The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cel...The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cellular level, the structural effects resulting from topical application of a hand-cream onto normal skin and to investigate the potential repair mechanisms induced by the emollient on altered tissue. Transmission electron microscopy (TEM) was used to compare the architectures of the horny layers from: 1) ex-vivo cultured human skin;2) skin treated by topical application of a hand-cream emulsion;3) explants exposed to sodium lauryl sulfate (SLS);4) SLS-treated explants that underwent subsequent topical application of the emollient emulsion. These TEM assessments allowed identifying the structural changes occurring in the stratum corneum of skin explants exposed to SLS and/or treated with an emollient. Results strongly suggest that both, SLS-induced damage and emollient-driven repair process take place in the stratum corneum, at the cellular level. One can envisage that the observed restructuring effects after topical application of the skin-care product are likely to ameliorate or restore the barrier function of the stratum corneum. In this, the properties of the emollient go beyond the cosmetic feel.展开更多
Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to...Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to regulate the administration time and dosage[2].The depth of drug permeability is mainly impeded by geometry obstruction and diffusional resistance of the stratum corneum,which consists of 10 to 30 layers of keratinized corneocytes embedded in an extracellular lipid matrix.It is a great challenge to overcome stratum corneum to enhance drug permeation across skin[3].The latest publication in Advanced Materials from the teams of Cai,Cui,and Bai introduced a new type of nanobubble ultrasonic coupling hydrogel,which is built by dynamic Schiff base cross-linking between nanobubbles and aminated hyaluronic acid(HA)[4].This ultrasound coupling hydrogel opens new insights in noninvasive drug delivery because it effciently overcomes the skin barrier and achieves precise spatiotemporal drug delivery by ultrasound-amplified cavitation effect.展开更多
文摘The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cellular level, the structural effects resulting from topical application of a hand-cream onto normal skin and to investigate the potential repair mechanisms induced by the emollient on altered tissue. Transmission electron microscopy (TEM) was used to compare the architectures of the horny layers from: 1) ex-vivo cultured human skin;2) skin treated by topical application of a hand-cream emulsion;3) explants exposed to sodium lauryl sulfate (SLS);4) SLS-treated explants that underwent subsequent topical application of the emollient emulsion. These TEM assessments allowed identifying the structural changes occurring in the stratum corneum of skin explants exposed to SLS and/or treated with an emollient. Results strongly suggest that both, SLS-induced damage and emollient-driven repair process take place in the stratum corneum, at the cellular level. One can envisage that the observed restructuring effects after topical application of the skin-care product are likely to ameliorate or restore the barrier function of the stratum corneum. In this, the properties of the emollient go beyond the cosmetic feel.
基金support from the UMCG Research Fundssupport from China Scholarship Council.
文摘Noninvasive drug delivery systems are well applied due to their safety,convenience,and patient compliance[1].However,drug permeability in traditional noninvasive drug delivery systems is limited,and it is difficult to regulate the administration time and dosage[2].The depth of drug permeability is mainly impeded by geometry obstruction and diffusional resistance of the stratum corneum,which consists of 10 to 30 layers of keratinized corneocytes embedded in an extracellular lipid matrix.It is a great challenge to overcome stratum corneum to enhance drug permeation across skin[3].The latest publication in Advanced Materials from the teams of Cai,Cui,and Bai introduced a new type of nanobubble ultrasonic coupling hydrogel,which is built by dynamic Schiff base cross-linking between nanobubbles and aminated hyaluronic acid(HA)[4].This ultrasound coupling hydrogel opens new insights in noninvasive drug delivery because it effciently overcomes the skin barrier and achieves precise spatiotemporal drug delivery by ultrasound-amplified cavitation effect.
