Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluct...Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.展开更多
Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibra...Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibration.An active damping device(ADD)is used to the vibration of the pump valve pipeline system to apply the control force,to achieve the active control of the pipeline vibration.A pump-valve pipeline vibration test bench was built to compare the control effect of active damping device on pipeline vibration under different pump valve working conditions,and the results show that applying ADD control could effectively suppress the vibration of the pump valve pipeline and enhance the stability of the equipment during operation.At different pump operating rotation frequencies,the vibration amplitude of the pump valve pipeline in working frequency and its multiple frequencies are also effectively suppressed,with the maximum amplitude reduction of more than 60%.For the valve vibration caused by different operating openings,the vibration of the highest reduction of 68%,and the centrifugal pump drive shaft vi-bration reduced by up to 73%,which provides a new idea for vibration control of pump valve pipeline system.展开更多
Achieving long spin coherence times is crucial for quantum precision measurements,and closed-loop control techniques are often employed to accomplish this goal.Here,we demonstrate the impact of closed-loop feedback co...Achieving long spin coherence times is crucial for quantum precision measurements,and closed-loop control techniques are often employed to accomplish this goal.Here,we demonstrate the impact of closed-loop feedback control on nuclear spin precession in a metastability exchange optical pumping(MEOP)-based polarized^(3)He system.We analyze the effects of feedback theoretically and validate our predictions experimentally.With optimized feedback parameters,the spin coherence time T_(2)is extended by an order of magnitude.When the feedback strength surpasses a critical threshold,robust maser oscillations are spontaneously excited,demonstrating remarkable resistance to environmental noise and maintaining stable oscillation.This proof-of-principle experiment highlights the viability of MEOP-based^(3)He spin oscillators,especially in low-frequency domains.The operational simplicity and easy integration associated with MEOP-based systems make them particularly promising for fast,high-precision magnetic field measurements.展开更多
To enhance energy interaction among low-voltage stations(LVSs)and reduce the line loss of the distribution network,a novel operation mode of the micro-pumped storage system(mPSS)has been proposed based on the common r...To enhance energy interaction among low-voltage stations(LVSs)and reduce the line loss of the distribution network,a novel operation mode of the micro-pumped storage system(mPSS)has been proposed based on the common reservoir.First,some operation modes of mPSS are analyzed,which include the separated reservoir mode(SRM)and common reservoir mode(CRM).Then,based on the SRM,and CRM,an energy mutual assistance control model between LVSs has been built to optimize energy loss.Finally,in the simulation,compared to the model without pumped storage in the LVS,the SRMand CLRMcan decrease the total energy loss by 294.377 and 432.578 kWh,respectively.The configuration of mPSS can improve the utilization rate of the new energy source generation system,and relieve the pressure of transformer capacity in the LVS.Compared with the SRM,the proposed CRM has reduced the total energy loss by 138.201 kWh,increased the new energy consumption by 161.642 kWh,and decreased the line loss by 7.271 kWh.With the efficiency of the mPSS improving,the total energy loss reduction of CRM will be 3.5 times that of SRM.Further,the CRMcan significantly reduce the reservoir capacity construction of mPSS and ismore suitable for scenarios where the capacity configuration of mPSS is limited.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus d...BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.展开更多
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ...In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.展开更多
In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regiona...In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regional controllability is more adapted to systems described by dynamic systems.Regional controllability results in a strategic area were established for vibrating plates by the Hilbertian Uniqueness Method.展开更多
Pump controlled motor electrohydraulic servo systems are much used in circumstances where high power drive is needed. This kind of system has the advantage of energy-saving. But, it also has some defects that have to ...Pump controlled motor electrohydraulic servo systems are much used in circumstances where high power drive is needed. This kind of system has the advantage of energy-saving. But, it also has some defects that have to be improved. Microcomputer control of a pump controlled motor electrohydraulic servo system is studied. A PID controller is first adopted on the closed loop control system, and experimental results are obtained. Then, a model reference adaptive controller is designed and realised on the same system applying a single board microcomputer. Experimental results show that the dynamic properties of the adaptive control system is much better than those of the PID system under different inertia load conditions.展开更多
