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Study on Affecting Factors of the Consistency of Printed Electrodes Based on an Online Pressure Monitoring System
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作者 CAI Zi-mu GU Jin-tao +2 位作者 CHENG Guang-kai XU Guang-yi LI Yan 《印刷与数字媒体技术研究》 北大核心 2025年第2期91-97,共7页
In order to address the current inability of screen printing to monitor printing pressure online,an online printing pressure monitoring system applied to screen printing machines was designed in this study.In this stu... In order to address the current inability of screen printing to monitor printing pressure online,an online printing pressure monitoring system applied to screen printing machines was designed in this study.In this study,the consistency of printed electrodes was measured by using a confocal microscope and the pressure distribution detected by online pressure monitoring system was compared to investigate the relationship.The results demonstrated the relationship between printing pressure and the consistency of printed electrodes.As printing pressure increases,the ink layer at the corresponding position becomes thicker and that higher printing pressure enhances the consistency of the printed electrodes.The experiment confirms the feasibility of the online pressure monitoring system,which aids in predicting and controlling the consistency of printed electrodes,thereby improving their performance. 展开更多
关键词 Printing pressure consistency of printed electrodes Screen printing Online monitoring
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Chinese Blackbirds(Turdus mandarinus)mimic electric moped sounds withlower consistency and frequencies
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作者 Changjian Fu Vishal Kumar Prasad +1 位作者 Xiaochun Wang Zhongqiu Li 《Avian Research》 2025年第2期176-184,共9页
Passerine mimics often imitate various vocalizations from other bird species and incorporate these sounds into their song repertoires.While a few anecdotes reported that wild songbirds imitated human-associated sounds... Passerine mimics often imitate various vocalizations from other bird species and incorporate these sounds into their song repertoires.While a few anecdotes reported that wild songbirds imitated human-associated sounds,besides captive parrots and songbirds,systemic and quantitative studies on human-made sound mimicry in wild birds remain scarce.In this study,we investigated the mimetic accuracy and consistency of electric moped sounds imitated by an urban bird,the Chinese Blackbird(Turdus mandarinus).We found that:(1)Only one type of electric moped sound was imitated,i.e.,13 of 26 males mimicked the first part of the antitheft alarm,a phrase containing a series of identical notes.(2)The mimicry produced by male Chinese Blackbirds had fewer notes and lower consistency within phrases compared to the model alarms.(3)The mimicry of male Chinese Blackbirds was imperfect,i.e.,most of the acoustic parameters differed from the model alarms.Additionally,mimetic notes were lower in frequency than the models.Mimetic notes from two areas were also different in acoustic structures,suggesting Chinese Blackbirds might learn mimicry mainly from conspecific neighbors within each area respectively rather than electric mopeds,namely the secondary mimicry.Imperfect mimicry of human-made sounds could result from cost and physical constraints,associated with high consistency,frequency,and repetitions.Consequently,Chinese Blackbirds copied a simplified version of electric moped alarms.We recommend further attention to mimic species inhabiting urban ecosystems to better understand vocal mimicry's adaptation to ongoing urbanization. 展开更多
关键词 BIRDSONG Human-made sound Mimetic accuracy Turdus mandarinus Vocal consistency Vocal mimicry
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The Development of Artificial Intelligence:Toward Consistency in the Logical Structures of Datasets,AI Models,Model Building,and Hardware?
