OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which...OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.展开更多
Objective:The concept of constitution in traditional Chinese medicine(TCM)has been increasingly recognized as a crucial factor in both the prevention and treatment of insomnia.However,rigorous statistical evidence on ...Objective:The concept of constitution in traditional Chinese medicine(TCM)has been increasingly recognized as a crucial factor in both the prevention and treatment of insomnia.However,rigorous statistical evidence on the correlation between TCM constitutions—particularly mixed constitutions—and insomnia disorder remains limited.This study aimed to investigate the association between specific TCM constitutions and insomnia disorder.Methods:A cross-sectional study was conducted at the Department of Preventive Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,from November 2022 to December 2023.TCM constitutions were assessed using the Constitution in Chinese Medicine Questionnaire.Insomnia disorder was diagnosed by experienced internal medicine physicians according to the criteria of the International Classification of Sleep Disorders,Third Edition.A total of 1065 eligible participants(242 with insomnia disorder and 823 controls)were included in the final analysis.Results:Among the participants,862(80.94%)exhibited biased constitutions,with 75.30%of these having mixed constitutions.Logistic regression analysis revealed a negative association between the gentleness constitution and insomnia disorder,whereas qi-deficiency,yang-deficiency,phlegm-dampness and qidepression constitutions were positively associated with insomnia disorder.These associations remained significant after adjusting for potential confounders and were further validated through sensitivity analysis using propensity score matching.Conclusion:Significant associations between TCM constitutions and insomnia disorder were demonstrated.Future research should further investigate these relationships and explore the underlying mechanisms through rigorous longitudinal and interventional studies to improve understanding and clinical applications.展开更多
Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12...Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.展开更多
[Objectives]To investigate differences in BMI and renal function across constitution types and influencing factors of blood pressure.[Methods]92 college student volunteers aged 18-25 from January 2023 to December 2024...[Objectives]To investigate differences in BMI and renal function across constitution types and influencing factors of blood pressure.[Methods]92 college student volunteers aged 18-25 from January 2023 to December 2024 were selected.BMI,blood pressure,and renal function markers—blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA),were compared across constitution types.Multiple stepwise regression analysis was applied to identify the influencing factors of blood pressure.[Results]Among 92 healthy participants aged 18-25,Shar-predominant constitution accounted for 50%,Khii-predominant for 25%,and Badgan-predominant for 20.65%.Significant differences existed in mean systolic and diastolic blood pressure across constitution types(systolic:F=4.56,P=0.001;diastolic:F=3.78,P=0.005).Shar-predominant group showed significantly higher systolic blood pressure than other types(P<0.05),while Khii-predominant group had higher diastolic pressure.Shar-predominant constitution demonstrated significantly greater height,weight,and BMI compared to other types(P<0.05).Males exhibited significantly higher height,weight,and BMI than females(P<0.05).Shar-predominant group showed significantly elevated urea,uric acid,and creatinine levels compared to other constitution types(P<0.05).Males had significantly higher mean urea,uric acid,and creatinine levels than females(P<0.05).Correlation analysis revealed stronger associations between BMI,renal function,and blood pressure in Shar-predominant group(r>0.50,P<0.05).Multiple regression analysis identified BMI as the primary influencing factor for blood pressure,followed by urea and uric acid.In Shar-predominant group,BMI exerted the strongest effect on blood pressure(β=0.60-0.65,P<0.001).[Conclusions]This study provides important evidence for health management in populations with different constitution types.展开更多
OBJECTIVE:To find more influencing factors Qideficiency constitution of Traditional Chinese Medicine(TCM)using dynamic and comprehensive information.METHODS:Because grey relational analysis(GRA)is good at processing i...OBJECTIVE:To find more influencing factors Qideficiency constitution of Traditional Chinese Medicine(TCM)using dynamic and comprehensive information.METHODS:Because grey relational analysis(GRA)is good at processing incomplete information and has no special requirements for sample size and distribution.We acquired 2122 pieces of valid Qi-deficiency constitution dynamic data after preprocessing,and used GRA combing withχ~2 test and multivariate logistic regression analysis to discover and sort the influencing factors of Qideficiency constitution.RESULTS:For the calculation results of GRA,there were 10(62.5%)aspects whose grey correlation degrees were greater than 0.6.The results ofχ~2 test showed that all the above 10 aspects were statistically significant with Qideficiency constitution.The analysis results of multivariate logistic regression analysis showed the following factors were positively correlated with Qi-deficiency constitution:premature birth,sleeping late and getting up early,sleeping late and getting up late,irregular sleeping,sleeping 6.0-6.9 h per day,artificial feeding,female,age at 18-19,and father's age at 18-19 years old when a baby at birth.The following factors were negatively correlated with Qi-deficiency constitution:sleeping 8.0-8.9 h per day and≥9.0 h per day,and age at 30-39 and 40-49 years old.CONCLUSIONS:It is necessary to pay attention to these innate and acquired information of individuals which may lead to Qi-deficiency constitution.And our research also provides a novel methodological thinking for analyzing the influential factors of TCM constitution.展开更多
Objectives:By investigating the distinct speech and voice phenotype among TCM constitution for adults,this study aims at providing a convenient and objective methodological reference for judging TCM constitution.Metho...Objectives:By investigating the distinct speech and voice phenotype among TCM constitution for adults,this study aims at providing a convenient and objective methodological reference for judging TCM constitution.Methods:Acoustic analysis and TCM constitution assessment were performed for all 620 participants using Praat software and the CCMQ,respectively.Results:For formant features,the speech duration of special constitution participants was shorter than that of neutral,phlegm-dampness,dampness-heat,Yin-deficiency,or Yang-deficiency participants when pronuncing the vowels/a/,/i/,and/u/.Compare to Yang-deficiency,Qi-deficiency participants had a shorter speech duration when pronucing/i/.For/u/,blood-stasis participants exhibited a lower F1 value than neutral participants.For vocal features,special constitution participants showed higher local jitter than neutral,dampness-heat,and Yang-deficiency participants(for/a/,/i/,and/u/).Higher absolute local jitter than neutral or dampness-heat participants.Compared with neutral or Yang-deficiency participants,special participants owned a higher local shimmer(dB).Special participants had a lower harmonicity autocorrelation than neutral,dampness-heat,or Yang-deficiency participants.Conclusions:Formant features may effectively differentiate special constitution from neutral,phlegm-dampness,dampness-heat,Yin-deficiency,or Yang-deficiency constitutions based on vowel duration measurements(/a/,/i/,/u/).For the vowel/u/,F1 values may help distinguish blood-stasis from neutral constitution.Vocal features appear particularly useful for distinguishing special constitution from neutral,dampness-heat,or Yang-deficiency constitution,with local jitter and harmonicity autocorrelation showing significant discriminatory power.展开更多
