Objective: to analyze and study the influence of continuous midwifery service nursing on the rate of non drug analgesia delivery and natural delivery of primipara. Methods: 90 primiparas were randomly selected as the ...Objective: to analyze and study the influence of continuous midwifery service nursing on the rate of non drug analgesia delivery and natural delivery of primipara. Methods: 90 primiparas were randomly selected as the research object, and randomly divided into control group and observation group, with 45 cases in each group. The control group was given routine nursing, and the observation group was given continuous midwifery nursing. The effects of the two nursing methods on the choice of delivery mode, delivery process, postpartum bleeding and satisfaction of primiparas were compared. Results: the natural delivery rate in the observation group was significantly higher than that in the control group (P < 0.05). The delivery time and bleeding volume in the observation group were significantly lower than those in the control group (P < 0.05). The maternal satisfaction in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: after the intervention of continuous midwifery nursing, more primiparas choose natural delivery and complete it smoothly, which is conducive to improve the nursing satisfaction of primiparas.展开更多
Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations...Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations,while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced PD.All three strategies are considered examples of continuous dopaminergic stimulation achieved through CDD.A central premise of the CDD is to achieve stable control of the parkinsonian motor and non-motor states and avoid emergence of‘OFF’periods.However,data suggest that despite their efficacy in reducing the number and duration of‘OFF’periods,these strategies still do not prevent‘OFF’periods in the middle to late stages of PD,thus contradicting the widely held concepts of continuous drug delivery and continuous dopaminergic stimulation.Why these emergent‘OFF’periods still occur is unknown.In this review,we analyse the potential reasons for their persistence.The contribution of drug-and device-related involvement,and the problems related to site-specific drug delivery are analysed.We propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent‘OFF’periods unresponsive to dopaminergic therapy delivered via CDD.展开更多
文摘Objective: to analyze and study the influence of continuous midwifery service nursing on the rate of non drug analgesia delivery and natural delivery of primipara. Methods: 90 primiparas were randomly selected as the research object, and randomly divided into control group and observation group, with 45 cases in each group. The control group was given routine nursing, and the observation group was given continuous midwifery nursing. The effects of the two nursing methods on the choice of delivery mode, delivery process, postpartum bleeding and satisfaction of primiparas were compared. Results: the natural delivery rate in the observation group was significantly higher than that in the control group (P < 0.05). The delivery time and bleeding volume in the observation group were significantly lower than those in the control group (P < 0.05). The maternal satisfaction in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: after the intervention of continuous midwifery nursing, more primiparas choose natural delivery and complete it smoothly, which is conducive to improve the nursing satisfaction of primiparas.
文摘Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations,while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced PD.All three strategies are considered examples of continuous dopaminergic stimulation achieved through CDD.A central premise of the CDD is to achieve stable control of the parkinsonian motor and non-motor states and avoid emergence of‘OFF’periods.However,data suggest that despite their efficacy in reducing the number and duration of‘OFF’periods,these strategies still do not prevent‘OFF’periods in the middle to late stages of PD,thus contradicting the widely held concepts of continuous drug delivery and continuous dopaminergic stimulation.Why these emergent‘OFF’periods still occur is unknown.In this review,we analyse the potential reasons for their persistence.The contribution of drug-and device-related involvement,and the problems related to site-specific drug delivery are analysed.We propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent‘OFF’periods unresponsive to dopaminergic therapy delivered via CDD.
