Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medi...Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (P <0.001) release of transforming growth factor-β1 (TGF-β1) from autologous bone within 10 min versus a delayed bone morphogenetic protein-2 (BMP-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMP-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMP-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMP-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMP-2-induced osteoblast differentiation due to prolonged BMP signaling and reduced expression of the BMP-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.展开更多
In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of O...In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance.展开更多
SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Co...SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Cooperati on Commissi on in the UK from June 10 to 17.展开更多
MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proli...MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proliferation, apoptosis,heart disease and human cancers.We investigated miR-133 expression and its potential role in a high glucose-induced myocardium in Streptozotocin(STZ)-induced C57bl6 mouse model of diabetes.miR-133 expression was significantly increased in myocardium in a time-dependent manner after STZ treatment.IGF1 receptor(IGF1R) protein was dramatically decreased without obvious up-regulation of its mRNA level post hyperglycemia.IGF1R protein level was decreaed with increase of its transcript level in neonatal mouse ventricular cardiomyocytes induced by high D-glucose concentration. Dual luciferase assay revealed that miR133 could interact with specific sites in the 3’UTR of IGF1R gene.p-ERK and p-Akt levels were reduced in neonatal mouse cardiomyocytes over-expressed with miR133 after IGF treatment.Introduction of functional miR-133,IGF1R siRNA into neonatal mouse cardiomyocytes could enhance cardiomyocyte apoptosis.These results implicate that miR-133 is involved in contributing to high glucose-induced cardiomyocyte apoptosis via regulating IGF1R expression post-transcriptionally.展开更多
Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"r...Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"respect for human rights".In 2004,the idea that"the State respects and protects human rights"was written into展开更多
The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside ...The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside class reading plays a positive role in English learning. Furthermore, some suggestions are made in the end.展开更多
Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributio...Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributions the contact term must be carefully included in any assessment of DCX reaction and can not be discarded a priori.展开更多
Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following...Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following DNA damage, ataxia telangiectasia mutated （ATM）, a protein kinase, was acti- vated and a cytosolic complex containing ATM, NEMO, RIP1 were formed （Biton and Ashkenazi, 2011）.展开更多
Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully ...Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully understood. Previous studies have shown that genome segment A, especically VP2 protein, plays the most important role in the tropism and pathogenicity of serotype 1 IBDV （Brandt et al., 2001）. VP2 is,however, unlikely to be the only factor for the virulence of vvIBDV （Boot et al., 2000）.展开更多
Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking ...Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,展开更多
Understory bryophytes play unique and disproportionately important roles in water retention,biogeochemical cycling,and biodiversity conservation,and serve as bioindicators of environmental health in forest ecosystems....Understory bryophytes play unique and disproportionately important roles in water retention,biogeochemical cycling,and biodiversity conservation,and serve as bioindicators of environmental health in forest ecosystems.However,biogeographical research on the biomass of forest bryophytes is inadequately studied and has been limited to elevational gradients.We conducted a systematic cross-regional survey of bryophyte biomass across 413 forest sites in Sichuan Province,China.We analyzed how each environmental variable,including climatic and atmospheric factors,overstory covers,and soil nutrients,relates to bryophyte biomass and quantified their relative contributions.The results indicate that,largely similar to previous local investigations and experiments,at a large scale,bryophytes are abundant in forests with lower temperature,nitrogen deposition,vapor pressure deficit,and tree and herb covers,as well as higher light availability.Moreover,bryophyte biomass is positively associated with soil carbon and nitrogen content.These environmental variables are closely related and jointly influence bryophyte biomass,with mean annual temperature being the most significant factor(accounting for 83%of the relative contribution).The biogeographical patterns of bryophyte biomass contribute to deepening our understanding of their adaptations to multiple environmental variables and enable us to predict their responses to global climate change.These patterns also provide essential evidence for establishing more accurate terrestrial vegetation ecosystem models.展开更多
Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic effici...Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic efficiency.In this paper,aiming at the uncertainty of distributed wind power and photovoltaic output,considering the coupling relationship between power,carbon trading,and green cardmarket,the optimal operationmodel and bidding scheme of VPP in spot market,carbon trading market,and green card market are established.On this basis,through the Shapley value and independent risk contribution theory in cooperative game theory,the quantitative analysis of the total income and risk contribution of various distributed resources in the virtual power plant is realized.Moreover,the scheduling strategies of virtual power plants under different risk preferences are systematically compared,and the feasibility and accuracy of the combination of Shapley value and independent risk contribution theory in ensuring fair income distribution and reasonable risk assessment are emphasized.A comprehensive solution for virtual power plants in the multi-market environment is constructed,which integrates operation strategy,income distribution mechanism,and risk control system into a unified analysis framework.Through the simulation of multi-scenario examples,the CPLEXsolver inMATLAB software is used to optimize themodel.The proposed joint optimization scheme can increase the profit of VPP participating in carbon trading and green certificate market by 29%.The total revenue of distributed resources managed by VPP is 9%higher than that of individual participation.展开更多
The Guangdong,Jiangxi and Fujian(GJF)provinces,located in the subtropical region of southeastern China,is one of the national key regions for soil erosion control and ecological restoration.This region is characterize...The Guangdong,Jiangxi and Fujian(GJF)provinces,located in the subtropical region of southeastern China,is one of the national key regions for soil erosion control and ecological restoration.This region is characterized by extensive red soil development and high rainfall erosivity,making it a representative landscape for exploring the interactions between land use change(LUC)and ecosystem services(ES).Despite the recognized importance of ES in hilly regions,comprehensive assessing the impacts of LUC on ES remain limited.This study investigates five key ES:water yield,soil conservation,carbon conservation,food supply,and habitat quality in GJF region from 2000 to 2020.By applying the InVEST model and the Geodetector method,we assessed the trade-offs,synergies,and transitions among ES,identified the natural and social drivers of ES dynamics,and quantified the contribution of LUC to ES changes using the ecosystem service contribution index.The results showed that cropland and woodland were the dominant land use types.Ecological restoration efforts positively influenced ES,with synergies intensifying and trade-offs diminishing over time.Land use conversions,particularly among woodland,grassland,and cropland,exerted significant impacts on ES.In particular,the conversion of woodland to other land uses had markedly negative effects on soil conservation,carbon conservation,and habitat quality.Forest cover was identified as a major driver of ES dynamics.These findings highlight the importance of maintaining and expanding forest and grassland cover,strengthening red soil conservation,and optimizing land use structure to achieve coordinated ecological protection and socioeconomic development in the subtropical hilly regions of southern China.展开更多
Dear Editor,On July 25,2024,an Oncologic Drugs Advisory Committee meeting was held to discuss the design of the AEGEAN trial,which evaluated the perioperative use of durvalumab for resectable non-small cell lung cance...Dear Editor,On July 25,2024,an Oncologic Drugs Advisory Committee meeting was held to discuss the design of the AEGEAN trial,which evaluated the perioperative use of durvalumab for resectable non-small cell lung cancer(NSCLC)[1].The Food and Drug Administration(FDA)stated that the two-arm trial was not designed to isolate contributions of neoadjuvant and adjuvant phases.Since the clinical benefit of adjuvant durvalumab remains uncertain,this limitation raises concerns about potential over-treatment.展开更多