In Eastern medicine,an individual’s health and longevity is believed to depend on the balance of their metabolic energies,classified as body constitution.Traditional Mongolian Medicine categorizes the body into seven...In Eastern medicine,an individual’s health and longevity is believed to depend on the balance of their metabolic energies,classified as body constitution.Traditional Mongolian Medicine categorizes the body into seven constitution types based on metabolic dominance,influencing physical traits,behavioral tendencies,disease susceptibility,and adaptability to environmental factors.This study aims to analyze the principles of disease prevention based on body constitution in Eastern medicine,with a focus on Traditional Mongolian and Tibetan medical perspectives.It looks to clarify body constitution classifications,explore dietary management strategies,and highlight their significance in maintaining health and preventing diseases.This study adopts a literature review approach,incorporating source analysis,synthesis,and hermeneutic methodology to examine traditional medical theories related to body constitution.Classical texts from Traditional Tibetan medicine,including the rGyud-bZhi and Golden Subtitles,were analyzed alongside comparative research on Traditional Chinese and Korean constitutional medicine.The study integrates historical perspectives with modern biomedical insights to establish a comprehensive understanding of constitution-based health management.The findings indicate that the three principal metabolic energies—rLung,mKhris,and Bad-Kan—serve as symbolic codes representing physiological and metabolic states.By recognizing their body constitution,individuals can adopt constitutionally tailored dietary and lifestyle practices to maintain balance and prevent diseases.A comparative analysis reveals similarities and differences among different Eastern medical systems,while still demonstrating the potential for integrating constitutional medicine with modern healthcare approaches.展开更多
Non-tuberculous mycobacterial(NTM)pulmonary disease and pulmonary tuberculosis(TB)are mycobacterium-associated lung disorders that share overlapping clinical and radiological features,yet diverge significantly in path...Non-tuberculous mycobacterial(NTM)pulmonary disease and pulmonary tuberculosis(TB)are mycobacterium-associated lung disorders that share overlapping clinical and radiological features,yet diverge significantly in pathogenic mechanisms,therapeutic regimens,and long-term prognoses.Traditional east Medicine(TCM)constitution theory,a foundational framework for personalized healthcare,exerts a pivotal influence on disease susceptibility,pathological progression,and clinical outcomes.This review synthesizes state-of-the-art clinical evidence to systematically dissect key discrepancies in TCM constitution distribution between the two conditions,focusing on three core dimensions:distinctive patterns of constitution type distribution,the interplay between constitution and clinical variables,and the clinical relevance of these constitutional differences.Its primary goal is to deliver rigorous theoretical support and actionable guidance for TCM-based differential diagnosis,syndrome-specific interventions,and preventive healthcare strategies for both diseases.展开更多
The understanding of the scope of protection for the right to health should not be limited to fragmented descriptions in departmental laws,such as those focusing on rights,interests,or legal benefits.Instead,it should...The understanding of the scope of protection for the right to health should not be limited to fragmented descriptions in departmental laws,such as those focusing on rights,interests,or legal benefits.Instead,it should be analyzed holistically within the constitutional framework of fundamental rights.From the perspective of defense right function,the right to health addresses physiological harm that progresses through stages of“risk-danger-infringement,”psychological harm that targets inner distress,and minor harm arising from challenges in social adaptation,to clarify the negative defensive obligations of the state to prevent health-related harm.From the perspectives of the beneficiary right function and the objective value order function,the right to health requires a minimum level of constitutional protection and delineating the positive obligations of the state to ensure it through the fulfillment of basic obligations in healthcare and health promotion.展开更多
Promoting environmental sustainability in South Africa’s cities through public participation is vital for foster-ing inclusive governance and equitable decision-making.Currently,63%of South Africa’s population—and ...Promoting environmental sustainability in South Africa’s cities through public participation is vital for foster-ing inclusive governance and equitable decision-making.Currently,63%of South Africa’s population—and 64%of its youth—live in urban areas,with this figure expected to rise to nearly 80%by 2050.Rapid urbanisation brings significant environmental challenges,including air and noise pollution,greenhouse gas(GHG)emissions,and inadequate waste management.Globally,cities contribute over 70%of GHG emissions and consume two-thirds of the world’s energy.South African cities face similar issues:worsening air quality in regions like the Highveld,water scarcity,urban flooding,waste management problems,and biodiversity loss due to urban sprawl.This article explores how South Africa’s consti-tutional and legislative frameworks support public participation in promoting urban environmental sustainability.Using doctrinal research,it examines key legal instruments—including the Constitution and environmental laws—that establish participatory rights and promote transparency,accountability,and inclusivity.The article draws on court decisions and case studies to highlight ongoing barriers to meaningful participation,particularly for marginalised communities.These include administrative inefficiencies,political interference,and unequal access to information and resources.The article concludes by proposing strategies such as capacity-building initiatives,the integration of traditional knowledge systems,and enhanced institutional coordination to strengthen public participation and improve urban environmental outcomes,addressing both global environmental pressures and South Africa’s unique urban sustainability challenges.展开更多
The complex phenomena that occur during the plastic deformation process of aluminum alloys,such as strain rate hardening,dynamic recovery,recrystallization,and damage evolution,can significantly affect the properties ...The complex phenomena that occur during the plastic deformation process of aluminum alloys,such as strain rate hardening,dynamic recovery,recrystallization,and damage evolution,can significantly affect the properties of these alloys and limit their applications.Therefore,studying the high-temperature flow stress characteristics of these materials and developing accurate constitutive models has significant scientific research value.In this study,quasi-static tensile tests were conducted on 5754 aluminum alloy using an electronic testing machine combined with a hightemperature environmental chamber to explore its plastic flow behavior under main deformation parameters(such as deformation temperatures,strain rates,and strain).On the basis of true strain-stress data,a BP neural network constitutive model of the alloy was built,aiming to reveal the influence laws of main deformation parameters on flow stress.To further improve the model performance,the ant colony optimization algorithm is introduced to optimize the BP neural network constitutive model,and the relationship between the prediction stability of the model and the parameter settings is explored.Furthermore,the predictability of the two models was evaluated by the statistical indicators,including the correlation coefficient(R^(2)),RMSE,MAE,and confidence intervals.The research results indicate that the prediction accuracy,stability,and generalization ability of the optimized BP neural network constitutive model have been significantly enhanced.展开更多
Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public heal...Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public health.The heterogeneity of these diseases,along with their intricate pathogenesis and propensity for recur-rence,has spurred an escalating demand for efficacious therapeutic strategies.Notwithstanding the advance-ments in western medicine(WM),treatment modalities like antihistamines,sulfonamides,and glucocorticoids exhibit side effects,especially for the neurotoxicity and the adverse reactions of the digestive system.Addi-tionally,physical therapies utilized in allergy management frequently perturb skin metabolism,potentially resulting in stratum corneum impairment,atrophy,pigmentation,and relapse,thereby mandating further investigation and optimization.The management of allergic disorders is often typified by recurrence and diffi-culties in attaining a definitive cure,instigating the pursuit of alternative or adjunctive therapeutic regimens.In this regard,Traditional Chinese Medicine(TCM),which adopts a comprehensive and holistic view of health and disease,confers remarkable advantages in the treatment of allergic conditions.TCM accentuates the significance of personalized treatment,custom-tailored to each patient’s idiosyncratic constitution and disease manifestations,a principle that is especially germane in allergic conditions where standardized treatments frequently fall short.Moreover,TCM interventions,including herbal remedies,acupuncture,and other modalities,are generally associated with a lower incidence of adverse effects compared to conventional therapies,rendering them appealing options for long-term management.The holistic paradigm of TCM permits the concurrent modulation of multiple physiological systems,not only alleviating the symptoms but also rectifying the underlying imbalances that underpin the development and perpetuation of allergic diseases.This approach,in conjunction with the capacity to individualize treatments,implies that TCM harbors sub-stantial potential in conferring more comprehensive and sustainable relief from allergic symptoms.This article delves into the TCM perspective on allergic diseases and the contemporary value of TCM in their treatment.It further explores the developmental pathway of TCM in addressing allergic diseases,dissects the intersection points between traditional theories and modern science,summarizes the key findings and conclusions,and emphasizes the potential and prospects of TCM in this domain.展开更多
Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and...Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and thereby are attributed to socio‐psychological reasons and treated by psychological interventions,such as cognitive behavior treatment.However,it is not ideal to rationalize and manage the PPS lack of pathophysiological explanation relying on psychological approaches.The entrenched disease‐centered biomedical mode limits the perception of PPS.Traditional medicine is a unique methodology of medicine independent from biomedical mode.Traditional Chinese medicine(TCM),achieved knowledge of health and disease from extensive observation and developed theoretical framework based on ancient mathematics using the principles of ancient naive materialism and dialectical materialism,has amassed extensive experience in symptom management.Particularly,the system of body constitution in TCM serves a reference model of evidence‐based integration of traditional and modern medicine in healthcare,and offers a promising approach for managing PPS.Nine types of body constitution were identified and validated through a series of scientific research.Individuals with a specific type of body constitution tend to present a corresponding cluster of symptoms,physical signs,disease susceptibility and prognosis.Adjustment of unhealthy constitution helps the symptom control and disease management.Standardized protocol of body constitution classification was established as an industry standard,and that of body constitution adjustment was compiled as clinical guidelines for quality control.Taken together,such evidence‐based integration of traditional medicine with modern medicine provides new avenues for managing PPS effectively.展开更多
Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the pred...Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the prediction and prevention of AMS.Methods:A caseecontrol study was conducted to recruit participants who experienced or did not experience AMS after entering a plateau.The data was collected through online questionnaires for convenient sampling.Demographic characteristics,body constitution,and related states or behaviors were investigated before and after entering the plateau.The participants were divided into case and control groups based on the incidence of AMS.The distributions of relevant factors were compared.Binary logistic regression analysis was used to screen for risk and protective factors.Results:There were 167 participants who completed the questionnaire.A total of 54 cases were excluded,and 113 participants were included,including 52 in the case group and 61 in the control group.In the case group,37,13,and 2 patients had mild,moderate,and severe AMS,respectively.In terms of the Tibetan medicine constitution,the case group had the highest proportion of Bad-rlung(25.0%)and Rlung types(21.2%),whereas the control group had the highest proportion of Bad-rlung(29.5%)and Mkhrisbad types(24.6%).There was no significant difference in the distribution of the constitutional types between the two groups.Insomnia or insufficient sleep within the week prior to entering the plateau and fatigue after arrival were risk factors for AMS,with odds ratios(OR)and 95%confidence intervals(CI)of 5.012(1.871e13.426)and 3.387(1.393e8.236),respectively.A history of short-term plateau travel is a protective factor for AMS(OR:0.32,95%CI:0.129 to 0.792).Conclusion:Insomnia or lack of sleep before ascending to a plateau and fatigue after arrival are risk factors for AMS.The Rlung constitution might be related to the incidence of AMS;however,this still needs to be verified in large-sample observational studies.The risk factors identified in this study can provide a reference for the prevention practice and research of AMS.展开更多
BACKGROUND The Asia-Pacific Colorectal Screening(APCS)score was designed with the purpose of distinguishing individuals at high risk(HR)for colorectal advanced neoplasia(AN).Traditional Chinese medicine(TCM)constituti...BACKGROUND The Asia-Pacific Colorectal Screening(APCS)score was designed with the purpose of distinguishing individuals at high risk(HR)for colorectal advanced neoplasia(AN).Traditional Chinese medicine(TCM)constitution was also linked with colorectal cancer(CRC).AIM To integrate the APCS score with TCM constitution identification as a new algorithm to screen for CRC.METHODS A cross-sectional multicenter study was carried out in three hospitals,enrolling 1430 patients who were asymptomatic and undergoing screening colonoscopy from 2022 to 2023.Patients were considered to have average risk,moderate risk,or HR with their APCS score.Odd ratios assessed the relationship between TCM constitution and disease progression.A TCM constitution risk score was created.The sensitivity and specificity of the new algorithm were calculated to evaluate diagnostic performance in detecting advanced adenoma(AA),CRC,and AN.RESULTS Of the 1430 patients,370(25.9%)were categorized as average risk,755(52.8%)as moderate risk,and 305(21.3%)as HR.Using the combined APCS score and the TCM constitution(damp-heat,qi-deficiency,yang-deficiency,phlegm-dampness,and inherited special constitution as positive)algorithm,72.2%of patients with AA and 73.7%of patients with AN were detected.Compared with the APCS score alone,the new algorithm significantly improved the sensitivity for screening AA[72.2%,95%confidence interval(CI):64.4%-80.0%vs 49.2%,95%CI:40.5%-57.9%]and AN(73.7%,95%CI:66.4%-81.1%vs 51.1%,95%CI:42.7%-59.5%).CONCLUSION The combination of APCS and TCM constitution identification questionnaires was valuable in identifying Chinese individuals who were asymptomatic for colorectal screening prioritization.展开更多
The phase constitution,microstructure,damping capacity,and mechanical properties of as-cast AlxCrFe3Ni(x=0.5,0.52,0.54,and 0.56,respectively)medium entropy alloys were investigated.It is found that the volume fraction...The phase constitution,microstructure,damping capacity,and mechanical properties of as-cast AlxCrFe3Ni(x=0.5,0.52,0.54,and 0.56,respectively)medium entropy alloys were investigated.It is found that the volume fraction of BCC phase increases while that of FCC decreases with increasing the Al content.When the content of Al is 0.54,the alloy is composed of 82.1vol.%BCC matrix and 17.9vol.%FCC phase.Wherein the FCC phase is distributed on the BCC matrix,forming a structure where the hard BCC matrix is surrounded by soft FCC phase.This results in a hindering effect on the propagation process of vibration waves.The damping performance of Al0.54CrFe_(3)Ni alloy,characterized by an internal friction of Q^(-1) is as high as 0.059,is higher than that of most FeCr damping alloys.The volume fraction of the BCC phase and the peculiar distribution of the FCC phase are identified as the key factors affecting the damping capacity.In addition,the Al0.54CrFe3Ni alloy exhibits a high yield strength of 811.16 MPa.展开更多
Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sect...Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sectional data from seven geographical regions across Chinese mainland.The Changsha version of the Montreal Cognitive Assessment was used to assess cognitive function.A“least absolute shrinkage and selection operator”(LASSO)model,multivariate linear regression analysis,and random forest(RF)model were used.Subgroup analyses were performed to examine the correlation between key TCM constitution types and cognitive function in different population subgroups.Results:A total of 24803 individuals aged 60 and above were included in the study.We selected 18 influential factors using the LASSO model.Higher education,being married,and having insurance were positively correlated with cognitive function in the elderly(all P<0.05).In contrast,poor sleep,vision impairment,hearing impairment,basic activities of daily living disability,instrumental activities of daily living disability,depression,hypertension,coronary heart disease,diabetes,stroke,yang-deficiency constitution(YADC),yin-deficiency constitution(YIDC),qi deficiency constitution(QDC),and blood stasis constitution(BSC)were negatively correlated with cognitive function(all P<0.05).YIDC and BSC affected all dimensions of cognitive function(all P<0.05).YADC mainly affected attention,language,abstraction(verbal analogies),memory,and orientation to time and place dimensions(P<0.001).QDC mainly affected language and abstraction(verbal analogies)dimensions(P<0.05).The negative correlations between BSC,YADC,YIDC,and QDC scores and cognitive function revealed statistically significant dif-ferences across most subgroups.The RF model identified education,BSC,and poor sleep quality as the three most influential factors in our study.Conclusion:BSC,YADC,YIDC,and QDC were associated with cognitive decline in the elderly.Our findings provide new perspectives and significant references for interventions for early-stage cognitive disorders.展开更多
Objective:To review the scientific research results of early puberty in children in the past decade,and to explore the current status,hot spots and frontiers of research in the field of early puberty in children.Metho...Objective:To review the scientific research results of early puberty in children in the past decade,and to explore the current status,hot spots and frontiers of research in the field of early puberty in children.Methods:From January 1,2014 to April 30,2024,literature on early puberty in children was retrieved from CNKI database and Web of Science(WOS)core collection.CiteSpace6.3.R1 software was used for bibliometric analysis of authors,institutions and key words,and related visual maps were drawn.Results:A total of 1548 English literatures and 1113 Chinese literatures were included.The number of published papers in both Chinese and English showed an increasing trend.The authors of the high production in Chinese were Ye Jin and Yang Li,and the high production institutions were the pediatrics department of Hubei University of Chinese Medicine and Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine.The authors are Latronico,Ana Claudia,and Universidade de Sao Paulo.Hot topics in Chinese and English studies include bone age,hormones,genetic inheritance,the correlation between precocious puberty and obesity and short stature.Conclusion:There is an increasing trend of research in the field of early puberty in children.The research on physical identification of children with precocious puberty and the dynamic detection of precocious puberty,height and obesity by Internet is worthy of continuous attention by domestic scholars.展开更多
OBJECTIVE:To explore the effect of Traditional Chinese Medicine(TCM)constitution on cognitive impairment(CI)in patients with cerebral small vessel disease(CSVD)and its underlying neuroimaging mechanism and to provide ...OBJECTIVE:To explore the effect of Traditional Chinese Medicine(TCM)constitution on cognitive impairment(CI)in patients with cerebral small vessel disease(CSVD)and its underlying neuroimaging mechanism and to provide countermeasures for health management of CSVD patients.METHODS:A total of 241 CSVD patients were recruited from the Department of Neurology.All subjects underwent head magnetic resonance imaging(MRI),Chinese Medicine Questionnaire(CCMQ)and cognitive function examination.The CSVD patients were divided according to the Montreal Cognitive Assessment(MoCA)score into a normal cognitive group(73 cases)and a CI group(168 cases).Logistic regression was used to analyse the risk constitution of CSVD-CI and to construct a risk prediction model.3DT1 MRI images and FreeSurfer 6.0 software(Athinoula A.Martinos,Boston,MA,USA)were used to further explore the involvement of hippocampal subregion volume in patients with at-risk constitution and its correlation with cognitive function.RESULTS:Logistic regression analysis showed that Yang-deficiency constitution(YADC)(P=0.020),older age(P=0.008)and hypertension(P=0.011)were risk factors for CSVD-CI but that balanced constitution(P=0.003)and education(P<0.001)were protective factors.A receiver operating characteristic curve(ROC)was drawn,and the area under the curve was 0.820.Further comparison of overall hippocampal and 12 hippocampal subregion volumes between YADC and non-YADC patients revealed decreased total volume of the left and right hippocampus,bilateral subiculum,presubiculum,molecular layer and right fimbria in the YADC group(P<0.05/13,13 is the number of hypothesis tests).Moreover,in the YADC group,the cognitive function of CSVD patients correlated positively with the overall volume of the left hippocampus(r=0.304,P<0.05)and the molecular layer volume of the left hippocampus(r=0.288,P<0.05).CONCLUSION:CSVD patients with YADC are more prone towards developing CI,and asymmetric atrophy of the hippocampus might be the underlying neuroimaging mechanism.In particular,the volume of the left whole hippocampus and the left hippocampal molecular layer correlated significantly with general cognitive function.展开更多
OBJECTIVE:To utilize the Traditional Chinese Medicine constitution(TCMC)as a complementary and alternative approach for early disease detection and treatment,with a focus on Yin and Yang deficiency constitutions,which...OBJECTIVE:To utilize the Traditional Chinese Medicine constitution(TCMC)as a complementary and alternative approach for early disease detection and treatment,with a focus on Yin and Yang deficiency constitutions,which serve as key references for disease prevention and management.METHODS:The dataset containing the data of Yin and Yang deficiency constitution was identified through the Gene Expression Omnibus database.This database was used for differential expression genes(DEGs)analysis and weighted gene co-expression network analysis(WGCNA),and the characteristic genes were then obtained in the dataset using a machine learning method.The hub genes of Yin and Yang deficiency constitution were obtained after analysis using the above three methods,and the hub genes were enriched and analyzed.Subsequently,the hub genes of Yin and Yang deficiency constitution were validated using external datasets.Receiver operating characteristic(ROC)analysis was used on each hub genes of the two groups to further understand their diagnostic performance.The mi RNA–lnc RNA-gene network was used to further analyze the hub genes.Immunoinfiltration and gene set enrichment analysis were performed on the shared hub genes.RESULTS:The GSE87474 dataset was used for DEGs analysis and WGCNA.Using machine learning analyses,we identified 15 and 14 hub genes for Yin and Yang deficiency constitutions,respectively.The results of enrichment analyses showed that Yin deficiency constitution was associated with interleukin-17 signaling pathway,whereas Yang deficiency constitution was associated with glycosaminoglycan biosynthesis–keratan sulfate.The validation dataset GSE56116 showed statistically significant data for s-adenosylmethionine sensor upstream of MTORC1(SAMTOR,also named C7orf60),cofilin 2(CFL2),cytohesin 1 interacting protein(CYTIP),G protein-coupled receptor 183(GPR183),hippocampus abundant transcript 1(HIAT1),kelch like family member 15(KLHL15),mitogen-activated protein kinase 6(MAPK6),and prostaglandin-endoperoxide synthase 2(PTGS2)in Yin deficiency and fucosyltransferase 8(FUT8),TATA-box binding protein associated factor,RNA polymerase I subunit D(TAF1D),zinc finger protein 24(ZNF24),MAPK6,and leptin receptor overlapping transcript like 1(LEPROTL1)in Yang deficiency.The ROC results indicated that these genes have diagnostic value.MAPK6 is a shared hub gene for Yin and Yang deficiencies.CONCLUSIONS:This study identified C7orf60,CFL2,CYTIP,GPR183,HIAT1,KLHL15,MAPK6,and PTGS2 in Yin deficiency and FUT8,TAF1D,ZNF24,MAPK6,and LEPROTL1 in Yang deficiency as potential biomarkers,providing insights into their pathogenesis.This theory not only guides the diagnostic approach in TCM but also extends its influence to various scientific research fields.展开更多
基金National Nonprofit Institute Research Grant for the Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences:Mechanism of Regulating Phlegm-Dampness Constitution to Prevent Metabolic Diseases based on Gut Microbiota-host DNA Methylation(No.YZ-202151)。
文摘OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.
