Ecological footprint theory and its application achievements in global and regional sustainable development systems are studied by consulting the published literature, which finds that the application of ecological fo...Ecological footprint theory and its application achievements in global and regional sustainable development systems are studied by consulting the published literature, which finds that the application of ecological footprint theory to regional sustainability evaluation has leaded to a perplexity that the indicated result was inconsistent with the philosophy of sustainable development theory. Illuminated by the mechanical system of the movement of matters, it comes up that ecological footprint based on consumption of biologic production could not tell whether the ecological pressure acts on the specified region, and the original ecological footprint theory also undervalued the development impartiality of a region. A modification on this theory is made by introducing consumptive ecological footprint and productive ecological footprint, in which the latter is taken as the indicator of regional sustainability. The development impartiality can be demonstrated by comparison between the global ecological deficit per capita and regional consumptive ecological deficit per capita.展开更多
Digital services interfaced with mobile phone lines are gradually being regarded as a core product in this modern age due to the high transmission speed of mobile technology.The research in this paper is based on the ...Digital services interfaced with mobile phone lines are gradually being regarded as a core product in this modern age due to the high transmission speed of mobile technology.The research in this paper is based on the concept of product inter-dependence and actively explores the different consumptive motivations between the consumers' behavior of phone-call users and those who use digital services.This study also attempts to use a modifi ed diffusion model to estimate the consumers' collective behavior with a longitudinal approach.In this study,it can be inferred that psychological consumer motivations should dominate marketing policies.Thus,it was found that digital service users have more self-motivation and autonomy when adopting a new product because they have significantly higher innovative at-tributes than the segment of phone-call users.With these findings,we claim that we have discovered an unprec-edented concept for marketing managers who welcome the challenges of mobile digital services in the future.展开更多
The sensor system is one of the modern and important methods of irrigation management in arid and semi-arid areas, which is water as the limiting factor for crop production. The study was applied for 2016 and 2017 sea...The sensor system is one of the modern and important methods of irrigation management in arid and semi-arid areas, which is water as the limiting factor for crop production. The study was applied for 2016 and 2017 seasons out in Al-Yousifya, 15 km Southwest of Baghdad. A study was conducted to evaluate coefficient uniformity, uniformity distribution and application efficiency for furrow, surface drip and subsurface drip irrigation methods and it was (98, 97 and 89)% and (97, 96 and 88)% for 2016 and 2017 seasons;respectively. And control the volumetric moisture content according to the rhizosphere depth for depths of 10, 20 and 30 cm by means of the sensor system. The results indicated that the height consumptive water use of furrow 707.91 and 689.69 mm<span style="white-space:nowrap;">·</span>season<sup>-1</sup> and the lowest for subsurface drip with emitter deep at 20 cm 313.93 and 293.50 mm<span style="white-space:nowrap;">·</span>season<sup>-1</sup> for 2016 and 2017 seasons;respectively. As well, the highest value of water use efficiency for subsurface in drip irrigation at a depth of 20 cm, was 2.71 and 2.99 kg<span style="white-space:nowrap;">·</span>m<sup>-3</sup> and the lowest value for furrow irrigation was 1.12 and 1.20 kg<span style="white-space:nowrap;">·</span>m<sup>-3</sup> for the 2016 and 2017 seasons;respectively.展开更多
The current study was carried out at Agricultural College, University of Baghdad in the vegetable farm, Department of Horticulture during 2013 spring growing season. Yield response to irrigation of different crops is ...The current study was carried out at Agricultural College, University of Baghdad in the vegetable farm, Department of Horticulture during 2013 spring growing season. Yield response to irrigation of different crops is of major importance in production planning where water resources are limited. This study aims to determine the effect of different irrigation treatment （deficit irrigation） and potassium humate fertilizer on yield, content of nitrogen, potassium, and phosphor in tuber of potato and water use efficiency in the Abu-Graib Region, Iraq. Potato was grown under drip irrigation with three treatments： irrigation applied when evaporation 75%, 100% and 125% from pan A, and three potassium humate fertilizers： 0, 1.2 and 2.4 kg/ha with three times additions. The seasonal potato evapotranspiration ranged from 267 mm to 372 mm. The drip irrigation treatment had significant effecting tuber yield of potato recorder 29,530, 27,630 and 24,880 kg/ha for 125%, 100% and 75% from pan A evapotranspiration, respectively. Humus fertilizers addition has the lowest value of ETa 309 mm and maximum value of yield 2,930 kg/ha. Water use efficiency （WUE） and irrigation water use efficiency （IWUE） values increased with increasing humus fertilizers, recording 9.92, 14.52, 8.59, 12.42 and 7.51, 10.70 kg/m3 for potassium humate K3 （2.4 kg/ha）, K2 （1.2 kg/ha） and KI （0.0 kg/ha）, respectively. Plants irrigated with 125% from class pans A evaporation, produced a significant increase in N, P and K content in tubers recorder 0.96%, 0.58% and 1.52%, respectively. Potassium humus-fertilizer significant differences among K1, K2 and K3 on high of plants reached 41.52, 50.08 and 56.39 cm, respectively, number of stems/plant 2.69, 3.22 and 3.78, respectively, leaves area index recorder 2.80, 3.35 and 3.73.展开更多
Consumptive hypothyroidism is often the clinical condition that results from neoplasms producing their own selenodionases that convert T4 needed to be converted to active T3 into an active form of thyroid hormone, rT3...Consumptive hypothyroidism is often the clinical condition that results from neoplasms producing their own selenodionases that convert T4 needed to be converted to active T3 into an active form of thyroid hormone, rT3. This often requires treatment with high doses of IV T4, with or without doses of T3 as well, until the neoplasm is treated. This principle is demonstrated in the below case of a 65 y/o female with medical history significant for Ia Kappa multiple myeloma, complete heart block s/p AICD placement, and papillary thyroid cancer status post thyroidectomy in 2020, who had initially presented <span>with persistent bone pain, progressive encephalopathy and failure to thrive</span> with more than a 50 lb weight loss over a few months. Labs on presentation <span>were not remarkable for progression of her underlying multiple myeloma</span>, however<span style="font-family:;" "="">,</span><span style="font-family:;" "=""> she was found to have a new significantly elevated TSH. She underwent imaging with a CT chest, abdomen, and pelvis, which showed new hepatic lesions, subcutaneous nodules, and new pulmonary nodules with associated lymphadenopathy and a left-sided pleural effusion. CT-guided liver biopsy evinced a metastatic neuroendocrine carcinoma, further supported by an elevated calcitonin and chromogranin. She was treated with high dose IV T4 at 1.38 mcg/kg however continued to worsening thyroid function labs. She was then started on Liothyronine at 20 mcg and subsequently improved. This <span>patient’s case illustrates the importance of considering consumptive hypo</span>thy<span>roidism when thyroid profile abnormalities and symptoms of severe hypo</span>thyroidism are seen in the context of malignant neoplasms, and further illu<span>strates the important of considering T3 as part of the treatment regimen</span> when IV T4 is not resulting in improvement.</span>展开更多
