An enhanced least mean square(LMS)error identification algorithm integrated with Kalman filtering is proposed to resolve accuracy degradation induced by nonlinear dynamics and parameter uncertainties in continuous rot...An enhanced least mean square(LMS)error identification algorithm integrated with Kalman filtering is proposed to resolve accuracy degradation induced by nonlinear dynamics and parameter uncertainties in continuous rotary electro-hydraulic servo systems.This enhancement accelerates convergence and improves accuracy compared with traditional LMS.A fifth-order identification mod-el is developed based on valve-controlled hydraulic motors,with parameters identified using Kalman filter state estimation and gradient smoothing.The results indicate that the improved LMS effectively enhances parameter identification.An advanced disturbance rejection controller(ADRC)is de-signed,and its performance is compared with an optimal proportional integral derivative(PID)con-troller through Simulink simulations.The results show that the ADRC fulfills the control specifications and expands the system’s operational bandwidth.展开更多
Traditional centralized Proportional Integral(PI)controller design methods based on Equivalent Transfer Functions(ETFs)have poor decoupling effect in turboprop engines.In this paper,a centralized PI design method base...Traditional centralized Proportional Integral(PI)controller design methods based on Equivalent Transfer Functions(ETFs)have poor decoupling effect in turboprop engines.In this paper,a centralized PI design method based on dynamic imaginary matrix and equivalent transfer function is proposed.Firstly,a method for solving equivalent transfer functions based on the dynamic imaginary matrix is proposed,which adopts dynamic imaginary matrix to describe the dynamic characteristics of the system,and obtains the equivalent transfer function based on the dynamic imaginary matrix characteristics.Secondly,for the equivalent transfer function,a central-ized PI control gain is designed using the Taylor expansion method.Meanwhile,this paper further proves that the centralized PI design method proposed in this paper has integral stability.Consid-ering the impact of altitude and Mach number on turboprop engines,a linear feedforward control method based on the transfer function matrix is further proposed based on the centralized PI con-troller,and the stability of the entire comprehensive control method is proved.Finally,to ensure the safe and effective operation of the turboprop engine,a temperature and torque limiting protection controller is designed for the turboprop engine.Simulation results show that the centralized PI con-troller design method and linear feedforward control method proposed can effectively improve the control quality of turboprop engine control systems.展开更多
Optimal formation reconfiguration control of multiple Uninhabited Combat Air Vehicles （UCAVs） is a complicated global optimum problem. Particle Swarm Optimization （PSO） is a population based stochastic optimizatio...Optimal formation reconfiguration control of multiple Uninhabited Combat Air Vehicles （UCAVs） is a complicated global optimum problem. Particle Swarm Optimization （PSO） is a population based stochastic optimization technique inspired by social behaviour of bird flocking or fish schooling. PSO can achieve better results in a faster, cheaper way compared with other bio-inspired computational methods, and there are few parameters to adjust in PSO. In this paper, we propose an improved PSO model for solving the optimal formation reconfiguration control problem for multiple UCAVs. Firstly, the Control Parameterization and Time Diseretization （CPTD） method is designed in detail. Then, the mutation strategy and a special mutation-escape operator are adopted in the improved PSO model to make particles explore the search space more efficiently. The proposed strategy can produce a large speed value dynamically according to the variation of the speed, which makes the algorithm explore the local and global minima thoroughly at the same time. Series experimental results demonstrate the feasibility and effectiveness of the proposed method in solving the optimal formation reconfiguration control problem for multiple UCAVs.展开更多
By adopting the method of controlling parameters this paper describes the construction of various kinds of cubic curve segment and curved surface fragment with rational and non rational parameters, and discusses the ...By adopting the method of controlling parameters this paper describes the construction of various kinds of cubic curve segment and curved surface fragment with rational and non rational parameters, and discusses the relationship between controlling parameters, weighted factors and types, kinds and characteristics of curve segments and curved surface fragments. A mathematical method is provided for CAGD with abundant connotations, broad covering region, convenience, flexibility and direct simplicity.展开更多
BACKGROUND Liver imaging and transient elastography(TE)are both tools used to assess liver fibrosis and steatosis among people with hepatitis C virus(HCV)infection.However,the diagnostic accuracy of conventional imagi...BACKGROUND Liver imaging and transient elastography(TE)are both tools used to assess liver fibrosis and steatosis among people with hepatitis C virus(HCV)infection.However,the diagnostic accuracy of conventional imaging in detecting fibrosis and steatosis in this patient population remains unclear.AIM To investigate the correlation between steatosis and fibrosis and abnormal findings on liver imaging in patients with HCV.METHODS We conducted a retrospective cross-sectional analysis of patients with HCV at Grady Liver Clinic who had TE exams between 2018-2019.We analyzed the correlation of controlled attenuation parameter and liver stiffness measurement on TE and abnormal findings on liver