In physics,our expectations for system behavior are often guided by intuitive arithmetic.For systems composed of identical units,we anticipate synergy of the contributions from these units,where 1+1=2.Conversely,for s...In physics,our expectations for system behavior are often guided by intuitive arithmetic.For systems composed of identical units,we anticipate synergy of the contributions from these units,where 1+1=2.Conversely,for systems built from opposing units,we expect cancellation of their contributions,where 1-1=0.This intuitive arithmetic has long underpinned our understanding of physical properties of materials,from electronic transport to optical responses.However,scientific breakthroughs often occur when nature reveals ways to circumvent these seemingly fundamental rules,opening new possibilities that challenge our deepest assumptions about material behavior.展开更多
In the context of large language model(LLM)reshaping software engineering education,this paper presents OSSerCopilot,a LLM-based tutoring system designed to address the critical challenge faced by newcomers(especially...In the context of large language model(LLM)reshaping software engineering education,this paper presents OSSerCopilot,a LLM-based tutoring system designed to address the critical challenge faced by newcomers(especially student contributors)in open source software(OSS)communities.Leveraging natural language processing,code semantic understanding,and learner profiling,the system functions as an intelligent tutor to scaffold three core competency domains:contribution guideline interpretation,project architecture comprehension,and personalized task matching.By transforming traditional onboarding barriers-such as complex contribution documentation and opaque project structures-into interactive learning journeys,OSSerCopilot enables newcomers to complete their first OSS contribution more easily and confidently.This paper highlights how LLM technologies can redefine software engineering education by bridging the gap between theoretical knowledge and practical OSS participation,offering implications for curriculum design,competency assessment,and sustainable OSS ecosystem cultivation.A demonstration video of the system is available at https://figshare.com/articles/media/OSSerCopilot_Introduction_mp4/29510276.展开更多
The accuracy of photovoltaic(PV)power prediction is significantly influenced by meteorological and environmental factors.To enhance ultra-short-term forecasting precision,this paper proposes an interpretable feedback ...The accuracy of photovoltaic(PV)power prediction is significantly influenced by meteorological and environmental factors.To enhance ultra-short-term forecasting precision,this paper proposes an interpretable feedback prediction method based on a parallel dual-stream Temporal Convolutional Network-Bidirectional Long Short-Term Memory(TCN-BiLSTM)architecture incorporating a spatiotemporal attention mechanism.Firstly,during data preprocessing,the optimal historical time window is determined through autocorrelation analysis while highly correlated features are selected as model inputs using Pearson correlation coefficients.Subsequently,a parallel dual-stream TCN-BiLSTM model is constructed where the TCN branch extracts localized transient features and the BiLSTM branch captures long-term periodic patterns,with spatiotemporal attention dynamically weighting spatiotemporal dependencies.Finally,Shapley Additive explanations(SHAP)additive analysis quantifies feature contribution rates and provides optimization feedback to the model.Validation using operational data from a PV power station in Northeast China demonstrates that compared to conventional deep learning models,the proposed method achieves a 17.6%reduction in root mean square error(RMSE),a 5.4%decrease in training time consumption,and a 4.78%improvement in continuous ranked probability score(CRPS),exhibiting significant advantages in both prediction accuracy and generalization capability.This approach enhances the application effectiveness of ultra-short-term PV power forecasting while simultaneously improving prediction accuracy and computational efficiency.展开更多
Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of mineral...Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of minerals,with reserves of at least 38 of over 80 widely used minerals worldwide accounting for more than30%of the global total reserves.Asia continent experienced three main tectonic evolution and mineralization stages:The Precambrian,the Paleozoic,and the Mesozoic to Cenozoic.The abundant mineral resources in this continent can be divided into seven first-order metallogenic belts(metallogenic domains),18 second-order metallogenic belts(metallogenic provinces),61 third-order metallogenic belts(metallogenic zones),and nine main minerogenetic series.Asia continent exhibits the most significant metallogenic specialization among all continents.Specifically,granite belts of Asia continent manifest pronounced metallogenic specialization of tin,rare metals,and porphyry Cu-Au-Mo deposits.Its maficultramafic