This article explores controllable Borel spaces, stationary, homogeneous Markov processes, discrete time with infinite horizon, with bounded cost functions and using the expected total discounted cost criterion. The p...This article explores controllable Borel spaces, stationary, homogeneous Markov processes, discrete time with infinite horizon, with bounded cost functions and using the expected total discounted cost criterion. The problem of the estimation of stability for this type of process is set. The central objective is to obtain a bounded stability index expressed in terms of the Lévy-Prokhorov metric;likewise, sufficient conditions are provided for the existence of such inequalities.展开更多
Fiber quality measurement in spinning preparation is crucial for optimizing waste and meeting yarn quality specifications.The brand-new Uster AFIS 6–the next-generation laboratory instrument from Uster Technologies–...Fiber quality measurement in spinning preparation is crucial for optimizing waste and meeting yarn quality specifications.The brand-new Uster AFIS 6–the next-generation laboratory instrument from Uster Technologies–uniquely tests man-made fiber properties in addition to cotton.It provides critical data to optimize fiber process control for cotton,man-made fibers,and blended yarns.展开更多
During the sintering process of iron ore,a large amount of nitrogen oxides is generated,for which there is currently no efficient and economical treatment process.Therefore,it is necessary to implement process control...During the sintering process of iron ore,a large amount of nitrogen oxides is generated,for which there is currently no efficient and economical treatment process.Therefore,it is necessary to implement process control in sintering production to keep the mass concentration of NO_(x)in sintering flue gas at a low level.Through industrial trials at sintering sites,methods such as correlation analysis,path analysis,and multiple linear regression were applied to analyze the influence of various factors on NO emissions during the sintering process.The results indicate that negative correlations exist between nitrogen monoxide(NO)emissions and negative pressure,permeability index,O_(2) concentration,CO concentration,and flue gas temperature.Conversely,positive correlations exist between NO emissions and dust concentration,water vapor volume fraction,and sintering bed speed.Among these factors,O_(2) concentration and dust concentration are identified as the most significant influencing factors on NO emissions.By analyzing the masses and modes of influence of different factors,the mechanisms of action of each factor were obtained.Specifically,O_(2) concentration,dust concentration,permeability index,CO concentration,and flue gas temperature play a direct dominant role in NO emissions during the sintering process,while water vapor volume fraction,sintering trolley speed,and negative pressure have an indirect effect.A predictive model for NO mass concentration in flue gas was established with an accuracy rate of 91.6%,showing consistent overall trends with actual values.Finally,denitrification strategies for sintering industrial production were proposed,along with prospects for preliminary denitrification of sintering flue gas using fluidized bed conditions in the duct.展开更多
A mathematical model of the decarburization reaction zone was established for the Ruhrstahl–Heraeus (RH) forced oxygen blowing decarburization process by Matlab R2022b software. For the problem of inaccurate predicti...A mathematical model of the decarburization reaction zone was established for the Ruhrstahl–Heraeus (RH) forced oxygen blowing decarburization process by Matlab R2022b software. For the problem of inaccurate prediction due to the large variation range of oxygen absorption rate under different process conditions, we statistically analyzed the main factors affecting the oxygen absorption rate. The backpropagation neural network was used to train and predict the oxygen absorption rate and was used to calculate the RH decarburization reaction zone model. We designed and developed a mathematical modeling software with process control of decarburization in RH degasser, which can realize the change of operating process parameters in the dynamic prediction process. The optimized mathematical model has more than 95% of the furnaces whose absolute error in calculation of carbon content is within ± 5 × 10^(−6), more than 90% of the heats whose relative error in calculation of oxygen content is within ± 15%, and the average absolute error of calculation of oxygen content is 26.4 × 10^(−6). Finally, we studied the influence of oxygen blowing timing, oxygen blowing volume and initial oxygen content on the forced decarburization process.展开更多
This study presents an innovative development of the exponentially weighted moving average(EWMA)control chart,explicitly adapted for the examination of time series data distinguished by seasonal autoregressive moving ...This study presents an innovative development of the exponentially weighted moving average(EWMA)control chart,explicitly adapted for the examination of time series data distinguished by seasonal autoregressive moving average behavior—SARMA(1,1)L under exponential white noise.Unlike previous works that rely on simplified models such as AR(1)or assume independence,this research derives for the first time an exact two-sided Average Run Length(ARL)formula for theModified EWMAchart under SARMA(1,1)L conditions,using a mathematically rigorous Fredholm integral approach.The derived formulas are validated against numerical integral equation(NIE)solutions,showing strong agreement and significantly reduced computational burden.Additionally,a performance comparison index(PCI)is introduced to assess the chart’s detection capability.Results demonstrate that the proposed method exhibits superior sensitivity to mean shifts in autocorrelated environments,outperforming existing approaches.The findings offer a new,efficient framework for real-time quality control in complex seasonal processes,with potential applications in environmental monitoring and intelligent manufacturing systems.展开更多