基金supported by the Special Clinical Research Project of the Health Industry by the Shanghai Municipal Health Commission(No.202240055)。
文摘Objective:The concept of constitution in traditional Chinese medicine(TCM)has been increasingly recognized as a crucial factor in both the prevention and treatment of insomnia.However,rigorous statistical evidence on the correlation between TCM constitutions—particularly mixed constitutions—and insomnia disorder remains limited.This study aimed to investigate the association between specific TCM constitutions and insomnia disorder.Methods:A cross-sectional study was conducted at the Department of Preventive Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,from November 2022 to December 2023.TCM constitutions were assessed using the Constitution in Chinese Medicine Questionnaire.Insomnia disorder was diagnosed by experienced internal medicine physicians according to the criteria of the International Classification of Sleep Disorders,Third Edition.A total of 1065 eligible participants(242 with insomnia disorder and 823 controls)were included in the final analysis.Results:Among the participants,862(80.94%)exhibited biased constitutions,with 75.30%of these having mixed constitutions.Logistic regression analysis revealed a negative association between the gentleness constitution and insomnia disorder,whereas qi-deficiency,yang-deficiency,phlegm-dampness and qidepression constitutions were positively associated with insomnia disorder.These associations remained significant after adjusting for potential confounders and were further validated through sensitivity analysis using propensity score matching.Conclusion:Significant associations between TCM constitutions and insomnia disorder were demonstrated.Future research should further investigate these relationships and explore the underlying mechanisms through rigorous longitudinal and interventional studies to improve understanding and clinical applications.
基金supported by the National Natural Science Foundation of China(T2341019)NSFC-Guangdong Joint Fund(U1132001)+9 种基金General Program of the National Natural Science Foundation of China(82174243 and 82204948)Natural Science Foundation of Guangdong Province,China(2023A1515110757)Guangzhou Science and Technology Plan Project(2024B03J1343)Major Scientific and Technological Project of Guangzhou Municipal Health Commission(20252D003)Research Project of Traditional Chinese Medicine Bureau of Guangdong Province(20241208)General project of Beijing Natural Science Foundation(7242227)Fundamental Research Funds for the Central Universities(BZY-JMZY-2022-001 and 2023-JYB-JBZD-009)High-level Key Discipline of the National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(zyyzdxk-2023251)Major Science and Technology Special Projects in Hubei Province(2023BCA005)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0002).
文摘Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.
基金Supported by Project of Science and Technology Department of Inner Mongolia Autonomous Region(2021GG0117).
文摘[Objectives]To investigate differences in BMI and renal function across constitution types and influencing factors of blood pressure.[Methods]92 college student volunteers aged 18-25 from January 2023 to December 2024 were selected.BMI,blood pressure,and renal function markers—blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA),were compared across constitution types.Multiple stepwise regression analysis was applied to identify the influencing factors of blood pressure.[Results]Among 92 healthy participants aged 18-25,Shar-predominant constitution accounted for 50%,Khii-predominant for 25%,and Badgan-predominant for 20.65%.Significant differences existed in mean systolic and diastolic blood pressure across constitution types(systolic:F=4.56,P=0.001;diastolic:F=3.78,P=0.005).Shar-predominant group showed significantly higher systolic blood pressure than other types(P<0.05),while Khii-predominant group had higher diastolic pressure.Shar-predominant constitution demonstrated significantly greater height,weight,and BMI compared to other types(P<0.05).Males exhibited significantly higher height,weight,and BMI than females(P<0.05).Shar-predominant group showed significantly elevated urea,uric acid,and creatinine levels compared to other constitution types(P<0.05).Males had significantly higher mean urea,uric acid,and creatinine levels than females(P<0.05).Correlation analysis revealed stronger associations between BMI,renal function,and blood pressure in Shar-predominant group(r>0.50,P<0.05).Multiple regression analysis identified BMI as the primary influencing factor for blood pressure,followed by urea and uric acid.In Shar-predominant group,BMI exerted the strongest effect on blood pressure(β=0.60-0.65,P<0.001).[Conclusions]This study provides important evidence for health management in populations with different constitution types.
基金National Natural Science:Grey Correlation Analysis based on Dynamic Data to Construct A Knowledge Map of the Dynamic Change Law of Chinese Medicine Constitution(No.81904324)National Natural Science Foundation:Discovery and Algorithm Research of"Hierarchical Feature Association Network"for Subjective and Objective Symptoms of Diseases and Bioinformatics based on Data Lake Technology-Taking Diabetes as an Example(No.82174236)。
文摘OBJECTIVE:To find more influencing factors Qideficiency constitution of Traditional Chinese Medicine(TCM)using dynamic and comprehensive information.METHODS:Because grey relational analysis(GRA)is good at processing incomplete information and has no special requirements for sample size and distribution.We acquired 2122 pieces of valid Qi-deficiency constitution dynamic data after preprocessing,and used GRA combing withχ~2 test and multivariate logistic regression analysis to discover and sort the influencing factors of Qideficiency constitution.RESULTS:For the calculation results of GRA,there were 10(62.5%)aspects whose grey correlation degrees were greater than 0.6.The results ofχ~2 test showed that all the above 10 aspects were statistically significant with Qideficiency constitution.The analysis results of multivariate logistic regression analysis showed the following factors were positively correlated with Qi-deficiency constitution:premature birth,sleeping late and getting up early,sleeping late and getting up late,irregular sleeping,sleeping 6.0-6.9 h per day,artificial feeding,female,age at 18-19,and father's age at 18-19 years old when a baby at birth.The following factors were negatively correlated with Qi-deficiency constitution:sleeping 8.0-8.9 h per day and≥9.0 h per day,and age at 30-39 and 40-49 years old.CONCLUSIONS:It is necessary to pay attention to these innate and acquired information of individuals which may lead to Qi-deficiency constitution.And our research also provides a novel methodological thinking for analyzing the influential factors of TCM constitution.
基金supported by the National Natural Science Foundation of China(Nos.81730107 and 81973883)the National Science&Technology Basic Research Project(No.2015FY111700)the Shanghai Pudong New District New Area Project(No.PW2022A-78(WQZ)).
文摘Objectives:By investigating the distinct speech and voice phenotype among TCM constitution for adults,this study aims at providing a convenient and objective methodological reference for judging TCM constitution.Methods:Acoustic analysis and TCM constitution assessment were performed for all 620 participants using Praat software and the CCMQ,respectively.Results:For formant features,the speech duration of special constitution participants was shorter than that of neutral,phlegm-dampness,dampness-heat,Yin-deficiency,or Yang-deficiency participants when pronuncing the vowels/a/,/i/,and/u/.Compare to Yang-deficiency,Qi-deficiency participants had a shorter speech duration when pronucing/i/.For/u/,blood-stasis participants exhibited a lower F1 value than neutral participants.For vocal features,special constitution participants showed higher local jitter than neutral,dampness-heat,and Yang-deficiency participants(for/a/,/i/,and/u/).Higher absolute local jitter than neutral or dampness-heat participants.Compared with neutral or Yang-deficiency participants,special participants owned a higher local shimmer(dB).Special participants had a lower harmonicity autocorrelation than neutral,dampness-heat,or Yang-deficiency participants.Conclusions:Formant features may effectively differentiate special constitution from neutral,phlegm-dampness,dampness-heat,Yin-deficiency,or Yang-deficiency constitutions based on vowel duration measurements(/a/,/i/,/u/).For the vowel/u/,F1 values may help distinguish blood-stasis from neutral constitution.Vocal features appear particularly useful for distinguishing special constitution from neutral,dampness-heat,or Yang-deficiency constitution,with local jitter and harmonicity autocorrelation showing significant discriminatory power.
