An in-depth analysis on the cooperativity of intermolecular interactions including hydrogen bonding andπ-π stacking in 1,3,5-triamino-2,4,6-trinitrobenzene(TATB) crystal was studied. Two quantities, cooperativity ra...An in-depth analysis on the cooperativity of intermolecular interactions including hydrogen bonding andπ-π stacking in 1,3,5-triamino-2,4,6-trinitrobenzene(TATB) crystal was studied. Two quantities, cooperativity rate and energy, were defined to evaluate the nature and strength of cooperativity in a series of clusters diverging from 1D to 3D prototypes. The origin and mechanism of the cooperative effect were settled to demonstrate that the nature of cooperativity is determined by whether the non-covalent interactions compete or promote with each other, which is manifested by the changing trend of electron transfer. There exists obvious cooperative effect in intra-layer and inter-layer structures as they own the equivalent non-covalent interactions, while anti-cooperative effect is also observed if two interactions correlate with each other. On the whole, in the process of crystal formation, the apparent cooperativity is the check and balance of the two effects, which is capable to support a global interaction among all of molecules and contribute to the stabilization of system. Based on the results, one may get a new insight to understand the relationship between non-covalent interactions and low impact sensitivity.展开更多
Molecular dynamics method was employed to study the binding energies of the selected crystal planes of the 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane（HMX）/1,3-dimethyl-2-imidazolidinone（DMI） cocrystal in differ...Molecular dynamics method was employed to study the binding energies of the selected crystal planes of the 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane（HMX）/1,3-dimethyl-2-imidazolidinone（DMI） cocrystal in different molecular molar ratios. The mechanical properties were estimated in different molar ratios. Solvent effects were evaluated and the cooperativity effects were discussed in the HMX···HF···DMI ternary by using the M06-2x/6-311＋G（2df,2p） and MP2（full）/6-311＋G（2df,2p） methods. The results indicate that the substituted patterns（020） and（100） own the highest binding energies. The stabilities of cocrystals in the 1：1 and 2：1 ratios are the greatest, and thus the HMX/DMI cocrystals prefer cocrystallizing in the 1：1 and 2：1 molar ratios, which have good mechanical properties. The sensitivity change of cocrystal originates from not only the formation of intermolecular interaction but also the increment of bond dissociation energy of the N–NO2 bond. The cooperativity effect appears in the linear complex while the anti-cooperativity effect is found in the cyclic system. DMI binding to HMX is not energetically and structurally favored in the presence of HF. This is perhaps the reason that the solvent with large dielectric constant weakens the stability of the HMX/DMI cocrystals. Therefore, the solvents with low dielectric constants should be chosen in the preparation of HMX/DMI cocrystals.展开更多
A bifunctional heterogeneous catalyst containing two mutually incompatible acidic and basic sites, which exhibits cooperative catalytic behavior in the aldol condensation of acetone and various aldehydes, was synthesi...A bifunctional heterogeneous catalyst containing two mutually incompatible acidic and basic sites, which exhibits cooperative catalytic behavior in the aldol condensation of acetone and various aldehydes, was synthesized by postgrafting of 1,5,7- triazabicyclo[4.4.0] dec-5-ene （TBD, a sterically hindered organic base） onto AI-MCM-41 molecular sieve. 2009 Xiao Bing Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
