Obstructive pulmonary diseases(OPDs)are the leading causes of mortality and disability worldwide.The International Classification of Functioning,Disability and Health(ICF)provides a framework for systemat-ically asses...Obstructive pulmonary diseases(OPDs)are the leading causes of mortality and disability worldwide.The International Classification of Functioning,Disability and Health(ICF)provides a framework for systemat-ically assessing functioning and disability in patients with chronic diseases.To date,the ICF core sets for OPDs have not been validated by respiratory physicians in China’s mainland.This study was aimed at validating the brief ICF core set for OPDs from the perspective of Chinese respiratory physicians.A three-round,consensus-building survey was conducted with Chinese respiratory physicians from Shanghai,Jiangsu,and Zhejiang from December 2 to December 16,2017,using the Delphi technique.Their answers were analyzed for consensus degree.In this study,52 experts(about 67.3%men)with a mean working experience of(19.3±6.3)years completed the consensus process.After 3 rounds,the following 13 ICF categories were considered crucial for the assessment of OPDs,with an agreement of over 70%:4 in body functions(b410-heart functions,b440-respiratory functions,b455-exercise tolerance functions,and b460-sensations associated with cardiovascular and respiratory functions),2 in body structures(s410-structure of cardiovascular system,and s430-structure of respiratory system),4 in activities and participation(d230-carrying out daily routine,d450-walking,d455-moving around,and d640-doing housework),and 3 in environmental factors(e110-products or substances for personal consumption,e225-climate,and e260-air quality).Twelve(70.6%)categories in the current brief ICF core set were validated,and one additional category,b410-heart functions,was added.In conclusion,Chinese respiratory physicians largely supported the current brief ICF core set for OPDs.However,the newly added and unconfirmed categories need further investigation.展开更多
Objective:This study aimed to develop a core outcome set(COS)for use in future studies of stable angina pectoris(SAP)in traditional Chinese medicine(TCM).Methods:Systematic literature reviews and qualitative interview...Objective:This study aimed to develop a core outcome set(COS)for use in future studies of stable angina pectoris(SAP)in traditional Chinese medicine(TCM).Methods:Systematic literature reviews and qualitative interviews with cardiologists and patients with SAP treated using TCM were conducted to generate a set of outcomes.Outcomes were prioritized by stakeholders via two rounds of an online Delphi survey and face-to-face consensus meetings.Following the final consensus meeting,a final COS was generated.Results:An initial set of 324 outcomes was identified.A preliminary list of 65 outcomes was employed in the Delphi study.In total,223 participants from seven stakeholder groups were invited to score outcomes in the first Delphi round:87 completed round 1 and 47 completed round 2.Thirty-one participants attended the consensus meeting and agreed on a final core set of outcomes comprising six items across four domains:frequency of angina attack,duration of angina attack,Seattle angina questionnaire,total exercise duration in the exercise treadmill test,cardiovascular events,and QT interval on electrocardiography.Conclusions:The COS developed in this study provides the minimum requirements for measurement and reporting in future TCM clinical trials for the treatment of SAP.The employment of this COS may reduce heterogeneity across trials and facilitate evidencebased decision-making for stakeholders.展开更多