文摘In Eastern medicine,an individual’s health and longevity is believed to depend on the balance of their metabolic energies,classified as body constitution.Traditional Mongolian Medicine categorizes the body into seven constitution types based on metabolic dominance,influencing physical traits,behavioral tendencies,disease susceptibility,and adaptability to environmental factors.This study aims to analyze the principles of disease prevention based on body constitution in Eastern medicine,with a focus on Traditional Mongolian and Tibetan medical perspectives.It looks to clarify body constitution classifications,explore dietary management strategies,and highlight their significance in maintaining health and preventing diseases.This study adopts a literature review approach,incorporating source analysis,synthesis,and hermeneutic methodology to examine traditional medical theories related to body constitution.Classical texts from Traditional Tibetan medicine,including the rGyud-bZhi and Golden Subtitles,were analyzed alongside comparative research on Traditional Chinese and Korean constitutional medicine.The study integrates historical perspectives with modern biomedical insights to establish a comprehensive understanding of constitution-based health management.The findings indicate that the three principal metabolic energies—rLung,mKhris,and Bad-Kan—serve as symbolic codes representing physiological and metabolic states.By recognizing their body constitution,individuals can adopt constitutionally tailored dietary and lifestyle practices to maintain balance and prevent diseases.A comparative analysis reveals similarities and differences among different Eastern medical systems,while still demonstrating the potential for integrating constitutional medicine with modern healthcare approaches.
文摘Non-tuberculous mycobacterial(NTM)pulmonary disease and pulmonary tuberculosis(TB)are mycobacterium-associated lung disorders that share overlapping clinical and radiological features,yet diverge significantly in pathogenic mechanisms,therapeutic regimens,and long-term prognoses.Traditional east Medicine(TCM)constitution theory,a foundational framework for personalized healthcare,exerts a pivotal influence on disease susceptibility,pathological progression,and clinical outcomes.This review synthesizes state-of-the-art clinical evidence to systematically dissect key discrepancies in TCM constitution distribution between the two conditions,focusing on three core dimensions:distinctive patterns of constitution type distribution,the interplay between constitution and clinical variables,and the clinical relevance of these constitutional differences.Its primary goal is to deliver rigorous theoretical support and actionable guidance for TCM-based differential diagnosis,syndrome-specific interventions,and preventive healthcare strategies for both diseases.
文摘The understanding of the scope of protection for the right to health should not be limited to fragmented descriptions in departmental laws,such as those focusing on rights,interests,or legal benefits.Instead,it should be analyzed holistically within the constitutional framework of fundamental rights.From the perspective of defense right function,the right to health addresses physiological harm that progresses through stages of“risk-danger-infringement,”psychological harm that targets inner distress,and minor harm arising from challenges in social adaptation,to clarify the negative defensive obligations of the state to prevent health-related harm.From the perspectives of the beneficiary right function and the objective value order function,the right to health requires a minimum level of constitutional protection and delineating the positive obligations of the state to ensure it through the fulfillment of basic obligations in healthcare and health promotion.
基金supported by the National Research Foundation(NRF)of South Africa grant number[115581].
文摘Promoting environmental sustainability in South Africa’s cities through public participation is vital for foster-ing inclusive governance and equitable decision-making.Currently,63%of South Africa’s population—and 64%of its youth—live in urban areas,with this figure expected to rise to nearly 80%by 2050.Rapid urbanisation brings significant environmental challenges,including air and noise pollution,greenhouse gas(GHG)emissions,and inadequate waste management.Globally,cities contribute over 70%of GHG emissions and consume two-thirds of the world’s energy.South African cities face similar issues:worsening air quality in regions like the Highveld,water scarcity,urban flooding,waste management problems,and biodiversity loss due to urban sprawl.This article explores how South Africa’s consti-tutional and legislative frameworks support public participation in promoting urban environmental sustainability.Using doctrinal research,it examines key legal instruments—including the Constitution and environmental laws—that establish participatory rights and promote transparency,accountability,and inclusivity.The article draws on court decisions and case studies to highlight ongoing barriers to meaningful participation,particularly for marginalised communities.These include administrative inefficiencies,political interference,and unequal access to information and resources.The article concludes by proposing strategies such as capacity-building initiatives,the integration of traditional knowledge systems,and enhanced institutional coordination to strengthen public participation and improve urban environmental outcomes,addressing both global environmental pressures and South Africa’s unique urban sustainability challenges.
基金funded by the Talent Introduction Project of Anhui Science and Technology University(RCYJ202105)Design and Key Technology Research of Multi Parameter Intelligent Control Instrument Junction Box(tzy202218)+3 种基金Natural Science Research Project of Higher Education Institutions in Anhui Province(2024AH050296)Research and Development of Fermentation Feed Drying Automatic Line(881314)Anhui Provincial Key Laboratory of Functional Agriculture and Functional Food,Anhui Science and Technology University(iFAST-2024-6)Key Technologies and Applications of Impinging Stream Based Plant Protection Hedge Spray System(2024AH050318).
文摘The complex phenomena that occur during the plastic deformation process of aluminum alloys,such as strain rate hardening,dynamic recovery,recrystallization,and damage evolution,can significantly affect the properties of these alloys and limit their applications.Therefore,studying the high-temperature flow stress characteristics of these materials and developing accurate constitutive models has significant scientific research value.In this study,quasi-static tensile tests were conducted on 5754 aluminum alloy using an electronic testing machine combined with a hightemperature environmental chamber to explore its plastic flow behavior under main deformation parameters(such as deformation temperatures,strain rates,and strain).On the basis of true strain-stress data,a BP neural network constitutive model of the alloy was built,aiming to reveal the influence laws of main deformation parameters on flow stress.To further improve the model performance,the ant colony optimization algorithm is introduced to optimize the BP neural network constitutive model,and the relationship between the prediction stability of the model and the parameter settings is explored.Furthermore,the predictability of the two models was evaluated by the statistical indicators,including the correlation coefficient(R^(2)),RMSE,MAE,and confidence intervals.The research results indicate that the prediction accuracy,stability,and generalization ability of the optimized BP neural network constitutive model have been significantly enhanced.
基金supported by the General program of National Natural Science Foundation of China(No.82174243,82204948)the General project of Beijing Natural Science Foundation(No.7242227).
文摘Allergic diseases,encompassing a wide array of conditions such as allergic rhinitis(AR),allergic asthma(AAS),atopic dermatitis(AD),and food allergy(FA),among others,represent a significant menace to global public health.The heterogeneity of these diseases,along with their intricate pathogenesis and propensity for recur-rence,has spurred an escalating demand for efficacious therapeutic strategies.Notwithstanding the advance-ments in western medicine(WM),treatment modalities like antihistamines,sulfonamides,and glucocorticoids exhibit side effects,especially for the neurotoxicity and the adverse reactions of the digestive system.Addi-tionally,physical therapies utilized in allergy management frequently perturb skin metabolism,potentially resulting in stratum corneum impairment,atrophy,pigmentation,and relapse,thereby mandating further investigation and optimization.The management of allergic disorders is often typified by recurrence and diffi-culties in attaining a definitive cure,instigating the pursuit of alternative or adjunctive therapeutic regimens.In this regard,Traditional Chinese Medicine(TCM),which adopts a comprehensive and holistic view of health and disease,confers remarkable advantages in the treatment of allergic conditions.TCM accentuates the significance of personalized treatment,custom-tailored to each patient’s idiosyncratic constitution and disease manifestations,a principle that is especially germane in allergic conditions where standardized treatments frequently fall short.Moreover,TCM interventions,including herbal remedies,acupuncture,and other modalities,are generally associated with a lower incidence of adverse effects compared to conventional therapies,rendering them appealing options for long-term management.The holistic paradigm of TCM permits the concurrent modulation of multiple physiological systems,not only alleviating the symptoms but also rectifying the underlying imbalances that underpin the development and perpetuation of allergic diseases.This approach,in conjunction with the capacity to individualize treatments,implies that TCM harbors sub-stantial potential in conferring more comprehensive and sustainable relief from allergic symptoms.This article delves into the TCM perspective on allergic diseases and the contemporary value of TCM in their treatment.It further explores the developmental pathway of TCM in addressing allergic diseases,dissects the intersection points between traditional theories and modern science,summarizes the key findings and conclusions,and emphasizes the potential and prospects of TCM in this domain.
