ningxia Hui Autonomous Region(2020BFG03007).
文摘Thymus quinquecostatus Celak.,a traditional aromatic edible plant from Lamiaceae,is widely used as food additive,food condiment,spice,and herbal teas.Polyphenol-rich fraction of T.quinquecostatus(PRF)has been proven to be effective protective effect for cerebral ischemia reperfusion injury(CIRI)in our previous study.In this study,we developed a novel“Gut flora-Compound-Target-Pathway”(GCTP)network based on network pharmacology coupled with gastrointestinal metabolism for screening bio-active components,key targets and gut floras through the classical technique for order preference by similarity to ideal solution(TOPSIS).This compensates for the lack of gut floras and gastrointestinal metabolism in network pharmacology.Firstly,four incubation models covering simulated gastric juice,simulated intestinal juice,gut floras of normal and transient middle cerebral artery occlusion(tMCAO)rat in vitro were applied to PRF.The 109 proto-components and 64 metabolites were elucidated by ultra-high performance liquid chromatography Q exactive orbitrap-mass spectrometry(UPLC-QE-Orbitrap-MS).Then,the key targets of matrix metalloproteinase 9(MMP9),prostaglandin-endoperoxide synthase 2(PTGS2),tyrosine-protein kinase fyn(FYN),estrogen receptor 1(ESR1),amyloid precursor protein(APP),and epidermal growth factor receptor(EGFR),and gut floras of Enterococcus avium LY1 were selected.Moreover,the selected key proto components were rosmarinic acid,daidzein,quercetin,luteolin,apigenin,methyl rosmarinate,kaempferol,luteoloside,and caffeic acid,and the key metabolites were isokaempferide,isorhamnetin,isoquercetin,and mangiferin.Binding of compounds to the key proteins was analyzed by molecular docking,and also verified though an 2,2'-azobis(2-amidinopropane)dihydrochloride(AAPH)induced oxidative stress zebrafish model and real-time quantitative polymerase chain reaction(RT-qPCR)assays.This study provides a new idea and a better understanding of PRF for its protective effects on CIRI and its underlying mechanisms.
基金supported by Anhui Provincial Natural Science Foundation(2408085QA030)Natural Science Research Project of Anhui Educational Committee,China(2022AH050825)+3 种基金Medical Special Cultivation Project of Anhui University of Science and Technology(YZ2023H2C008)the Excellent Research and Innovation Team of Anhui Province,China(2022AH010052)the Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology,China(2021yjrc51)Collaborative Innovation Program of Hefei Science Center,CAS,China(2019HSC-CIP006).
文摘In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing.
基金supported by the National Natural Science Foundation of China(12401482)the second author was supported by the National Natural Science Foundation of China(12371371,12261160361,11971366)supported by the Open Research Fund of Hubei Key Laboratory of Computational Science,Wuhan University.
文摘A new quadrilateral edge element method is proposed and analyzed for Maxwell equations.This proposed method is based on Duan-Liang quadrilateral element(Math.Comp.73(2004),pp.1–18).When applied to the eigenvalue problem,the method is spectral-correct and spurious-free.Stability and error estimates are obtained,including the interpolation error estimates and the error estimates between the finite element solution and the exact solution.The method is suitable for singular solution as well as smooth solution,and consequently,the method is valid for nonconvex domains which may have a number of reentrant corners.Of course,the method is suitable for arbitrary quadrilaterals(under the usual shape-regular condition).
基金funded by the Beijing Engineering Research Center of Electric Rail Transportation.
文摘Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.
基金supported by the National Key Research and Develop-ment Program(No.2022YFC3701103)the National Natural Science Foundation of China(Nos.42130714 and 41931287).