On the basis of the description of the rare-earth countercurrent extraction process, the on-line detecting method and equipments of rare-earth elements and the application in the process of the rare-earth countercurre...On the basis of the description of the rare-earth countercurrent extraction process, the on-line detecting method and equipments of rare-earth elements and the application in the process of the rare-earth countercurrent extraction are summarized. The procedure simulation of the computer, the automation control method and its current application are also mentioned in the process of rare-earth countercurrent extraction. The method of soft sensor is proposed. Optimal control method based on object-oriented rare-earth countercurrent extraction process and integrated automation system composed of process management system and process control system are presented, which are the developing direction of the automation of rare-earth countercurrent extraction process.展开更多
We presented a control strategy for tablet manufacturing processes based on continuous direct compression.The work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory aut...We presented a control strategy for tablet manufacturing processes based on continuous direct compression.The work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in Japan.Among different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch manufacturing.The control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW feeder.Based on these ideas,the concept of process control using RTD was summarized.展开更多
Neurons and glial cells, particularly astrocytes, are the two main cell populations in the central nervous system. While it is established that brain functions primarily rely on neuronal activity, an active contributi...Neurons and glial cells, particularly astrocytes, are the two main cell populations in the central nervous system. While it is established that brain functions primarily rely on neuronal activity, an active contribution of astrocytes to information processing is only starting to be considered. There is growing evidence that astrocytes, as part of the tripartite synapse, participate in this challenge by receiving and integrating neuronal signals and, in turn, by sending signals that target neurons[1]. The involvement of astrocytes in information processing has mainly been studied at the level of the single astrocyte, often missing the role of astrocyte networks in this process.展开更多
Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous...Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.展开更多
Purpose-The purpose of this paper is to eliminate the fluctuations in train arrival and departure times caused by skewed distributions in interval operation times.These fluctuations arise from random origin and proces...Purpose-The purpose of this paper is to eliminate the fluctuations in train arrival and departure times caused by skewed distributions in interval operation times.These fluctuations arise from random origin and process factors during interval operations and can accumulate over multiple intervals.The aim is to enhance the robustness of high-speed rail station arrival and departure track utilization schemes.Design/methodologylapproach-To achieve this objective,the paper simulates actual train operations,incorporating the fluctuations in interval operation times into the utilization of arrival and departure tracks at the station.The Monte Carlo simulation method is adopted to solve this problem.This approach transforms a nonlinear model,which includes constraints from probability distribution functions and is difficult to solve directly,into a linear programming model that is easier to handle.The method then linearly weights two objectives to optimize the solution.Findings-Through the application of Monte Carlo simulation,the study successfully converts the complex nonlinear model with probability distribution function constraints into a manageable linear programming model.By continuously adjusting the weighting coefficients of the linear objectives,the method is able to optimize the Pareto solution.Notably,this approach does not require extensive scene data to obtain a satisfactory Pareto solution set.Originality/value-The paper contributes to the field by introducing a novel method for optimizing high-speed rail station arrival and departure track utilization in the presence of fluctuations in interval operation times.The use of Monte Carlo simulation to transform the problem into a tractable linear programming model represents a significant advancement.Furthermore,the method's ability to produce satisfactory Pareto solutions without relying on extensive data sets adds to its practical value and applicability in real-world scenarios.展开更多