基金the Natural Science Foundation of Beijing(L232118)the National Natural Science Foundation of China(T2341006)+1 种基金the Beijing University of Chinese Medicine Basic Research Operating Funds(2023‐JYB‐JBZD‐023the High‐Level Key Discipline of National Administration of Traditional Chinese Medicine—Traditional Chinese Constitutional Medicine(zyyzdxk‐2023251).
文摘Persistent physical symptom(PPS)is a common condition in sub‐healthy population and patients with chronic disease,and significantly influences the quality of life.Many PPS cannot be explained by any known disease,and thereby are attributed to socio‐psychological reasons and treated by psychological interventions,such as cognitive behavior treatment.However,it is not ideal to rationalize and manage the PPS lack of pathophysiological explanation relying on psychological approaches.The entrenched disease‐centered biomedical mode limits the perception of PPS.Traditional medicine is a unique methodology of medicine independent from biomedical mode.Traditional Chinese medicine(TCM),achieved knowledge of health and disease from extensive observation and developed theoretical framework based on ancient mathematics using the principles of ancient naive materialism and dialectical materialism,has amassed extensive experience in symptom management.Particularly,the system of body constitution in TCM serves a reference model of evidence‐based integration of traditional and modern medicine in healthcare,and offers a promising approach for managing PPS.Nine types of body constitution were identified and validated through a series of scientific research.Individuals with a specific type of body constitution tend to present a corresponding cluster of symptoms,physical signs,disease susceptibility and prognosis.Adjustment of unhealthy constitution helps the symptom control and disease management.Standardized protocol of body constitution classification was established as an industry standard,and that of body constitution adjustment was compiled as clinical guidelines for quality control.Taken together,such evidence‐based integration of traditional medicine with modern medicine provides new avenues for managing PPS effectively.
基金funded by the institutional program of China Tibetology Research Center(CTRC20236JS08).
文摘Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the prediction and prevention of AMS.Methods:A caseecontrol study was conducted to recruit participants who experienced or did not experience AMS after entering a plateau.The data was collected through online questionnaires for convenient sampling.Demographic characteristics,body constitution,and related states or behaviors were investigated before and after entering the plateau.The participants were divided into case and control groups based on the incidence of AMS.The distributions of relevant factors were compared.Binary logistic regression analysis was used to screen for risk and protective factors.Results:There were 167 participants who completed the questionnaire.A total of 54 cases were excluded,and 113 participants were included,including 52 in the case group and 61 in the control group.In the case group,37,13,and 2 patients had mild,moderate,and severe AMS,respectively.In terms of the Tibetan medicine constitution,the case group had the highest proportion of Bad-rlung(25.0%)and Rlung types(21.2%),whereas the control group had the highest proportion of Bad-rlung(29.5%)and Mkhrisbad types(24.6%).There was no significant difference in the distribution of the constitutional types between the two groups.Insomnia or insufficient sleep within the week prior to entering the plateau and fatigue after arrival were risk factors for AMS,with odds ratios(OR)and 95%confidence intervals(CI)of 5.012(1.871e13.426)and 3.387(1.393e8.236),respectively.A history of short-term plateau travel is a protective factor for AMS(OR:0.32,95%CI:0.129 to 0.792).Conclusion:Insomnia or lack of sleep before ascending to a plateau and fatigue after arrival are risk factors for AMS.The Rlung constitution might be related to the incidence of AMS;however,this still needs to be verified in large-sample observational studies.The risk factors identified in this study can provide a reference for the prevention practice and research of AMS.
文摘BACKGROUND The Asia-Pacific Colorectal Screening(APCS)score was designed with the purpose of distinguishing individuals at high risk(HR)for colorectal advanced neoplasia(AN).Traditional Chinese medicine(TCM)constitution was also linked with colorectal cancer(CRC).AIM To integrate the APCS score with TCM constitution identification as a new algorithm to screen for CRC.METHODS A cross-sectional multicenter study was carried out in three hospitals,enrolling 1430 patients who were asymptomatic and undergoing screening colonoscopy from 2022 to 2023.Patients were considered to have average risk,moderate risk,or HR with their APCS score.Odd ratios assessed the relationship between TCM constitution and disease progression.A TCM constitution risk score was created.The sensitivity and specificity of the new algorithm were calculated to evaluate diagnostic performance in detecting advanced adenoma(AA),CRC,and AN.RESULTS Of the 1430 patients,370(25.9%)were categorized as average risk,755(52.8%)as moderate risk,and 305(21.3%)as HR.Using the combined APCS score and the TCM constitution(damp-heat,qi-deficiency,yang-deficiency,phlegm-dampness,and inherited special constitution as positive)algorithm,72.2%of patients with AA and 73.7%of patients with AN were detected.Compared with the APCS score alone,the new algorithm significantly improved the sensitivity for screening AA[72.2%,95%confidence interval(CI):64.4%-80.0%vs 49.2%,95%CI:40.5%-57.9%]and AN(73.7%,95%CI:66.4%-81.1%vs 51.1%,95%CI:42.7%-59.5%).CONCLUSION The combination of APCS and TCM constitution identification questionnaires was valuable in identifying Chinese individuals who were asymptomatic for colorectal screening prioritization.
基金supported by the Natural Science Foundation of Liaoning Province(No.2022-BS-181).
文摘The phase constitution,microstructure,damping capacity,and mechanical properties of as-cast AlxCrFe3Ni(x=0.5,0.52,0.54,and 0.56,respectively)medium entropy alloys were investigated.It is found that the volume fraction of BCC phase increases while that of FCC decreases with increasing the Al content.When the content of Al is 0.54,the alloy is composed of 82.1vol.%BCC matrix and 17.9vol.%FCC phase.Wherein the FCC phase is distributed on the BCC matrix,forming a structure where the hard BCC matrix is surrounded by soft FCC phase.This results in a hindering effect on the propagation process of vibration waves.The damping performance of Al0.54CrFe_(3)Ni alloy,characterized by an internal friction of Q^(-1) is as high as 0.059,is higher than that of most FeCr damping alloys.The volume fraction of the BCC phase and the peculiar distribution of the FCC phase are identified as the key factors affecting the damping capacity.In addition,the Al0.54CrFe3Ni alloy exhibits a high yield strength of 811.16 MPa.
基金supported by the National Key R&D Program of China(2020YFC2003102).
文摘Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sectional data from seven geographical regions across Chinese mainland.The Changsha version of the Montreal Cognitive Assessment was used to assess cognitive function.A“least absolute shrinkage and selection operator”(LASSO)model,multivariate linear regression analysis,and random forest(RF)model were used.Subgroup analyses were performed to examine the correlation between key TCM constitution types and cognitive function in different population subgroups.Results:A total of 24803 individuals aged 60 and above were included in the study.We selected 18 influential factors using the LASSO model.Higher education,being married,and having insurance were positively correlated with cognitive function in the elderly(all P<0.05).In contrast,poor sleep,vision impairment,hearing impairment,basic activities of daily living disability,instrumental activities of daily living disability,depression,hypertension,coronary heart disease,diabetes,stroke,yang-deficiency constitution(YADC),yin-deficiency constitution(YIDC),qi deficiency constitution(QDC),and blood stasis constitution(BSC)were negatively correlated with cognitive function(all P<0.05).YIDC and BSC affected all dimensions of cognitive function(all P<0.05).YADC mainly affected attention,language,abstraction(verbal analogies),memory,and orientation to time and place dimensions(P<0.001).QDC mainly affected language and abstraction(verbal analogies)dimensions(P<0.05).The negative correlations between BSC,YADC,YIDC,and QDC scores and cognitive function revealed statistically significant dif-ferences across most subgroups.The RF model identified education,BSC,and poor sleep quality as the three most influential factors in our study.Conclusion:BSC,YADC,YIDC,and QDC were associated with cognitive decline in the elderly.Our findings provide new perspectives and significant references for interventions for early-stage cognitive disorders.