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作者 Li Guo Jinghai Li 《Engineering》 2025年第7期13-17,共5页
The aim of this article is to explore potential directions for the development of artificial intelligence(AI).It points out that,while current AI can handle the statistical properties of complex systems,it has difficu... The aim of this article is to explore potential directions for the development of artificial intelligence(AI).It points out that,while current AI can handle the statistical properties of complex systems,it has difficulty effectively processing and fully representing their spatiotemporal complexity patterns.The article also discusses a potential path of AI development in the engineering domain.Based on the existing understanding of the principles of multilevel com-plexity,this article suggests that consistency among the logical structures of datasets,AI models,model-building software,and hardware will be an important AI development direction and is worthy of careful consideration. 展开更多
关键词 consistency datasets model building ai models artificial intelligence ai explore potential directions HARDWARE artificial intelligence
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A Facial Expression Recognition Network Using Rebalance-Based Regulation of Attention Consistency and Focus
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作者 Xiaoliang Zhu Hao Chen +2 位作者 Xin Yang Zhicheng Dai Liang Zhao 《Computers, Materials & Continua》 2025年第10期1585-1602,共18页
Facial expression datasets commonly exhibit imbalances between various categories or between difficult and simple samples.This imbalance introduces bias into feature extraction within facial expression recognition(FER... Facial expression datasets commonly exhibit imbalances between various categories or between difficult and simple samples.This imbalance introduces bias into feature extraction within facial expression recognition(FER)models,which hinders the algorithm’s comprehension of emotional states and reduces the overall recognition accuracy.A novel FER model is introduced to address these issues.It integrates rebalancing mechanisms to regulate attention consistency and focus,offering enhanced efficacy.Our approach proposes the following improvements:(i)rebalancing weights are used to enhance the consistency between the heatmaps of an original face sample and its horizontally flipped counterpart;(ii)coefficient factors are incorporated into the standard cross entropy loss function,and rebalancing weights are incorporated to fine-tune the loss adjustment.Experimental results indicate that the FER model outperforms the current leading algorithm,MEK,achieving 0.69%and 2.01%increases in overall and average recognition accuracies,respectively,on the RAF-DB dataset.The model exhibits accuracy improvements of 0.49%and 1.01%in the AffectNet dataset and 0.83%and 1.23%in the FERPlus dataset,respectively.These outcomes validate the superiority and stability of the proposed FER model. 展开更多
关键词 FER attention consistency focus regulation RAF-DB rebalancing
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Entropy Consistency-Based Adaptive Sampling Method for Determining the Scale Effect in the Joint Roughness Coefficient
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作者 Jibo Qin Jun Ye +1 位作者 Xiaoming Sun Shigui Du 《Journal of Earth Science》 2025年第2期644-653,共10页
The joint roughness coefficient(JRC) is one of the key parameters for evaluating the shear strength of rock joints.Because of the scale effect in the JRC,reliable JRC values are of great importance for most rock engin... The joint roughness coefficient(JRC) is one of the key parameters for evaluating the shear strength of rock joints.Because of the scale effect in the JRC,reliable JRC values are of great importance for most rock engineering projects.During the collection process of JRC samples,the redundancy or insufficiency of representative rock joint surface topography(RJST) information in serial length JRC samples is the essential reason that affects the reliability of the scale effect results.Therefore,this paper proposes an adaptive sampling method,in which we use the entropy consistency measure Q(a) to evaluate the consistency of the joint morphology information contained in adjacent JRC samples.Then the sampling interval is automatically adjusted according to the threshold Q(at) of the entropy consistency measure to ensure that the degree of change of RJST information between JRC samples is the same,and ultimately makes the representative RJST information in the collected JRC samples more balanced.The application results of actual cases show that the proposed method can obtain the scale effect in the JRC efficiently and reliably. 展开更多
关键词 sampling method joint roughness coefficient(JRC) scale effect entropy consistency measure rock joint engineering geology
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Analysis of the consistency status and influencing factors of binary symptom assessment in patients with heart failure
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作者 Chen-Ming Li Gu-Yue Yan +2 位作者 Lu Yu Qi Zhang Qing Wu 《Nursing Communications》 2025年第22期1-12,共12页
