There is evidence that the development of plant communities determines the composition and structure of the orthoptera assemblages. This is the reason for using the orthoptera biodiversity as an indicator of environme...There is evidence that the development of plant communities determines the composition and structure of the orthoptera assemblages. This is the reason for using the orthoptera biodiversity as an indicator of environmental recovery processes in revegetated areas. This research is a part of the monitoring actions included in the Breña’s Compensation Project, linked to the construction of the Breña II damp. It is aimed to assess the biodiversity of the Orthopteran assemblages settled in the restored river copses after nine years following (2007-2016). The results will be interpreted as an indirect measure of the success of the environmental improvement performed. In 2016, two forest farms named “Las Mesas” and “Cerro del Trigo” located in the Sierra de Hornachuelos Natural Park (Córdoba, Southern Iberian Peninsula) were selected for monitoring. These sampling sites were also selected in a previous following phase, which makes comparisons easier and more reliable. At each of these sampling sites, two revegetated enclosures corresponding to the environmental model “restored river copses” and their respective control areas were selected for the study. From the values of the specimen’s number recorded in each sampling plot, the same population indices that in the previous phase (Richness, Abundance, Dominance, Shannon Diversity, and Evenness) were calculated. The diversity profiles using Rényi’s family of uni-parametric diversity indices were also obtained. Differences in the indices were statistically tested by resampling bootstrapping for inferential statistics. Based on our results, the environmental differences between revegetated and control areas have not led to significant changes in the composition and structure of the orthopteran communities they host. In consequence, the environmental restoration carried out in the study area has not been as successful as could be expected and the previous environmental alterations have not been minimized nor have those derived from the environmental rehabilitation itself been compensated.展开更多
The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-ca...The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns,prognostic value,gene mutations,immune infiltration,correlation analysis,and functional enrichment assessment.Results showed that COPS6 was highly correlated with prognosis,immune cell infiltration level,tumor mutation burden,and microsatellite instability in patients with a range of tumor types.This suggests that COPS6 may be a potential target for cancer treatment.Overall,this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.展开更多
COPS(Concurrent Official Production System)是将产生式系统程序设计语言OPS5和面向进程的程序设计范例相结合,而设计的用于支持协同式问题求解的程序系统。本文详细阐述了COPS通讯原语的设计及其对应的语法和语义。COPS不仅能在单机...COPS(Concurrent Official Production System)是将产生式系统程序设计语言OPS5和面向进程的程序设计范例相结合,而设计的用于支持协同式问题求解的程序系统。本文详细阐述了COPS通讯原语的设计及其对应的语法和语义。COPS不仅能在单机上实现,而且也可以直接的移植到分布式系统上。展开更多
目的研究构成型光形态建成同源亚基3(COPS3)在肝癌中的表达。方法应用免疫组织化学SP法及RT-PCR法检测肝癌组织中COPS3表达情况。结果肝癌组织中COPS3蛋白表达阳性率〔46.7%(14/30)〕明显高于正常肝脏组织〔23.3%(7/30),χ2=5.654,P=0....目的研究构成型光形态建成同源亚基3(COPS3)在肝癌中的表达。方法应用免疫组织化学SP法及RT-PCR法检测肝癌组织中COPS3表达情况。结果肝癌组织中COPS3蛋白表达阳性率〔46.7%(14/30)〕明显高于正常肝脏组织〔23.3%(7/30),χ2=5.654,P=0.017〕及肝硬变组织〔36.7%(11/30),χ2=4.979,P=0.026〕,差异具有统计学意义。肝癌组织中COPS3 m RNA的转录水平亦明显高于肝硬变及正常肝脏组织,差异具有统计学意义(P<0.05);在肝癌组织中,COPS3在细胞核中的表达阳性率明显高于在细胞浆中的表达阳性率(χ2=6.674,P=0.009)。结论 COPS3在肝癌组织中表达水平和定位均发生改变,可能参与了肝癌的发生和发展过程。展开更多
BACKGROUND The COP9 signalosome subunit 6(COPS6)has been implicated in cancer progression,while its precise role in most types of cancer remains elusive.AIM To investigate the functional and clinical relevance of COPS...BACKGROUND The COP9 signalosome subunit 6(COPS6)has been implicated in cancer progression,while its precise role in most types of cancer remains elusive.AIM To investigate the functional and clinical relevance of COPS6 across various tumor types using publicly available databases.METHODS We used R software and online analysis databases to analyze the differential expression,prognosis,mutation and related functions of COPS6 in pan-cancer.RESULTS Differential expression analysis and survival analysis demonstrated that COPS6 was highly expressed and associated with high-risk profiles in the majority of cancer types.Possible associations between COPS6 expression level and prognostic outcomes were found using data from public databases.Mutational analysis revealed that missense mutations were the predominant type of COPS6 mutation.Additionally,positive correlations were identified between COPS6 expression level and tumor mutational burden and microsatellite instability in most types of cancer.Immune infiltration analysis demonstrated a negative correlation between COPS6 expression level and CD8+T cell infiltration in certain types of cancer.The correlation between COPS6 expression level and cancerassociated fibroblast infiltration exhibited heterogeneity,in which a positive correlation was found in head and neck squamous cell carcinoma and tenosynovial giant cell tumor,and a negative correlation was identified in diffuse large B-cell lymphoma and thymoma.The correlation between COPS6 expression level and macrophage infiltration was closely related to macrophage type.Gene co-expression and enrichment analysis highlighted transcription elongation factor B polypeptide 2 and G protein pathway suppressor 1 were significantly and positively associated with COPS6 expression level.These genes were predominantly involved in processes,such as ubiquitin-mediated proteolysis and human immunodeficiency virus 1 infection.CONCLUSION In conclusion,this study systematically explored the significance of COPS6 across different tumor types,providing a solid foundation for considering COPS6 as a novel biomarker in cancer research.展开更多
