To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator a...To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator at temperatures of 380-440℃and strain rates of 0.05-1 s^(−1).The Johnson-Cook model,Hensel-Spittel model,strain-compensated Arrhenius model,and critical fracture strain model were established.Results show that through the evaluation of the models using the correlation coefficient(R)and the average absolute relative error,the strain-compensated Arrhenius model can represent the flow behavior of the alloy more accurately.Shear bands are more pronounced in the as-homogenized specimens,whereas dynamic recrystallization is predominantly observed in as-rolled specimens.Fracture morphology analysis reveals that a mixed fracture mechanism is prevalent in the as-homogenized specimen,whereas a ductile fracture mechanism is predominant in the as-rolled specimen.The processing maps indicate that the unstable region is reduced in the as-rolled specimens compared with that in the as-homogenized specimens.The optimal hot working windows for the as-homogenized and as-rolled specimens are determined as 410-440℃/0.14-1 s^(−1)and 380-400℃/0.05-0.29 s^(−1),respectively.展开更多
The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we condu...The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.展开更多
To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests ...To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97.展开更多
Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening pa...Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.展开更多
Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstruct...Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)based on TCM constitution theory.Methods:A total of 300 AECOPD patients in the high-risk window period(54-66 cases for each constitution)were randomly divided into two groups(150 cases each).The control group received fluticasone furoate/umeclidinium/vilanterol inhalation therapy,while the experimental group was additionally given constitution-specific TCM decoctions(e.g.,Erchen Decoction combined with Sanzi Yangqin Decoction for Phlegm-Dampness constitution).The treatment course was 8 weeks with a 6-month follow-up.CAT score,TCM syndrome score,pulmonary function,6-minute walking distance(6MWD),and levels of CRP and IL-6 were observed.Recurrence and safety indicators were recorded.Results:After treatment,all indicators improved significantly in both groups(p<0.05),with the experimental group showing superior improvements in CAT score,TCM syndrome score,FEV1,6MWD,and inflammatory indicators(p<0.01).The recurrence rate was lower in the experimental group during follow-up(p<0.05).No severe adverse reactions or abnormalities in liver/kidney function were observed in either group.Conclusion:TCM syndrome differentiation treatment guided by constitution theory can improve symptoms,quality of life,and pulmonary function,reduce inflammatory levels and recurrence rate in AECOPD patients during the high-risk window period,with good safety.展开更多
The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Dia...The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Diaion HP 20 macroporous adsorption resin column chromatography(CC)of the 60%EtOH extract of展开更多
To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me ...To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me for the past few years,regarding the possibility that SC constitutes a phenotype of TTS,or whether it is an altogether different pathophysiological entity.展开更多
With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Aca...With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences(CAS),unraveled the important role of lake sedimentary biogenic silica(BSi)from diatoms as a significant global sink for aluminium(Al),which was published in Nature Communications(2019,10:4829).展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which...OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.展开更多
The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is great...The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is greater than that under creep conditions,indicating that the dynamic stress field significantly influences the rheological behaviours of sandstone.Following the rheological tests,the number of small pores in the sandstone decreased,while the number of medium-sized pores increased,forming new seepage channels.The high initial rheological stress accelerated fracture compression and the closure of seepage channels,resulting in reduction in the permeability of sandstone.Based on the principles of generalized rheology and the experimental findings,a novel rock rheological constitutive model incorporating both the dynamic stress field and seepage properties has been developed.Numerical simulations of surrounding rock deformation in geotechnical engineering were carried out using a secondary development version of this model,which confirmed the applicability of the generalized rheological numerical simulation method.These results provide theoretical support for the long-term stability evaluation of engineering rock masses and for predicting the deformation of surrounding rock.展开更多
A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary ...A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.展开更多