Background:To investigate the consistency level of binary symptom assessment in patients with heart failure and their primary caregivers,and to analyze the related factors influencing consistency.Methods:By using the ... Background:To investigate the consistency level of binary symptom assessment in patients with heart failure and their primary caregivers,and to analyze the related factors influencing consistency.Methods:By using the convenience sampling method,patients with heart failure and their main caregivers in the Department of Cardiology of a tertiary hospital in Suzhou from May to November 2023 were selected as the research subjects.The HFSS scale was used for data collection.The paired t-test or paired Wilcoxon test was used to evaluate the differences in the binary symptom assessment scores of heart failure.The intraclass correlation coefficient was used to assess the consistency level of the binary symptom assessment.The Pearson correlation test was used to examine the correlation of the binary symptom assessment.Regression analysis was employed to explore the factors related to the consistency assessment.Results:A total of 103 pairs of valid questionnaires were collected.The consistency levels of symptom evaluations in patients with heart failure and their primary caregivers were statistically significant(P<0.05).The most frequently reported and severe symptom by patients with heart failure and their primary caregivers is shortness of breath during activity.Both have a high consensus on the severity and urgency of most heart failure symptoms.The patient’s gender,body mass index,number of children,history of diabetes,number of comorbidities,mean arterial pressure,LVEF,number of stents,whether a defibrillator was implanted,as well as the gender,marital status,education level,relationship with the patient,care time,whether they lived together,and communication and interaction situation of the main caregiver were the influencing factors for the consistency of binary symptom assessment of heart failure(P<0.05).Conclusion:The degree of consistency in binary symptom assessment between patients with heart failure and their primary caregivers was moderate or higher,which emphasizes the importance of including binary groups in clinical assessment. 展开更多
关键词 heart failure symptom assessment BINARY consistency study
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Identifying Suitable Sites for CSP Plants Using AHP,Fuzzy AHP,and Full Consistency Method:A Case Study of CHAD
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作者 Bernard Bayangbe Ababacar Thiam +1 位作者 El hadji I.Cissé Kory Faye 《Energy Engineering》 2025年第3期943-969,共27页
Concentrating Solar Power(CSP)is one of the most promising solar technologies for sustainable power generation in countrieswith high solar potential,likeChad.Identifying suitable sites is of great importance for deplo... Concentrating Solar Power(CSP)is one of the most promising solar technologies for sustainable power generation in countrieswith high solar potential,likeChad.Identifying suitable sites is of great importance for deploying solar power plants.This work focuses on the identification of potential sites for the installation of solar power plants in Chad as well as a comparative analysis using the Analytical Hierarchy Process(AHP),Fuzzy Analytical Hierarchy Process(FAHP),and Full Consistency Method(FUCOM).The results show that 35%of the Chadian territory,i.e.,an area of 449,400 km2,is compatible with the implementation of Concentrating Solar Power.The North,North,East,Southeast,and East zones are the most suitable.The main criteria for influence are direct normal irradiation,the soil slope,and the water resource.FUCOM gave a weight of 41.9%for Direct Normal Irradiation(DNI)compared to 32.71%and 31.81%for AHP and FAHP.This method can be applied to other renewable energy technologies such as photovoltaics,wind power,and biomass.Combining its different analyses will be a valuable tool for planning any renewable energy project in Chad.This work should also facilitate the techno-economic analysis of future CSP plants in Chad. 展开更多
关键词 Concentrating solar power analytical hierarchy process fuzzy analytical hierarchy process full consistency method geographic information system direct normal irradiation
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A Two-Layer Energy Management Strategy for Fuel Cell Ships Considering the Performance Consistency of Fuel Cells
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作者 Yi Zhang Diju Gao +1 位作者 Yide Wang Zhaoxia Huang 《Energy Engineering》 2025年第9期3681-3702,共22页