文摘There is evidence that the development of plant communities determines the composition and structure of the orthoptera assemblages. This is the reason for using the orthoptera biodiversity as an indicator of environmental recovery processes in revegetated areas. This research is a part of the monitoring actions included in the Breña’s Compensation Project, linked to the construction of the Breña II damp. It is aimed to assess the biodiversity of the Orthopteran assemblages settled in the restored river copses after nine years following (2007-2016). The results will be interpreted as an indirect measure of the success of the environmental improvement performed. In 2016, two forest farms named “Las Mesas” and “Cerro del Trigo” located in the Sierra de Hornachuelos Natural Park (Córdoba, Southern Iberian Peninsula) were selected for monitoring. These sampling sites were also selected in a previous following phase, which makes comparisons easier and more reliable. At each of these sampling sites, two revegetated enclosures corresponding to the environmental model “restored river copses” and their respective control areas were selected for the study. From the values of the specimen’s number recorded in each sampling plot, the same population indices that in the previous phase (Richness, Abundance, Dominance, Shannon Diversity, and Evenness) were calculated. The diversity profiles using Rényi’s family of uni-parametric diversity indices were also obtained. Differences in the indices were statistically tested by resampling bootstrapping for inferential statistics. Based on our results, the environmental differences between revegetated and control areas have not led to significant changes in the composition and structure of the orthopteran communities they host. In consequence, the environmental restoration carried out in the study area has not been as successful as could be expected and the previous environmental alterations have not been minimized nor have those derived from the environmental rehabilitation itself been compensated.
文摘The COP9 signalosome subunit 6(COPS6)is abnormally overexpressed in many malignancies,yet its precise role in carcinogenesis is unknown.To gain a better understanding of COPS6's role,the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns,prognostic value,gene mutations,immune infiltration,correlation analysis,and functional enrichment assessment.Results showed that COPS6 was highly correlated with prognosis,immune cell infiltration level,tumor mutation burden,and microsatellite instability in patients with a range of tumor types.This suggests that COPS6 may be a potential target for cancer treatment.Overall,this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.
文摘COPS(Concurrent Official Production System)是将产生式系统程序设计语言OPS5和面向进程的程序设计范例相结合,而设计的用于支持协同式问题求解的程序系统。本文详细阐述了COPS通讯原语的设计及其对应的语法和语义。COPS不仅能在单机上实现,而且也可以直接的移植到分布式系统上。
文摘目的研究构成型光形态建成同源亚基3(COPS3)在肝癌中的表达。方法应用免疫组织化学SP法及RT-PCR法检测肝癌组织中COPS3表达情况。结果肝癌组织中COPS3蛋白表达阳性率〔46.7%(14/30)〕明显高于正常肝脏组织〔23.3%(7/30),χ2=5.654,P=0.017〕及肝硬变组织〔36.7%(11/30),χ2=4.979,P=0.026〕,差异具有统计学意义。肝癌组织中COPS3 m RNA的转录水平亦明显高于肝硬变及正常肝脏组织,差异具有统计学意义(P<0.05);在肝癌组织中,COPS3在细胞核中的表达阳性率明显高于在细胞浆中的表达阳性率(χ2=6.674,P=0.009)。结论 COPS3在肝癌组织中表达水平和定位均发生改变,可能参与了肝癌的发生和发展过程。
基金Supported by National Natural Science Foundation of China,No.31900558the Hubei Provincial Youth Talents Program for Public Health,No.WSJKRC2022013Wuhan Young and Middle-Aged Medical Backbone Talents Training Project,No.WHQG201904.
文摘BACKGROUND The COP9 signalosome subunit 6(COPS6)has been implicated in cancer progression,while its precise role in most types of cancer remains elusive.AIM To investigate the functional and clinical relevance of COPS6 across various tumor types using publicly available databases.METHODS We used R software and online analysis databases to analyze the differential expression,prognosis,mutation and related functions of COPS6 in pan-cancer.RESULTS Differential expression analysis and survival analysis demonstrated that COPS6 was highly expressed and associated with high-risk profiles in the majority of cancer types.Possible associations between COPS6 expression level and prognostic outcomes were found using data from public databases.Mutational analysis revealed that missense mutations were the predominant type of COPS6 mutation.Additionally,positive correlations were identified between COPS6 expression level and tumor mutational burden and microsatellite instability in most types of cancer.Immune infiltration analysis demonstrated a negative correlation between COPS6 expression level and CD8+T cell infiltration in certain types of cancer.The correlation between COPS6 expression level and cancerassociated fibroblast infiltration exhibited heterogeneity,in which a positive correlation was found in head and neck squamous cell carcinoma and tenosynovial giant cell tumor,and a negative correlation was identified in diffuse large B-cell lymphoma and thymoma.The correlation between COPS6 expression level and macrophage infiltration was closely related to macrophage type.Gene co-expression and enrichment analysis highlighted transcription elongation factor B polypeptide 2 and G protein pathway suppressor 1 were significantly and positively associated with COPS6 expression level.These genes were predominantly involved in processes,such as ubiquitin-mediated proteolysis and human immunodeficiency virus 1 infection.CONCLUSION In conclusion,this study systematically explored the significance of COPS6 across different tumor types,providing a solid foundation for considering COPS6 as a novel biomarker in cancer research.