The clinical pharmacokinetics of osmotic pump controlled release tablets of terazosin hydrochloride in healthy volunteers was studied.A sensitive and rapid HPLC method was used to determine the terazosin plasma concen...The clinical pharmacokinetics of osmotic pump controlled release tablets of terazosin hydrochloride in healthy volunteers was studied.A sensitive and rapid HPLC method was used to determine the terazosin plasma concentrations,and single and multiple doses of terazosin hydrochloride regular tablets（reference tablets）and osmotic pump controlled release tablets were orally administrated in randomized crossover design.The results showed that the C_（max）of the reference tablets after single oral dose（（120.56±23.15）ng/mL）in 20 healthy volunteers was significantly higher than that of controlled release tablets （（95.27±16.35）ng/mL）.The T_（max）of the controlled release tablets（（2.65±0.82）h）was significantly longer than that of reference tablets（（1.27±0.61）h）（P0.05）.The relative bioavailability of the controlled release tablets was found to be（105.85±6.12）%. The multiple oral dose pharmacokinetic parameters of the regular tablets and controlled release tablets were as follows：AUC_（SS） were（1275.17±175.35）and（1382.65±205.31）ng·h/mL respectively,C_（max）were（128.15±22.37）and（98.57±18.16）ng/mL respectively,T_（max）were（1.35±0.71）and（2.76±0.85）h respectively,C_（av）were（53.13±9.12）and（57.61±9.25）ng/mL respectively, and DF were（2.25±0.26）%and（1.62±0.25）%respectively.The relative bioavailability of the controlled release tablets to the reference tablets was（108.43±6.26）%.The controlled release tablet of terazosin hydrochloride was bioequivalent to the reference tablet.The controlled release tablet exhibited a sustained-release property with a significantly longer T_（max）and lower C_（max）.展开更多
The variable pump displacement and variable motor speed electro-hydrostatic actuator(EHA),one of the three types of EHAs,has advantages such as short response time,flexible speed regulation,and high efficiency.However...The variable pump displacement and variable motor speed electro-hydrostatic actuator(EHA),one of the three types of EHAs,has advantages such as short response time,flexible speed regulation,and high efficiency.However,the nonlinearity of its double-input single-output system poses a great challenge for system control.This study proposes a novel EHA with adaptive pump displacement and variable motor speed(EHA-APVM).A closed-loop position is realized using a servomotor.Moreover,the displacement varies with the system pressure;thus,the EHA-APVM is a single-input and single-output system.Firstly,the working principles of the EHA-APVM and the pump used in the system are introduced.Secondly,a nonlinear mathematical model of the proposed EHA-APVM control system is established,and a feedback back-stepping(FBBS)control algorithm is introduced to transform the complex nonlinear system into a linear system on the basis of the back-stepping control theory.Finally,simulation results prove that the EHA-APVM has a quick response and high robustness to variations of the load and the pump displacement.In this work,the size and weight of the motor are significantly reduced because the maximum power requirement is reduced,which is very beneficial for using the actuator in airborne equipment.展开更多
To control the position of differential cylinder closed loop without usingany throttle elements, a flew idea that two speed variable pumps are used to compensate thenon-symmetric flow of differential cylinder is carri...To control the position of differential cylinder closed loop without usingany throttle elements, a flew idea that two speed variable pumps are used to compensate thenon-symmetric flow of differential cylinder is carried out. According to the leaking property of thesystem, a speed offset principle is also proposed to eliminate the cavitation and tension caused bythe leakage and condensation of oil, which makes the system be in the same state as a valvecontrolled circuit. This principle is explained theoretically and experimentally. Further therelationship that the pressures in cylinder chambers change with load and leakage, and therelationship between biasing speed and pre-load pressures in cylinder chambers are established. Theresearch has proved that the new system has similar technique features as those of controlled withservo valves, but due to the elimination of all the throttle lose the efficiency of system can beimproved greatly.展开更多
Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal ce...Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal cells, gastrin can also behave as a growth factor and stimulate gastric cell proliferation. It is also reported that gastrin promotes β cell neogenesis in the pancreatic ductal complex, modest pancreatic β cell replication, and improvement of glucose tolerance in animal models, in which the remodeling of pancreatic tissues is promoted. These findings suggest the possibility that gastrin has the potential to promote an increase of β cell mass in pancreas, and therefore that gastrin may improve glucose tolerance. Proton pump inhibitors(PPIs) are wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. PPIs indirectly elevate serum gastrin levels via a negative feedback effect. Recent evidence has revealed the beneficial effect of PPIs on glycemic control especially in patients with type 2 diabetes mellitus(T2DM), probably via the elevation of the levels of serum gastrin, although the detailed mechanism remains unclear. In addition, the beneficial effects of a combination therapy of gastrin or a PPI with a glucagon-like peptide-1 receptor agonist on glycemic control in animal models have been demonstrated. Although PPIs may be possible candidates for a new approach in the therapy of diabetes, a prospective, longterm, randomized, double-blind, placebo-controlled study is needed to establish the effect of PPIs on glycemic control in a large number of patients with T2 DM.展开更多
Shearer and hydraulic support are matching equipments. To increase the operating speed of the shearer, the following speed of hydraulic support must be increased. This means increasing the volume of flow from emulsion...Shearer and hydraulic support are matching equipments. To increase the operating speed of the shearer, the following speed of hydraulic support must be increased. This means increasing the volume of flow from emulsion power station. Analyzing the operating characteristics of hydraulic supports, the number of simultaneously operating supports is obtained by means of pressure parameter and time history at a certain time, which is a theory base for development of control system to multi-pump emulsion power station.展开更多
The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor...The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products.展开更多
This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID（proportional-integral-derivative）controllers is proposed with the assumption t...This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID（proportional-integral-derivative）controllers is proposed with the assumption that a PID controller has additive gain perturbations.An H-infinite robust PID controller can be obtained by solving a linear matrix inequality.This approach can guarantee that the closed-loop control systems is asymptotically stable and the H-infinite norm of the transfer function from the disturbance to the output of a controlled system is less than a given constant to attenuate disturbances.The simulation case shows that the control performance of the proposed strategy is significantly better than the traditional PID approach in the situation with perturbations of controller parameters.展开更多
This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this system....This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this system.The void fraction in two-phase fluid region was calculated by Harms model.And based on distributed parameter model and Harms model,the refrigerant charge inventory in condenser and evaporator were calculated and analyzed in air-conditioning conditions and heat-pump conditions,respectively.The calculating results of different refrigerant mass between refrigeration and heating conditions indicate that the optimal refrigerant charge inventory in heat-pump conditions is lower than that in air-conditioning conditions.To avoid the decrease of COP due to the surplus refrigerant in heating conditions,we introduced the liquid reservoir control method and associate capillary control method.Both of them could increase the heating capacity of the air-source heat pump.The difference of optimal refrigerant charge inventory in air-conditioning and heat-pump system can be controlled by the liquid reservoir or the associate capillary.展开更多
The kinetic characteristics of the clamping unit of plastic injection molding machine that is controlled by close loop with newly developed double speed variable pump unit are investigated. Considering the wide variat...The kinetic characteristics of the clamping unit of plastic injection molding machine that is controlled by close loop with newly developed double speed variable pump unit are investigated. Considering the wide variation of the cylinder equivalent mass caused by the transmission ratio of clamping unit and the severe instantaneous impact force acted on the cylinder during the mold closing and opening process, an adaptive control principle of parameter and structure is proposed to improve its kinetic performance. The adaptive correlation between the acceleration feedback gain and the variable mass is derived. The pressure differential feedback is introduced to improve the dynamic performance in the case of small inertia and heavy impact load. The adaptation of sum pressure to load is used to reduce the energy loss of the system. The research results are verified by the simulation and experiment, The investigation method and the conclusions are also suitable for the differential cylinder system controlled by the traditional servo pump unit.展开更多