The comprehensive evaluation method of enterprise core competitiveness is proposed by combining rough sets and gray correlation theories. Firstly,the initial index is screened through rough set attribute reduction alg...The comprehensive evaluation method of enterprise core competitiveness is proposed by combining rough sets and gray correlation theories. Firstly,the initial index is screened through rough set attribute reduction algorithm,and the evaluation weight of each index is obtained through the rough set theory. Then,based on the gray correlation theory, an evaluation model is built for empirical analysis. The 30 financial institutions on the Yangtze River Delta are examined from the theoretical and empirical perspective.The result demonstrates not only the feasibility of rough set attribute reduction algorithm in the core competitiveness index system of the financial institution,but also the accuracy of the combination of these two methods in the comprehensive evaluation of corporate core competitiveness.展开更多
背景消化性溃疡(PUD)是消化系统常见疾病,中医药治疗作为PUD的有效治疗措施,但目前针对中医药治疗PUD的随机对照试验(RCT)中,方法学质量、结局指标的选择等存在较大局限性,给疗效评价、资料整合分析等带来一定挑战。目的本文系统梳理近1...背景消化性溃疡(PUD)是消化系统常见疾病,中医药治疗作为PUD的有效治疗措施,但目前针对中医药治疗PUD的随机对照试验(RCT)中,方法学质量、结局指标的选择等存在较大局限性,给疗效评价、资料整合分析等带来一定挑战。目的本文系统梳理近15年中医药干预PUD的RCT结局指标应用状况与试验设计要点,旨在为构建中医药治疗PUD核心指标集及优化临床试验设计提供参考依据。方法计算机检索中文数据库:中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统,以及国际权威数据库:PubMed、Embase、Cochrane Library、Web of Science中关于中医药治疗PUD的RCT文献;检索时限为2010—2024年。对纳入文献进行Cochrane偏倚风险评估,并统计、归纳、分析相关结局指标。结果共纳入323篇RCT文献,34933例患者,单项研究样本量最大为498例,最小为40例,平均样本量为108例;171篇报告中医证型,其中使用频次最高为脾胃虚寒(31篇,18.13%);47篇采用纯中医治疗,276篇采用中西医结合治疗;治疗疗程多为4周(119次,36.84%);结局指标按照功能属性划分为6类,共报道了170种结局指标,总频次为1962次,其中使用频次较高的结局指标是临床总有效率(233次,11.88%)、幽门螺杆菌根除率(165次,8.41%)、不良反应(155次,7.90%);纳入文献偏倚风险评估多数为不明确。结论中医药治疗PUD的RCT尚存在中医辨证分型与疾病分期欠规范、方法学设计(盲法、分配隐藏)待完善、主次结局指标区分不明确、临床疗效标准未统一、结局指标测量时间差距大、中医证候/症状积分评分标准多元化、伦理注册待重视、安全性指标报告不规范等问题。建议积极开展中医药治疗PUD的核心指标集研究,优化完善方法学质量,为中医药治疗PUD的临床实践提供科学性、可靠性、实用性证据。展开更多
In this paper, the definition of weak dominance is proposed for a NTU game and two new solution concepts of NTU games are introduced: the refined core and weakly stable set. The relationship is explored among the core...In this paper, the definition of weak dominance is proposed for a NTU game and two new solution concepts of NTU games are introduced: the refined core and weakly stable set. The relationship is explored among the core, the weakly stable set and the refined core.展开更多
A DFT conformational and vibrational analysis of a single molecule of cisplatin (cis-[Pt(NH3)2Cl2]) was performed by means of PW91 functional and LANL08 ECP basis set for the Pt atom. 3-21G and 3-21G* Basis sets were ...A DFT conformational and vibrational analysis of a single molecule of cisplatin (cis-[Pt(NH3)2Cl2]) was performed by means of PW91 functional and LANL08 ECP basis set for the Pt atom. 3-21G and 3-21G* Basis sets were used for the remaining atoms. All the initially chosen conformations were found to converge to the global minimum conformation of C2v symmetry with H atoms lying in the coordination plane and pointing to the Cl atoms. The computational results were compared with the newest experimental structural data and with the vibrational spectroscopic data for cisplatin, obtained by other workers. The chosen level of theory was found to describe satisfactory the molecular structure (r. m. s. of the relative deviations ≤ 6%) and the harmonic vibrational frequencies (r. m. s. of the relative deviations ≤ 5%) of cisplatin.展开更多
该研究参考核心指标集研制规范(core outcome set standards for development, COS-STAD),旨在构建中医药治疗单纯性肥胖临床研究的核心指标集(core outcome set, COS)。全面检索中英文数据库,收集中医药治疗单纯性肥胖的随机对照试验(R...该研究参考核心指标集研制规范(core outcome set standards for development, COS-STAD),旨在构建中医药治疗单纯性肥胖临床研究的核心指标集(core outcome set, COS)。全面检索中英文数据库,收集中医药治疗单纯性肥胖的随机对照试验(RCT)与系统评价中报告的结局指标;通过患者半结构化访谈和临床医生开放式问卷调查,获取补充结局指标,并将所有指标合并整理形成原始指标池,经工作组讨论后形成初步指标清单;与临床医生、方法学专家及患者进行2轮德尔菲问卷调查,对各指标的重要性进行评分;召开共识会议建立中医药治疗单纯性肥胖临床研究COS。结果纳入221篇RCTs和12篇系统评价,整理并结合补充指标后形成原始指标池,包含141个结局指标。经过咨询小组会议讨论,确定初步指标清单包含指标33个,分为9个指标域;通过2轮德尔菲调查及共识会议,最终确定中医药治疗单纯性肥胖临床研究的COS,包含8个结局指标[中医证候积分、体质量指数(BMI)、腰臀比、腰围、内脏脂肪指数、体脂率、生活质量、安全性],分为4个指标域(中医相关指标、人体测量学指标、生活质量相关指标、安全性评价指标)。该研究初步构建了中医药治疗单纯性肥胖临床研究的COS,有利于减少同类临床研究结局指标选择和报告的异质性,提高研究结果的可比性与合并分析的可行性,为临床实践提供更高水平的证据支持。展开更多
基金the Shanghai Jiao Tong University“Medicine-Engineering Interdisciplinary”Project,and the Project of Shanghai Municipal Commission of Health and Family Planning(No.201740032)。