Thermodynamic data were determined for the reversible binding of O 2 to two compounds of dicobalt(II) di(meso tetra phenyl)porphyrin derivatives with different lengths of diamidoaliphatic bridge (abbreviated to Co ...Thermodynamic data were determined for the reversible binding of O 2 to two compounds of dicobalt(II) di(meso tetra phenyl)porphyrin derivatives with different lengths of diamidoaliphatic bridge (abbreviated to Co 2PP 8 and Co 2PP 4) in N,N dimethylformamide at room temperature. The partial pressure of dioxygen necessary for half oxygenation ( P 1/2 ) and Hill coefficient ( n ) at 298 K were determined as follows: P 1/2 =54.2 kPa, n =2.0 for Co 2PP 8 and P 1/2 =6.8 kPa, n =1.8 for Co 2PP 4,respectively. The rate equations of reversible oxygen binding by Co 2PP 8 were determined and the reaction path was proposed. The results of thermodynamic and kinetic studies indicate that there exists strong cooperative effect during oxygenation of the compounds. The ESR observation reveals that the dioxygen complexes formed in the solutions are of superoxo (Co O - 2) type.展开更多
Here we examine the findings obtained for disaccharide/water mixtures near glass transition that involves cooperative relaxation features on kinetic by viscosity and on thermodynamic behaviour by neutron scattering. T...Here we examine the findings obtained for disaccharide/water mixtures near glass transition that involves cooperative relaxation features on kinetic by viscosity and on thermodynamic behaviour by neutron scattering. Then to address cooperative phenomena that mitigate the Debye-Waller behaviour we invoke Adam-Gibbs’ idea of a cooperative rearranging region. Neutron results suggest that the excess mean square displacement behaves as free volume and is closely connected to an elementary step of the structural relaxation. Then viscosity data evidence a breakdown of the Einstein-Debye relation, decoupling attributed to the intermolecular cooperativity.展开更多
The Arabidopsis phosphoinositide kinases PI4Kβ1 and PIP5K5 have been implicated in the control of directional vesicle trafficking underlying polar tip growth in pollen tubes. PI4Kβ1 and PIP5K5 catalyze key consecuti...The Arabidopsis phosphoinositide kinases PI4Kβ1 and PIP5K5 have been implicated in the control of directional vesicle trafficking underlying polar tip growth in pollen tubes. PI4Kβ1 and PIP5K5 catalyze key consecutive steps of phosphoinositide conversion, and it appears obvious that phosphatidylinositol-4-phosphate formed by PI4Kβ1 might act as a substrate for phosphatidylinositol-4,5-bisphosphate formation by PIP5K5. However, this hypothesis has not been experimentally addressed and distinct localization patterns of PI4Kβ1, PIP5K5, and also PI-synthases （PIS） generating phosphatidylinositol suggest additional complexity. Here, the synergistic functionality of enzymes of phosphoinositide conversion was assessed. In tobacco and Arabidopsis pollen tubes, phosphoinositides influence the apical secretion of pectin, and increased pectin deposition results in characteristic morphological alterations. Catalytically active and dominant negative variants of PI4Kβ1 and PIP5K5 were systematically co-expressed in tobacco pollen tubes and the incidence of morphologies related to enhanced pectin secretion was evaluated. The data support a proposed functional interplay of PI4Kβ1 and PIP5K5 at the trans-Golgi network, mediating directional vesicle trafficking. Co-expression experiments additionally including PIS isoforms, PIS1 or PIS2, indicate that pectin secretion is synergistically mediated by PI4Kβ1 and PIPSK5 acting on Ptdlns formed by PIS2 rather than PIS1. Possible ramifications for the preferential channeling of phosphoinositide intermediates between particular isoforms of PI pathway enzymes are discussed.展开更多
This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based...This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based on the internal model principle,a distributed dynamic output feedback control law is proposed to achieve both robust output regulation of the closed-loop system and plant input sharing among the actuators.A practical example of five motors cooperatively driving an uncertain shaft under an external load torque is presented to show the effectiveness of the proposed control law.展开更多