文摘The application of nitrogen fertilizers in agricultural fields can lead to the release of nitrogen-containing gases(NCGs),such as NO_(x),NH_(3) and N_(2)O,which can significantly impact regional atmospheric environment and con-tribute to global climate change.However,there remain considerable research gaps in the accurate measurement of NCGs emissions from agricultural fields,hindering the development of effective emission reduction strategies.We improved an open-top dynamic chambers(OTDCs)system and evaluated the performance by comparing the measured and given fluxes of the NCGs.The results showed that the measured fluxes of NO,N_(2)O and NH_(3)were 1%,2%and 7%lower than the given fluxes,respectively.For the determination of NH_(3) concentration,we employed a stripping coil-ion chromatograph(SC-IC)analytical technique,which demonstrated an absorption efficiency for atmospheric NH_(3) exceeding 96.1%across sampling durations of 6 to 60 min.In the summer maize season,we utilized the OTDCs system to measure the exchange fluxes of NO,NH_(3),and N_(2)O from the soil in the North China Plain.Substantial emissions of NO,NH_(3) and N_(2)O were recorded following fertilization,with peaks of 107,309,1239 ng N/(m^(2)·s),respectively.Notably,significant NCGs emissions were observed following sus-tained heavy rainfall one month after fertilization,particularly with NH_(3) peak being 4.5 times higher than that observed immediately after fertilization.Our results demonstrate that the OTDCs system accurately reflects the emission characteristics of soil NCGs and meets the requirements for long-term and continuous flux observation.
基金Supported by the Natural Science Foundation of Guangxi Province(Grant Nos.2023GXNSFAA026067,2024GXN SFAA010521)the National Natural Science Foundation of China(Nos.12361079,12201149,12261026).
文摘Convex feasibility problems are widely used in image reconstruction, sparse signal recovery, and other areas. This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery. We first derive the projection formulas for a vector onto the feasible sets. The centralized circumcentered-reflection method is designed to solve the convex feasibility problem. Some numerical experiments demonstrate the feasibility and effectiveness of the proposed algorithm, showing superior performance compared to conventional alternating projection methods.
基金Supported by the National Natural Science Foundation of China under Grant No.51975138the High-Tech Ship Scientific Research Project from the Ministry of Industry and Information Technology under Grant No.CJ05N20the National Defense Basic Research Project under Grant No.JCKY2023604C006.
文摘Marine thin plates are susceptible to welding deformation owing to their low structural stiffness.Therefore,the efficient and accurate prediction of welding deformation is essential for improving welding quality.The traditional thermal elastic-plastic finite element method(TEP-FEM)can accurately predict welding deformation.However,its efficiency is low because of the complex nonlinear transient computation,making it difficult to meet the needs of rapid engineering evaluation.To address this challenge,this study proposes an efficient prediction method for welding deformation in marine thin plate butt welds.This method is based on the coupled temperature gradient-thermal strain method(TG-TSM)that integrates inherent strain theory with a shell element finite element model.The proposed method first extracts the distribution pattern and characteristic value of welding-induced inherent strain through TEP-FEM analysis.This strain is then converted into the equivalent thermal load applied to the shell element model for rapid computation.The proposed method-particularly,the gradual temperature gradient-thermal strain method(GTG-TSM)-achieved improved computational efficiency and consistent precision.Furthermore,the proposed method required much less computation time than the traditional TEP-FEM.Thus,this study lays the foundation for future prediction of welding deformation in more complex marine thin plates.
文摘Advanced intensity measures(IMs)based on an inelastic deformation spectrum improved the evaluation of the median engineering demand parameters(EDPs)and reduced dispersion.In this regard,an optimized two-degreefreedom(2DOF)modal pushover-based scaling procedure(2DMPS)has been developed for a nonlinear dynamic analysis of asymmetric in-plan buildings.The 2DMPS procedure scales ground motions to approach close enough to a target value of the inelastic displacement of the first-mode inelastic 2DOF modal stick,extended for structures with significant contributions of higher modes.Further,4-,6-and 13-story RC SMRF buildings were selected for analyses using ground motion records scaled by the 2DMPS procedure,the modal pushover-based scaling method(MPS),and ASCE/SEI 7-16 scaling procedures.The median values of EDPs on scaled records closely matched the benchmark results.The bias in the EDP values due to the scaled records in every group regarding their median value was lower than the dispersion of the 21 unscaled records.These results generally demonstrate the accuracy and efficiency of the 2DMPS method.Additionally,the 2DOF modal stick’s inelastic response spectra are better suited for calculating seismic demands for one-way asymmetric-plan structures than the SDOF inelastic response spectra.