imaging.Liver imaging findings(hepatic steatosis,increased echogenicity,cirrhosis,and chronic liver disease)were further evaluated for their diagnostic performance in detecting fibrosis(≥F2,≥F3,≥F4)and steatosis(≥S1,≥S2,≥S3).RESULTS Of 959 HCV patients who underwent TE,651 had liver imaging.Higher controlled attenuation parameter scores were observed in patients with abnormal liver findings(P=0.0050),hepatic steatosis(P<0.0001),and increased echogenicity(P<0.0001).Higher liver stiffness measurement values were also noted in those with abnormal liver(P<0.0001)and increased echogenicity(P=0.0026).Steatosis severity correlated with hepatic steatosis(r=0.195,P<0.001)and increased echogenicity(r=0.209,P<0.001).For fibrosis detection,abnormal liver imaging had moderate sensitivity(81.7%)and specificity(70.4%)for cirrhosis(≥F4),while cirrhosis on imaging had high specificity(99.2%)but low sensitivity(18.3%).Increased echogenicity showed high specificity(92.8%)but low sensitivity(20.9%)for steatosis detection.CONCLUSION Liver imaging detects advanced fibrosis and steatosis but lacks early-stage sensitivity.Integrating TE with imaging may improve evaluation in patients with HCV.展开更多
The Cross-domain Heuristic Search Challenge(CHeSC)is a competition focused on creating efficient search algorithms adaptable to diverse problem domains.Selection hyper-heuristics are a class of algorithms that dynamic...The Cross-domain Heuristic Search Challenge(CHeSC)is a competition focused on creating efficient search algorithms adaptable to diverse problem domains.Selection hyper-heuristics are a class of algorithms that dynamically choose heuristics during the search process.Numerous selection hyper-heuristics have different imple-mentation strategies.However,comparisons between them are lacking in the literature,and previous works have not highlighted the beneficial and detrimental implementation methods of different components.The question is how to effectively employ them to produce an efficient search heuristic.Furthermore,the algorithms that competed in the inaugural CHeSC have not been collectively reviewed.This work conducts a review analysis of the top twenty competitors from this competition to identify effective and ineffective strategies influencing algorithmic performance.A summary of the main characteristics and classification of the algorithms is presented.The analysis underlines efficient and inefficient methods in eight key components,including search points,search phases,heuristic selection,move acceptance,feedback,Tabu mechanism,restart mechanism,and low-level heuristic parameter control.This review analyzes the components referencing the competition’s final leaderboard and discusses future research directions for these components.The effective approaches,identified as having the highest quality index,are mixed search point,iterated search phases,relay hybridization selection,threshold acceptance,mixed learning,Tabu heuristics,stochastic restart,and dynamic parameters.Findings are also compared with recent trends in hyper-heuristics.This work enhances the understanding of selection hyper-heuristics,offering valuable insights for researchers and practitioners aiming to develop effective search algorithms for diverse problem domains.展开更多
BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the eff...BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B (CHB). METHODS: Patients with CHB receiving enticavir for initial antiviral therapy were studied; they were divided into the high CAP group and normal CAP group at baseline according to the CAP values. The effect of the antiviral therapy between the two groups were compared at week 12, 24 and 48. Patients with high CAP value at baseline were divided into three subgroups, mild, moderate and severe elevation; the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP. RESULTS: A total of 153 patients were enrolled. Among them, 63 were in the high CAP group and 90 in the normal CAP group. Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12, 24 and 48. Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24; while the difference was not significant between the patients with normal CAP and those with severely elevated CAP. The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12, 24 and 48. CONCLUSION: CHB patients with high CAP had poor response to antiviral therapy.展开更多
This article investigates gain self-scheduled H 1 robust control system design for a tailless fold- ing-wing morphing aircraft in the wing shape varying process. During the wing morphing phase, the aircraft＇s dynamic...This article investigates gain self-scheduled H 1 robust control system design for a tailless fold- ing-wing morphing aircraft in the wing shape varying process. During the wing morphing phase, the aircraft＇s dynamic response will be governed by time-varying aerodynamic forces and moments. Nonlinear dynamic equations of the morphing aircraft are linearized by using Jacobian linearization approach, and a linear parameter varying （LPV） model of the morphing aircraft in wing folding is obtained. A multi-loop controller for the morphing aircraft is formulated to guarantee stability for the wing shape transition process. The proposed controller uses a set of inner-loop gains to provide stability using classical techniques, whereas a gain self-scheduled H 1 outer-loop controller is devised to guarantee a specific level of robust stability and performance for the time-varying dynamics. The closed-loop simulations show that speed and altitude vary slightly during the whole wing folding process, and they converge rapidly after the process ends. This proves that the gain self-scheduled H 1 robust controller can guarantee a satisfactory dynamic performance for the morphing aircraft during the whole wing shape transition process. Finally, the flight control system＇s robustness for the wing folding process is verified according to uncertainties of the aerodynamic parameters in the nonlinear model.展开更多