Given the considerable global interest in the preparation of Ti and TiC,a novel reduction method for TiO_(2) in a CH_(4)-H_(2) atmosphere was proposed,and the reduction thermodynamic behavior,phase equilibrium,and ene...Given the considerable global interest in the preparation of Ti and TiC,a novel reduction method for TiO_(2) in a CH_(4)-H_(2) atmosphere was proposed,and the reduction thermodynamic behavior,phase equilibrium,and energy consumption of TiO_(2) during its reaction with a CH_(4)-H_(2) gas mixture were investigated.The results indicate that the reaction proceeds via a stepwise reduction pathway from TiO_(2) to Ti(C,O),with the Magnéli phase(TinO_(2n-1))and Ti_(3)O_(5) serving as intermediate phases.Notably,the reduction of TiO_(2) by H_(2) is more challenging than that by CH_(4),which may be attributed to the inhibitory effect of H_(2) on the surface carbon precipitation.For the complete carbonization of 1 mol TiO_(2),the total energy required at 1000,1100,and 1200℃is 1159,925,and 977 kJ/mol,respectively,which may be related to the shift of gas-phase equilibrium and the increase in side reactions at high temperatures.展开更多
China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing ...China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.展开更多
Mesenchymal stem cell-derived extracellular vesicles have emerged as a promising form of regenerative and immunomodulatory therapy;indeed,micro(mi)RNAs contained within mesenchymal stem cell-derived extracellular vesi...Mesenchymal stem cell-derived extracellular vesicles have emerged as a promising form of regenerative and immunomodulatory therapy;indeed,micro(mi)RNAs contained within mesenchymal stem cell-derived extracellular vesicles modulate target gene expression and impact disease-associated pathways.Chronic alcohol consumption leads to neuroinflammation,brain damage,and impaired cognition.Evidence indicates that females are more vulnerable to alcohol-induced damage than males.While mesenchymal stem cell-derived extracellular vesicles have been studied in various neuroinflammatory conditions,their potential to counteract alcohol-induced brain damage remains unclear.In this study,we investigated whether repeated intravenous administration of mesenchymal stem cell-derived extracellular vesicles could ameliorate neuroinflammation and behavioral impairment induced by chronic alcohol consumption in female mice.Mesenchymal stem cell-derived extracellular vesicles diminished the increased binding of a micro-positron emission tomography tracer(^(18)F-FDG)when analyzing whole-brain 3D images and brain coronal sections of ethanol-treated mice.Mesenchymal stem cell-derived extracellular vesicle administration protected against ethanol-induced proinflammatory gene upregulation,cognitive dysfunction,and the conditioned rewarding effects of cocaine.MiRNA sequencing data from mesenchymal stem cell-derived extracellular vesicles revealed the elevated expression of extracellular vesicle-derived miR-483-5p and miR-140-3p in the brains of ethanol-treated female mice following mesenchymal stem cell-derived extracellular vesicle administration.In addition,mesenchymal stem cell-derived extracellular vesicles modulated the expression of pro-inflammatory-related miRNA target genes(e.g.,Socs3,Tnf,Mtor,and Atf6)in the brains of ethanol-treated female mice.These results suggest that mesenchymal stem cell-derived extracellular vesicles could function as a neuroprotective therapy to ameliorate the neuroinflammation,cognitive dysfunction,and conditioned rewarding effects of cocaine associated with chronic alcohol consumption.展开更多
The Double Take column looks at a single topic from an African and Chinese perspective.This month,we discuss how to understand the growing emphasis on emotional returns among young people.Emotional value has emerged a...The Double Take column looks at a single topic from an African and Chinese perspective.This month,we discuss how to understand the growing emphasis on emotional returns among young people.Emotional value has emerged as a central force shaping youth decision-making across work,consumption,relationships and lifestyle choices.Unlike traditional economic rationality that prioritises income and material security,emotional value focuses on how choices make individuals feel and how they align with personal meaning.This shift is particularly evident in rapidly transforming societies such as China and Ghana,where economic restructuring,globalisation and social change have reshaped pathways to adulthood.展开更多
Objective To examine national trends in antibiotic consumption and antimicrobial resistance(AMR)among six WHO-priority bacterial pathogens in China from 2016 to 2022.Methods This ecological study analyzed national and...Objective To examine national trends in antibiotic consumption and antimicrobial resistance(AMR)among six WHO-priority bacterial pathogens in China from 2016 to 2022.Methods This ecological study analyzed national and provincial data from the China Antibacterial Resistance Surveillance System(CARSS)and the National Hospital Information Network.Beta regression models assessed temporal trends,and hierarchical models evaluated associations between antibiotic use and resistance.Results From 2016 to 2022,carbapenem resistance in Acinetobacter baumannii and Pseudomonas aeruginosa,and vancomycin resistance in Enterococcus faecium and E.faecalis significantly declined(β<0,P<0.010),while carbapenem-resistant Klebsiella pneumoniae increased(β=0.081,P<0.001).Nationwide antibiotic consumption rose across 10 major classes.Positive associations were found between carbapenem use and resistance in A.baumannii(z=2.719,P=0.007)and P.aeruginosa(z=3.241,P=0.001),and between vancomycin use and resistance in E.faecium(z=4.510,P=0.001)and E.faecalis(z=3.210,P=0.001).Conclusion Carbapenem-resistant K.pneumoniae increased significantly in China,while other resistant pathogens declined.Resistance patterns were linked to the use of multiple antibiotic classes,underscoring the need for strengthened antibiotic stewardship and surveillance.展开更多
“A sound consumer finance environment is vital in helping to prosper the holiday market and stimulating consumption vitality.”——Guo Wuping,Spokesperson of the National Financial Regulatory Administration and direc...“A sound consumer finance environment is vital in helping to prosper the holiday market and stimulating consumption vitality.”——Guo Wuping,Spokesperson of the National Financial Regulatory Administration and directorgeneral of the Policy Research Department of the NFRA.展开更多
AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This o...AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This observational clinical study utilized a cross-sectional and prospective design,focusing on chronic alcohol consumers alongside a non-consuming control group.OCT/OCTA imaging parameters including central retinal subfield thickness(CST),subfoveal choroidal thickness(SCT),foveal avascular zone(FAZ)and vessel density(VD)in the superficial and deep capillary plexuses in both the macular and optic disc(OD)regions were recorded.Data were analyzed using SPSS 15.0;descriptive statistics were reported,group comparisons were performed with Chisquare,Kruskal–Wallis,and Bonferroni-corrected Mann–Whitney U tests,and relationships were assessed using Spearman correlation,with statistical significance set at P<0.05.RESULTS:A total of 160 eyes of 160 participants(110 females and 50 males with mean age 38.7±9.9y)who don’t smoke were divided into five groups:never,occasional,monthly,weekly and daily drinkers.The mean CST was 216.6±14.2μm and the mean SCT was 358.9±84.5μm.There was no statistically significantly difference in CST and SCT among the groups(P=0.890,0.799).Foveal superficial capillary plexuses(SCPs)VD was higher in monthly drinkers compared to occasional drinkers(P=0.015).Foveal VD in deep capillary plexus was also higher in monthly drinkers than in never and occasional drinkers(P=0.004,0.006).Nasal SCPs VD at the OD was higher in monthly drinkers compared to never drinkers(P=0.005).There was no significant difference FAZ area among the groups(P=0.071).CONCLUSION:Both superficial and deep microvascular structures in the inferior quadrants of macula are positively correlated with frequency of alcohol use.Also in our study results is that the monthly drinker group has uniquely higher VDs in both macula and OD.This leads us to consider moderate alcohol consumption may also have protective effects on retinal microcirculation.展开更多
Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forc...Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.展开更多
The concept of hybrid ships has gained significant attention in recent years,as they offer an effective means of enhancing energy utilization and reducing environmental pollution.However,the navigational environments ...The concept of hybrid ships has gained significant attention in recent years,as they offer an effective means of enhancing energy utilization and reducing environmental pollution.However,the navigational environments of ships are often subject to changes,which in turn affect their energy efficiency in a complex manner.It is therefore evident that enhancing the energy efficiency of hybrid ships is a worthwhile goal.In this study,we take a diesel-electric hybrid ship navigating in inland waterways as the research object,and propose a hierarchical optimization method for ship energy efficiency.The upper-layer control establishes a predictive model for propulsion motor speed and fuel consumption through multivariate time series predictions,and employs the model predictive control(MPC)method to optimize the propulsion motor speed.The lower-layer control utilizes an equivalent fuel consumption minimization method,which is based on improving the equivalence factor.This involves combining the variation of the supercapacitor’s state of charge(SOC)with the propulsion motor speed obtained from the MPC optimization in the upper-layer control.Furthermore,a proportional integral(PI)controller is used to adjust the equivalence factor,in order to adapt the equivalent fuel consumption minimization method to the working conditions.Our results demonstrate that the proposed hierarchical optimization method can reduce the energy efficiency operating indicator(EEOI)by approximately 11.54%and the fuel consumption by approximately 9.47%in comparison to the pre-optimization scenario.展开更多
Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptio...Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptions due to its subtropical monsoon climate,including typhoons and gusty winds,present ongoing challenges.Despite the growing focus on operational costs and third-party risks,research on low-altitude urban wind fields remains scarce.This study addresses this gap by integrating wind field analysis into UAV path planning,introducing key innovations to the classical model.First,UAV wind resistance and turbulence constraints are analyzed,mapping high-wind-speed and turbulence-prone zones in the airspace.Second,wind dynamics are incorporated into path planning by considering airspeed and groundspeed variation,optimizing waypoint selection and flight speed adjustments to improve overall energy efficiency.Additionally,a wind-aware Theta*algorithm is proposed,leveraging wind vectors to expedite search process,while Computational Fluid Dynamics(CFD)techniques are employed to calculate wind fields.A case study of Shenzhen,examining wind patterns over the past decade,demonstrates a 6.23%improvement in groundspeed and a 7.69%reduction in energy consumption compared to wind-agnostic models.This framework advances UAV logistics by enhancing route safety and energy efficiency,contributing to more cost-effective operations.展开更多
Coke oven gas(COG)and natural gas(NG),both high-calorific by-products derived from the steel industry,have gained prominence as alternative fuels in the sintering process,thereby supporting dual objectives of emission...Coke oven gas(COG)and natural gas(NG),both high-calorific by-products derived from the steel industry,have gained prominence as alternative fuels in the sintering process,thereby supporting dual objectives of emission reduction and carbon neutrality.While existing research on hydrogen-rich gas injection has predominantly concentrated on conventional thin-bed sintering,investigations into its application within thick-bed sintering remain comparatively scarce.Thick-bed sintering,recognized for enhancing energy efficiency and increasing sinter output,encounters challenges such as uneven heat distribution and diminished permeability,which can negatively impact process efficiency and product quality.To address these issues,sinter pot experiments were conducted to assess the effects of NG and COG injection on thick-bed sintering performance.Findings reveal that NG injection in thick beds mirrors the behavior observed in conventional thin-bed sintering,effectively optimizing the process and achieving a carbon reduction potential exceeding 10%.In contrast,COG injection in thick-bed conditions demonstrates notable differences,substantially lowering the solid fuel consumption rate but detrimentally affecting sinter strength and overall production.However,by optimizing the timing of COG injection,it is feasible to improve sinter yield while concurrently reducing solid fuel usage.These outcomes provide valuable insights for the advancement of gas injection technologies in thick-bed sintering,thereby contributing to energy conservation and emission mitigation efforts within the sintering industry.展开更多