rock belts and ophiolite belts display notable metallogenic specialization of lateritic nickel deposits and magmatic type chromite deposits,while its Mesozoic to Cenozoic basalt belts show remarkable metallogenic specialization of lateritic bauxite deposits.Consequently,many giant metallogenic belts were formed,including the Southeast Asian tin belt,the Qinghai-Xizang Plateau rare metal metallogenic belt,the Tethyan porphyry Cu-Au-Mo metallogenic belt,the circum-Pacific porphyry Cu-Au-Mo metallogenic belt,the Southeast Asian lateritic bauxite metallogenic belt,the Deccan Plateau lateritic bauxite metallogenic belt in India,the Southeast Asian lateritic nickel metallogenic belt,and the Tethyan magmatic type chromite metallogenic belt—all of which are significant metallogenic belts in Asia continent.Future mineral exploration in Asia should focus primarily on the Precambrian mineralization of ancient cratons,the Paleozoic mineralization of the Central Asian-Mongolian orogenic belt,and the Mesozoic to Cenozoic mineralization of the Tethyan and circum-Pacific mobile belts.Asia's mining industry not only underpins its own economic growth but also propels global economic development and industrialization,contributing significantly to the world economy.Asia boasts the highest production value of minerals,the largest annual production of minerals,and the greatest trade value of mineral products among all the continents,having emerged as the trade center of global mineral products and the center of the mining industry economy.China is identified as one of the few countries that possess the most comprehensive kinds of minerals,and its mining industry has supported and driven the economic development and industrialization of Asia and even the world.Standing as the largest mineral producer worldwide,China ranked first in the production of 28 mineral commodities in the world in 2022.Besides,China exhibits the highest annual production value of minerals and the largest trade value of mineral products among all countries.Therefore,China's demand for global mineral products influences the global supply and demand patterns of minerals and the world economic situation.展开更多
基金supported by a grant from the ITI International Team for Implantology Foundation 1235_2017 to M.B.A
文摘Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (P <0.001) release of transforming growth factor-β1 (TGF-β1) from autologous bone within 10 min versus a delayed bone morphogenetic protein-2 (BMP-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMP-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMP-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMP-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMP-2-induced osteoblast differentiation due to prolonged BMP signaling and reduced expression of the BMP-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.
基金supported by the National Natural Science Foundation of China(31501244)Chinese Academy of Agricultural Sciences Elite Youth Program Grant to Yubin Lithe Fundamental Research Funds for Central Non-profit Scientific Institution(1610392019001)。
文摘In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance.
文摘SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Cooperati on Commissi on in the UK from June 10 to 17.
文摘MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proliferation, apoptosis,heart disease and human cancers.We investigated miR-133 expression and its potential role in a high glucose-induced myocardium in Streptozotocin(STZ)-induced C57bl6 mouse model of diabetes.miR-133 expression was significantly increased in myocardium in a time-dependent manner after STZ treatment.IGF1 receptor(IGF1R) protein was dramatically decreased without obvious up-regulation of its mRNA level post hyperglycemia.IGF1R protein level was decreaed with increase of its transcript level in neonatal mouse ventricular cardiomyocytes induced by high D-glucose concentration. Dual luciferase assay revealed that miR133 could interact with specific sites in the 3’UTR of IGF1R gene.p-ERK and p-Akt levels were reduced in neonatal mouse cardiomyocytes over-expressed with miR133 after IGF treatment.Introduction of functional miR-133,IGF1R siRNA into neonatal mouse cardiomyocytes could enhance cardiomyocyte apoptosis.These results implicate that miR-133 is involved in contributing to high glucose-induced cardiomyocyte apoptosis via regulating IGF1R expression post-transcriptionally.
文摘Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"respect for human rights".In 2004,the idea that"the State respects and protects human rights"was written into
文摘The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside class reading plays a positive role in English learning. Furthermore, some suggestions are made in the end.
文摘Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributions the contact term must be carefully included in any assessment of DCX reaction and can not be discarded a priori.