AIM To determine the impact of upwards titration of proton pump inhibition(PPI)on acid reflux,symptom scores and histology,compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett&#...AIM To determine the impact of upwards titration of proton pump inhibition(PPI)on acid reflux,symptom scores and histology,compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE)patients were studied.In group 1(n=24),increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization.At each assessment,ambulatory 24 h p H recording,endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire,GERD/HRLQ)were performed.Group 2(n=30)consisted of patients with a previous fundoplication.RESULTS In group 1,acid reflux normalized in 23 of 24 patients,resulting in improved GERD/HRQL scores(P=0.001),which were most pronounced after the starting dose of PPI(P<0.001).PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P=0.5).Normalization of acid reflux in both groups was associated with reduction in papillary length,basal cell layer thickness,intercellular space dilatation,and acute and chronic inflammation of squamous epithelium.CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients,especially after the first dose of PPI,reaching the same level as after a successful fundoplication.Minor changes were found among GERD markers at the morphological level.展开更多
Peristalsis is widely seen in nature, as this pumping action is important in digestive systems for conveying sustenance to every corner of the body. In this paper, we propose a muscle-powered tubular micro pump that p...Peristalsis is widely seen in nature, as this pumping action is important in digestive systems for conveying sustenance to every corner of the body. In this paper, we propose a muscle-powered tubular micro pump that provides peristaltic transport. We utilized Drosophila melanogaster larvae that express channelrhodopsin-2 (ChR2) on the cell membrane of skeletal muscles to obtain light-responsive muscle tissues. The larvae were forced to contract with blue light stimulation. While changing the speed of the propagating light stimulation, we observed displacement on the surface of the contractile muscle tissues. We obtained peristaltic pumps from the larvae by dissecting them into tubular structures. The average inner diameter of the tubular structures was about 400 lm and the average outer diameter was about 750 lm. Contractions of this tubular structure could be controlled with the same blue light stimulation. To make the inner flow visible, we placed microbeads into the peristaltic pump, and thus determined that the pump could transport microbeads at a speed of 120 lm-s1.展开更多
基金supported by the National Natural Science Foundation of China(Project No.52377082)the Scientific Research Program of Jilin Provincial Department of Education(Project No.JJKH20230123KJ).
文摘Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.
基金The Fundamental Research Funds for the Central Universities(JD2423)。
文摘Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibration.An active damping device(ADD)is used to the vibration of the pump valve pipeline system to apply the control force,to achieve the active control of the pipeline vibration.A pump-valve pipeline vibration test bench was built to compare the control effect of active damping device on pipeline vibration under different pump valve working conditions,and the results show that applying ADD control could effectively suppress the vibration of the pump valve pipeline and enhance the stability of the equipment during operation.At different pump operating rotation frequencies,the vibration amplitude of the pump valve pipeline in working frequency and its multiple frequencies are also effectively suppressed,with the maximum amplitude reduction of more than 60%.For the valve vibration caused by different operating openings,the vibration of the highest reduction of 68%,and the centrifugal pump drive shaft vi-bration reduced by up to 73%,which provides a new idea for vibration control of pump valve pipeline system.
基金supported by the National Natural Science Foundation of China(Grant No.U2230207)。
文摘Achieving long spin coherence times is crucial for quantum precision measurements,and closed-loop control techniques are often employed to accomplish this goal.Here,we demonstrate the impact of closed-loop feedback control on nuclear spin precession in a metastability exchange optical pumping(MEOP)-based polarized^(3)He system.We analyze the effects of feedback theoretically and validate our predictions experimentally.With optimized feedback parameters,the spin coherence time T_(2)is extended by an order of magnitude.When the feedback strength surpasses a critical threshold,robust maser oscillations are spontaneously excited,demonstrating remarkable resistance to environmental noise and maintaining stable oscillation.This proof-of-principle experiment highlights the viability of MEOP-based^(3)He spin oscillators,especially in low-frequency domains.The operational simplicity and easy integration associated with MEOP-based systems make them particularly promising for fast,high-precision magnetic field measurements.