L2 reading is not only an important channel for people to obtain information and knowledge,but also the main way for people to learn a foreign language.Reading information processing can be divided into controlled pro...L2 reading is not only an important channel for people to obtain information and knowledge,but also the main way for people to learn a foreign language.Reading information processing can be divided into controlled processing and automatic processing.Controlled information processing is a conscious and resource-intensive processing model,while automatic information processing is an unconscious and automatic processing model.This study investigates the characteristics and interactivity of controlled and automatic information processing in L2 reading,and explores the roles of controlled and automatic information processing strategies in improving L2 reading ability.The findings are as follows:(a)controlled and automatic information processing is interactive in L2 reading;and(b)the uses of controlled and automatic information processing strategies are beneficial to the improvement of the reading ability of L2 learners.This study has important theoretical and practical value in improving the efficiency of L2 reading teaching and learning.展开更多
The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and...The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and the character of neural network on exactly describing nonlinear and uncertainty dynamic process organically. The method implements functions of adaptive and self-learning by adjusting weighting parameters. Adaptive neural network can make some output trail given hoping value to decouple in static state. The simulation result indicates the validity, veracity and robustness of the method used in the timber drying process展开更多
The elemental segregation,microstructure,and mechanical properties of thermo-mechanical control process(TMCP)treated high-manganese wear-resistant steel(HMWS)were experimentally investigated.Firstly,the initial elemen...The elemental segregation,microstructure,and mechanical properties of thermo-mechanical control process(TMCP)treated high-manganese wear-resistant steel(HMWS)were experimentally investigated.Firstly,the initial elemental segregation in the continuous casting slab of HMWS was characterized using the original position analysis.The results showed that the elemental segregation predominantly occurred near the quarter and the center regions of the slab.The homogenization of manganese(Mn)in the slab was not as obvious as that of other elements after the heating process.Subsequently,a series of hot-rolling tests were carried out on HMWS slab samples under different TMCP conditions,and the elemental segregation and microstructure of the TMCP-treated HMWS were investigated by microscopic analysis methods.The findings demonstrated that the segregations of carbon and silicon were effectively eliminated after the TMCP treatment,while Mn segregation presented a band-shaped arrangement and could be reduced at lower finishing rolling temperatures.The matrix phase of HMWS remained austenite regardless of the TMCP conditions,and the average size of austenite grains increased with the increasing finishing rolling temperature.Carbide particles were observed to form within austenite grains and even along grain boundaries at higher coiling temperatures.Finally,the mechanical tests were performed on the TMCP-treated HMWS at room temperature.The mechanical properties including tensile stress,yield stress,Charpy impact energy,and microhardness were discussed considering the effects of Mn segregation band,microstructure,and carbide precipitation.展开更多
High strength low alloy（HSLA） steels have been widely used in pipelines,power plant components,civil structures and so on,due to their outstanding mechanical properties as high strength and toughness,and excellent w...High strength low alloy（HSLA） steels have been widely used in pipelines,power plant components,civil structures and so on,due to their outstanding mechanical properties as high strength and toughness,and excellent weldability.Multi-phase microstructures containing acicular ferrite or acicular ferrite dominated phase have been proved to possess good comprehensive properties in HSLA steels.This paper mainly focuses on the formation mechanisms and control methods of acicular ferrite in HSLA steels.Effect of austenitizing conditions,continuous cooling rate,and isothermal quenching time and temperature on acicular ferrite transformation was reviewed.Furthermore,the modified process to control the formation of multi-phase microstructures containing acicular ferrite,as intercritical heat treatments,step quenching treatments and thermo-mechanical controlled processing,was summarized.The favorable combination of mechanical properties can be achieved by these modified treatments.展开更多
A constrained decoupling (generalized predictive control) GPC algorithm is proposed for MIMO (malti-input multi-output) system. This algorithm takes account of all constraints of inputs and their increments. By solvin...A constrained decoupling (generalized predictive control) GPC algorithm is proposed for MIMO (malti-input multi-output) system. This algorithm takes account of all constraints of inputs and their increments. By solving matrix equations, the multi-step predictive decoupling controllers are realized. This algorithm need not solve Diophantine functions, and weakens the cross-coupling of the variables. At last the simulation results demon- strate the effectiveness of this proposed strategy.展开更多