文摘Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following DNA damage, ataxia telangiectasia mutated （ATM）, a protein kinase, was acti- vated and a cytosolic complex containing ATM, NEMO, RIP1 were formed （Biton and Ashkenazi, 2011）.
基金supported by the National Natural Science Foundation of China (31500129, 31430087)
文摘Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully understood. Previous studies have shown that genome segment A, especically VP2 protein, plays the most important role in the tropism and pathogenicity of serotype 1 IBDV （Brandt et al., 2001）. VP2 is,however, unlikely to be the only factor for the virulence of vvIBDV （Boot et al., 2000）.
文摘Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,
基金supported by the National Natural Science Foundation of China(No.31600316)the Sichuan Science and Technology Program(2023NSFSC0198)。
文摘Understory bryophytes play unique and disproportionately important roles in water retention,biogeochemical cycling,and biodiversity conservation,and serve as bioindicators of environmental health in forest ecosystems.However,biogeographical research on the biomass of forest bryophytes is inadequately studied and has been limited to elevational gradients.We conducted a systematic cross-regional survey of bryophyte biomass across 413 forest sites in Sichuan Province,China.We analyzed how each environmental variable,including climatic and atmospheric factors,overstory covers,and soil nutrients,relates to bryophyte biomass and quantified their relative contributions.The results indicate that,largely similar to previous local investigations and experiments,at a large scale,bryophytes are abundant in forests with lower temperature,nitrogen deposition,vapor pressure deficit,and tree and herb covers,as well as higher light availability.Moreover,bryophyte biomass is positively associated with soil carbon and nitrogen content.These environmental variables are closely related and jointly influence bryophyte biomass,with mean annual temperature being the most significant factor(accounting for 83%of the relative contribution).The biogeographical patterns of bryophyte biomass contribute to deepening our understanding of their adaptations to multiple environmental variables and enable us to predict their responses to global climate change.These patterns also provide essential evidence for establishing more accurate terrestrial vegetation ecosystem models.
基金funded by the Department of Education of Liaoning Province and was supported by the Basic Scientific Research Project of the Department of Education of Liaoning Province(Grant No.LJ222411632051)and(Grant No.LJKQZ2021085)Natural Science Foundation Project of Liaoning Province(Grant No.2022-BS-222).
文摘Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic efficiency.In this paper,aiming at the uncertainty of distributed wind power and photovoltaic output,considering the coupling relationship between power,carbon trading,and green cardmarket,the optimal operationmodel and bidding scheme of VPP in spot market,carbon trading market,and green card market are established.On this basis,through the Shapley value and independent risk contribution theory in cooperative game theory,the quantitative analysis of the total income and risk contribution of various distributed resources in the virtual power plant is realized.Moreover,the scheduling strategies of virtual power plants under different risk preferences are systematically compared,and the feasibility and accuracy of the combination of Shapley value and independent risk contribution theory in ensuring fair income distribution and reasonable risk assessment are emphasized.A comprehensive solution for virtual power plants in the multi-market environment is constructed,which integrates operation strategy,income distribution mechanism,and risk control system into a unified analysis framework.Through the simulation of multi-scenario examples,the CPLEXsolver inMATLAB software is used to optimize themodel.The proposed joint optimization scheme can increase the profit of VPP participating in carbon trading and green certificate market by 29%.The total revenue of distributed resources managed by VPP is 9%higher than that of individual participation.