文摘Obstructive pulmonary diseases(OPDs)are the leading causes of mortality and disability worldwide.The International Classification of Functioning,Disability and Health(ICF)provides a framework for systemat-ically assessing functioning and disability in patients with chronic diseases.To date,the ICF core sets for OPDs have not been validated by respiratory physicians in China’s mainland.This study was aimed at validating the brief ICF core set for OPDs from the perspective of Chinese respiratory physicians.A three-round,consensus-building survey was conducted with Chinese respiratory physicians from Shanghai,Jiangsu,and Zhejiang from December 2 to December 16,2017,using the Delphi technique.Their answers were analyzed for consensus degree.In this study,52 experts(about 67.3%men)with a mean working experience of(19.3±6.3)years completed the consensus process.After 3 rounds,the following 13 ICF categories were considered crucial for the assessment of OPDs,with an agreement of over 70%:4 in body functions(b410-heart functions,b440-respiratory functions,b455-exercise tolerance functions,and b460-sensations associated with cardiovascular and respiratory functions),2 in body structures(s410-structure of cardiovascular system,and s430-structure of respiratory system),4 in activities and participation(d230-carrying out daily routine,d450-walking,d455-moving around,and d640-doing housework),and 3 in environmental factors(e110-products or substances for personal consumption,e225-climate,and e260-air quality).Twelve(70.6%)categories in the current brief ICF core set were validated,and one additional category,b410-heart functions,was added.In conclusion,Chinese respiratory physicians largely supported the current brief ICF core set for OPDs.However,the newly added and unconfirmed categories need further investigation.
基金supported by the National Natural Science Foundation of China(No.81473544).
文摘Objective:This study aimed to develop a core outcome set(COS)for use in future studies of stable angina pectoris(SAP)in traditional Chinese medicine(TCM).Methods:Systematic literature reviews and qualitative interviews with cardiologists and patients with SAP treated using TCM were conducted to generate a set of outcomes.Outcomes were prioritized by stakeholders via two rounds of an online Delphi survey and face-to-face consensus meetings.Following the final consensus meeting,a final COS was generated.Results:An initial set of 324 outcomes was identified.A preliminary list of 65 outcomes was employed in the Delphi study.In total,223 participants from seven stakeholder groups were invited to score outcomes in the first Delphi round:87 completed round 1 and 47 completed round 2.Thirty-one participants attended the consensus meeting and agreed on a final core set of outcomes comprising six items across four domains:frequency of angina attack,duration of angina attack,Seattle angina questionnaire,total exercise duration in the exercise treadmill test,cardiovascular events,and QT interval on electrocardiography.Conclusions:The COS developed in this study provides the minimum requirements for measurement and reporting in future TCM clinical trials for the treatment of SAP.The employment of this COS may reduce heterogeneity across trials and facilitate evidencebased decision-making for stakeholders.
基金Supported by National Natural Science Foundation of China(60675039)National High Technology Research and Development Program of China(863 Program)(2006AA04Z217)Hundred Talents Program of Chinese Academy of Sciences
文摘The comprehensive evaluation method of enterprise core competitiveness is proposed by combining rough sets and gray correlation theories. Firstly,the initial index is screened through rough set attribute reduction algorithm,and the evaluation weight of each index is obtained through the rough set theory. Then,based on the gray correlation theory, an evaluation model is built for empirical analysis. The 30 financial institutions on the Yangtze River Delta are examined from the theoretical and empirical perspective.The result demonstrates not only the feasibility of rough set attribute reduction algorithm in the core competitiveness index system of the financial institution,but also the accuracy of the combination of these two methods in the comprehensive evaluation of corporate core competitiveness.