The methylotrophic yeast Pichia pastoris is a highly successful system for production of a variety of heterologous proteins due to its unique features/abilities for effective protein expression, and tremendous efforts...The methylotrophic yeast Pichia pastoris is a highly successful system for production of a variety of heterologous proteins due to its unique features/abilities for effective protein expression, and tremendous efforts have been made to increase heterologous protein productivity by P. pastoris in recent years. When new engineered yeast strains are constructed and are ready to use tot industrial protein production, process control and optimization techniques should be applied to improve the fermentation performance in the following aspects： （1） increase recombinant cell concentrations in fermentor to high density during growth phase; （2） effectively induce heterologous proteins by enhancing/stabilizing titers or concentrations of the proteins during induction phase; （3） decrease operation costs by relieving the working loads of heat-exchange and oxygen supply. This article reviews and discusses the key and commonly used techniques in heterologous protein production by P. pastoris, with the focus on optimizations of fermentation media and basic operation conditions, development of optimal glycerol feeding strategies for achieving high density cultivation of P. pastoris and effective heterologous protein induction methods by regulating specific growth rate, methanol concentration, temperatures, mixture ratio of multi-carbon substrates, etc. Metabolic analysis for recombinant protein production by P. pastoris is also introduced to interpret the mechanism of sub-optimal heterologous protein production and to explore further optimal expression methods.展开更多
The effect of martensite–austenite(M–A)constituents formed in thermo-mechanical controlled process on impact toughness of 20CrNi2MoV steel was investigated.The variation in fraction,size and morphology of M–A const...The effect of martensite–austenite(M–A)constituents formed in thermo-mechanical controlled process on impact toughness of 20CrNi2MoV steel was investigated.The variation in fraction,size and morphology of M–A constituent and its effect on toughness under different cooling rates were carried out.The result shows that there was no significant change in the fraction of M–A constituent under different cooling rates,but the distribution and size of M–A constituent were greatly influenced by cooling rate,which consequently influenced toughness.The amount of large blocky M–A constituents decreased from 4.7%to 1.7%,while that of elongated M–A constituents increased from 3.8%to 8.6%with the cooling rate increasing from 7 to 26°C/s,and the corresponding impact energy decreased from 132 to 84 J.The deterioration of impact toughness could be related to the increase in the elongated M–A constituents.The elongated M–A constituents existing along the prior austenite grain boundaries in samples of 26°C/s could easily lead to the formation of cleavage crack,which then results in the lower crack initiation energy than that of low cooling rate samples.展开更多
For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique du...For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique due to some difficulties,such as long response time,many un-measurable disturbances,and the reliability and precision issues of product quality soft-sensors.In this paper,based on the first principle analysis and dynamic simulation of a distillation process,a new predictive control scheme is proposed by using the split ratio of distillate flow rate to that of bottoms as an essential controlled variable.Correspondingly,a new strategy with integrated control and on-line optimization is developed,which consists of model predictive control of the split ratio,surrogate model based on radial basis function neural network for optimization,and modified differential evolution optimization algorithm. With the strategy,the process achieves its steady state quickly,so more profit can be obtained.The proposed strategy has been successfully applied to a gas separation plant for more than three years,which shows that the strategy is feasible and effective.展开更多
The Made in China 2025 initiative will require full automation in all sectors, from customers to production. This will result in great challenges to manufacturing systems in all sectors. In the future of manufacturing...The Made in China 2025 initiative will require full automation in all sectors, from customers to production. This will result in great challenges to manufacturing systems in all sectors. In the future of manufacturing, all devices and systems should have sensing and basic intelligence capabilities for control and adaptation. In this study, after discussing multiscale dynamics of the modern manufacturing system, a five-layer functional structure is proposed for uncertainties processing. Multiscale dynamics include： multi-time scale, spacetime scale, and multi-level dynamics. Control action will differ at different scales, with more design being required at both fast and slow time scales. More quantitative action is required in low-level operations, while more qualitative action is needed regarding high-level supervision. Intelligent manufacturing systems should have the capabilities of flexibility, adaptability, and intelligence. These capabilities will require the control action to be distributed and integrated with different approaches, including smart sensing, optimal design, and intelligent learning. Finally, a typical jet dispensing system is taken as a real-world example for multiscale modeling and control.展开更多
文摘This article explores controllable Borel spaces, stationary, homogeneous Markov processes, discrete time with infinite horizon, with bounded cost functions and using the expected total discounted cost criterion. The problem of the estimation of stability for this type of process is set. The central objective is to obtain a bounded stability index expressed in terms of the Lévy-Prokhorov metric;likewise, sufficient conditions are provided for the existence of such inequalities.