基金sponsored by the State Grid Corporation of China Technology Project(Research on Key Technologies and Equipment Development of Micro Pumped Storage for Distributed New Energy Consumption in Distribution Networks,5400-202324196A-1-1-ZN).
文摘To enhance energy interaction among low-voltage stations(LVSs)and reduce the line loss of the distribution network,a novel operation mode of the micro-pumped storage system(mPSS)has been proposed based on the common reservoir.First,some operation modes of mPSS are analyzed,which include the separated reservoir mode(SRM)and common reservoir mode(CRM).Then,based on the SRM,and CRM,an energy mutual assistance control model between LVSs has been built to optimize energy loss.Finally,in the simulation,compared to the model without pumped storage in the LVS,the SRMand CLRMcan decrease the total energy loss by 294.377 and 432.578 kWh,respectively.The configuration of mPSS can improve the utilization rate of the new energy source generation system,and relieve the pressure of transformer capacity in the LVS.Compared with the SRM,the proposed CRM has reduced the total energy loss by 138.201 kWh,increased the new energy consumption by 161.642 kWh,and decreased the line loss by 7.271 kWh.With the efficiency of the mPSS improving,the total energy loss reduction of CRM will be 3.5 times that of SRM.Further,the CRMcan significantly reduce the reservoir capacity construction of mPSS and ismore suitable for scenarios where the capacity configuration of mPSS is limited.
文摘BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.
基金Supported in part by Natural Science Foundation of Guangxi(2023GXNSFAA026246)in part by the Central Government's Guide to Local Science and Technology Development Fund(GuikeZY23055044)in part by the National Natural Science Foundation of China(62363003)。
文摘In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method.
文摘In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regional controllability is more adapted to systems described by dynamic systems.Regional controllability results in a strategic area were established for vibrating plates by the Hilbertian Uniqueness Method.
基金The Project Supported by Doctoral Programme Foundation of Institution of Higher Education
文摘Pump controlled motor electrohydraulic servo systems are much used in circumstances where high power drive is needed. This kind of system has the advantage of energy-saving. But, it also has some defects that have to be improved. Microcomputer control of a pump controlled motor electrohydraulic servo system is studied. A PID controller is first adopted on the closed loop control system, and experimental results are obtained. Then, a model reference adaptive controller is designed and realised on the same system applying a single board microcomputer. Experimental results show that the dynamic properties of the adaptive control system is much better than those of the PID system under different inertia load conditions.
文摘The clinical pharmacokinetics of osmotic pump controlled release tablets of terazosin hydrochloride in healthy volunteers was studied.A sensitive and rapid HPLC method was used to determine the terazosin plasma concentrations,and single and multiple doses of terazosin hydrochloride regular tablets（reference tablets）and osmotic pump controlled release tablets were orally administrated in randomized crossover design.The results showed that the C_（max）of the reference tablets after single oral dose（（120.56±23.15）ng/mL）in 20 healthy volunteers was significantly higher than that of controlled release tablets （（95.27±16.35）ng/mL）.The T_（max）of the controlled release tablets（（2.65±0.82）h）was significantly longer than that of reference tablets（（1.27±0.61）h）（P0.05）.The relative bioavailability of the controlled release tablets was found to be（105.85±6.12）%. The multiple oral dose pharmacokinetic parameters of the regular tablets and controlled release tablets were as follows：AUC_（SS） were（1275.17±175.35）and（1382.65±205.31）ng·h/mL respectively,C_（max）were（128.15±22.37）and（98.57±18.16）ng/mL respectively,T_（max）were（1.35±0.71）and（2.76±0.85）h respectively,C_（av）were（53.13±9.12）and（57.61±9.25）ng/mL respectively, and DF were（2.25±0.26）%and（1.62±0.25）%respectively.The relative bioavailability of the controlled release tablets to the reference tablets was（108.43±6.26）%.The controlled release tablet of terazosin hydrochloride was bioequivalent to the reference tablet.The controlled release tablet exhibited a sustained-release property with a significantly longer T_（max）and lower C_（max）.