The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,...The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,three novel strain compensation constitutive equations were developed and rigorously assessed.The results indicate that the power function model(correlation coefficients r=0.98544)demonstrates greater prediction accuracy compared to other functions,with a calculated average activation energy of 507.968 kJ mol−1.Additionally,electron backscattered diffraction technology and transmission electron microscopy were used to analyze the evolution of the alloy microstructure during dynamic recrystallization under different deformation conditions.The results show that under high-temperature and large deformation conditions,the dislocation density and the degree of grain rotation increase,which promotes the formation and growth of new recrystallized grains,so that recrystallization is completed when the deformation amount reaches 30%.Besides,the increase in the temperature not only enhances the thermal activation mechanism,but also improves the grain size uniformity and texture consistency.Meanwhile,the carbide inhibits grain overgrowth by pinning grain boundaries,maintaining a fine and uniform grain structure of the alloy,and thereby improving the plasticity of the material.展开更多
Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This s...Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.展开更多
Expanded polystyrene(EPS)concrete,known for its environmental friendliness,energy absorption capacity,and low impedance,has significant potential application in the fields of wave absorption and vibration reduction.Th...Expanded polystyrene(EPS)concrete,known for its environmental friendliness,energy absorption capacity,and low impedance,has significant potential application in the fields of wave absorption and vibration reduction.This study designed and prepared EPS concrete materials with four levels of density.Quasi-static uniaxial compression and Split Hopkinson Pressure Bar(SHPB)impact tests were conducted to obtain stress-strain curves,elastic moduli,failure modes,energy absorptions,and strain rate effects of the EPS concrete under quasi-static and dynamic loading conditions.The influences of density on various performance indicators were analyzed.By combining the Zhu-Wang-Tang(ZWT)constitutive model with a modified elastic-brittle model,a modified dynamic constitutive model was proposed.The accuracy of the model was validated by the experimental data.The results indicate that the addition of EPS particles enhances the ductility of the EPS concrete.The EPS concrete has significant strain rate effect,which gets stronger as density increases.The modifiedconstitutive model accurately characterizes the dynamic stress-strain curves of the EPS concrete.展开更多
Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological s...Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological structures,the underlying micro-behaviors involving time-dependent deformation are poorly understood.For this,an abnormal phenomenon was observed where the axial and lateral creep deformations were mutually independent by a series of triaxial tests under constant stress and strain rate conditions.The significantly large lateral creep deformation implies that the creep process cannot be described in continuum mechanics regime.Herein,it is hypothesized that sliding mechanism of crystal cleavages dominates the lateral creep deformation in coral reef limestone.Then,approaches of polarizing microscope(PM)and scanning electronic microscope(SEM)are utilized to validate the hypothesis.It shows that the sliding behavior of crystal cleavages combats with conventional creep micro-mechanisms at certain condition.The former is sensitive to time and strain rate,and is merely activated in the creep regime.展开更多
A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional ...A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional flow rule.The yield function includes parameters that govern the evolution of yield surface,enabling an accurate description of three-dimensional stress states.The direction of plastic flow is governed by the two different fractional orders,which are functions of the plastic internal variable.Additionally,a detailed process is proposed for identifying the yield function parameters and fractional orders.Subsequently,the relationship between the fractional order and the direction of plastic flow in the meridian and deviatoric planes is examined,characterized by the dilation angle and the plastic deflection angle,respectively.The non-orthogonal flow rule,also referred to as the fractional flow rule,allows for a border range of plastic deflection and dilation angles compared to the orthogonal flow rule,thereby significantly enhancing its applicability.The validity and accuracy of proposed model are verified by comparing the analytical solution of the constitutive model with the experimental data.A comparison between the non-orthogonal flow rule and orthogonal flow rule is conducted in both the deviatoric and meridian planes.The further comparison of the stress-strain curves for the non-orthogonal and orthogonal flow rules demonstrates the superiority of the fractional constitutive model.展开更多
The fatigue fracture under cyclic dynamic direct tensions of brittle rock is an important mechanical characteristic index for the evaluation of geological disasters and underground engineering safety.However,most stud...The fatigue fracture under cyclic dynamic direct tensions of brittle rock is an important mechanical characteristic index for the evaluation of geological disasters and underground engineering safety.However,most studies focus on macroscopic fracture mechanical properties,and the mechanism linking the macroscopic fracture with the microcrack growth during the cyclic dynamic direct tensile loading of brittle rocks is rarely studied.In this paper,a micro-macro fracture model explaining the stress-strain constitutive relationship is established at the last impact failure after being subjected to multiple cyclic direct tensile impacts of brittle rocks.This model is based on the wing crack extension model under direct tensile loading,the quasi-static and dynamic fracture toughness relationship,the suggested crack rate and strain rate relationship,the relationship of damage and dynamic tensile fatigue life N,the relationship of dynamic fracture toughness and dynamic tensile fatigue life N.The variations of dynamic mechanical properties of rocks with dynamic tensile fatigue life for different initial crack sizes and angles within the rocks are further discussed.The compressive strength,elastic modulus,crack initiation stress,limit crack extension length and crack extension rate descend and the failure strain ascends with an increment of dynamic tensile fatigue life in rocks.This study's results provide help for the safety and stability of the underground surrounding rocks under blasting working or seismic disasters.展开更多