文摘Fiber quality measurement in spinning preparation is crucial for optimizing waste and meeting yarn quality specifications.The brand-new Uster AFIS 6–the next-generation laboratory instrument from Uster Technologies–uniquely tests man-made fiber properties in addition to cotton.It provides critical data to optimize fiber process control for cotton,man-made fibers,and blended yarns.
基金supported by the National Natural Science Foundation of China(No.51974131)Hebei Outstanding Youth Fund Project(No.E2020209082),Tangshan Key R&D Program project(No.22150232J)Sixth Division Wujiaqu City Science and Technology Plan Project(2410).
文摘During the sintering process of iron ore,a large amount of nitrogen oxides is generated,for which there is currently no efficient and economical treatment process.Therefore,it is necessary to implement process control in sintering production to keep the mass concentration of NO_(x)in sintering flue gas at a low level.Through industrial trials at sintering sites,methods such as correlation analysis,path analysis,and multiple linear regression were applied to analyze the influence of various factors on NO emissions during the sintering process.The results indicate that negative correlations exist between nitrogen monoxide(NO)emissions and negative pressure,permeability index,O_(2) concentration,CO concentration,and flue gas temperature.Conversely,positive correlations exist between NO emissions and dust concentration,water vapor volume fraction,and sintering bed speed.Among these factors,O_(2) concentration and dust concentration are identified as the most significant influencing factors on NO emissions.By analyzing the masses and modes of influence of different factors,the mechanisms of action of each factor were obtained.Specifically,O_(2) concentration,dust concentration,permeability index,CO concentration,and flue gas temperature play a direct dominant role in NO emissions during the sintering process,while water vapor volume fraction,sintering trolley speed,and negative pressure have an indirect effect.A predictive model for NO mass concentration in flue gas was established with an accuracy rate of 91.6%,showing consistent overall trends with actual values.Finally,denitrification strategies for sintering industrial production were proposed,along with prospects for preliminary denitrification of sintering flue gas using fluidized bed conditions in the duct.
基金supported by the Central Government Guides Local Science and Technology Development Foundation(No.2023JH6/100100046)the Project funded by China Postdoctoral Science Foundation(No.2023M730230).
文摘A mathematical model of the decarburization reaction zone was established for the Ruhrstahl–Heraeus (RH) forced oxygen blowing decarburization process by Matlab R2022b software. For the problem of inaccurate prediction due to the large variation range of oxygen absorption rate under different process conditions, we statistically analyzed the main factors affecting the oxygen absorption rate. The backpropagation neural network was used to train and predict the oxygen absorption rate and was used to calculate the RH decarburization reaction zone model. We designed and developed a mathematical modeling software with process control of decarburization in RH degasser, which can realize the change of operating process parameters in the dynamic prediction process. The optimized mathematical model has more than 95% of the furnaces whose absolute error in calculation of carbon content is within ± 5 × 10^(−6), more than 90% of the heats whose relative error in calculation of oxygen content is within ± 15%, and the average absolute error of calculation of oxygen content is 26.4 × 10^(−6). Finally, we studied the influence of oxygen blowing timing, oxygen blowing volume and initial oxygen content on the forced decarburization process.
基金financially by the National Research Council of Thailand(NRCT)under Contract No.N42A670894.