The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide ele...The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide electricity users in carbon reduction and promote power industry low-carbon transformation.Fundamentally,calculating indirect carbon emissions involves allocating direct carbon emission data from the power source side,indicating that accurate indirect emission results rely on the precise measurement of power source emissions.However,existing research on indirect carbon emissions in large-scale power systems rarely accounts for variations in carbon emission characteristics under different operating conditions of power sources,such as rated/non-rated operating conditions and ramping up/down conditions,making it difficult to reflect source-side and load-side carbon emission information variation during providing ancillary services.Quadratic and exponential functions are proposed to characterize the energy consumption profiles of coal-fired and gas-fired power generation,respectively,to construct a refined carbon emission model for power sources.By leveraging the theory of power system carbon flow,we analyze how variable operating conditions of power sources impact indirect carbon emissions.Case studies demonstrate that changes in power source emissions under variable conditions have a significant effect on the indirect carbon emissions of power grids.展开更多
This paper conducts an in-depth analysis of the theory and methods for differentiating and treating insomnia in Bu Ju Ji by Wu Cheng,a physician of the Qing Dynasty.By systematically sorting out the origin of Wu Cheng...This paper conducts an in-depth analysis of the theory and methods for differentiating and treating insomnia in Bu Ju Ji by Wu Cheng,a physician of the Qing Dynasty.By systematically sorting out the origin of Wu Cheng’s academic thoughts,this study explores his unique perspective on differentiating and treating insomnia,analyzes the compatibility rules of his core formulas and herbs,and reveals the characteristics of his medication use as well as its guiding value for later clinical practice.Research shows that Wu Cheng integrated the principles of the I Ching(Book of Changes)with medical theories to construct a theoretical system for consumptive diseases.In the differentiation and treatment of insomnia,he emphasized the dynamic balance of zang-fu organs,Qi,blood,Yin and Yang,with special attention to the impact of spleen-Yin deficiency on insomnia.He thus formed distinctive academic features,including treating both deficiency and excess,taking into account both Qi and blood,and regulating the spleen to protect the body’s defense system.In terms of medication,he was skilled in using herbs that are sweet and warm in nature for tonification,harmonizing Qi and blood,and invigorating the spleen to nourish Yin.These insights hold significant reference value for modern TCM(Traditional Chinese Medicine)in the treatment of insomnia.展开更多
The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exace...The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exacerbated this issue by increasing selective pressure within bacterial populations.This study aimed to investigate the association between carbapenem consumption and resistance rates in four priority Gram-negative bacteria:Escherichia coli(EC),Klebsiella pneumoniae(KP),Acinetobacter baumannii(AB),and Pseudomonas aeruginosa(PA).Retrospective data were collected from the First Affiliated Hospital of Zhengzhou University,covering the period from January 2010 to December 2022.Trends in carbapenem consumption and resistance were analyzed using the Mann-Kendall test to assess statistical significance and the Sen’s slope(SS)estimator to determine the magnitude of change.Correlations between carbapenem use and bacterial resistance rates were evaluated via Spearman correlation analysis.Over the study period,the consumption of meropenem,imipenem,biapenem,and total carbapenems exhibited a significant upward trend(|Z|>1.96,SS>0).Correspondingly,the resistance rates of EC and KP to meropenem and imipenem also increased significantly(|Z|>1.96,SS>0).A strong positive correlation was observed between the resistance rate of EC to meropenem and the defined daily doses(DDDs)of meropenem(r=0.732,P<0.05)and between EC resistance to imipenem and its DDDs(r=0.49,P<0.05).Similar significant correlations were identified for KP.However,no significant associations were found between carbapenem resistance in AB or PA and carbapenem consumption.These findings underscored the strong correlation between carbapenem use and the resistance rates of EC and KP,highlighting the urgent need for stringent control and stewardship of carbapenem use in clinical settings to mitigate or delay the development of bacterial drug resistance.展开更多
Phase change absorbents based on amine chemical absorption for CO_(2)capture exhibit energy-saving potential,but generally suffer from difficulties in CO_(2)regeneration.Alcohol,characterized as a protic reagent with ...Phase change absorbents based on amine chemical absorption for CO_(2)capture exhibit energy-saving potential,but generally suffer from difficulties in CO_(2)regeneration.Alcohol,characterized as a protic reagent with a low dielectric constant,can provide free protons to the rich phase of the absorbent,thereby facilitating CO_(2)regeneration.In this investigation,N-aminoethylpiperazine(AEP)/sulfolane/H_(2)O was employed as the liquid-liquid phase change absorbent,with alcohol serving as the regulator.First,appropriate ion pair models were constructed to simulate the solvent effect of the CO_(2)products in different alcohol solutions.The results demonstrated that these ion pair products reached the maximum solvation-free energy(△E_(solvation))in the rich phase containing ethanol(EtOH).Desorption experiment results validated that the inclusion of EtOH led to a maximum regeneration rate of 0.00763 mol/min,thus confirming EtOH’s suitability as the preferred regulator.Quantum chemical calculations and^(13)C NMR characterization were performed,revealing that the addition of EtOH resulted in the partial conversion of AEP-carbamate(AEPCOO−)into a new product known as ethyl carbonate(C_(2)H_(5)OCOO−),which enhanced the regeneration reactivity.In addition,the decomposition paths of different CO_(2)products were simulated visually,and every reaction’s activation energy(△E_(act))was calculated.Remarkably,the△E_(act)for the decomposition of C_(2)H_(5)OCOO−(9.465 kJ/mol)was lower than that of the AEPCOO−(26.163 kJ/mol),implying that CO_(2)was more likely to be released.Finally,the regeneration energy consumption of the alcohol-regulated absorbentwas estimated to be only 1.92 GJ/ton CO_(2),which had excellent energy-saving potential.展开更多
文摘Ecological footprint theory and its application achievements in global and regional sustainable development systems are studied by consulting the published literature, which finds that the application of ecological footprint theory to regional sustainability evaluation has leaded to a perplexity that the indicated result was inconsistent with the philosophy of sustainable development theory. Illuminated by the mechanical system of the movement of matters, it comes up that ecological footprint based on consumption of biologic production could not tell whether the ecological pressure acts on the specified region, and the original ecological footprint theory also undervalued the development impartiality of a region. A modification on this theory is made by introducing consumptive ecological footprint and productive ecological footprint, in which the latter is taken as the indicator of regional sustainability. The development impartiality can be demonstrated by comparison between the global ecological deficit per capita and regional consumptive ecological deficit per capita.
