Facial synkinesis,a sequela of peripheral facial nerve palsy,is characterized by simultaneous involuntary facial movement during a voluntary desired one.Maladaptive cortical plasticity might be involved in the dysfunc...Facial synkinesis,a sequela of peripheral facial nerve palsy,is characterized by simultaneous involuntary facial movement during a voluntary desired one.Maladaptive cortical plasticity might be involved in the dysfunction of facial muscles.This cohort study investigated the cortical functional alterations in patients with unilateral facial synkinesis,using the task functional magnetic resonance imaging.Facial motor tasks,including blinking and smiling,were performed by 16 patients（aged 30.6 ± 4.5 years,14 females/2 males） and 24 age-and sex-matched healthy controls（aged 29.1 ± 4.2 years,19 females/5 males）.Results demonstrated that activation in the cortico-facial motor representation area was lower during tasks in patients with facial synkinesis compared with healthy controls.Facial movements on either side performed by patients caused more intensive activation of the supplementary motor area on the contralateral side of the affected face,than those on the unaffected side.Our results revealed that there was cortical reorganization in the primary sensorimotor area and the supplementary motor area.This study was registered in Chinese Clinical Trial Registry（registration number： Chi CTR1800014630）.展开更多
Malformations of cortical development(MCDs)represent one of the most common causes of childhood-onset epilepsy,and are often refractory to antiseizure medications(Guerrini,2006;Guerrini and Dobyns,2014;Severino et al....Malformations of cortical development(MCDs)represent one of the most common causes of childhood-onset epilepsy,and are often refractory to antiseizure medications(Guerrini,2006;Guerrini and Dobyns,2014;Severino et al.,2020).Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy(MOGHE)is a newly recognized subtype of Focal Cortical Dysplasia(FCD),which was officially added to the FCD classification in 2022 by the International League Against Epilepsy(ILAE)(Najm et al.,2022).展开更多
基金supported by the Youth Researcher Foundation of Shanghai Municipal Commission of Health and Family Planning,No.20144Y0095
文摘Facial synkinesis,a sequela of peripheral facial nerve palsy,is characterized by simultaneous involuntary facial movement during a voluntary desired one.Maladaptive cortical plasticity might be involved in the dysfunction of facial muscles.This cohort study investigated the cortical functional alterations in patients with unilateral facial synkinesis,using the task functional magnetic resonance imaging.Facial motor tasks,including blinking and smiling,were performed by 16 patients（aged 30.6 ± 4.5 years,14 females/2 males） and 24 age-and sex-matched healthy controls（aged 29.1 ± 4.2 years,19 females/5 males）.Results demonstrated that activation in the cortico-facial motor representation area was lower during tasks in patients with facial synkinesis compared with healthy controls.Facial movements on either side performed by patients caused more intensive activation of the supplementary motor area on the contralateral side of the affected face,than those on the unaffected side.Our results revealed that there was cortical reorganization in the primary sensorimotor area and the supplementary motor area.This study was registered in Chinese Clinical Trial Registry（registration number： Chi CTR1800014630）.
基金support from the following grants:the Natural Science Foundation of Beijing Municipality(7242149,L202034,7244416)the E-Town Cooperation&Development Foundation(YCXJ-JZ-2023-017)+3 种基金the National Natural Science Foundation of China(82171694,81901155)National High Level Hospital Clinical Research Funding(High Quality Clinical Research Project of Peking University First Hospital)(23cz020202)National High Level Hospital Clinical Research Funding(Youth Clinical Research Project of Peking University First Hospital)(2023YC19)National High Level Hospital Clinical Research Funding(Scientific Research Seed Fund of Peking University First Hospital)(2023SF42).
文摘Malformations of cortical development(MCDs)represent one of the most common causes of childhood-onset epilepsy,and are often refractory to antiseizure medications(Guerrini,2006;Guerrini and Dobyns,2014;Severino et al.,2020).Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy(MOGHE)is a newly recognized subtype of Focal Cortical Dysplasia(FCD),which was officially added to the FCD classification in 2022 by the International League Against Epilepsy(ILAE)(Najm et al.,2022).