文摘This study presents an innovative development of the exponentially weighted moving average(EWMA)control chart,explicitly adapted for the examination of time series data distinguished by seasonal autoregressive moving average behavior—SARMA(1,1)L under exponential white noise.Unlike previous works that rely on simplified models such as AR(1)or assume independence,this research derives for the first time an exact two-sided Average Run Length(ARL)formula for theModified EWMAchart under SARMA(1,1)L conditions,using a mathematically rigorous Fredholm integral approach.The derived formulas are validated against numerical integral equation(NIE)solutions,showing strong agreement and significantly reduced computational burden.Additionally,a performance comparison index(PCI)is introduced to assess the chart’s detection capability.Results demonstrate that the proposed method exhibits superior sensitivity to mean shifts in autocorrelated environments,outperforming existing approaches.The findings offer a new,efficient framework for real-time quality control in complex seasonal processes,with potential applications in environmental monitoring and intelligent manufacturing systems.
文摘On the basis of the description of the rare-earth countercurrent extraction process, the on-line detecting method and equipments of rare-earth elements and the application in the process of the rare-earth countercurrent extraction are summarized. The procedure simulation of the computer, the automation control method and its current application are also mentioned in the process of rare-earth countercurrent extraction. The method of soft sensor is proposed. Optimal control method based on object-oriented rare-earth countercurrent extraction process and integrated automation system composed of process management system and process control system are presented, which are the developing direction of the automation of rare-earth countercurrent extraction process.
文摘We presented a control strategy for tablet manufacturing processes based on continuous direct compression.The work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in Japan.Among different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch manufacturing.The control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW feeder.Based on these ideas,the concept of process control using RTD was summarized.
文摘Neurons and glial cells, particularly astrocytes, are the two main cell populations in the central nervous system. While it is established that brain functions primarily rely on neuronal activity, an active contribution of astrocytes to information processing is only starting to be considered. There is growing evidence that astrocytes, as part of the tripartite synapse, participate in this challenge by receiving and integrating neuronal signals and, in turn, by sending signals that target neurons[1]. The involvement of astrocytes in information processing has mainly been studied at the level of the single astrocyte, often missing the role of astrocyte networks in this process.
基金supported by the Zhejiang Key Science and Technology Project(2023C03116)National Natural Science Foundation of China(22078286)National Key Research and Development Program of China(2021YFE0113300).
文摘Dynamic control is essential to guarantee the stable performance of continuous chromatography.AutoMAb dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of breakthrough.In this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by us.The effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were investigated.The results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of feedstock.However,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein loss.It was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.
文摘Purpose-The purpose of this paper is to eliminate the fluctuations in train arrival and departure times caused by skewed distributions in interval operation times.These fluctuations arise from random origin and process factors during interval operations and can accumulate over multiple intervals.The aim is to enhance the robustness of high-speed rail station arrival and departure track utilization schemes.Design/methodologylapproach-To achieve this objective,the paper simulates actual train operations,incorporating the fluctuations in interval operation times into the utilization of arrival and departure tracks at the station.The Monte Carlo simulation method is adopted to solve this problem.This approach transforms a nonlinear model,which includes constraints from probability distribution functions and is difficult to solve directly,into a linear programming model that is easier to handle.The method then linearly weights two objectives to optimize the solution.Findings-Through the application of Monte Carlo simulation,the study successfully converts the complex nonlinear model with probability distribution function constraints into a manageable linear programming model.By continuously adjusting the weighting coefficients of the linear objectives,the method is able to optimize the Pareto solution.Notably,this approach does not require extensive scene data to obtain a satisfactory Pareto solution set.Originality/value-The paper contributes to the field by introducing a novel method for optimizing high-speed rail station arrival and departure track utilization in the presence of fluctuations in interval operation times.The use of Monte Carlo simulation to transform the problem into a tractable linear programming model represents a significant advancement.Furthermore,the method's ability to produce satisfactory Pareto solutions without relying on extensive data sets adds to its practical value and applicability in real-world scenarios.