Fatty acid binding and oxidation kinetics for wild type P450_(BM3)(CYP102A1)from Bacillus megaterium have been found to display chain length-dependent homotropic behavior.Laurate and 13-methyl-myristate display Michae...Fatty acid binding and oxidation kinetics for wild type P450_(BM3)(CYP102A1)from Bacillus megaterium have been found to display chain length-dependent homotropic behavior.Laurate and 13-methyl-myristate display Michaelis-Menten behavior while there are slight deviations with myristate at low ionic strengths.Palmitate shows Michaelis-Menten kinetics and hyperbolic binding behavior in 100 mmol/L phosphate,pH 7.4,but sigmoidal kinetics(with an apparent intercept)in low ionic strength buffers and at physiological phosphate concentrations.In low ionic strength buffers both the heme domain and the full-length enzyme show complex palmitate binding behavior that indicates a minimum of four fatty acid binding sites,with high cooperativity for the binding of the fourth palmitate molecule,and the full-length enzyme showing tighter palmitate binding than the heme domain.The first flavin-to-heme electron transfer is faster for laurate,myristate and palmitate in 100 mmol/L phosphate than in 50mmol/L Tris(pH 7.4),yet each substrate induces similar high-spin heme content.For palmitate in low phosphate buffer concentrations,the rate constant of the first electron transfer is much larger than kcat.The results suggest that phosphate has a specific effect in promoting the first electron transfer step,and that P450_(BM3) could modulate Bacillus membrane morphology and fluidity via palmitate oxidation in response to the external phosphate concentration.展开更多
The year 2025 marked the 80th anniversary of the victory in the World Anti-Fascist War as well as the 10th anniversary of the Lancang-Mekong Cooperation (LMC) mechanism.Over the past decade, the six LMC countries have...The year 2025 marked the 80th anniversary of the victory in the World Anti-Fascist War as well as the 10th anniversary of the Lancang-Mekong Cooperation (LMC) mechanism.Over the past decade, the six LMC countries have maintained good-neighborly friendship, focused on development-oriented and pragmatic cooperation, and promoted inclusive, peoplecentered outcomes.展开更多
On October 28,2025,China and ASEAN signed the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol in Kuala Lumpur,Malaysia,in the presence of Chinese Premier Li Qiang,Malaysian Prime Minister Anwar Ibrahim,and lead...On October 28,2025,China and ASEAN signed the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol in Kuala Lumpur,Malaysia,in the presence of Chinese Premier Li Qiang,Malaysian Prime Minister Anwar Ibrahim,and leaders of other ASEAN member states.A close look at the protocol shows that the upgraded agreement marks substantive advances on several fronts.展开更多
China and Southeast Asia are entering a new phase of economic cooperation with the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol,in which the green economy has emerged as a central pillar of regional integrat...China and Southeast Asia are entering a new phase of economic cooperation with the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol,in which the green economy has emerged as a central pillar of regional integration.Negotiations were substantially concluded in October 2024,but the protocol wasn’t officially signed until October 28,2025,in Kuala Lumpur.The agreement moves beyond traditional tariff reductions to expand cooperation into nine major areas and introduces five new pillars:the digital economy,green economy,supply chain connectivity,competition and consumer protection,and support for micro,small,and medium-sized enterprises(MSMEs).展开更多
The shift to the China-ASEAN Free Trade Area(CAFTA)3.0 version marked more than just a technical update to an existing trade agreement.It signaled a recalibration ofregional economic cooperation as global trade has in...The shift to the China-ASEAN Free Trade Area(CAFTA)3.0 version marked more than just a technical update to an existing trade agreement.It signaled a recalibration ofregional economic cooperation as global trade has increasingly become shaped by digitalization,sustainability concerns,and fragile supply chains.For Indonesia,Southeast Asia’s largest economy and one of its most demographically dynamic,CAFTA 3.0 offers a framework that could materially strengthen its long-term economic position,if navigated with care and intent.展开更多