The study focuses on the creep characteristics of significant yellow sandstone for water conservancy, hydropower, and other waterrelated slope excavation unloading rock-graded loading creep characteristics. It conduct...The study focuses on the creep characteristics of significant yellow sandstone for water conservancy, hydropower, and other waterrelated slope excavation unloading rock-graded loading creep characteristics. It conducts a uniaxial graded loading creep test on yellow sandstone under different pre-peak unloading and wetting-drying cycles. The improved nonlinear Nishihara model was obtained by introducing a nonlinear viscous element with an accelerated creep threshold switch. The sensitivity characteristics of the parameters of the improved creep model were analyzed and a nonlinear creep constitutive model was established, considering the unloading-cyclic intrinsic damage induced by water intrusion. The research results show that:(1)With an increase in the unloading point, the porosity of the rock samples initially decreases and then increases. As the number of cyclic water intrusions rises, the porosity of the rock samples gradually increases, reaching a maximum of 9.58% at an unloading point of 70% uniaxial compression stress(0.7 Rc) after five cycles.(2) Total creep deformation increases with the number of cyclic water intrusions;however, with an increase in the unloading ratio, the original samples show an initial decrease, followed by an increase in creep deformation. With a higher unloading ratio and various instances of cyclic water intrusion, the total creep time of the rock samples,compared to the original samples, is reduced by 21.8%and 23.02%. The creep damage mode gradually changes from shear damage to tensile damage.(3) The sensitivity characteristics of the improved creep model parameters show that transient elasticity modulus E1 is affected by the coupling of unloading and cyclic water intrusion. The viscoelastic modulus E2 and viscous coefficient η1 are mainly affected by unloading and cyclic water intrusion.(4) Based on the strain equivalence principle of damage mechanics, the damage treatment of the parameters in the original model is improved to construct a nonlinear creep constitutive model that considers unloading-cyclic water intrusion damage. A parameter inversion and comparison to the traditional Nishihara model reveal an average relative standard deviation of 0.271%,significantly less than 1%, indicating a more accurate nonlinear creep constitutive model. The research results are crucial for analyzing the long-term stability of water-related steep rocky slopes post-excavation and unloading and for preventing and controlling creep-type landslide disasters.展开更多
The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique natu...The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.展开更多
文摘To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator at temperatures of 380-440℃and strain rates of 0.05-1 s^(−1).The Johnson-Cook model,Hensel-Spittel model,strain-compensated Arrhenius model,and critical fracture strain model were established.Results show that through the evaluation of the models using the correlation coefficient(R)and the average absolute relative error,the strain-compensated Arrhenius model can represent the flow behavior of the alloy more accurately.Shear bands are more pronounced in the as-homogenized specimens,whereas dynamic recrystallization is predominantly observed in as-rolled specimens.Fracture morphology analysis reveals that a mixed fracture mechanism is prevalent in the as-homogenized specimen,whereas a ductile fracture mechanism is predominant in the as-rolled specimen.The processing maps indicate that the unstable region is reduced in the as-rolled specimens compared with that in the as-homogenized specimens.The optimal hot working windows for the as-homogenized and as-rolled specimens are determined as 410-440℃/0.14-1 s^(−1)and 380-400℃/0.05-0.29 s^(−1),respectively.
基金support to this study from the National Natural Science Foundation of China,NSFC(Grant No.52278367)The Belt and Road Special Foundation of the National Key Laboratory ofWater Disaster Prevention(Grant No.2024nkms08).
文摘The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.
基金supported by the Yunnan Province Science and Technology Plan Project(No.202403AA080001-4)the Key Research and Development Project of Guangxi,China(No.guikeAB24010144)the National Key Research and Development Project of China(Nos.2021YFB3901402 and 2018YFC1504802)。
文摘To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97.
基金financial support of the National Natural Science Foundation of China(No.52371103)the Fundamental Research Funds for the Central Universities,China(No.2242023K40028)+1 种基金the Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials,China(No.AMM2023B01).financial support of the Research Fund of Shihezi Key Laboratory of AluminumBased Advanced Materials,China(No.2023PT02)financial support of Guangdong Province Science and Technology Major Project,China(No.2021B0301030005)。
文摘Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.