文摘L2 reading is not only an important channel for people to obtain information and knowledge,but also the main way for people to learn a foreign language.Reading information processing can be divided into controlled processing and automatic processing.Controlled information processing is a conscious and resource-intensive processing model,while automatic information processing is an unconscious and automatic processing model.This study investigates the characteristics and interactivity of controlled and automatic information processing in L2 reading,and explores the roles of controlled and automatic information processing strategies in improving L2 reading ability.The findings are as follows:(a)controlled and automatic information processing is interactive in L2 reading;and(b)the uses of controlled and automatic information processing strategies are beneficial to the improvement of the reading ability of L2 learners.This study has important theoretical and practical value in improving the efficiency of L2 reading teaching and learning.
基金the Key Technologies R&D Program of Harbin (0111211102).
文摘The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and the character of neural network on exactly describing nonlinear and uncertainty dynamic process organically. The method implements functions of adaptive and self-learning by adjusting weighting parameters. Adaptive neural network can make some output trail given hoping value to decouple in static state. The simulation result indicates the validity, veracity and robustness of the method used in the timber drying process
基金support for this research provided by the High-end Foreign Experts Recruitment Plan of China(Grant No.G2022105011L).
文摘The elemental segregation,microstructure,and mechanical properties of thermo-mechanical control process(TMCP)treated high-manganese wear-resistant steel(HMWS)were experimentally investigated.Firstly,the initial elemental segregation in the continuous casting slab of HMWS was characterized using the original position analysis.The results showed that the elemental segregation predominantly occurred near the quarter and the center regions of the slab.The homogenization of manganese(Mn)in the slab was not as obvious as that of other elements after the heating process.Subsequently,a series of hot-rolling tests were carried out on HMWS slab samples under different TMCP conditions,and the elemental segregation and microstructure of the TMCP-treated HMWS were investigated by microscopic analysis methods.The findings demonstrated that the segregations of carbon and silicon were effectively eliminated after the TMCP treatment,while Mn segregation presented a band-shaped arrangement and could be reduced at lower finishing rolling temperatures.The matrix phase of HMWS remained austenite regardless of the TMCP conditions,and the average size of austenite grains increased with the increasing finishing rolling temperature.Carbide particles were observed to form within austenite grains and even along grain boundaries at higher coiling temperatures.Finally,the mechanical tests were performed on the TMCP-treated HMWS at room temperature.The mechanical properties including tensile stress,yield stress,Charpy impact energy,and microhardness were discussed considering the effects of Mn segregation band,microstructure,and carbide precipitation.
基金the China National Funds for Distinguished Young Scientists (Grant No.51325401)the National Magnetic Confinement Fusion Energy Research Project (Grant No.2015GB119001)the National Natural Science Foundation of China (Grant Nos.51501126,51474156 and U1660201) for grant and financial support
文摘High strength low alloy（HSLA） steels have been widely used in pipelines,power plant components,civil structures and so on,due to their outstanding mechanical properties as high strength and toughness,and excellent weldability.Multi-phase microstructures containing acicular ferrite or acicular ferrite dominated phase have been proved to possess good comprehensive properties in HSLA steels.This paper mainly focuses on the formation mechanisms and control methods of acicular ferrite in HSLA steels.Effect of austenitizing conditions,continuous cooling rate,and isothermal quenching time and temperature on acicular ferrite transformation was reviewed.Furthermore,the modified process to control the formation of multi-phase microstructures containing acicular ferrite,as intercritical heat treatments,step quenching treatments and thermo-mechanical controlled processing,was summarized.The favorable combination of mechanical properties can be achieved by these modified treatments.
基金Supported by the National Natural Science Foundation of China (No.60374037, No.60574036), the Program for New Century Excellent Talents in University of China (NCET), and the Specialized Research Fund for the Doctoral Program of Higher Edu-cation of China (No.20050055013).
文摘A constrained decoupling (generalized predictive control) GPC algorithm is proposed for MIMO (malti-input multi-output) system. This algorithm takes account of all constraints of inputs and their increments. By solving matrix equations, the multi-step predictive decoupling controllers are realized. This algorithm need not solve Diophantine functions, and weakens the cross-coupling of the variables. At last the simulation results demon- strate the effectiveness of this proposed strategy.