This paper is concerned with a systematic method of smooth switching linear parameter- varying （LPV） controllers design for a morphing aircraft with a variable wing sweep angle. The morphing aircraft is modeled as a...This paper is concerned with a systematic method of smooth switching linear parameter- varying （LPV） controllers design for a morphing aircraft with a variable wing sweep angle. The morphing aircraft is modeled as an LPV system, whose scheduling parameter is the variation rate of the wing sweep angle. By dividing the scheduling parameter set into subsets with overlaps, output feedback controllers which consider smooth switching are designed and the controllers in over- lapped subsets are interpolated from two adjacent subsets. A switching law without constraint on the average dwell time is obtained which makes the conclusion less conservative. Furthermore, a systematic algorithm is developed to improve the efficiency of the controllers design process. The parameter set is divided into the fewest subsets on the premise that the closed-loop system has a desired performance. Simulation results demonstrate the effectiveness of this approach.展开更多
This paper aims at developing a novel method of constructing a class of multi-wing chaotic and hyperchaotic system by introducing a unified step function. In order to overcome the essential difficulties in iteratively...This paper aims at developing a novel method of constructing a class of multi-wing chaotic and hyperchaotic system by introducing a unified step function. In order to overcome the essential difficulties in iteratively adjusting multiple parameters of conventional multi-parameter control, this paper introduces a unified step function controlled by a single parameter for constructing various multi-wing chaotic and hyperchaotic systems. In particular, to the best of the authors＇ knowledge, this is also the first time to find a non-equilibrium multi-wing hyperchaotic system by means of the unified step function control. According to the heteroclinic loop Shilnikov theorem, some properties for multi-wing attractors and its chaos mechanism are further discussed and analyzed. A circuit for multi-wing systems is designed and implemented for demonstration, which verifies the effectiveness of the proposed approach.展开更多
AIM: To study the diagnostic value of controlled attenuation parameter (CAP), evaluated by transient elastography, for liver steatosis in patients with chronic hepatitis B (CHB).
A modified harmony search algorithm with co-evolutional control parameters(DEHS), applied through differential evolution optimization, is proposed. In DEHS, two control parameters, i.e., harmony memory considering rat...A modified harmony search algorithm with co-evolutional control parameters(DEHS), applied through differential evolution optimization, is proposed. In DEHS, two control parameters, i.e., harmony memory considering rate and pitch adjusting rate, are encoded as a symbiotic individual of an original individual(i.e., harmony vector). Harmony search operators are applied to evolving the original population. DE is applied to co-evolving the symbiotic population based on feedback information from the original population. Thus, with the evolution of the original population in DEHS, the symbiotic population is dynamically and self-adaptively adjusted, and real-time optimum control parameters are obtained. The proposed DEHS algorithm has been applied to various benchmark functions and two typical dynamic optimization problems. The experimental results show that the performance of the proposed algorithm is better than that of other HS variants. Satisfactory results are obtained in the application.展开更多
In this paper, we present a new algorithm to solve a two-dimensional parabolic inverse problem with a source parameter, which appears in many physical phenomena. A linearized compact difference scheme for this problem...In this paper, we present a new algorithm to solve a two-dimensional parabolic inverse problem with a source parameter, which appears in many physical phenomena. A linearized compact difference scheme for this problem is constructed using the finite difference method. The discretization accuracy is second-order in time and fourth-order in space. We obtain the unique solvability and present an alternating direction implicit algorithm to solve this difference scheme. The results of numerical experiments are presented to demonstrate the accuracy of this algorithm.展开更多
This article proposes a linear parameter varying （LPV） switching tracking control scheme for a flexible air-breathing hypersonic vehicle （FAHV）. First, a polytopic LPV model is constructed to represent the complex...This article proposes a linear parameter varying （LPV） switching tracking control scheme for a flexible air-breathing hypersonic vehicle （FAHV）. First, a polytopic LPV model is constructed to represent the complex nonlinear longitudinal model of the FAHV by using Jacobian linearization and tensor-product （T-P） model transformation approach. Second, for less conservative controller design purpose, the flight envelope is divided into four sub-regions and a non-fragile LPV controller is designed for each parameter sub-region. These non-fragile LPV controllers are then switched in order to guarantee the closed-loop FAHV system to be asymptotically stable and satisfy a specified performance criterion. The desired non-fragile LPV switching controller is found by solving a convex constraint problem which can be efficiently solved using available linear matrix inequality （LMI） techniques, and robust stability analysis of the closed-loop FAHV system is verified based on multiple Lypapunov functions （MLFs）. Finally, numerical simulations have demonstrated the effectiveness of the proposed approach.展开更多