基金Longquan Yi District Health Bureau Project(Project No.:WJKY2023009)。
文摘Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)based on TCM constitution theory.Methods:A total of 300 AECOPD patients in the high-risk window period(54-66 cases for each constitution)were randomly divided into two groups(150 cases each).The control group received fluticasone furoate/umeclidinium/vilanterol inhalation therapy,while the experimental group was additionally given constitution-specific TCM decoctions(e.g.,Erchen Decoction combined with Sanzi Yangqin Decoction for Phlegm-Dampness constitution).The treatment course was 8 weeks with a 6-month follow-up.CAT score,TCM syndrome score,pulmonary function,6-minute walking distance(6MWD),and levels of CRP and IL-6 were observed.Recurrence and safety indicators were recorded.Results:After treatment,all indicators improved significantly in both groups(p<0.05),with the experimental group showing superior improvements in CAT score,TCM syndrome score,FEV1,6MWD,and inflammatory indicators(p<0.01).The recurrence rate was lower in the experimental group during follow-up(p<0.05).No severe adverse reactions or abnormalities in liver/kidney function were observed in either group.Conclusion:TCM syndrome differentiation treatment guided by constitution theory can improve symptoms,quality of life,and pulmonary function,reduce inflammatory levels and recurrence rate in AECOPD patients during the high-risk window period,with good safety.
文摘The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Diaion HP 20 macroporous adsorption resin column chromatography(CC)of the 60%EtOH extract of
文摘To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me for the past few years,regarding the possibility that SC constitutes a phenotype of TTS,or whether it is an altogether different pathophysiological entity.
文摘With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences(CAS),unraveled the important role of lake sedimentary biogenic silica(BSi)from diatoms as a significant global sink for aluminium(Al),which was published in Nature Communications(2019,10:4829).
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
基金National Nonprofit Institute Research Grant for the Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences:Mechanism of Regulating Phlegm-Dampness Constitution to Prevent Metabolic Diseases based on Gut Microbiota-host DNA Methylation(No.YZ-202151)。
文摘OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.
基金supported and financed by Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology (No.2024yjrc96)Anhui Provincial University Excellent Research and Innovation Team Support Project (No.2022AH010053)+2 种基金National Key Research and Development Program of China (Nos.2023YFC2907602 and 2022YFF1303302)Anhui Provincial Major Science and Technology Project (No.202203a07020011)Open Foundation of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining (No.EC2023020)。
文摘The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is greater than that under creep conditions,indicating that the dynamic stress field significantly influences the rheological behaviours of sandstone.Following the rheological tests,the number of small pores in the sandstone decreased,while the number of medium-sized pores increased,forming new seepage channels.The high initial rheological stress accelerated fracture compression and the closure of seepage channels,resulting in reduction in the permeability of sandstone.Based on the principles of generalized rheology and the experimental findings,a novel rock rheological constitutive model incorporating both the dynamic stress field and seepage properties has been developed.Numerical simulations of surrounding rock deformation in geotechnical engineering were carried out using a secondary development version of this model,which confirmed the applicability of the generalized rheological numerical simulation method.These results provide theoretical support for the long-term stability evaluation of engineering rock masses and for predicting the deformation of surrounding rock.
基金supported by the National Key R&D Program of China(No.2021YFB3400900)the National Natural Science Foundation of China(Nos.52175373,52205435)+1 种基金Natural Science Foundation of Hunan Province,China(No.2022JJ40621)the Innovation Fund of National Commercial Aircraft Manufacturing Engineering Technology Center,China(No.COMACSFGS-2022-1875)。
文摘A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.
基金supported by the National Key R&D Program of China(No.2021YFB3700403).
文摘The hot deformation behavior of the premium GH4738 alloy was investigated in the temperature range of 1313 to 1353 K at strain rates of 0.01 to 1 s^(−1)using the hot compression test.To accurately predict flow stress,three novel strain compensation constitutive equations were developed and rigorously assessed.The results indicate that the power function model(correlation coefficients r=0.98544)demonstrates greater prediction accuracy compared to other functions,with a calculated average activation energy of 507.968 kJ mol−1.Additionally,electron backscattered diffraction technology and transmission electron microscopy were used to analyze the evolution of the alloy microstructure during dynamic recrystallization under different deformation conditions.The results show that under high-temperature and large deformation conditions,the dislocation density and the degree of grain rotation increase,which promotes the formation and growth of new recrystallized grains,so that recrystallization is completed when the deformation amount reaches 30%.Besides,the increase in the temperature not only enhances the thermal activation mechanism,but also improves the grain size uniformity and texture consistency.Meanwhile,the carbide inhibits grain overgrowth by pinning grain boundaries,maintaining a fine and uniform grain structure of the alloy,and thereby improving the plasticity of the material.