基金Supported by the Key Agricultral Technology Program of Shanghai Science & Technology Committee(073919108)MajorState Basic Research Development Program of China(2007CB714303)
文摘The methylotrophic yeast Pichia pastoris is a highly successful system for production of a variety of heterologous proteins due to its unique features/abilities for effective protein expression, and tremendous efforts have been made to increase heterologous protein productivity by P. pastoris in recent years. When new engineered yeast strains are constructed and are ready to use tot industrial protein production, process control and optimization techniques should be applied to improve the fermentation performance in the following aspects： （1） increase recombinant cell concentrations in fermentor to high density during growth phase; （2） effectively induce heterologous proteins by enhancing/stabilizing titers or concentrations of the proteins during induction phase; （3） decrease operation costs by relieving the working loads of heat-exchange and oxygen supply. This article reviews and discusses the key and commonly used techniques in heterologous protein production by P. pastoris, with the focus on optimizations of fermentation media and basic operation conditions, development of optimal glycerol feeding strategies for achieving high density cultivation of P. pastoris and effective heterologous protein induction methods by regulating specific growth rate, methanol concentration, temperatures, mixture ratio of multi-carbon substrates, etc. Metabolic analysis for recombinant protein production by P. pastoris is also introduced to interpret the mechanism of sub-optimal heterologous protein production and to explore further optimal expression methods.
文摘The effect of martensite–austenite(M–A)constituents formed in thermo-mechanical controlled process on impact toughness of 20CrNi2MoV steel was investigated.The variation in fraction,size and morphology of M–A constituent and its effect on toughness under different cooling rates were carried out.The result shows that there was no significant change in the fraction of M–A constituent under different cooling rates,but the distribution and size of M–A constituent were greatly influenced by cooling rate,which consequently influenced toughness.The amount of large blocky M–A constituents decreased from 4.7%to 1.7%,while that of elongated M–A constituents increased from 3.8%to 8.6%with the cooling rate increasing from 7 to 26°C/s,and the corresponding impact energy decreased from 132 to 84 J.The deterioration of impact toughness could be related to the increase in the elongated M–A constituents.The elongated M–A constituents existing along the prior austenite grain boundaries in samples of 26°C/s could easily lead to the formation of cleavage crack,which then results in the lower crack initiation energy than that of low cooling rate samples.
基金Supported by the National High Technology Research and Development Program of China（2007AA04Z193） the National Natural Science Foundation of China（60974008 60704032）
文摘For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique due to some difficulties,such as long response time,many un-measurable disturbances,and the reliability and precision issues of product quality soft-sensors.In this paper,based on the first principle analysis and dynamic simulation of a distillation process,a new predictive control scheme is proposed by using the split ratio of distillate flow rate to that of bottoms as an essential controlled variable.Correspondingly,a new strategy with integrated control and on-line optimization is developed,which consists of model predictive control of the split ratio,surrogate model based on radial basis function neural network for optimization,and modified differential evolution optimization algorithm. With the strategy,the process achieves its steady state quickly,so more profit can be obtained.The proposed strategy has been successfully applied to a gas separation plant for more than three years,which shows that the strategy is feasible and effective.
基金partially supported by a GRF project from RGC of Hong Kong China (City U: 11207714)+2 种基金a SRG grant from City University of Hong Kong China (7004909)a National Basic Research Program of China (2011CB013104)
文摘The Made in China 2025 initiative will require full automation in all sectors, from customers to production. This will result in great challenges to manufacturing systems in all sectors. In the future of manufacturing, all devices and systems should have sensing and basic intelligence capabilities for control and adaptation. In this study, after discussing multiscale dynamics of the modern manufacturing system, a five-layer functional structure is proposed for uncertainties processing. Multiscale dynamics include： multi-time scale, spacetime scale, and multi-level dynamics. Control action will differ at different scales, with more design being required at both fast and slow time scales. More quantitative action is required in low-level operations, while more qualitative action is needed regarding high-level supervision. Intelligent manufacturing systems should have the capabilities of flexibility, adaptability, and intelligence. These capabilities will require the control action to be distributed and integrated with different approaches, including smart sensing, optimal design, and intelligent learning. Finally, a typical jet dispensing system is taken as a real-world example for multiscale modeling and control.