文摘Digital services interfaced with mobile phone lines are gradually being regarded as a core product in this modern age due to the high transmission speed of mobile technology.The research in this paper is based on the concept of product inter-dependence and actively explores the different consumptive motivations between the consumers' behavior of phone-call users and those who use digital services.This study also attempts to use a modifi ed diffusion model to estimate the consumers' collective behavior with a longitudinal approach.In this study,it can be inferred that psychological consumer motivations should dominate marketing policies.Thus,it was found that digital service users have more self-motivation and autonomy when adopting a new product because they have significantly higher innovative at-tributes than the segment of phone-call users.With these findings,we claim that we have discovered an unprec-edented concept for marketing managers who welcome the challenges of mobile digital services in the future.
文摘The sensor system is one of the modern and important methods of irrigation management in arid and semi-arid areas, which is water as the limiting factor for crop production. The study was applied for 2016 and 2017 seasons out in Al-Yousifya, 15 km Southwest of Baghdad. A study was conducted to evaluate coefficient uniformity, uniformity distribution and application efficiency for furrow, surface drip and subsurface drip irrigation methods and it was (98, 97 and 89)% and (97, 96 and 88)% for 2016 and 2017 seasons;respectively. And control the volumetric moisture content according to the rhizosphere depth for depths of 10, 20 and 30 cm by means of the sensor system. The results indicated that the height consumptive water use of furrow 707.91 and 689.69 mm<span style="white-space:nowrap;">·</span>season<sup>-1</sup> and the lowest for subsurface drip with emitter deep at 20 cm 313.93 and 293.50 mm<span style="white-space:nowrap;">·</span>season<sup>-1</sup> for 2016 and 2017 seasons;respectively. As well, the highest value of water use efficiency for subsurface in drip irrigation at a depth of 20 cm, was 2.71 and 2.99 kg<span style="white-space:nowrap;">·</span>m<sup>-3</sup> and the lowest value for furrow irrigation was 1.12 and 1.20 kg<span style="white-space:nowrap;">·</span>m<sup>-3</sup> for the 2016 and 2017 seasons;respectively.
文摘The current study was carried out at Agricultural College, University of Baghdad in the vegetable farm, Department of Horticulture during 2013 spring growing season. Yield response to irrigation of different crops is of major importance in production planning where water resources are limited. This study aims to determine the effect of different irrigation treatment （deficit irrigation） and potassium humate fertilizer on yield, content of nitrogen, potassium, and phosphor in tuber of potato and water use efficiency in the Abu-Graib Region, Iraq. Potato was grown under drip irrigation with three treatments： irrigation applied when evaporation 75%, 100% and 125% from pan A, and three potassium humate fertilizers： 0, 1.2 and 2.4 kg/ha with three times additions. The seasonal potato evapotranspiration ranged from 267 mm to 372 mm. The drip irrigation treatment had significant effecting tuber yield of potato recorder 29,530, 27,630 and 24,880 kg/ha for 125%, 100% and 75% from pan A evapotranspiration, respectively. Humus fertilizers addition has the lowest value of ETa 309 mm and maximum value of yield 2,930 kg/ha. Water use efficiency （WUE） and irrigation water use efficiency （IWUE） values increased with increasing humus fertilizers, recording 9.92, 14.52, 8.59, 12.42 and 7.51, 10.70 kg/m3 for potassium humate K3 （2.4 kg/ha）, K2 （1.2 kg/ha） and KI （0.0 kg/ha）, respectively. Plants irrigated with 125% from class pans A evaporation, produced a significant increase in N, P and K content in tubers recorder 0.96%, 0.58% and 1.52%, respectively. Potassium humus-fertilizer significant differences among K1, K2 and K3 on high of plants reached 41.52, 50.08 and 56.39 cm, respectively, number of stems/plant 2.69, 3.22 and 3.78, respectively, leaves area index recorder 2.80, 3.35 and 3.73.
文摘Consumptive hypothyroidism is often the clinical condition that results from neoplasms producing their own selenodionases that convert T4 needed to be converted to active T3 into an active form of thyroid hormone, rT3. This often requires treatment with high doses of IV T4, with or without doses of T3 as well, until the neoplasm is treated. This principle is demonstrated in the below case of a 65 y/o female with medical history significant for Ia Kappa multiple myeloma, complete heart block s/p AICD placement, and papillary thyroid cancer status post thyroidectomy in 2020, who had initially presented <span>with persistent bone pain, progressive encephalopathy and failure to thrive</span> with more than a 50 lb weight loss over a few months. Labs on presentation <span>were not remarkable for progression of her underlying multiple myeloma</span>, however<span style="font-family:;" "="">,</span><span style="font-family:;" "=""> she was found to have a new significantly elevated TSH. She underwent imaging with a CT chest, abdomen, and pelvis, which showed new hepatic lesions, subcutaneous nodules, and new pulmonary nodules with associated lymphadenopathy and a left-sided pleural effusion. CT-guided liver biopsy evinced a metastatic neuroendocrine carcinoma, further supported by an elevated calcitonin and chromogranin. She was treated with high dose IV T4 at 1.38 mcg/kg however continued to worsening thyroid function labs. She was then started on Liothyronine at 20 mcg and subsequently improved. This <span>patient’s case illustrates the importance of considering consumptive hypo</span>thy<span>roidism when thyroid profile abnormalities and symptoms of severe hypo</span>thyroidism are seen in the context of malignant neoplasms, and further illu<span>strates the important of considering T3 as part of the treatment regimen</span> when IV T4 is not resulting in improvement.</span>
文摘Given the considerable global interest in the preparation of Ti and TiC,a novel reduction method for TiO_(2) in a CH_(4)-H_(2) atmosphere was proposed,and the reduction thermodynamic behavior,phase equilibrium,and energy consumption of TiO_(2) during its reaction with a CH_(4)-H_(2) gas mixture were investigated.The results indicate that the reaction proceeds via a stepwise reduction pathway from TiO_(2) to Ti(C,O),with the Magnéli phase(TinO_(2n-1))and Ti_(3)O_(5) serving as intermediate phases.Notably,the reduction of TiO_(2) by H_(2) is more challenging than that by CH_(4),which may be attributed to the inhibitory effect of H_(2) on the surface carbon precipitation.For the complete carbonization of 1 mol TiO_(2),the total energy required at 1000,1100,and 1200℃is 1159,925,and 977 kJ/mol,respectively,which may be related to the shift of gas-phase equilibrium and the increase in side reactions at high temperatures.