The Royal Tropical Institute(KIT)in Amsterdam is an independent centre of knowledge and expertise in the areas of international and intercultural cooperation,operating at the interface between theory and practice and ...The Royal Tropical Institute(KIT)in Amsterdam is an independent centre of knowledge and expertise in the areas of international and intercultural cooperation,operating at the interface between theory and practice and between policy and implementation.The Institute contributes to sustainable development,poverty alleviation and cultural preservation and exchange.展开更多
British Prime Minister Keir Starmer’s visit to China underscores economic cooperation and strategic stability amid global uncertainties.U.K.Prime Minister Keir Starmer’s visit to China in January marks a significant...British Prime Minister Keir Starmer’s visit to China underscores economic cooperation and strategic stability amid global uncertainties.U.K.Prime Minister Keir Starmer’s visit to China in January marks a significant shift of Britain toward a more pragmatic and stability-oriented approach in Sino-British relations.After years of political tensions and limited high-level engagement,this trip underscores London’s intent to rebuild ties based on mutual economic and strategic interests.展开更多
The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supporte...The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supported Africa in addressing historical injustices at diplomatic and political levels and firmly backed South Africa in hosting the G20 Leaders’Summit,further deepening China-Africa strategic mutual trust.展开更多
The China Expo Forum for International Cooperation(CEFCO)2026 was held in Wuhan,Hubei Province,China,on January 22.The opening ceremony was attended by Li Qing Shuang,Vice President of the China Council for the Promot...The China Expo Forum for International Cooperation(CEFCO)2026 was held in Wuhan,Hubei Province,China,on January 22.The opening ceremony was attended by Li Qing Shuang,Vice President of the China Council for the Promotion of International Trade(CCPIT);Zhu Yuji,Deputy Secretary of the Hubei Provincial Committee of the Communist Party of China;Sheng Yue Chun,Member of the Standing Committee of the Hubei Provincial Committee of the Communist Party of China and Secretary of the Wuhan Municipal Committee;Punita Bhansal,President of the Global Association of the Exhibition Industry(UFI);Marsha Flanagan,President and CEO of the International Association of Exhibitions and Events(IAEE);Vincent Polito,CEO of the Society of Independent Show Organizers(SISO);and Leonie Ashford,Board Member of the International Congress and Convention Association(ICCA).展开更多
May 5-7,Dubai,United Arab Emirates The ITU Global CyberDrill 2026 (3rd Edition) will be held from May 5 to 7,2026,at the Dubai Exhibition Centre (DEC),Expo City Dubai,United Arab Emirates (UAE).This event will take pl...May 5-7,Dubai,United Arab Emirates The ITU Global CyberDrill 2026 (3rd Edition) will be held from May 5 to 7,2026,at the Dubai Exhibition Centre (DEC),Expo City Dubai,United Arab Emirates (UAE).This event will take place during GISEC Global 2026 conference and exhibition.The first day will feature a high-level conference for senior government officials and relevant authorities to discuss cybersecurity and digital resilience,and strengthen national coordination and international cooperation.展开更多
President Xi Jinping Chooses Southeast Asia for First Overseas Visit of 2025 From April 14 to 18,2025,Chinese President Xi Jinping conducted state visits to Vietnam,Malaysia,and Cambodia.China and Vietnam are socialis...President Xi Jinping Chooses Southeast Asia for First Overseas Visit of 2025 From April 14 to 18,2025,Chinese President Xi Jinping conducted state visits to Vietnam,Malaysia,and Cambodia.China and Vietnam are socialist neighbors linked by mountains and rivers,and the China-Vietnam community with a shared future carries strategic significance.展开更多
Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-borde...Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-border trade and investment.The ASEAN region enjoys strong economic growth momentum with a distinct demographic advantage while China boasts a complete industrial system and manufacturing capacity.展开更多