基金supported by the National Natural Science Foundation of China(Project No.42307555).
文摘At present,there is currently a lack of unified standard methods for the determination of antimony content in groundwater in China.The precision and trueness of related detection technologies have not yet been systematically and quantitatively evaluated,which limits the effective implementation of environmental monitoring.In response to this key technical gap,this study aimed to establish a standardized method for determining antimony in groundwater using Hydride Generation–Atomic Fluorescence Spectrometry(HG-AFS).Ten laboratories participated in inter-laboratory collaborative tests,and the statistical analysis of the test data was carried out in strict accordance with the technical specifications of GB/T 6379.2—2004 and GB/T 6379.4—2006.The consistency and outliers of the data were tested by Mandel's h and k statistics,the Grubbs test and the Cochran test,and the outliers were removed to optimize the data,thereby significantly improving the reliability and accuracy.Based on the optimized data,parameters such as the repeatability limit(r),reproducibility limit(R),and method bias value(δ)were determined,and the trueness of the method was statistically evaluated.At the same time,precision-function relationships were established,and all results met the requirements.The results show that the lower the antimony content,the lower the repeatability limit(r)and reproducibility limit(R),indicating that the measurement error mainly originates from the detection limit of the method and instrument sensitivity.Therefore,improving the instrument sensitivity and reducing the detection limit are the keys to controlling the analytical error and improving precision.This study provides reliable data support and a solid technical foundation for the establishment and evaluation of standardized methods for the determination of antimony content in groundwater.
基金National Key Research and Development Program of China under Grant No.2022YFC3003601National Natural Science Foundation of China under Grant No.52478570+1 种基金Heilongjiang Provincial Natural Science Foundation Outstanding Youth Program under Grant No.J020245002the Key Research and Development Program of Xinjiang Production and Construction Corps under Grant No.2024AB077。
文摘The stochastic extended finite-fault simulation method(EXSIM)is a widely used tool in seismological research,with applications in ground motion prediction and simulation,seismic hazard analysis,and engineering studies.However,recent studies have revealed a significant limitation:EXSIM tends to overpredict ground motions in the low-to-intermediate frequency range,particularly for large thrust earthquakes that are often characterized by a double-corner-frequency source model.To address this issue and enhance simulation accuracy,this study introduces two key improvements:(1)a novel asperity-distributed stress-drop composite fault model and(2)a hybrid application of EXSIM with the composite fault model.The proposed method is validated through its application to the 2013 M_(w)6.7 Lushan earthquake that occurred in China and six thrust earthquakes with an M_(w)≥6.5 in Japan.By comparing the simulated ground motions with recorded data,the results demonstrate that the improved method achieves consistent accuracy across the high-and low-frequency spectrum(combined goodness-of-fit:CGOF<0.35).This study significantly broadens the applicability of stochastic finite-fault simulations,enabling more reliable predictions for a wider range of seismic scenarios,including complex thrust faulting events.