基金financially supported by the National Natural Science Foundation of China(No’s.51375029 and 51775013).
文摘The variable pump displacement and variable motor speed electro-hydrostatic actuator(EHA),one of the three types of EHAs,has advantages such as short response time,flexible speed regulation,and high efficiency.However,the nonlinearity of its double-input single-output system poses a great challenge for system control.This study proposes a novel EHA with adaptive pump displacement and variable motor speed(EHA-APVM).A closed-loop position is realized using a servomotor.Moreover,the displacement varies with the system pressure;thus,the EHA-APVM is a single-input and single-output system.Firstly,the working principles of the EHA-APVM and the pump used in the system are introduced.Secondly,a nonlinear mathematical model of the proposed EHA-APVM control system is established,and a feedback back-stepping(FBBS)control algorithm is introduced to transform the complex nonlinear system into a linear system on the basis of the back-stepping control theory.Finally,simulation results prove that the EHA-APVM has a quick response and high robustness to variations of the load and the pump displacement.In this work,the size and weight of the motor are significantly reduced because the maximum power requirement is reduced,which is very beneficial for using the actuator in airborne equipment.
基金This project is supported by National Natural Science Foundation of China(No.50275102) National Foundation for Abroad Return People, China (No.2001345).
文摘To control the position of differential cylinder closed loop without usingany throttle elements, a flew idea that two speed variable pumps are used to compensate thenon-symmetric flow of differential cylinder is carried out. According to the leaking property of thesystem, a speed offset principle is also proposed to eliminate the cavitation and tension caused bythe leakage and condensation of oil, which makes the system be in the same state as a valvecontrolled circuit. This principle is explained theoretically and experimentally. Further therelationship that the pressures in cylinder chambers change with load and leakage, and therelationship between biasing speed and pre-load pressures in cylinder chambers are established. Theresearch has proved that the new system has similar technique features as those of controlled withservo valves, but due to the elimination of all the throttle lose the efficiency of system can beimproved greatly.
文摘Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal cells, gastrin can also behave as a growth factor and stimulate gastric cell proliferation. It is also reported that gastrin promotes β cell neogenesis in the pancreatic ductal complex, modest pancreatic β cell replication, and improvement of glucose tolerance in animal models, in which the remodeling of pancreatic tissues is promoted. These findings suggest the possibility that gastrin has the potential to promote an increase of β cell mass in pancreas, and therefore that gastrin may improve glucose tolerance. Proton pump inhibitors(PPIs) are wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. PPIs indirectly elevate serum gastrin levels via a negative feedback effect. Recent evidence has revealed the beneficial effect of PPIs on glycemic control especially in patients with type 2 diabetes mellitus(T2DM), probably via the elevation of the levels of serum gastrin, although the detailed mechanism remains unclear. In addition, the beneficial effects of a combination therapy of gastrin or a PPI with a glucagon-like peptide-1 receptor agonist on glycemic control in animal models have been demonstrated. Although PPIs may be possible candidates for a new approach in the therapy of diabetes, a prospective, longterm, randomized, double-blind, placebo-controlled study is needed to establish the effect of PPIs on glycemic control in a large number of patients with T2 DM.
文摘Shearer and hydraulic support are matching equipments. To increase the operating speed of the shearer, the following speed of hydraulic support must be increased. This means increasing the volume of flow from emulsion power station. Analyzing the operating characteristics of hydraulic supports, the number of simultaneously operating supports is obtained by means of pressure parameter and time history at a certain time, which is a theory base for development of control system to multi-pump emulsion power station.
文摘The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products.
基金Supported by the National Natural Science Foundation of China（60604015） the Key Research Program of Education Department of Zhejiang Province（Z200803521）
文摘This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID（proportional-integral-derivative）controllers is proposed with the assumption that a PID controller has additive gain perturbations.An H-infinite robust PID controller can be obtained by solving a linear matrix inequality.This approach can guarantee that the closed-loop control systems is asymptotically stable and the H-infinite norm of the transfer function from the disturbance to the output of a controlled system is less than a given constant to attenuate disturbances.The simulation case shows that the control performance of the proposed strategy is significantly better than the traditional PID approach in the situation with perturbations of controller parameters.