Metal ion homeostasis plays a pivotal role in maintaining cellular functions,and its disruption can initiate regulated cell death pathways.Despite its therapeutic potential,metal ion therapy for breast cancer has been...Metal ion homeostasis plays a pivotal role in maintaining cellular functions,and its disruption can initiate regulated cell death pathways.Despite its therapeutic potential,metal ion therapy for breast cancer has been hampered by inefficient ion delivery and the intrinsic resistance mechanisms of cancer cells.In this work,a cuproptosis amplifier of copper-telaglenastat coordinate(denoted as Cu-CB) is developed to trigger cell ferroptosis for synergistic breast cancer treatment.Telaglenastat(CB-839),a glutaminase inhibitor,is identified as an effective copper ionophore that facilitates the formation of Cu-CB.Specially,Cu-CB can promote the aggregation of lipoylated proteins to initiate cuproptosis,while also inhibiting glutathione(GSH) synthesis and downregulating glutathione peroxidase 4(GPX4) to trigger ferroptosis.The interplay between these cuproptosis and apoptosis pathways,mediated by Cu-CB,significantly amplifies reactive oxygen species(ROS) production and lipid peroxidation,culminating in the synergistic suppression of breast cancer.Both in vitro and in vivo studies validate the superior antitumor effects of Cu-CB through the induction of cuproptosis and ferroptosis,which may provide a new insight for metal ion delivery systems and metal ion-based tumor therapies.展开更多
基金the support from the National Natural Science Foundation of China (No. 21875184)the Natural Science Foundation of Shaanxi Province (No. 2022JC-10)Youth Talent of Shaanxi “TeZhi” Program。
文摘An in-depth analysis on the cooperativity of intermolecular interactions including hydrogen bonding andπ-π stacking in 1,3,5-triamino-2,4,6-trinitrobenzene(TATB) crystal was studied. Two quantities, cooperativity rate and energy, were defined to evaluate the nature and strength of cooperativity in a series of clusters diverging from 1D to 3D prototypes. The origin and mechanism of the cooperative effect were settled to demonstrate that the nature of cooperativity is determined by whether the non-covalent interactions compete or promote with each other, which is manifested by the changing trend of electron transfer. There exists obvious cooperative effect in intra-layer and inter-layer structures as they own the equivalent non-covalent interactions, while anti-cooperative effect is also observed if two interactions correlate with each other. On the whole, in the process of crystal formation, the apparent cooperativity is the check and balance of the two effects, which is capable to support a global interaction among all of molecules and contribute to the stabilization of system. Based on the results, one may get a new insight to understand the relationship between non-covalent interactions and low impact sensitivity.
文摘Molecular dynamics method was employed to study the binding energies of the selected crystal planes of the 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane（HMX）/1,3-dimethyl-2-imidazolidinone（DMI） cocrystal in different molecular molar ratios. The mechanical properties were estimated in different molar ratios. Solvent effects were evaluated and the cooperativity effects were discussed in the HMX···HF···DMI ternary by using the M06-2x/6-311＋G（2df,2p） and MP2（full）/6-311＋G（2df,2p） methods. The results indicate that the substituted patterns（020） and（100） own the highest binding energies. The stabilities of cocrystals in the 1：1 and 2：1 ratios are the greatest, and thus the HMX/DMI cocrystals prefer cocrystallizing in the 1：1 and 2：1 molar ratios, which have good mechanical properties. The sensitivity change of cocrystal originates from not only the formation of intermolecular interaction but also the increment of bond dissociation energy of the N–NO2 bond. The cooperativity effect appears in the linear complex while the anti-cooperativity effect is found in the cyclic system. DMI binding to HMX is not energetically and structurally favored in the presence of HF. This is perhaps the reason that the solvent with large dielectric constant weakens the stability of the HMX/DMI cocrystals. Therefore, the solvents with low dielectric constants should be chosen in the preparation of HMX/DMI cocrystals.