文摘China’s booming performing arts sector is reshaping cultural experiences and creating vibrant new spaces for leisure,tourism and creativity The year 2025 marked a period of vigorous expansion for China’s performing arts sector,as the industry evolved from a traditional entertainment field into a comprehensive engine of cultural consumption.
基金supported by the Spanish Ministry of Health‐Plan Nacional sobre Drogas(2023‐I024)the the Ministry of Science,Innovation and Universities/State ResearchAgency/10.13039/501100011033(PID2023-146865OB-I00)+2 种基金Generalitat Valenciana(CIAICO/2021/203)the Primary Addiction Care Research Network(RD21/0009/0005)FEDER Funds,GVA.
文摘Mesenchymal stem cell-derived extracellular vesicles have emerged as a promising form of regenerative and immunomodulatory therapy;indeed,micro(mi)RNAs contained within mesenchymal stem cell-derived extracellular vesicles modulate target gene expression and impact disease-associated pathways.Chronic alcohol consumption leads to neuroinflammation,brain damage,and impaired cognition.Evidence indicates that females are more vulnerable to alcohol-induced damage than males.While mesenchymal stem cell-derived extracellular vesicles have been studied in various neuroinflammatory conditions,their potential to counteract alcohol-induced brain damage remains unclear.In this study,we investigated whether repeated intravenous administration of mesenchymal stem cell-derived extracellular vesicles could ameliorate neuroinflammation and behavioral impairment induced by chronic alcohol consumption in female mice.Mesenchymal stem cell-derived extracellular vesicles diminished the increased binding of a micro-positron emission tomography tracer(^(18)F-FDG)when analyzing whole-brain 3D images and brain coronal sections of ethanol-treated mice.Mesenchymal stem cell-derived extracellular vesicle administration protected against ethanol-induced proinflammatory gene upregulation,cognitive dysfunction,and the conditioned rewarding effects of cocaine.MiRNA sequencing data from mesenchymal stem cell-derived extracellular vesicles revealed the elevated expression of extracellular vesicle-derived miR-483-5p and miR-140-3p in the brains of ethanol-treated female mice following mesenchymal stem cell-derived extracellular vesicle administration.In addition,mesenchymal stem cell-derived extracellular vesicles modulated the expression of pro-inflammatory-related miRNA target genes(e.g.,Socs3,Tnf,Mtor,and Atf6)in the brains of ethanol-treated female mice.These results suggest that mesenchymal stem cell-derived extracellular vesicles could function as a neuroprotective therapy to ameliorate the neuroinflammation,cognitive dysfunction,and conditioned rewarding effects of cocaine associated with chronic alcohol consumption.
文摘The Double Take column looks at a single topic from an African and Chinese perspective.This month,we discuss how to understand the growing emphasis on emotional returns among young people.Emotional value has emerged as a central force shaping youth decision-making across work,consumption,relationships and lifestyle choices.Unlike traditional economic rationality that prioritises income and material security,emotional value focuses on how choices make individuals feel and how they align with personal meaning.This shift is particularly evident in rapidly transforming societies such as China and Ghana,where economic restructuring,globalisation and social change have reshaped pathways to adulthood.
基金supported by the Beijing Natural Science Foundation(L242149)Research Project on High Quality Development of Hospital Pharmacy,National Institute of Hospital Administration,NHC,China(NIHAYS2332)+1 种基金National High Level Hospital Clinical Research Funding(BJ-2023-199)Capital Funds for Health Improvement and Research(CFH)(2024-1-4052).
文摘Objective To examine national trends in antibiotic consumption and antimicrobial resistance(AMR)among six WHO-priority bacterial pathogens in China from 2016 to 2022.Methods This ecological study analyzed national and provincial data from the China Antibacterial Resistance Surveillance System(CARSS)and the National Hospital Information Network.Beta regression models assessed temporal trends,and hierarchical models evaluated associations between antibiotic use and resistance.Results From 2016 to 2022,carbapenem resistance in Acinetobacter baumannii and Pseudomonas aeruginosa,and vancomycin resistance in Enterococcus faecium and E.faecalis significantly declined(β<0,P<0.010),while carbapenem-resistant Klebsiella pneumoniae increased(β=0.081,P<0.001).Nationwide antibiotic consumption rose across 10 major classes.Positive associations were found between carbapenem use and resistance in A.baumannii(z=2.719,P=0.007)and P.aeruginosa(z=3.241,P=0.001),and between vancomycin use and resistance in E.faecium(z=4.510,P=0.001)and E.faecalis(z=3.210,P=0.001).Conclusion Carbapenem-resistant K.pneumoniae increased significantly in China,while other resistant pathogens declined.Resistance patterns were linked to the use of multiple antibiotic classes,underscoring the need for strengthened antibiotic stewardship and surveillance.
文摘“A sound consumer finance environment is vital in helping to prosper the holiday market and stimulating consumption vitality.”——Guo Wuping,Spokesperson of the National Financial Regulatory Administration and directorgeneral of the Policy Research Department of the NFRA.
文摘AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This observational clinical study utilized a cross-sectional and prospective design,focusing on chronic alcohol consumers alongside a non-consuming control group.OCT/OCTA imaging parameters including central retinal subfield thickness(CST),subfoveal choroidal thickness(SCT),foveal avascular zone(FAZ)and vessel density(VD)in the superficial and deep capillary plexuses in both the macular and optic disc(OD)regions were recorded.Data were analyzed using SPSS 15.0;descriptive statistics were reported,group comparisons were performed with Chisquare,Kruskal–Wallis,and Bonferroni-corrected Mann–Whitney U tests,and relationships were assessed using Spearman correlation,with statistical significance set at P<0.05.RESULTS:A total of 160 eyes of 160 participants(110 females and 50 males with mean age 38.7±9.9y)who don’t smoke were divided into five groups:never,occasional,monthly,weekly and daily drinkers.The mean CST was 216.6±14.2μm and the mean SCT was 358.9±84.5μm.There was no statistically significantly difference in CST and SCT among the groups(P=0.890,0.799).Foveal superficial capillary plexuses(SCPs)VD was higher in monthly drinkers compared to occasional drinkers(P=0.015).Foveal VD in deep capillary plexus was also higher in monthly drinkers than in never and occasional drinkers(P=0.004,0.006).Nasal SCPs VD at the OD was higher in monthly drinkers compared to never drinkers(P=0.005).There was no significant difference FAZ area among the groups(P=0.071).CONCLUSION:Both superficial and deep microvascular structures in the inferior quadrants of macula are positively correlated with frequency of alcohol use.Also in our study results is that the monthly drinker group has uniquely higher VDs in both macula and OD.This leads us to consider moderate alcohol consumption may also have protective effects on retinal microcirculation.