This paper deals with the problem of non-fragile linear parameter-varying（LPV） H_∞ control for morphing aircraft with asynchronous switching.The switched LPV model of morphing aircraft is established by Jacobian li...This paper deals with the problem of non-fragile linear parameter-varying（LPV） H_∞ control for morphing aircraft with asynchronous switching.The switched LPV model of morphing aircraft is established by Jacobian linearization approach according to the nonlinear model.The data missing is taken into account in the link from sensors to controllers and the link from controllers to actuators,which satisfies Bernoulli distribution.The non-fragile switched LPV controllers are constructed with consideration of the uncertainties of controllers and asynchronous switching phenomenon.The parameter-dependent Lyapunov functional method and mode-dependent average dwell time（MDADT） method are combined to guarantee the stability and prescribed performance of the system.The sufficient conditions on the solvability of the problem are derived in the form of linear matrix inequalities（LMI）.In order to achieve higher efficiency of the designing process,an algorithm is applied to divide the whole set into subsets automatically.Simulation results are provided to verify the effectiveness and superiority of the method in the paper.展开更多
The search efficiency of differential evolution （DE） algorithm is greatly impacted by its control parameters. Although many adaptation/self-adaptation techniques can automatically find suitable control parameters fo...The search efficiency of differential evolution （DE） algorithm is greatly impacted by its control parameters. Although many adaptation/self-adaptation techniques can automatically find suitable control parameters for the DE, most techniques are based on pop- ulation information which may be misleading in solving complex optimization problems. Therefore, a self-adaptive DE （i.e., JADE） using two-phase parameter control scheme （TPC-JADE） is proposed to enhance the performance of DE in the current study. In the TPC-JADE, an adaptation technique is utilized to generate the control parameters in the early population evolution, and a well-known empirical guideline is used to update the control parameters in the later evolution stages. The TPC-JADE is compared with four state-of-the-art DE variants on two famous test suites （i.e., IEEE CEC2005 and IEEE CEC2015）. Results indicate that the overall performance of the TPC-JADE is better than that of the other compared algorithms. In addition, the proposed algorithm is utilized to obtain optimal nutrient and inducer feeding for the Lee-Ramirez bioreactor. Experimental results show that the TPC-JADE can perform well on an actual dynamic optimization problem.展开更多
BACKGROUND Hepatic steatosis commonly occurs in some chronic liver diseases and may affect disease progression.AIM To investigate the performance of controlled attenuation parameter(CAP)for the diagnosis of hepatic st...BACKGROUND Hepatic steatosis commonly occurs in some chronic liver diseases and may affect disease progression.AIM To investigate the performance of controlled attenuation parameter(CAP)for the diagnosis of hepatic steatosis in patients with autoimmune liver diseases(AILDs).METHODS Patients who were suspected of having AILDs and underwent liver biopsy were consistently enrolled.Liver stiffness measurement(LSM)and CAP were performed by transient elastography.The area under the receiver operating characteristic(AUROC)curve was used to evaluate the performance of CAP for diagnosing hepatic steatosis compared with biopsy.RESULTS Among 190 patients with biopsy-proven hepatic steatosis,69 were diagnosed with autoimmune hepatitis(AIH),18 with primary biliary cholangitis(PBC),and 27 with AIH-PBC overlap syndrome.The AUROCs of CAP for the diagnosis of steatosis in AILDS were 0.878(0.791-0.965)for S1,0.764(0.676-0.853)for S2,and 0.821(0.716-0.926)for S3.The CAP value was significantly related to hepatic steatosis grade(P<0.001).Among 69 patients with AIH,the median CAP score was 205.63±47.36 dB/m for S0,258.41±42.83 dB/m for S1,293.00±37.18 dB/m for S2,and 313.60±27.89 dB/m for S3.Compared with patients with nonalcoholic fatty liver disease(NAFLD)presenting with autoimmune markers,patients with AIH concomitant with NAFLD were much older and had higher serum IgG levels and LSM values.CONCLUSION CAP can be used as a noninvasive diagnostic method to evaluate hepatic steatosis in patients with AILDs.Determination of LSM combined with CAP may help to identify patients with AIH concomitant with NAFLD from those with NAFLD with autoimmune phenomena.展开更多
基金Supported by the National Natural Science Foundation of China(No.52375037)the Outstanding Youth of Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture(No.GDRC 20220801)+1 种基金the Graduate Innovation Fund Project of Beijing University of Civil Engineering and Architecture(No.PG2025160)the Special Fund for Cultivation Projects of Beijing University of Civil Engineering and Architecture(No.X24026).
文摘An enhanced least mean square(LMS)error identification algorithm integrated with Kalman filtering is proposed to resolve accuracy degradation induced by nonlinear dynamics and parameter uncertainties in continuous rotary electro-hydraulic servo systems.This enhancement accelerates convergence and improves accuracy compared with traditional LMS.A fifth-order identification mod-el is developed based on valve-controlled hydraulic motors,with parameters identified using Kalman filter state estimation and gradient smoothing.The results indicate that the improved LMS effectively enhances parameter identification.An advanced disturbance rejection controller(ADRC)is de-signed,and its performance is compared with an optimal proportional integral derivative(PID)con-troller through Simulink simulations.The results show that the ADRC fulfills the control specifications and expands the system’s operational bandwidth.