基金support by a Foundation for the Author of National Excellent Doctoral Dissertation of China(No.FANEDD,200759)the Outstanding Young Scientist Foundation of NSFC(No.20625414)
文摘A bifunctional heterogeneous catalyst containing two mutually incompatible acidic and basic sites, which exhibits cooperative catalytic behavior in the aldol condensation of acetone and various aldehydes, was synthesized by postgrafting of 1,5,7- triazabicyclo[4.4.0] dec-5-ene （TBD, a sterically hindered organic base） onto AI-MCM-41 molecular sieve. 2009 Xiao Bing Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘Thermodynamic data were determined for the reversible binding of O 2 to two compounds of dicobalt(II) di(meso tetra phenyl)porphyrin derivatives with different lengths of diamidoaliphatic bridge (abbreviated to Co 2PP 8 and Co 2PP 4) in N,N dimethylformamide at room temperature. The partial pressure of dioxygen necessary for half oxygenation ( P 1/2 ) and Hill coefficient ( n ) at 298 K were determined as follows: P 1/2 =54.2 kPa, n =2.0 for Co 2PP 8 and P 1/2 =6.8 kPa, n =1.8 for Co 2PP 4,respectively. The rate equations of reversible oxygen binding by Co 2PP 8 were determined and the reaction path was proposed. The results of thermodynamic and kinetic studies indicate that there exists strong cooperative effect during oxygenation of the compounds. The ESR observation reveals that the dioxygen complexes formed in the solutions are of superoxo (Co O - 2) type.
文摘Here we examine the findings obtained for disaccharide/water mixtures near glass transition that involves cooperative relaxation features on kinetic by viscosity and on thermodynamic behaviour by neutron scattering. Then to address cooperative phenomena that mitigate the Debye-Waller behaviour we invoke Adam-Gibbs’ idea of a cooperative rearranging region. Neutron results suggest that the excess mean square displacement behaves as free volume and is closely connected to an elementary step of the structural relaxation. Then viscosity data evidence a breakdown of the Einstein-Debye relation, decoupling attributed to the intermolecular cooperativity.
文摘The Arabidopsis phosphoinositide kinases PI4Kβ1 and PIP5K5 have been implicated in the control of directional vesicle trafficking underlying polar tip growth in pollen tubes. PI4Kβ1 and PIP5K5 catalyze key consecutive steps of phosphoinositide conversion, and it appears obvious that phosphatidylinositol-4-phosphate formed by PI4Kβ1 might act as a substrate for phosphatidylinositol-4,5-bisphosphate formation by PIP5K5. However, this hypothesis has not been experimentally addressed and distinct localization patterns of PI4Kβ1, PIP5K5, and also PI-synthases （PIS） generating phosphatidylinositol suggest additional complexity. Here, the synergistic functionality of enzymes of phosphoinositide conversion was assessed. In tobacco and Arabidopsis pollen tubes, phosphoinositides influence the apical secretion of pectin, and increased pectin deposition results in characteristic morphological alterations. Catalytically active and dominant negative variants of PI4Kβ1 and PIP5K5 were systematically co-expressed in tobacco pollen tubes and the incidence of morphologies related to enhanced pectin secretion was evaluated. The data support a proposed functional interplay of PI4Kβ1 and PIP5K5 at the trans-Golgi network, mediating directional vesicle trafficking. Co-expression experiments additionally including PIS isoforms, PIS1 or PIS2, indicate that pectin secretion is synergistically mediated by PI4Kβ1 and PIPSK5 acting on Ptdlns formed by PIS2 rather than PIS1. Possible ramifications for the preferential channeling of phosphoinositide intermediates between particular isoforms of PI pathway enzymes are discussed.
基金Supported by the Shenzhen Key Laboratory of Control Theory and Intelligent Systems (ZDSYS20220330161800001)the National Natural Science Foundation of China (62303207)the Guangdong Basic and Applied Basic Research Foundation (2024A1515010725)。
文摘This paper studies cooperative robust parallel operation of multiple actuators over an undirected communication graph.The plant is modeled as an uncertain linear system,and the actuators are linear and identical.Based on the internal model principle,a distributed dynamic output feedback control law is proposed to achieve both robust output regulation of the closed-loop system and plant input sharing among the actuators.A practical example of five motors cooperatively driving an uncertain shaft under an external load torque is presented to show the effectiveness of the proposed control law.