文摘Electrical and electronic devices face significant challenges in heatmanagement due to their compact size and high heat flux,which negatively impact performance and reliability.Conventional coolingmethods,such as forced air cooling,often struggle to transfer heat efficiently.In contrast,thermoelectric coolers(TECs)provide an innovative active cooling solution to meet growing thermal management demands.In this research,a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases,in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems.This study evaluates the performance of a Peltierbased thermalmanagement systemby analyzing the effects of using two,three,and four Peltiermodules on cooling rates,power consumption,temperature reduction,and system efficiency.Experimental results indicate that increasing the number of Peltier modules significantly enhances cooling performance.The four-module system achieved an optimal balance between cooling speed and energy efficiency,reducing the temperature of a liquidmixture(30% mono ethylene glycol+70% distilled water plus laser dyes)to 8℃ in just 17 min.It demonstrated a cooling rate of 0.794℃/min and a high coefficient of performance(COP)of 1.2 while consuming less energy than the two-and three-module systems.Furthermore,the study revealed that increasing the number of modules led to faster air cooling and improved temperature reduction.These findings highlight the importance of selecting the optimal number of Peltier modules to enhance efficiency and cooling speed whileminimizing energy consumption.This makes TEC technology a sustainable and effective solution for applications requiring rapid and reliable thermal management.
基金supported by the National Natural Science Foundation of China(No.52571367)and the Commissions Project of China(No.CBG4N21).
文摘The concept of hybrid ships has gained significant attention in recent years,as they offer an effective means of enhancing energy utilization and reducing environmental pollution.However,the navigational environments of ships are often subject to changes,which in turn affect their energy efficiency in a complex manner.It is therefore evident that enhancing the energy efficiency of hybrid ships is a worthwhile goal.In this study,we take a diesel-electric hybrid ship navigating in inland waterways as the research object,and propose a hierarchical optimization method for ship energy efficiency.The upper-layer control establishes a predictive model for propulsion motor speed and fuel consumption through multivariate time series predictions,and employs the model predictive control(MPC)method to optimize the propulsion motor speed.The lower-layer control utilizes an equivalent fuel consumption minimization method,which is based on improving the equivalence factor.This involves combining the variation of the supercapacitor’s state of charge(SOC)with the propulsion motor speed obtained from the MPC optimization in the upper-layer control.Furthermore,a proportional integral(PI)controller is used to adjust the equivalence factor,in order to adapt the equivalent fuel consumption minimization method to the working conditions.Our results demonstrate that the proposed hierarchical optimization method can reduce the energy efficiency operating indicator(EEOI)by approximately 11.54%and the fuel consumption by approximately 9.47%in comparison to the pre-optimization scenario.
基金supported by the National Natural Science Foundation of China(No.U2433214)。
文摘Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptions due to its subtropical monsoon climate,including typhoons and gusty winds,present ongoing challenges.Despite the growing focus on operational costs and third-party risks,research on low-altitude urban wind fields remains scarce.This study addresses this gap by integrating wind field analysis into UAV path planning,introducing key innovations to the classical model.First,UAV wind resistance and turbulence constraints are analyzed,mapping high-wind-speed and turbulence-prone zones in the airspace.Second,wind dynamics are incorporated into path planning by considering airspeed and groundspeed variation,optimizing waypoint selection and flight speed adjustments to improve overall energy efficiency.Additionally,a wind-aware Theta*algorithm is proposed,leveraging wind vectors to expedite search process,while Computational Fluid Dynamics(CFD)techniques are employed to calculate wind fields.A case study of Shenzhen,examining wind patterns over the past decade,demonstrates a 6.23%improvement in groundspeed and a 7.69%reduction in energy consumption compared to wind-agnostic models.This framework advances UAV logistics by enhancing route safety and energy efficiency,contributing to more cost-effective operations.
基金supported by the National Natural Science Foundation of China(Grant No.52474347)Postdoctoral Science Foundation of China(Grant No.2024T171095)the Fundamental Research Funds for the Central Universities(Grant No.2024CDJXY003).
文摘Coke oven gas(COG)and natural gas(NG),both high-calorific by-products derived from the steel industry,have gained prominence as alternative fuels in the sintering process,thereby supporting dual objectives of emission reduction and carbon neutrality.While existing research on hydrogen-rich gas injection has predominantly concentrated on conventional thin-bed sintering,investigations into its application within thick-bed sintering remain comparatively scarce.Thick-bed sintering,recognized for enhancing energy efficiency and increasing sinter output,encounters challenges such as uneven heat distribution and diminished permeability,which can negatively impact process efficiency and product quality.To address these issues,sinter pot experiments were conducted to assess the effects of NG and COG injection on thick-bed sintering performance.Findings reveal that NG injection in thick beds mirrors the behavior observed in conventional thin-bed sintering,effectively optimizing the process and achieving a carbon reduction potential exceeding 10%.In contrast,COG injection in thick-bed conditions demonstrates notable differences,substantially lowering the solid fuel consumption rate but detrimentally affecting sinter strength and overall production.However,by optimizing the timing of COG injection,it is feasible to improve sinter yield while concurrently reducing solid fuel usage.These outcomes provide valuable insights for the advancement of gas injection technologies in thick-bed sintering,thereby contributing to energy conservation and emission mitigation efforts within the sintering industry.
基金supported by the Science and Technology Project of China Southern Power Grid Co.,Ltd.(ZBKTM20232244)the Project of National Natural of Science Foundation of China(52477103).