基金Shaanxi Provincial People’s Hospital Science and Technology Talent Support Program(Project No.:2023LJ-02)。
文摘Objective:To review the scientific research results of early puberty in children in the past decade,and to explore the current status,hot spots and frontiers of research in the field of early puberty in children.Methods:From January 1,2014 to April 30,2024,literature on early puberty in children was retrieved from CNKI database and Web of Science(WOS)core collection.CiteSpace6.3.R1 software was used for bibliometric analysis of authors,institutions and key words,and related visual maps were drawn.Results:A total of 1548 English literatures and 1113 Chinese literatures were included.The number of published papers in both Chinese and English showed an increasing trend.The authors of the high production in Chinese were Ye Jin and Yang Li,and the high production institutions were the pediatrics department of Hubei University of Chinese Medicine and Shuguang Hospital Affiliated to Shanghai University of Chinese Medicine.The authors are Latronico,Ana Claudia,and Universidade de Sao Paulo.Hot topics in Chinese and English studies include bone age,hormones,genetic inheritance,the correlation between precocious puberty and obesity and short stature.Conclusion:There is an increasing trend of research in the field of early puberty in children.The research on physical identification of children with precocious puberty and the dynamic detection of precocious puberty,height and obesity by Internet is worthy of continuous attention by domestic scholars.
基金Supported by National Natural Science Foundation of China:Role and Mechanism of Microglial Environmental Sensing Element P2RY13 in Ischemic Brain Injury (No.81920108017)Key Research and Development Program of Jiangsu Province of China:Research on the Early Diagnosis, Treatment and Evaluation System and Early Warning Model of Ischemic Cerebrovascular Disease (No.BE2020620)
文摘OBJECTIVE:To explore the effect of Traditional Chinese Medicine(TCM)constitution on cognitive impairment(CI)in patients with cerebral small vessel disease(CSVD)and its underlying neuroimaging mechanism and to provide countermeasures for health management of CSVD patients.METHODS:A total of 241 CSVD patients were recruited from the Department of Neurology.All subjects underwent head magnetic resonance imaging(MRI),Chinese Medicine Questionnaire(CCMQ)and cognitive function examination.The CSVD patients were divided according to the Montreal Cognitive Assessment(MoCA)score into a normal cognitive group(73 cases)and a CI group(168 cases).Logistic regression was used to analyse the risk constitution of CSVD-CI and to construct a risk prediction model.3DT1 MRI images and FreeSurfer 6.0 software(Athinoula A.Martinos,Boston,MA,USA)were used to further explore the involvement of hippocampal subregion volume in patients with at-risk constitution and its correlation with cognitive function.RESULTS:Logistic regression analysis showed that Yang-deficiency constitution(YADC)(P=0.020),older age(P=0.008)and hypertension(P=0.011)were risk factors for CSVD-CI but that balanced constitution(P=0.003)and education(P<0.001)were protective factors.A receiver operating characteristic curve(ROC)was drawn,and the area under the curve was 0.820.Further comparison of overall hippocampal and 12 hippocampal subregion volumes between YADC and non-YADC patients revealed decreased total volume of the left and right hippocampus,bilateral subiculum,presubiculum,molecular layer and right fimbria in the YADC group(P<0.05/13,13 is the number of hypothesis tests).Moreover,in the YADC group,the cognitive function of CSVD patients correlated positively with the overall volume of the left hippocampus(r=0.304,P<0.05)and the molecular layer volume of the left hippocampus(r=0.288,P<0.05).CONCLUSION:CSVD patients with YADC are more prone towards developing CI,and asymmetric atrophy of the hippocampus might be the underlying neuroimaging mechanism.In particular,the volume of the left whole hippocampus and the left hippocampal molecular layer correlated significantly with general cognitive function.
基金Supported by National Natural Science Foundation of China:Establishment and Validation of a High-throughput Screening System for Traditional Chinese Medicine Against Dry Eye Disease based on transforming growth factor-βand B-cell lymphoma-2(No.81574031)2023 Hunan Provincial Department of Education Scientific Research Project:Yiguanjian Decoction Regulates Th17/Treg Cell Balance and Its Intervention Mechanism in Dry Eye with Liver Yin Deficiency Syndrome(No.23A0300)。
文摘OBJECTIVE:To utilize the Traditional Chinese Medicine constitution(TCMC)as a complementary and alternative approach for early disease detection and treatment,with a focus on Yin and Yang deficiency constitutions,which serve as key references for disease prevention and management.METHODS:The dataset containing the data of Yin and Yang deficiency constitution was identified through the Gene Expression Omnibus database.This database was used for differential expression genes(DEGs)analysis and weighted gene co-expression network analysis(WGCNA),and the characteristic genes were then obtained in the dataset using a machine learning method.The hub genes of Yin and Yang deficiency constitution were obtained after analysis using the above three methods,and the hub genes were enriched and analyzed.Subsequently,the hub genes of Yin and Yang deficiency constitution were validated using external datasets.Receiver operating characteristic(ROC)analysis was used on each hub genes of the two groups to further understand their diagnostic performance.The mi RNA–lnc RNA-gene network was used to further analyze the hub genes.Immunoinfiltration and gene set enrichment analysis were performed on the shared hub genes.RESULTS:The GSE87474 dataset was used for DEGs analysis and WGCNA.Using machine learning analyses,we identified 15 and 14 hub genes for Yin and Yang deficiency constitutions,respectively.The results of enrichment analyses showed that Yin deficiency constitution was associated with interleukin-17 signaling pathway,whereas Yang deficiency constitution was associated with glycosaminoglycan biosynthesis–keratan sulfate.The validation dataset GSE56116 showed statistically significant data for s-adenosylmethionine sensor upstream of MTORC1(SAMTOR,also named C7orf60),cofilin 2(CFL2),cytohesin 1 interacting protein(CYTIP),G protein-coupled receptor 183(GPR183),hippocampus abundant transcript 1(HIAT1),kelch like family member 15(KLHL15),mitogen-activated protein kinase 6(MAPK6),and prostaglandin-endoperoxide synthase 2(PTGS2)in Yin deficiency and fucosyltransferase 8(FUT8),TATA-box binding protein associated factor,RNA polymerase I subunit D(TAF1D),zinc finger protein 24(ZNF24),MAPK6,and leptin receptor overlapping transcript like 1(LEPROTL1)in Yang deficiency.The ROC results indicated that these genes have diagnostic value.MAPK6 is a shared hub gene for Yin and Yang deficiencies.CONCLUSIONS:This study identified C7orf60,CFL2,CYTIP,GPR183,HIAT1,KLHL15,MAPK6,and PTGS2 in Yin deficiency and FUT8,TAF1D,ZNF24,MAPK6,and LEPROTL1 in Yang deficiency as potential biomarkers,providing insights into their pathogenesis.This theory not only guides the diagnostic approach in TCM but also extends its influence to various scientific research fields.