基金Supported by Hubei Provincial Natural Science Foundation(2008CDB363)
文摘This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this system.The void fraction in two-phase fluid region was calculated by Harms model.And based on distributed parameter model and Harms model,the refrigerant charge inventory in condenser and evaporator were calculated and analyzed in air-conditioning conditions and heat-pump conditions,respectively.The calculating results of different refrigerant mass between refrigeration and heating conditions indicate that the optimal refrigerant charge inventory in heat-pump conditions is lower than that in air-conditioning conditions.To avoid the decrease of COP due to the surplus refrigerant in heating conditions,we introduced the liquid reservoir control method and associate capillary control method.Both of them could increase the heating capacity of the air-source heat pump.The difference of optimal refrigerant charge inventory in air-conditioning and heat-pump system can be controlled by the liquid reservoir or the associate capillary.
基金This project is supported by National Natural Science Foundation of China (No.50275102)Opening Foundation of State Key Lab of Fluid Power Transmission and Control of Zhejiang University, China (No.GZKF2002004).
文摘The kinetic characteristics of the clamping unit of plastic injection molding machine that is controlled by close loop with newly developed double speed variable pump unit are investigated. Considering the wide variation of the cylinder equivalent mass caused by the transmission ratio of clamping unit and the severe instantaneous impact force acted on the cylinder during the mold closing and opening process, an adaptive control principle of parameter and structure is proposed to improve its kinetic performance. The adaptive correlation between the acceleration feedback gain and the variable mass is derived. The pressure differential feedback is introduced to improve the dynamic performance in the case of small inertia and heavy impact load. The adaptation of sum pressure to load is used to reduce the energy loss of the system. The research results are verified by the simulation and experiment, The investigation method and the conclusions are also suitable for the differential cylinder system controlled by the traditional servo pump unit.
文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI)on acid reflux,symptom scores and histology,compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE)patients were studied.In group 1(n=24),increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization.At each assessment,ambulatory 24 h p H recording,endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire,GERD/HRLQ)were performed.Group 2(n=30)consisted of patients with a previous fundoplication.RESULTS In group 1,acid reflux normalized in 23 of 24 patients,resulting in improved GERD/HRQL scores(P=0.001),which were most pronounced after the starting dose of PPI(P<0.001).PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P=0.5).Normalization of acid reflux in both groups was associated with reduction in papillary length,basal cell layer thickness,intercellular space dilatation,and acute and chronic inflammation of squamous epithelium.CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients,especially after the first dose of PPI,reaching the same level as after a successful fundoplication.Minor changes were found among GERD markers at the morphological level.
基金supported by Grant-in-Aid for Japan Society for the Promotion of Science(JSPS)Fellow(17J01742)JSPS,MEXT KAKENHI(21676002,23111705,26249027,and 17H01254)the Industrial Technology Research Grant Program from the New Energy and Industrial Technology Development Organization(NEDO)of Japan
文摘Peristalsis is widely seen in nature, as this pumping action is important in digestive systems for conveying sustenance to every corner of the body. In this paper, we propose a muscle-powered tubular micro pump that provides peristaltic transport. We utilized Drosophila melanogaster larvae that express channelrhodopsin-2 (ChR2) on the cell membrane of skeletal muscles to obtain light-responsive muscle tissues. The larvae were forced to contract with blue light stimulation. While changing the speed of the propagating light stimulation, we observed displacement on the surface of the contractile muscle tissues. We obtained peristaltic pumps from the larvae by dissecting them into tubular structures. The average inner diameter of the tubular structures was about 400 lm and the average outer diameter was about 750 lm. Contractions of this tubular structure could be controlled with the same blue light stimulation. To make the inner flow visible, we placed microbeads into the peristaltic pump, and thus determined that the pump could transport microbeads at a speed of 120 lm-s1.