基金support by the National Natural Science Foundation of China (No.52202474)China Postdoctoral Science Foundation (No.2023M731655)+3 种基金Major Projects of National Science and Technology,China (No.J2019-I-0020-0019)Advanced Aviation Power Innovation Workstation Project,China (No.HKCX2022-01-026-03)Basic Research Business Fees for Central Universities,China (No.NT2023004)Nanjing University of Aeronautics and Astronautics Forward-looking Layout Research Project,China (No.1002-ILA22037-1A22).
文摘Traditional centralized Proportional Integral(PI)controller design methods based on Equivalent Transfer Functions(ETFs)have poor decoupling effect in turboprop engines.In this paper,a centralized PI design method based on dynamic imaginary matrix and equivalent transfer function is proposed.Firstly,a method for solving equivalent transfer functions based on the dynamic imaginary matrix is proposed,which adopts dynamic imaginary matrix to describe the dynamic characteristics of the system,and obtains the equivalent transfer function based on the dynamic imaginary matrix characteristics.Secondly,for the equivalent transfer function,a central-ized PI control gain is designed using the Taylor expansion method.Meanwhile,this paper further proves that the centralized PI design method proposed in this paper has integral stability.Consid-ering the impact of altitude and Mach number on turboprop engines,a linear feedforward control method based on the transfer function matrix is further proposed based on the centralized PI con-troller,and the stability of the entire comprehensive control method is proved.Finally,to ensure the safe and effective operation of the turboprop engine,a temperature and torque limiting protection controller is designed for the turboprop engine.Simulation results show that the centralized PI con-troller design method and linear feedforward control method proposed can effectively improve the control quality of turboprop engine control systems.
基金supported by the Natural Science Foundation of China (Grant No.60604009)the Aero-nautical Science Foundation of China (Grant No. 2006ZC51039)+1 种基金the Beijing NOVA Program Foundation of China (Grant No. 2007A017)the Open Fund of the Provincial Key Laboratory for Information Proc-essing Technology, Suzhou University (Grant No. KJS0821)
文摘Optimal formation reconfiguration control of multiple Uninhabited Combat Air Vehicles （UCAVs） is a complicated global optimum problem. Particle Swarm Optimization （PSO） is a population based stochastic optimization technique inspired by social behaviour of bird flocking or fish schooling. PSO can achieve better results in a faster, cheaper way compared with other bio-inspired computational methods, and there are few parameters to adjust in PSO. In this paper, we propose an improved PSO model for solving the optimal formation reconfiguration control problem for multiple UCAVs. Firstly, the Control Parameterization and Time Diseretization （CPTD） method is designed in detail. Then, the mutation strategy and a special mutation-escape operator are adopted in the improved PSO model to make particles explore the search space more efficiently. The proposed strategy can produce a large speed value dynamically according to the variation of the speed, which makes the algorithm explore the local and global minima thoroughly at the same time. Series experimental results demonstrate the feasibility and effectiveness of the proposed method in solving the optimal formation reconfiguration control problem for multiple UCAVs.
文摘By adopting the method of controlling parameters this paper describes the construction of various kinds of cubic curve segment and curved surface fragment with rational and non rational parameters, and discusses the relationship between controlling parameters, weighted factors and types, kinds and characteristics of curve segments and curved surface fragments. A mathematical method is provided for CAGD with abundant connotations, broad covering region, convenience, flexibility and direct simplicity.
文摘BACKGROUND Liver imaging and transient elastography(TE)are both tools used to assess liver fibrosis and steatosis among people with hepatitis C virus(HCV)infection.However,the diagnostic accuracy of conventional imaging in detecting fibrosis and steatosis in this patient population remains unclear.AIM To investigate the correlation between steatosis and fibrosis and abnormal findings on liver imaging in patients with HCV.METHODS We conducted a retrospective cross-sectional analysis of patients with HCV at Grady Liver Clinic who had TE exams between 2018-2019.We analyzed the correlation of controlled attenuation parameter and liver stiffness measurement on TE and abnormal findings on liver imaging.Liver imaging findings(hepatic steatosis,increased echogenicity,cirrhosis,and chronic liver disease)were further evaluated for their diagnostic performance in detecting fibrosis(≥F2,≥F3,≥F4)and steatosis(≥S1,≥S2,≥S3).RESULTS Of 959 HCV patients who underwent TE,651 had liver imaging.Higher controlled attenuation parameter scores were observed in patients with abnormal liver findings(P=0.0050),hepatic steatosis(P<0.0001),and increased echogenicity(P<0.0001).Higher liver stiffness measurement values were also noted in those with abnormal liver(P<0.0001)and increased echogenicity(P=0.0026).Steatosis severity correlated with hepatic steatosis(r=0.195,P<0.001)and increased echogenicity(r=0.209,P<0.001).For fibrosis detection,abnormal liver imaging had moderate sensitivity(81.7%)and specificity(70.4%)for cirrhosis(≥F4),while cirrhosis on imaging had high specificity(99.2%)but low sensitivity(18.3%).Increased echogenicity showed high specificity(92.8%)but low sensitivity(20.9%)for steatosis detection.CONCLUSION Liver imaging detects advanced fibrosis and steatosis but lacks early-stage sensitivity.Integrating TE with imaging may improve evaluation in patients with HCV.
