Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms...Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive decline.The causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.展开更多
Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSC...Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSCLC)and its molecular mechanism using mice bearing Lewis lung carcinoma cells.LRC significantly suppressed the growth of NSCLC.Besides,RNA sequencing of mice tumors and hematoxylin&eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes,specifically GZMB~+CD8~+T lymphocytes,in tumor tissues.The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways,suggesting that LRC exerted its effects through the PDL1/PD-1 pathway.Further experiments revealed that LRC interacted with PD-L1,blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells.Together,these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC.展开更多
基于二阶广义积分器锁相环(second-order generalized integrator-phase-locked loop,SOGI-PLL)的图腾柱无桥功率因数校正变换器(totem pole bridgeless power factor correction,TBPFC)可有效滤除电网电压谐波,但对于包含谐波及直流分...基于二阶广义积分器锁相环(second-order generalized integrator-phase-locked loop,SOGI-PLL)的图腾柱无桥功率因数校正变换器(totem pole bridgeless power factor correction,TBPFC)可有效滤除电网电压谐波,但对于包含谐波及直流分量的复杂电网抑制谐波能力有限,锁相精确有待提高。为此提出4种改进SOGI-PLL的控制策略:嵌入型SOGI-PLL、级联型SOGI-PLL、并联型SOGI-PLL和增强并联型SOGI-PLL锁相设计方法。通过分别阐述4种策略的改进结构,将4种改进锁相方法与SOGI-PLL进行对比,分析出不同锁相策略的谐波及直流分量的抑制能力,并针对TBPFC变换器电流环比例积分控制器存在谐波抑制能力不足的问题,采用能够改善对电网谐波的抑制能力的比例积分谐振控制器,将该控制器与4种改进锁相环相结合重塑电流内环控制结构,实现谐波抑制,优化电感电流波形质量,降低总谐波失真。经仿真试验证明,与SOGI-PLL相比,所提出的4种改进策略的抑制谐波能力均优于SOGI-PLL,总谐波失真均低于SOGI-PLL。展开更多
Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairme...Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission.This review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain disorders.Improving understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these conditions.However,the mechanisms that regulate gamma-aminobutyric acidergic systems remain elusive.It is also unclear as to whether the mechanisms are presynaptic or postsynaptic.Further exploration of the complexities of this system may reveal new pathways for research and drug development.展开更多
文摘Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive decline.The causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.
基金supported by Natural Science Foundation of Guangdong Province,China(2022A1515011575)National Natural Science Foundation of China,China(81873154)President Foundation of Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,China(1202103010)。
文摘Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSCLC)and its molecular mechanism using mice bearing Lewis lung carcinoma cells.LRC significantly suppressed the growth of NSCLC.Besides,RNA sequencing of mice tumors and hematoxylin&eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes,specifically GZMB~+CD8~+T lymphocytes,in tumor tissues.The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways,suggesting that LRC exerted its effects through the PDL1/PD-1 pathway.Further experiments revealed that LRC interacted with PD-L1,blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells.Together,these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC.
文摘基于二阶广义积分器锁相环(second-order generalized integrator-phase-locked loop,SOGI-PLL)的图腾柱无桥功率因数校正变换器(totem pole bridgeless power factor correction,TBPFC)可有效滤除电网电压谐波,但对于包含谐波及直流分量的复杂电网抑制谐波能力有限,锁相精确有待提高。为此提出4种改进SOGI-PLL的控制策略:嵌入型SOGI-PLL、级联型SOGI-PLL、并联型SOGI-PLL和增强并联型SOGI-PLL锁相设计方法。通过分别阐述4种策略的改进结构,将4种改进锁相方法与SOGI-PLL进行对比,分析出不同锁相策略的谐波及直流分量的抑制能力,并针对TBPFC变换器电流环比例积分控制器存在谐波抑制能力不足的问题,采用能够改善对电网谐波的抑制能力的比例积分谐振控制器,将该控制器与4种改进锁相环相结合重塑电流内环控制结构,实现谐波抑制,优化电感电流波形质量,降低总谐波失真。经仿真试验证明,与SOGI-PLL相比,所提出的4种改进策略的抑制谐波能力均优于SOGI-PLL,总谐波失真均低于SOGI-PLL。
基金supported by the National Natural Science Foundation of China,Nos.82374561(to JD),82174490(to JF)the Medical and Health Science and Technology Program of Zhejiang Province,No.2021RC098(to JD)the Research Project of Zhejiang Chinese Medical University,Nos.2022JKZKTS44(to JD),2022FSYYZZ07(to JF).
文摘Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission.This review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain disorders.Improving understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these conditions.However,the mechanisms that regulate gamma-aminobutyric acidergic systems remain elusive.It is also unclear as to whether the mechanisms are presynaptic or postsynaptic.Further exploration of the complexities of this system may reveal new pathways for research and drug development.