基金support from the National Natural Science Foundation of China(No.52308316)the Scientific Research Foundation of Weifang University(Grant No.2024BS42)+2 种基金China Postdoctoral Science Foundation(No.2022M721885)the Key Laboratory of Rock Mechanics and Geohazards of Zhejiang Province(No.ZJRMG-2022-01)supported by Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences(NO.SKLGME023017).
文摘Investigating the combined effects of mining damage and creep damage on slope stability is crucial,as it can comprehensively reveal the non-linear deformation characteristics of rock under their joint influence.This study develops a fractional-order nonlinear creep constitutive model that incorporates the double damage effect and implements a non-linear creep subroutine for soft rock using the threedimensional finite difference method on the FLAC3D platform.Comparative analysis of the theoretical,numerical,and experimental results reveals that the fractional-order constitutive model,which incorporates the double damage effect,accurately reflects the distinct deformation stages of green mudstone during creep failure and effectively captures the non-linear deformation in the accelerated creep phase.The numerical results show a fitting accuracy exceeding 97%with the creep test curves,significantly outperforming the 61%accuracy of traditional creep models.
基金Supports from National Natural Science Foundation of China(U20A20286 and 12372135)。
文摘Expanded polystyrene(EPS)concrete,known for its environmental friendliness,energy absorption capacity,and low impedance,has significant potential application in the fields of wave absorption and vibration reduction.This study designed and prepared EPS concrete materials with four levels of density.Quasi-static uniaxial compression and Split Hopkinson Pressure Bar(SHPB)impact tests were conducted to obtain stress-strain curves,elastic moduli,failure modes,energy absorptions,and strain rate effects of the EPS concrete under quasi-static and dynamic loading conditions.The influences of density on various performance indicators were analyzed.By combining the Zhu-Wang-Tang(ZWT)constitutive model with a modified elastic-brittle model,a modified dynamic constitutive model was proposed.The accuracy of the model was validated by the experimental data.The results indicate that the addition of EPS particles enhances the ductility of the EPS concrete.The EPS concrete has significant strain rate effect,which gets stronger as density increases.The modifiedconstitutive model accurately characterizes the dynamic stress-strain curves of the EPS concrete.
基金supported by the National Natural Science Foundation of China(Grant Nos.41877267,41877260)the Priority Research Program of the Chinese Academy of Science(Grant No.XDA13010201).
文摘Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological structures,the underlying micro-behaviors involving time-dependent deformation are poorly understood.For this,an abnormal phenomenon was observed where the axial and lateral creep deformations were mutually independent by a series of triaxial tests under constant stress and strain rate conditions.The significantly large lateral creep deformation implies that the creep process cannot be described in continuum mechanics regime.Herein,it is hypothesized that sliding mechanism of crystal cleavages dominates the lateral creep deformation in coral reef limestone.Then,approaches of polarizing microscope(PM)and scanning electronic microscope(SEM)are utilized to validate the hypothesis.It shows that the sliding behavior of crystal cleavages combats with conventional creep micro-mechanisms at certain condition.The former is sensitive to time and strain rate,and is merely activated in the creep regime.
基金sponsored by the National Natural Science Foundation of China(Grant No.42141010).
文摘A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional flow rule.The yield function includes parameters that govern the evolution of yield surface,enabling an accurate description of three-dimensional stress states.The direction of plastic flow is governed by the two different fractional orders,which are functions of the plastic internal variable.Additionally,a detailed process is proposed for identifying the yield function parameters and fractional orders.Subsequently,the relationship between the fractional order and the direction of plastic flow in the meridian and deviatoric planes is examined,characterized by the dilation angle and the plastic deflection angle,respectively.The non-orthogonal flow rule,also referred to as the fractional flow rule,allows for a border range of plastic deflection and dilation angles compared to the orthogonal flow rule,thereby significantly enhancing its applicability.The validity and accuracy of proposed model are verified by comparing the analytical solution of the constitutive model with the experimental data.A comparison between the non-orthogonal flow rule and orthogonal flow rule is conducted in both the deviatoric and meridian planes.The further comparison of the stress-strain curves for the non-orthogonal and orthogonal flow rules demonstrates the superiority of the fractional constitutive model.