基金Under the auspices of the Natural Science Foundation of China(No.32371875,32001249)。
文摘Stand age plays a crucial role in forest biomass estimation and carbon cycle modeling.Assessing the uncertainty of stand age prediction models and identifying the key driving factors in the modeling process have become major challenges in forestry research.In this study,we selected the Shaanxi-Gansu-Ningxia region of Northeast China as the research area and utilized multi-source datasets from the summer of 2019 to extract information on spectral,textural,climatic,water balance,and stand characteristics.By integrating the Random Forest(RF)model with Monte Carlo(MC)simulation,we constructed six regression models based on different combina-tions of features and evaluated the uncertainty of each model.Furthermore,we investigated the driving factors influencing stand age modeling by analyzing the effects of different types of features on age inversion.Model performance and accuracy were assessed using the root mean square error(RMSE),mean absolute error(MAE),and the coefficient of determination(R^(2)),while the relative root mean square error(rRMSE)was employed to quantify model uncertainty.The results indicate that the scenarios with more obvious improve-ment in accuracy and effective reduction in uncertainty were Scenario 3 with the inclusion of climate and water balance information(RMSE=25.54 yr,MAE=18.03 yr,R^(2)=0.51,rRMSE=19.17%)and Scenario 5 with the inclusion of stand characterization informa-tion(RMSE=18.47 yr,MAE=13.05 yr,R^(2)=0.74,rRMSE=16.99%).Scenario 6,incorporating all feature types,achieved the highest accuracy(RMSE=17.60 yr,MAE=12.06 yr,R^(2)=0.77,rRMSE=14.19%).In this study,elevation,minimum temperature,and diameter at breast height(DBH)emerged as the key drivers of stand-age modeling.The proposed method can be used to identify drivers and to quantify uncertainty in stand-age estimation,providing a useful reference for improving model accuracy and uncertainty assessment.
文摘Cost-effectiveness analysis（CEA） is increasingly important in health care decision making.Cost-effectiveness threshold is a critical parameter in the cost-effectiveness analysis.This review introduces the concept of cost-effectiveness threshold, summarizes its determining methods,and classifies the existing methods into two kinds according to budget constraints,then analyzes the merit and demerit of every methods.When there is a flexible budget,the methods for determining the cost-effectiveness threshold include inferring the threshold from previous decisions,comparison with other health care technology or transfer from elsewhere in the public sector,social willingness-to-pay approach,GDP per capita criteria,and rule of thumb.When there is a fixed budget,the methods for determining the cost-effectiveness threshold include shadow price approach,opportunity cost approach,and ICER threshold-searcher model.Each approach to determining threshold has its strength and weakness.The aim of this article is to introduce the existing methods and discuss the features of each method.The background information,such as the definition of threshold,is also described.The basic theory of cost-effectiveness threshold is elaborated,and we recommend the establishment of a cost-effectiveness threshold in the Chinese health care.
基金funded by the Major Program of National Natural Science Foundation of China (40930101)National Technology Introduction Program of China (948 Program,2009-Z31)the Key Project of the Commonweal Foundation of China's National Academy (2010-02)~~
文摘Since the introduction of the concept, studies on valuation of ecosystem services have been overwhelming, in cognizance of its great significance. In this article, the authors took Northeast China as the study area and applied the published coefficients for the world by Costanza to calculate the ecosystem services values through a spatial convolution method. The convolution analysis was done with a square processor with 5×5 neighborhood cells. The results showed that the ecosystem services value for the study area in the year 2003 was US$44 990 million which is US$89 million less than the value without operation, and the main contributions for that decrease were from water bodies, wetlands and estuaries. It is expected that this article can attract more interest to explore this field adopting geographic methods.
基金supported by the Ph.D. programs Foundation of Ministry of Education of China (No.200802511022)
文摘Indium tin oxide （ITO） nanoparticles with crystallite size of 12.6 nm and specific surface area of 45.7 m 2 ·g-1 were synthesized by co-precipitation method.The indium solution was obtained by dissolving metal indium in HNO3.The tin solution was obtained by dissolving metal tin in HNO3 and followed by stabilizing with citric acid.The free of chlorine ions in the synthesis process brought several advantages：shortening the synthesis time,decreasing the particle agglomeration,decreasing the chlorine content in the ITO nanoparticles and improving the particle sinterability.This is the first time to report the synthesis of ITO nanoparticles free from chlorine contamination without using the expensive metal alkoxides as starting materials.