基金supported by grants from the Natural Sciences and Engineering Research Council(NSERC)Canada,and the Rhodes Trust(JY)the Higher Educational Funding Council for England.
文摘Fatty acid binding and oxidation kinetics for wild type P450_(BM3)(CYP102A1)from Bacillus megaterium have been found to display chain length-dependent homotropic behavior.Laurate and 13-methyl-myristate display Michaelis-Menten behavior while there are slight deviations with myristate at low ionic strengths.Palmitate shows Michaelis-Menten kinetics and hyperbolic binding behavior in 100 mmol/L phosphate,pH 7.4,but sigmoidal kinetics(with an apparent intercept)in low ionic strength buffers and at physiological phosphate concentrations.In low ionic strength buffers both the heme domain and the full-length enzyme show complex palmitate binding behavior that indicates a minimum of four fatty acid binding sites,with high cooperativity for the binding of the fourth palmitate molecule,and the full-length enzyme showing tighter palmitate binding than the heme domain.The first flavin-to-heme electron transfer is faster for laurate,myristate and palmitate in 100 mmol/L phosphate than in 50mmol/L Tris(pH 7.4),yet each substrate induces similar high-spin heme content.For palmitate in low phosphate buffer concentrations,the rate constant of the first electron transfer is much larger than kcat.The results suggest that phosphate has a specific effect in promoting the first electron transfer step,and that P450_(BM3) could modulate Bacillus membrane morphology and fluidity via palmitate oxidation in response to the external phosphate concentration.
文摘The year 2025 marked the 80th anniversary of the victory in the World Anti-Fascist War as well as the 10th anniversary of the Lancang-Mekong Cooperation (LMC) mechanism.Over the past decade, the six LMC countries have maintained good-neighborly friendship, focused on development-oriented and pragmatic cooperation, and promoted inclusive, peoplecentered outcomes.
文摘On October 28,2025,China and ASEAN signed the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol in Kuala Lumpur,Malaysia,in the presence of Chinese Premier Li Qiang,Malaysian Prime Minister Anwar Ibrahim,and leaders of other ASEAN member states.A close look at the protocol shows that the upgraded agreement marks substantive advances on several fronts.
文摘China and Southeast Asia are entering a new phase of economic cooperation with the China-ASEAN Free Trade Area(CAFTA)3.0 Upgrade Protocol,in which the green economy has emerged as a central pillar of regional integration.Negotiations were substantially concluded in October 2024,but the protocol wasn’t officially signed until October 28,2025,in Kuala Lumpur.The agreement moves beyond traditional tariff reductions to expand cooperation into nine major areas and introduces five new pillars:the digital economy,green economy,supply chain connectivity,competition and consumer protection,and support for micro,small,and medium-sized enterprises(MSMEs).
文摘The shift to the China-ASEAN Free Trade Area(CAFTA)3.0 version marked more than just a technical update to an existing trade agreement.It signaled a recalibration ofregional economic cooperation as global trade has increasingly become shaped by digitalization,sustainability concerns,and fragile supply chains.For Indonesia,Southeast Asia’s largest economy and one of its most demographically dynamic,CAFTA 3.0 offers a framework that could materially strengthen its long-term economic position,if navigated with care and intent.
文摘The Royal Tropical Institute(KIT)in Amsterdam is an independent centre of knowledge and expertise in the areas of international and intercultural cooperation,operating at the interface between theory and practice and between policy and implementation.The Institute contributes to sustainable development,poverty alleviation and cultural preservation and exchange.
文摘British Prime Minister Keir Starmer’s visit to China underscores economic cooperation and strategic stability amid global uncertainties.U.K.Prime Minister Keir Starmer’s visit to China in January marks a significant shift of Britain toward a more pragmatic and stability-oriented approach in Sino-British relations.After years of political tensions and limited high-level engagement,this trip underscores London’s intent to rebuild ties based on mutual economic and strategic interests.