基金supported by the National Natural Science Foundation of China(Grant Nos.51708016,52438007 and 12172036)the R&D program of Beijing Municipal Education Commission(Grant No.KM202110016014)+1 种基金the Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture(Grant No.JDYC20200307)the Graduate Innovation Program of Beijing University of Civil Engineering and Architecture(Grant No.PG2025060).
文摘The fatigue fracture under cyclic dynamic direct tensions of brittle rock is an important mechanical characteristic index for the evaluation of geological disasters and underground engineering safety.However,most studies focus on macroscopic fracture mechanical properties,and the mechanism linking the macroscopic fracture with the microcrack growth during the cyclic dynamic direct tensile loading of brittle rocks is rarely studied.In this paper,a micro-macro fracture model explaining the stress-strain constitutive relationship is established at the last impact failure after being subjected to multiple cyclic direct tensile impacts of brittle rocks.This model is based on the wing crack extension model under direct tensile loading,the quasi-static and dynamic fracture toughness relationship,the suggested crack rate and strain rate relationship,the relationship of damage and dynamic tensile fatigue life N,the relationship of dynamic fracture toughness and dynamic tensile fatigue life N.The variations of dynamic mechanical properties of rocks with dynamic tensile fatigue life for different initial crack sizes and angles within the rocks are further discussed.The compressive strength,elastic modulus,crack initiation stress,limit crack extension length and crack extension rate descend and the failure strain ascends with an increment of dynamic tensile fatigue life in rocks.This study's results provide help for the safety and stability of the underground surrounding rocks under blasting working or seismic disasters.
基金We gratefully acknowledge the financial support from the Key Laboratory of Geological Safety of Coastal Urban Underground Space,Ministry of Natural Resources(BHKF2022Y03)Shandong Provincial Colleges and Universities Youth Innovation Technology Support Program,Education Department of Shandong Province(grant number 2023KJ092).
文摘The study focuses on the creep characteristics of significant yellow sandstone for water conservancy, hydropower, and other waterrelated slope excavation unloading rock-graded loading creep characteristics. It conducts a uniaxial graded loading creep test on yellow sandstone under different pre-peak unloading and wetting-drying cycles. The improved nonlinear Nishihara model was obtained by introducing a nonlinear viscous element with an accelerated creep threshold switch. The sensitivity characteristics of the parameters of the improved creep model were analyzed and a nonlinear creep constitutive model was established, considering the unloading-cyclic intrinsic damage induced by water intrusion. The research results show that:(1)With an increase in the unloading point, the porosity of the rock samples initially decreases and then increases. As the number of cyclic water intrusions rises, the porosity of the rock samples gradually increases, reaching a maximum of 9.58% at an unloading point of 70% uniaxial compression stress(0.7 Rc) after five cycles.(2) Total creep deformation increases with the number of cyclic water intrusions;however, with an increase in the unloading ratio, the original samples show an initial decrease, followed by an increase in creep deformation. With a higher unloading ratio and various instances of cyclic water intrusion, the total creep time of the rock samples,compared to the original samples, is reduced by 21.8%and 23.02%. The creep damage mode gradually changes from shear damage to tensile damage.(3) The sensitivity characteristics of the improved creep model parameters show that transient elasticity modulus E1 is affected by the coupling of unloading and cyclic water intrusion. The viscoelastic modulus E2 and viscous coefficient η1 are mainly affected by unloading and cyclic water intrusion.(4) Based on the strain equivalence principle of damage mechanics, the damage treatment of the parameters in the original model is improved to construct a nonlinear creep constitutive model that considers unloading-cyclic water intrusion damage. A parameter inversion and comparison to the traditional Nishihara model reveal an average relative standard deviation of 0.271%,significantly less than 1%, indicating a more accurate nonlinear creep constitutive model. The research results are crucial for analyzing the long-term stability of water-related steep rocky slopes post-excavation and unloading and for preventing and controlling creep-type landslide disasters.
基金Project(42202318)supported by the National Natural Science Foundation of ChinaProject(252300421199)supported by the Natural Science Foundation of Henan Province,ChinaProject(2024JJ6219)supported by the Hunan Provincial Natural Science Foundation of China。
文摘The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.