文摘The real-time and accurate calculation of electricity indirect carbon emissions is not only the critical component for quantifying the carbon emission levels of the power system but also an effective mean to guide electricity users in carbon reduction and promote power industry low-carbon transformation.Fundamentally,calculating indirect carbon emissions involves allocating direct carbon emission data from the power source side,indicating that accurate indirect emission results rely on the precise measurement of power source emissions.However,existing research on indirect carbon emissions in large-scale power systems rarely accounts for variations in carbon emission characteristics under different operating conditions of power sources,such as rated/non-rated operating conditions and ramping up/down conditions,making it difficult to reflect source-side and load-side carbon emission information variation during providing ancillary services.Quadratic and exponential functions are proposed to characterize the energy consumption profiles of coal-fired and gas-fired power generation,respectively,to construct a refined carbon emission model for power sources.By leveraging the theory of power system carbon flow,we analyze how variable operating conditions of power sources impact indirect carbon emissions.Case studies demonstrate that changes in power source emissions under variable conditions have a significant effect on the indirect carbon emissions of power grids.
基金Key Scientific Research Project of Anhui Provincial Department of Education in 2021,“Literature Collation of Insomnia Syndrome in Xin’an Medical Classics and Analysis of Its Related Academic Thoughts”(Project No.:KJ2021A1282)Wanjiang Pilot Zone Project in 2021,“Modern Apprenticeship System for TCM(Traditional Chinese Medicine)Mentorship Education”(Project No.:WJ-RCPY-037)2023 Anhui Provincial-Level High-Level Vocational Colleges and High-Level Professional Groups,TCM Professional Group(Project No.:Wan Jiao Mi Gao[2023]No.5)。
文摘This paper conducts an in-depth analysis of the theory and methods for differentiating and treating insomnia in Bu Ju Ji by Wu Cheng,a physician of the Qing Dynasty.By systematically sorting out the origin of Wu Cheng’s academic thoughts,this study explores his unique perspective on differentiating and treating insomnia,analyzes the compatibility rules of his core formulas and herbs,and reveals the characteristics of his medication use as well as its guiding value for later clinical practice.Research shows that Wu Cheng integrated the principles of the I Ching(Book of Changes)with medical theories to construct a theoretical system for consumptive diseases.In the differentiation and treatment of insomnia,he emphasized the dynamic balance of zang-fu organs,Qi,blood,Yin and Yang,with special attention to the impact of spleen-Yin deficiency on insomnia.He thus formed distinctive academic features,including treating both deficiency and excess,taking into account both Qi and blood,and regulating the spleen to protect the body’s defense system.In terms of medication,he was skilled in using herbs that are sweet and warm in nature for tonification,harmonizing Qi and blood,and invigorating the spleen to nourish Yin.These insights hold significant reference value for modern TCM(Traditional Chinese Medicine)in the treatment of insomnia.
基金The Henan Key Research and Development and Promotion Project(Grant No.232102310245)the Joint Construction Project of Medical Science and Technology of Henan Province(Grant No.LHGJ20220426).
文摘The rise of antimicrobial resistance,particularly in healthcare-associated infections caused by carbapenem-resistant Gram-negative pathogens,poses a critical global challenge.The extensive use of carbapenems has exacerbated this issue by increasing selective pressure within bacterial populations.This study aimed to investigate the association between carbapenem consumption and resistance rates in four priority Gram-negative bacteria:Escherichia coli(EC),Klebsiella pneumoniae(KP),Acinetobacter baumannii(AB),and Pseudomonas aeruginosa(PA).Retrospective data were collected from the First Affiliated Hospital of Zhengzhou University,covering the period from January 2010 to December 2022.Trends in carbapenem consumption and resistance were analyzed using the Mann-Kendall test to assess statistical significance and the Sen’s slope(SS)estimator to determine the magnitude of change.Correlations between carbapenem use and bacterial resistance rates were evaluated via Spearman correlation analysis.Over the study period,the consumption of meropenem,imipenem,biapenem,and total carbapenems exhibited a significant upward trend(|Z|>1.96,SS>0).Correspondingly,the resistance rates of EC and KP to meropenem and imipenem also increased significantly(|Z|>1.96,SS>0).A strong positive correlation was observed between the resistance rate of EC to meropenem and the defined daily doses(DDDs)of meropenem(r=0.732,P<0.05)and between EC resistance to imipenem and its DDDs(r=0.49,P<0.05).Similar significant correlations were identified for KP.However,no significant associations were found between carbapenem resistance in AB or PA and carbapenem consumption.These findings underscored the strong correlation between carbapenem use and the resistance rates of EC and KP,highlighting the urgent need for stringent control and stewardship of carbapenem use in clinical settings to mitigate or delay the development of bacterial drug resistance.
基金supported by the National Natural Science Foundation of China(Nos.22278168 and 22276064)the MOE Key Laboratory of Resources and Environmental System Optimization(No.KLRE-KF202205)the Science and Technology Project of Fujian province(No.2022Y3007).
文摘Phase change absorbents based on amine chemical absorption for CO_(2)capture exhibit energy-saving potential,but generally suffer from difficulties in CO_(2)regeneration.Alcohol,characterized as a protic reagent with a low dielectric constant,can provide free protons to the rich phase of the absorbent,thereby facilitating CO_(2)regeneration.In this investigation,N-aminoethylpiperazine(AEP)/sulfolane/H_(2)O was employed as the liquid-liquid phase change absorbent,with alcohol serving as the regulator.First,appropriate ion pair models were constructed to simulate the solvent effect of the CO_(2)products in different alcohol solutions.The results demonstrated that these ion pair products reached the maximum solvation-free energy(△E_(solvation))in the rich phase containing ethanol(EtOH).Desorption experiment results validated that the inclusion of EtOH led to a maximum regeneration rate of 0.00763 mol/min,thus confirming EtOH’s suitability as the preferred regulator.Quantum chemical calculations and^(13)C NMR characterization were performed,revealing that the addition of EtOH resulted in the partial conversion of AEP-carbamate(AEPCOO−)into a new product known as ethyl carbonate(C_(2)H_(5)OCOO−),which enhanced the regeneration reactivity.In addition,the decomposition paths of different CO_(2)products were simulated visually,and every reaction’s activation energy(△E_(act))was calculated.Remarkably,the△E_(act)for the decomposition of C_(2)H_(5)OCOO−(9.465 kJ/mol)was lower than that of the AEPCOO−(26.163 kJ/mol),implying that CO_(2)was more likely to be released.Finally,the regeneration energy consumption of the alcohol-regulated absorbentwas estimated to be only 1.92 GJ/ton CO_(2),which had excellent energy-saving potential.