基金funded by Ministry of Higher Education(MoHE)Malaysia,under Transdisciplinary Research Grant Scheme(TRGS/1/2019/UKM/01/4/2).
文摘The Cross-domain Heuristic Search Challenge(CHeSC)is a competition focused on creating efficient search algorithms adaptable to diverse problem domains.Selection hyper-heuristics are a class of algorithms that dynamically choose heuristics during the search process.Numerous selection hyper-heuristics have different imple-mentation strategies.However,comparisons between them are lacking in the literature,and previous works have not highlighted the beneficial and detrimental implementation methods of different components.The question is how to effectively employ them to produce an efficient search heuristic.Furthermore,the algorithms that competed in the inaugural CHeSC have not been collectively reviewed.This work conducts a review analysis of the top twenty competitors from this competition to identify effective and ineffective strategies influencing algorithmic performance.A summary of the main characteristics and classification of the algorithms is presented.The analysis underlines efficient and inefficient methods in eight key components,including search points,search phases,heuristic selection,move acceptance,feedback,Tabu mechanism,restart mechanism,and low-level heuristic parameter control.This review analyzes the components referencing the competition’s final leaderboard and discusses future research directions for these components.The effective approaches,identified as having the highest quality index,are mixed search point,iterated search phases,relay hybridization selection,threshold acceptance,mixed learning,Tabu heuristics,stochastic restart,and dynamic parameters.Findings are also compared with recent trends in hyper-heuristics.This work enhances the understanding of selection hyper-heuristics,offering valuable insights for researchers and practitioners aiming to develop effective search algorithms for diverse problem domains.
基金Supported by The National Key Basic Research Project,No.2012CB517501Chinese Foundation for Hepatitis Prevention and Control–"WANG Bao-En"Liver Fibrosis Research Fund,No.XJS20120501+1 种基金Shanghai Science and Technology Committee,No.09140903500 and No.10411956300the 100-Talents Program of the Shanghai Municipal Health Bureau,No.XBR2011007
文摘AIM: To evaluate the performance of a novel non-invasive controlled attenuation parameter (CAP) to assess liver steatosis.
基金supported by grants from the National Science and Technology Major Project of China(2012ZX10002007-001-003 and 2013ZX10002005-002-003)the WBE Liver Fibrosis Foundation(XJS20120204)
文摘BACKGROUND: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis based on vibration-controlled transient elastography. The objective of this study was to investigate the effect of high value of CAP on antiviral therapy in patients with chronic hepatitis B (CHB). METHODS: Patients with CHB receiving enticavir for initial antiviral therapy were studied; they were divided into the high CAP group and normal CAP group at baseline according to the CAP values. The effect of the antiviral therapy between the two groups were compared at week 12, 24 and 48. Patients with high CAP value at baseline were divided into three subgroups, mild, moderate and severe elevation; the therapeutic response were compared among patients with normal CAP and subgroups of patients with elevated CAP. RESULTS: A total of 153 patients were enrolled. Among them, 63 were in the high CAP group and 90 in the normal CAP group. Patients with high CAP had lower rates of ALT normalization and HBV DNA clearance in response to antiviral therapy compared with those with normal CAP at week 12, 24 and 48. Further analysis showed that the rate of ALT normalization in patients with mildly and moderately elevated CAP were significant lower than those with normal CAP at week 12 and 24; while the difference was not significant between the patients with normal CAP and those with severely elevated CAP. The rate of HBV DNA clearance was significantly lower in patients with severely elevated CAP compared with those with normal CAP at week 12, 24 and 48. CONCLUSION: CHB patients with high CAP had poor response to antiviral therapy.