基金funded by the National Natural Science Foundation of China(42377326 and 42201267)National Research-Development Support Plan Projects of China(Grant No.2017YFC05054)the Fujian Provincial Water Resources Department Science and Technology Project(MSK202308)。
文摘The Guangdong,Jiangxi and Fujian(GJF)provinces,located in the subtropical region of southeastern China,is one of the national key regions for soil erosion control and ecological restoration.This region is characterized by extensive red soil development and high rainfall erosivity,making it a representative landscape for exploring the interactions between land use change(LUC)and ecosystem services(ES).Despite the recognized importance of ES in hilly regions,comprehensive assessing the impacts of LUC on ES remain limited.This study investigates five key ES:water yield,soil conservation,carbon conservation,food supply,and habitat quality in GJF region from 2000 to 2020.By applying the InVEST model and the Geodetector method,we assessed the trade-offs,synergies,and transitions among ES,identified the natural and social drivers of ES dynamics,and quantified the contribution of LUC to ES changes using the ecosystem service contribution index.The results showed that cropland and woodland were the dominant land use types.Ecological restoration efforts positively influenced ES,with synergies intensifying and trade-offs diminishing over time.Land use conversions,particularly among woodland,grassland,and cropland,exerted significant impacts on ES.In particular,the conversion of woodland to other land uses had markedly negative effects on soil conservation,carbon conservation,and habitat quality.Forest cover was identified as a major driver of ES dynamics.These findings highlight the importance of maintaining and expanding forest and grassland cover,strengthening red soil conservation,and optimizing land use structure to achieve coordinated ecological protection and socioeconomic development in the subtropical hilly regions of southern China.
基金supported by the Beijing Nova Program (20230484277)the National Natural Science Foundation of China (82303955)。
文摘Dear Editor,On July 25,2024,an Oncologic Drugs Advisory Committee meeting was held to discuss the design of the AEGEAN trial,which evaluated the perioperative use of durvalumab for resectable non-small cell lung cancer(NSCLC)[1].The Food and Drug Administration(FDA)stated that the two-arm trial was not designed to isolate contributions of neoadjuvant and adjuvant phases.Since the clinical benefit of adjuvant durvalumab remains uncertain,this limitation raises concerns about potential over-treatment.
基金supported by the National Natural Science Foundation of China (Grant No.12374109)the National Key Research and Development Program of China (Grant No.2023YFA1406600)。
文摘In physics,our expectations for system behavior are often guided by intuitive arithmetic.For systems composed of identical units,we anticipate synergy of the contributions from these units,where 1+1=2.Conversely,for systems built from opposing units,we expect cancellation of their contributions,where 1-1=0.This intuitive arithmetic has long underpinned our understanding of physical properties of materials,from electronic transport to optical responses.However,scientific breakthroughs often occur when nature reveals ways to circumvent these seemingly fundamental rules,opening new possibilities that challenge our deepest assumptions about material behavior.
基金supported by the National Natural Science Foundation of China (62202022, 92582204, and 62572030)the Fundamental Research Funds for the Central Universitiesthe exploratory elective projects of the State Key Laboratory of Complex and Critical Software Environments
文摘In the context of large language model(LLM)reshaping software engineering education,this paper presents OSSerCopilot,a LLM-based tutoring system designed to address the critical challenge faced by newcomers(especially student contributors)in open source software(OSS)communities.Leveraging natural language processing,code semantic understanding,and learner profiling,the system functions as an intelligent tutor to scaffold three core competency domains:contribution guideline interpretation,project architecture comprehension,and personalized task matching.By transforming traditional onboarding barriers-such as complex contribution documentation and opaque project structures-into interactive learning journeys,OSSerCopilot enables newcomers to complete their first OSS contribution more easily and confidently.This paper highlights how LLM technologies can redefine software engineering education by bridging the gap between theoretical knowledge and practical OSS participation,offering implications for curriculum design,competency assessment,and sustainable OSS ecosystem cultivation.A demonstration video of the system is available at https://figshare.com/articles/media/OSSerCopilot_Introduction_mp4/29510276.
基金funded by the National Natural Science Foundation of China(NSFC)(No.62066024)funded by Basic Scientific Research Projects of Higher Education Institutions in Liaoning Province(LJ212411632063)the National Undergraduate Training Program for Innovation and Entrepreneurship(S202511632045).
