Organic phosphorus compounds containing sp^(3)-C—P(O)bonds are increasingly widely applied in catalysis,pharmaceuticals,materials,pesticides,and other fields,and their synthesis has become a research hotspot in chemi...Organic phosphorus compounds containing sp^(3)-C—P(O)bonds are increasingly widely applied in catalysis,pharmaceuticals,materials,pesticides,and other fields,and their synthesis has become a research hotspot in chemistry.Diarylmethyl phosphine oxides are important organic phosphorus compounds containing sp^(3)-C—P(O)bonds,but their synthesis is limited.Traditional methods for their synthesis require the use of halogenated compounds and harsh reaction conditions.A new method for the copper-mediated synthesis of(diarylmethyl)diarylphosphine oxides has been developed.This method involves the cleavage of the sp^(3)-C—N bond in N-diarylmethylsulfonamides,leading to the formation of diarylmethyl carbocations.The carbocations then react with diarylphosphine oxides to construct sp^(3)-C—P(O)bonds.Our method only requires the addition of stoichiometric,inexpensive CuBr2 and produces a series of target compounds in satisfactory yields.Thus,it provides a convenient,and cost-effective pathway for the synthesis of diarylmethyl phosphine oxides.展开更多
文摘Organic phosphorus compounds containing sp^(3)-C—P(O)bonds are increasingly widely applied in catalysis,pharmaceuticals,materials,pesticides,and other fields,and their synthesis has become a research hotspot in chemistry.Diarylmethyl phosphine oxides are important organic phosphorus compounds containing sp^(3)-C—P(O)bonds,but their synthesis is limited.Traditional methods for their synthesis require the use of halogenated compounds and harsh reaction conditions.A new method for the copper-mediated synthesis of(diarylmethyl)diarylphosphine oxides has been developed.This method involves the cleavage of the sp^(3)-C—N bond in N-diarylmethylsulfonamides,leading to the formation of diarylmethyl carbocations.The carbocations then react with diarylphosphine oxides to construct sp^(3)-C—P(O)bonds.Our method only requires the addition of stoichiometric,inexpensive CuBr2 and produces a series of target compounds in satisfactory yields.Thus,it provides a convenient,and cost-effective pathway for the synthesis of diarylmethyl phosphine oxides.