基金supported by National Natural Science Foundation of China(61273108)the Fundamental Research Funds for the Central Universities(106112013CDJZR175501)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
基金co-supported by China Postdoctoral Science Foundation(Nos.20110490259,2012T50038)
文摘This article investigates gain self-scheduled H 1 robust control system design for a tailless fold- ing-wing morphing aircraft in the wing shape varying process. During the wing morphing phase, the aircraft＇s dynamic response will be governed by time-varying aerodynamic forces and moments. Nonlinear dynamic equations of the morphing aircraft are linearized by using Jacobian linearization approach, and a linear parameter varying （LPV） model of the morphing aircraft in wing folding is obtained. A multi-loop controller for the morphing aircraft is formulated to guarantee stability for the wing shape transition process. The proposed controller uses a set of inner-loop gains to provide stability using classical techniques, whereas a gain self-scheduled H 1 outer-loop controller is devised to guarantee a specific level of robust stability and performance for the time-varying dynamics. The closed-loop simulations show that speed and altitude vary slightly during the whole wing folding process, and they converge rapidly after the process ends. This proves that the gain self-scheduled H 1 robust controller can guarantee a satisfactory dynamic performance for the morphing aircraft during the whole wing shape transition process. Finally, the flight control system＇s robustness for the wing folding process is verified according to uncertainties of the aerodynamic parameters in the nonlinear model.
基金supported by the National Natural Science Foundation of China(Nos.61273083 and 61374012)
文摘This paper is concerned with a systematic method of smooth switching linear parameter- varying （LPV） controllers design for a morphing aircraft with a variable wing sweep angle. The morphing aircraft is modeled as an LPV system, whose scheduling parameter is the variation rate of the wing sweep angle. By dividing the scheduling parameter set into subsets with overlaps, output feedback controllers which consider smooth switching are designed and the controllers in over- lapped subsets are interpolated from two adjacent subsets. A switching law without constraint on the average dwell time is obtained which makes the conclusion less conservative. Furthermore, a systematic algorithm is developed to improve the efficiency of the controllers design process. The parameter set is divided into the fewest subsets on the premise that the closed-loop system has a desired performance. Simulation results demonstrate the effectiveness of this approach.
基金Project supported by the National Natural Science Foundation of China(Grant No.61403143)the Natural Science Foundation of Guangdong Province,China(Grant No.2014A030313739)+1 种基金the Science and Technology Foundation Program of Guangzhou City,China(Grant No.201510010124)the Excellent Doctorial Dissertation Foundation of Guangdong Province,China(Grant No.XM080054)
文摘This paper aims at developing a novel method of constructing a class of multi-wing chaotic and hyperchaotic system by introducing a unified step function. In order to overcome the essential difficulties in iteratively adjusting multiple parameters of conventional multi-parameter control, this paper introduces a unified step function controlled by a single parameter for constructing various multi-wing chaotic and hyperchaotic systems. In particular, to the best of the authors＇ knowledge, this is also the first time to find a non-equilibrium multi-wing hyperchaotic system by means of the unified step function control. According to the heteroclinic loop Shilnikov theorem, some properties for multi-wing attractors and its chaos mechanism are further discussed and analyzed. A circuit for multi-wing systems is designed and implemented for demonstration, which verifies the effectiveness of the proposed approach.
基金Supported by China Hepatitis Prevention and Treatment Foundation Wang Baoen Liver Fibrosis Research Fund,No.xjs20110402
文摘AIM: To study the diagnostic value of controlled attenuation parameter (CAP), evaluated by transient elastography, for liver steatosis in patients with chronic hepatitis B (CHB).
基金Project(2013CB733605)supported by the National Basic Research Program of ChinaProject(21176073)supported by the National Natural Science Foundation of China
文摘A modified harmony search algorithm with co-evolutional control parameters(DEHS), applied through differential evolution optimization, is proposed. In DEHS, two control parameters, i.e., harmony memory considering rate and pitch adjusting rate, are encoded as a symbiotic individual of an original individual(i.e., harmony vector). Harmony search operators are applied to evolving the original population. DE is applied to co-evolving the symbiotic population based on feedback information from the original population. Thus, with the evolution of the original population in DEHS, the symbiotic population is dynamically and self-adaptively adjusted, and real-time optimum control parameters are obtained. The proposed DEHS algorithm has been applied to various benchmark functions and two typical dynamic optimization problems. The experimental results show that the performance of the proposed algorithm is better than that of other HS variants. Satisfactory results are obtained in the application.
基金supported by the Natural Science Foundation of Shandong Province of China (Grant No. ZR2009AL012)the Scienceand Technology Program of Education Bureau of Shandong Province, China (Grant No. J09LA12)
文摘In this paper, we present a new algorithm to solve a two-dimensional parabolic inverse problem with a source parameter, which appears in many physical phenomena. A linearized compact difference scheme for this problem is constructed using the finite difference method. The discretization accuracy is second-order in time and fourth-order in space. We obtain the unique solvability and present an alternating direction implicit algorithm to solve this difference scheme. The results of numerical experiments are presented to demonstrate the accuracy of this algorithm.