文摘The accuracy of photovoltaic(PV)power prediction is significantly influenced by meteorological and environmental factors.To enhance ultra-short-term forecasting precision,this paper proposes an interpretable feedback prediction method based on a parallel dual-stream Temporal Convolutional Network-Bidirectional Long Short-Term Memory(TCN-BiLSTM)architecture incorporating a spatiotemporal attention mechanism.Firstly,during data preprocessing,the optimal historical time window is determined through autocorrelation analysis while highly correlated features are selected as model inputs using Pearson correlation coefficients.Subsequently,a parallel dual-stream TCN-BiLSTM model is constructed where the TCN branch extracts localized transient features and the BiLSTM branch captures long-term periodic patterns,with spatiotemporal attention dynamically weighting spatiotemporal dependencies.Finally,Shapley Additive explanations(SHAP)additive analysis quantifies feature contribution rates and provides optimization feedback to the model.Validation using operational data from a PV power station in Northeast China demonstrates that compared to conventional deep learning models,the proposed method achieves a 17.6%reduction in root mean square error(RMSE),a 5.4%decrease in training time consumption,and a 4.78%improvement in continuous ranked probability score(CRPS),exhibiting significant advantages in both prediction accuracy and generalization capability.This approach enhances the application effectiveness of ultra-short-term PV power forecasting while simultaneously improving prediction accuracy and computational efficiency.
基金funded by geological survey project of China Geological Survey(DD20211404)。
文摘Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of minerals,with reserves of at least 38 of over 80 widely used minerals worldwide accounting for more than30%of the global total reserves.Asia continent experienced three main tectonic evolution and mineralization stages:The Precambrian,the Paleozoic,and the Mesozoic to Cenozoic.The abundant mineral resources in this continent can be divided into seven first-order metallogenic belts(metallogenic domains),18 second-order metallogenic belts(metallogenic provinces),61 third-order metallogenic belts(metallogenic zones),and nine main minerogenetic series.Asia continent exhibits the most significant metallogenic specialization among all continents.Specifically,granite belts of Asia continent manifest pronounced metallogenic specialization of tin,rare metals,and porphyry Cu-Au-Mo deposits.Its maficultramafic rock belts and ophiolite belts display notable metallogenic specialization of lateritic nickel deposits and magmatic type chromite deposits,while its Mesozoic to Cenozoic basalt belts show remarkable metallogenic specialization of lateritic bauxite deposits.Consequently,many giant metallogenic belts were formed,including the Southeast Asian tin belt,the Qinghai-Xizang Plateau rare metal metallogenic belt,the Tethyan porphyry Cu-Au-Mo metallogenic belt,the circum-Pacific porphyry Cu-Au-Mo metallogenic belt,the Southeast Asian lateritic bauxite metallogenic belt,the Deccan Plateau lateritic bauxite metallogenic belt in India,the Southeast Asian lateritic nickel metallogenic belt,and the Tethyan magmatic type chromite metallogenic belt—all of which are significant metallogenic belts in Asia continent.Future mineral exploration in Asia should focus primarily on the Precambrian mineralization of ancient cratons,the Paleozoic mineralization of the Central Asian-Mongolian orogenic belt,and the Mesozoic to Cenozoic mineralization of the Tethyan and circum-Pacific mobile belts.Asia's mining industry not only underpins its own economic growth but also propels global economic development and industrialization,contributing significantly to the world economy.Asia boasts the highest production value of minerals,the largest annual production of minerals,and the greatest trade value of mineral products among all the continents,having emerged as the trade center of global mineral products and the center of the mining industry economy.China is identified as one of the few countries that possess the most comprehensive kinds of minerals,and its mining industry has supported and driven the economic development and industrialization of Asia and even the world.Standing as the largest mineral producer worldwide,China ranked first in the production of 28 mineral commodities in the world in 2022.Besides,China exhibits the highest annual production value of minerals and the largest trade value of mineral products among all countries.Therefore,China's demand for global mineral products influences the global supply and demand patterns of minerals and the world economic situation.
