Ovarian cancer,particularly high-grade serous ovariancancer(HGSOC),remains the most lethal gynecologicalmalignancy,with a 5-year survival rate of around 40%due to late diagnosis,recurrence,and the developmentof chemor...Ovarian cancer,particularly high-grade serous ovariancancer(HGSOC),remains the most lethal gynecologicalmalignancy,with a 5-year survival rate of around 40%due to late diagnosis,recurrence,and the developmentof chemoresistance[1,2].Mutations in tumor protein 53(TP53)occur in over 96%of HGSOC cases,impairing itstumor-suppressive functions,including cell cycle control,DNA repair,and apoptosis.Mutant TP53 promotes tumorprogression,genomic instability,and resistance to stan-dard therapies,thereby worsening patient outcomes[3,4].Death-associated protein kinase 1(DAPK1)is a key reg-ulator of apoptosis and autophagy[5,6].展开更多
基金supported by grants from Deutsche Kreb-shilfe(70116875)the German Cancer Consortium(DKTK,Heidelberg).
文摘Ovarian cancer,particularly high-grade serous ovariancancer(HGSOC),remains the most lethal gynecologicalmalignancy,with a 5-year survival rate of around 40%due to late diagnosis,recurrence,and the developmentof chemoresistance[1,2].Mutations in tumor protein 53(TP53)occur in over 96%of HGSOC cases,impairing itstumor-suppressive functions,including cell cycle control,DNA repair,and apoptosis.Mutant TP53 promotes tumorprogression,genomic instability,and resistance to stan-dard therapies,thereby worsening patient outcomes[3,4].Death-associated protein kinase 1(DAPK1)is a key reg-ulator of apoptosis and autophagy[5,6].