基金co-supported by National Outstanding Youth Science Foundation(No.61125306)National Natural Science Foundation of Major Research Plan(Nos.91016004,61034002)+1 种基金Research Fund for the Doctoral Program of Higher Education of China(No.20110092110020)the Scientific Research Foundation of Graduate School of Southeast University(No.YBJJ1103)
文摘This article proposes a linear parameter varying （LPV） switching tracking control scheme for a flexible air-breathing hypersonic vehicle （FAHV）. First, a polytopic LPV model is constructed to represent the complex nonlinear longitudinal model of the FAHV by using Jacobian linearization and tensor-product （T-P） model transformation approach. Second, for less conservative controller design purpose, the flight envelope is divided into four sub-regions and a non-fragile LPV controller is designed for each parameter sub-region. These non-fragile LPV controllers are then switched in order to guarantee the closed-loop FAHV system to be asymptotically stable and satisfy a specified performance criterion. The desired non-fragile LPV switching controller is found by solving a convex constraint problem which can be efficiently solved using available linear matrix inequality （LMI） techniques, and robust stability analysis of the closed-loop FAHV system is verified based on multiple Lypapunov functions （MLFs）. Finally, numerical simulations have demonstrated the effectiveness of the proposed approach.
基金supported by the National Natural Science Foundation of China(Nos.61374012,61273083 and 61403028)
文摘This paper deals with the problem of non-fragile linear parameter-varying（LPV） H_∞ control for morphing aircraft with asynchronous switching.The switched LPV model of morphing aircraft is established by Jacobian linearization approach according to the nonlinear model.The data missing is taken into account in the link from sensors to controllers and the link from controllers to actuators,which satisfies Bernoulli distribution.The non-fragile switched LPV controllers are constructed with consideration of the uncertainties of controllers and asynchronous switching phenomenon.The parameter-dependent Lyapunov functional method and mode-dependent average dwell time（MDADT） method are combined to guarantee the stability and prescribed performance of the system.The sufficient conditions on the solvability of the problem are derived in the form of linear matrix inequalities（LMI）.In order to achieve higher efficiency of the designing process,an algorithm is applied to divide the whole set into subsets automatically.Simulation results are provided to verify the effectiveness and superiority of the method in the paper.
基金supported by National Natural Science Foundation of China(Nos.61603244 and 41505001)Fundamental Research Funds for the Central Universities(No.222201717006)
文摘The search efficiency of differential evolution （DE） algorithm is greatly impacted by its control parameters. Although many adaptation/self-adaptation techniques can automatically find suitable control parameters for the DE, most techniques are based on pop- ulation information which may be misleading in solving complex optimization problems. Therefore, a self-adaptive DE （i.e., JADE） using two-phase parameter control scheme （TPC-JADE） is proposed to enhance the performance of DE in the current study. In the TPC-JADE, an adaptation technique is utilized to generate the control parameters in the early population evolution, and a well-known empirical guideline is used to update the control parameters in the later evolution stages. The TPC-JADE is compared with four state-of-the-art DE variants on two famous test suites （i.e., IEEE CEC2005 and IEEE CEC2015）. Results indicate that the overall performance of the TPC-JADE is better than that of the other compared algorithms. In addition, the proposed algorithm is utilized to obtain optimal nutrient and inducer feeding for the Lee-Ramirez bioreactor. Experimental results show that the TPC-JADE can perform well on an actual dynamic optimization problem.
基金Supported by National Natural Science Foundation of China,No.81470842 and No.81770572.
文摘BACKGROUND Hepatic steatosis commonly occurs in some chronic liver diseases and may affect disease progression.AIM To investigate the performance of controlled attenuation parameter(CAP)for the diagnosis of hepatic steatosis in patients with autoimmune liver diseases(AILDs).METHODS Patients who were suspected of having AILDs and underwent liver biopsy were consistently enrolled.Liver stiffness measurement(LSM)and CAP were performed by transient elastography.The area under the receiver operating characteristic(AUROC)curve was used to evaluate the performance of CAP for diagnosing hepatic steatosis compared with biopsy.RESULTS Among 190 patients with biopsy-proven hepatic steatosis,69 were diagnosed with autoimmune hepatitis(AIH),18 with primary biliary cholangitis(PBC),and 27 with AIH-PBC overlap syndrome.The AUROCs of CAP for the diagnosis of steatosis in AILDS were 0.878(0.791-0.965)for S1,0.764(0.676-0.853)for S2,and 0.821(0.716-0.926)for S3.The CAP value was significantly related to hepatic steatosis grade(P<0.001).Among 69 patients with AIH,the median CAP score was 205.63±47.36 dB/m for S0,258.41±42.83 dB/m for S1,293.00±37.18 dB/m for S2,and 313.60±27.89 dB/m for S3.Compared with patients with nonalcoholic fatty liver disease(NAFLD)presenting with autoimmune markers,patients with AIH concomitant with NAFLD were much older and had higher serum IgG levels and LSM values.CONCLUSION CAP can be used as a noninvasive diagnostic method to evaluate hepatic steatosis in patients with AILDs.Determination of LSM combined with CAP may help to identify patients with AIH concomitant with NAFLD from those with NAFLD with autoimmune phenomena.