文摘The year 2025 marks both the 25th anniversary of the Forum on China-Africa Cooperation(FOCAC)and the first year of implementation of the outcomes of the 2024 FOCAC Beijing Summit.Throughout the year,China has supported Africa in addressing historical injustices at diplomatic and political levels and firmly backed South Africa in hosting the G20 Leaders’Summit,further deepening China-Africa strategic mutual trust.
文摘The China Expo Forum for International Cooperation(CEFCO)2026 was held in Wuhan,Hubei Province,China,on January 22.The opening ceremony was attended by Li Qing Shuang,Vice President of the China Council for the Promotion of International Trade(CCPIT);Zhu Yuji,Deputy Secretary of the Hubei Provincial Committee of the Communist Party of China;Sheng Yue Chun,Member of the Standing Committee of the Hubei Provincial Committee of the Communist Party of China and Secretary of the Wuhan Municipal Committee;Punita Bhansal,President of the Global Association of the Exhibition Industry(UFI);Marsha Flanagan,President and CEO of the International Association of Exhibitions and Events(IAEE);Vincent Polito,CEO of the Society of Independent Show Organizers(SISO);and Leonie Ashford,Board Member of the International Congress and Convention Association(ICCA).
文摘May 5-7,Dubai,United Arab Emirates The ITU Global CyberDrill 2026 (3rd Edition) will be held from May 5 to 7,2026,at the Dubai Exhibition Centre (DEC),Expo City Dubai,United Arab Emirates (UAE).This event will take place during GISEC Global 2026 conference and exhibition.The first day will feature a high-level conference for senior government officials and relevant authorities to discuss cybersecurity and digital resilience,and strengthen national coordination and international cooperation.
文摘President Xi Jinping Chooses Southeast Asia for First Overseas Visit of 2025 From April 14 to 18,2025,Chinese President Xi Jinping conducted state visits to Vietnam,Malaysia,and Cambodia.China and Vietnam are socialist neighbors linked by mountains and rivers,and the China-Vietnam community with a shared future carries strategic significance.
文摘Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-border trade and investment.The ASEAN region enjoys strong economic growth momentum with a distinct demographic advantage while China boasts a complete industrial system and manufacturing capacity.
基金supported by the National Natural Science Foundation of China (Nos.82302355,32371394)Guangdong Basic and Applied Basic Research Foundation (No.2023A1515012628)+1 种基金the Characteristic Innovation Projects of General Colleges and Universities in Guangdong Province (No.2024KTSCX120)the Science and Technology Program of Guangzhou (Nos.2024A04J3324,2024A03J0078)。
文摘Metal ion homeostasis plays a pivotal role in maintaining cellular functions,and its disruption can initiate regulated cell death pathways.Despite its therapeutic potential,metal ion therapy for breast cancer has been hampered by inefficient ion delivery and the intrinsic resistance mechanisms of cancer cells.In this work,a cuproptosis amplifier of copper-telaglenastat coordinate(denoted as Cu-CB) is developed to trigger cell ferroptosis for synergistic breast cancer treatment.Telaglenastat(CB-839),a glutaminase inhibitor,is identified as an effective copper ionophore that facilitates the formation of Cu-CB.Specially,Cu-CB can promote the aggregation of lipoylated proteins to initiate cuproptosis,while also inhibiting glutathione(GSH) synthesis and downregulating glutathione peroxidase 4(GPX4) to trigger ferroptosis.The interplay between these cuproptosis and apoptosis pathways,mediated by Cu-CB,significantly amplifies reactive oxygen species(ROS) production and lipid peroxidation,culminating in the synergistic suppression of breast cancer.Both in vitro and in vivo studies validate the superior antitumor effects of Cu-CB through the induction of cuproptosis and ferroptosis,which may provide a new insight for metal ion delivery systems and metal ion-based tumor therapies.