文摘背景消化性溃疡(PUD)是消化系统常见疾病,中医药治疗作为PUD的有效治疗措施,但目前针对中医药治疗PUD的随机对照试验(RCT)中,方法学质量、结局指标的选择等存在较大局限性,给疗效评价、资料整合分析等带来一定挑战。目的本文系统梳理近15年中医药干预PUD的RCT结局指标应用状况与试验设计要点,旨在为构建中医药治疗PUD核心指标集及优化临床试验设计提供参考依据。方法计算机检索中文数据库:中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统,以及国际权威数据库:PubMed、Embase、Cochrane Library、Web of Science中关于中医药治疗PUD的RCT文献;检索时限为2010—2024年。对纳入文献进行Cochrane偏倚风险评估,并统计、归纳、分析相关结局指标。结果共纳入323篇RCT文献,34933例患者,单项研究样本量最大为498例,最小为40例,平均样本量为108例;171篇报告中医证型,其中使用频次最高为脾胃虚寒(31篇,18.13%);47篇采用纯中医治疗,276篇采用中西医结合治疗;治疗疗程多为4周(119次,36.84%);结局指标按照功能属性划分为6类,共报道了170种结局指标,总频次为1962次,其中使用频次较高的结局指标是临床总有效率(233次,11.88%)、幽门螺杆菌根除率(165次,8.41%)、不良反应(155次,7.90%);纳入文献偏倚风险评估多数为不明确。结论中医药治疗PUD的RCT尚存在中医辨证分型与疾病分期欠规范、方法学设计(盲法、分配隐藏)待完善、主次结局指标区分不明确、临床疗效标准未统一、结局指标测量时间差距大、中医证候/症状积分评分标准多元化、伦理注册待重视、安全性指标报告不规范等问题。建议积极开展中医药治疗PUD的核心指标集研究,优化完善方法学质量,为中医药治疗PUD的临床实践提供科学性、可靠性、实用性证据。
文摘In this paper, the definition of weak dominance is proposed for a NTU game and two new solution concepts of NTU games are introduced: the refined core and weakly stable set. The relationship is explored among the core, the weakly stable set and the refined core.
文摘A DFT conformational and vibrational analysis of a single molecule of cisplatin (cis-[Pt(NH3)2Cl2]) was performed by means of PW91 functional and LANL08 ECP basis set for the Pt atom. 3-21G and 3-21G* Basis sets were used for the remaining atoms. All the initially chosen conformations were found to converge to the global minimum conformation of C2v symmetry with H atoms lying in the coordination plane and pointing to the Cl atoms. The computational results were compared with the newest experimental structural data and with the vibrational spectroscopic data for cisplatin, obtained by other workers. The chosen level of theory was found to describe satisfactory the molecular structure (r. m. s. of the relative deviations ≤ 6%) and the harmonic vibrational frequencies (r. m. s. of the relative deviations ≤ 5%) of cisplatin.
文摘该研究参考核心指标集研制规范(core outcome set standards for development, COS-STAD),旨在构建中医药治疗单纯性肥胖临床研究的核心指标集(core outcome set, COS)。全面检索中英文数据库,收集中医药治疗单纯性肥胖的随机对照试验(RCT)与系统评价中报告的结局指标;通过患者半结构化访谈和临床医生开放式问卷调查,获取补充结局指标,并将所有指标合并整理形成原始指标池,经工作组讨论后形成初步指标清单;与临床医生、方法学专家及患者进行2轮德尔菲问卷调查,对各指标的重要性进行评分;召开共识会议建立中医药治疗单纯性肥胖临床研究COS。结果纳入221篇RCTs和12篇系统评价,整理并结合补充指标后形成原始指标池,包含141个结局指标。经过咨询小组会议讨论,确定初步指标清单包含指标33个,分为9个指标域;通过2轮德尔菲调查及共识会议,最终确定中医药治疗单纯性肥胖临床研究的COS,包含8个结局指标[中医证候积分、体质量指数(BMI)、腰臀比、腰围、内脏脂肪指数、体脂率、生活质量、安全性],分为4个指标域(中医相关指标、人体测量学指标、生活质量相关指标、安全性评价指标)。该研究初步构建了中医药治疗单纯性肥胖临床研究的COS,有利于减少同类临床研究结局指标选择和报告的异质性,提高研究结果的可比性与合并分析的可行性,为临床实践提供更高水平的证据支持。