Hydrogen fuel cell ships are one of the key solutions to achieving zero carbon emissions in shipping.Multi-fuel cell stacks(MFCS)systems are frequently employed to fulfill the power requirements of high-load power equ... Hydrogen fuel cell ships are one of the key solutions to achieving zero carbon emissions in shipping.Multi-fuel cell stacks(MFCS)systems are frequently employed to fulfill the power requirements of high-load power equipment on ships.Compared to single-stack system,MFCS may be difficult to apply traditional energy management strategies(EMS)due to their complex structure.In this paper,a two-layer power allocation strategy for MFCS of a hydrogen fuel cell ship is proposed to reduce the complexity of the allocation task by splitting it into each layer of the EMS.The first layer of the EMSis centered on the Nonlinear Model Predictive Control(NMPC).The Northern Goshawk Optimization(NGO)algorithm is used to solve the nonlinear optimization problem in NMPC,and the local fine search is performed using sequential quadratic programming(SQP).Based on the power allocation results of the first layer,the second layer is centered on a fuzzy rule-based adaptive power allocation strategy(AP-Fuzzy).The membership function bounds of the fuzzy controller are related to the aging level of the MFCS.The Particle Swarm Optimization(PSO)algorithm is used to optimize the parameters of the residual membership function to improve the performance of the proposed strategy.The effectiveness of the proposed EMS is verified by comparing it with the traditional EMS.The experimental results show that the EMS proposed in this paper can ensure reasonable hydrogen consumption,slow down the FC aging and equalize its performance,effectively extend the system life,and ensure that the ship has good endurance after completing the mission. 展开更多
关键词 Energy management strategy fuel cell nonlinear model predictive control fuzzy rule control performance consistency hydrogen fuel cell ship
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Teaching-Learning-Assessment Consistency of the 5E Teaching Model and Its Application of English Picture Book Teaching in Elementary School
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作者 HE Ai-jing YUAN Ling-na HUANG Lin-lin 《Journal of Literature and Art Studies》 2025年第7期580-586,共7页
The 5E model includes Engagement,Exploration,Explanation,Elaboration,and Evaluation,with“Evaluation”at the end,conflicting with teaching learning-evaluation consistency.Thus,formative levaluation is integrated into ... The 5E model includes Engagement,Exploration,Explanation,Elaboration,and Evaluation,with“Evaluation”at the end,conflicting with teaching learning-evaluation consistency.Thus,formative levaluation is integrated into the first four stages,and a summative evaluation table is designed for the fifth,enabling students to self-evaluate and reflect.Elementary school English picture book teaching is used as an example to demonstrate the optimized model's application. 展开更多
关键词 teaching and evaluation consistency 5E teaching model elementary English picture book teaching
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Learning monocular face reconstruction from in the wild images using rotation cycle consistency
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作者 Xinrong HU Kaifan YANG +2 位作者 Ruiqi LUO Tao PENG Junping LIU 《虚拟现实与智能硬件(中英文)》 2025年第4期379-392,共14页
With the popularity of the digital human body,monocular three-dimensional(3D)face reconstruction is widely used in fields such as animation and face recognition.Although current methods trained using single-view image... With the popularity of the digital human body,monocular three-dimensional(3D)face reconstruction is widely used in fields such as animation and face recognition.Although current methods trained using single-view image sets perform well in monocular 3D face reconstruction tasks,they tend to rely on the constraints of the a priori model or the appearance conditions of the input images,fundamentally because of the inability to propose an effective method to reduce the effects of two-dimensional(2D)ambiguity.To solve this problem,we developed an unsupervised training framework for monocular face 3D reconstruction using rotational cycle consistency.Specifically,to learn more accurate facial information,we first used an autoencoder to factor the input images and applied these factors to generate normalized frontal views.We then proceeded through a differentiable renderer to use rotational consistency to continuously perceive refinement.Our method provided implicit multi-view consistency constraints on the pose and depth information estimation of the input face,and the performance was accurate and robust in the presence of large variations in expression and pose.In the benchmark tests,our method performed more stably and realistically than other methods that used 3D face reconstruction in monocular 2D images. 展开更多
关键词 3D face reconstruction View synthesis Rotation cycle consistency
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极端天气下高速公路自洽能源系统应急资源优化调度方案
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作者 李艳波 张云锐 +4 位作者 杨凯 陈楚润 吕浩楠 武奇生 陈俊硕 《西安交通大学学报》 北大核心 2026年第1期190-200,共11页
针对近年来频发的极端天气灾害对高速公路交通及电力网络基础设施造成严重破坏,导致灾后应急资源调度困难的问题,提出了一种考虑交通网(TN)-电力网(PN)耦合网络的高速公路应急资源优化调度方案。分别搭建TN和PN模型以及TN-PN耦合网络模... 针对近年来频发的极端天气灾害对高速公路交通及电力网络基础设施造成严重破坏,导致灾后应急资源调度困难的问题,提出了一种考虑交通网(TN)-电力网(PN)耦合网络的高速公路应急资源优化调度方案。分别搭建TN和PN模型以及TN-PN耦合网络模型;结合历史气象数据构建极端天气模型并利用蒙特卡罗模拟抽样方法模拟故障场景,得到极端天气运行情况以及线路故障率曲线;利用Dijkstra算法分析应急资源移动路径并构建其调度模型,求出灾后最优调度路线;结合河南某高速公路自洽能源系统的相关数据进行灾后应急资源调度仿真。结果表明:所提优化调度方案比目前常用的两种方案能够提前1~2 h完成故障线路维修,故障负荷的平均负荷恢复量提高了5.95%和2.27%,恢复至正常运行状态所需时间缩短了31.38%和16.28%,可进一步提高应急资源调度效率和高速公路自洽能源系统弹性。 展开更多
关键词 自洽能源系统 极端天气 交通网-电力网耦合网络 应急资源调度
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Study of prestack elastic parameter consistency inversion methods 被引量:2
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作者 黄捍东 张如伟 +2 位作者 慎国强 郭飞 汪佳蓓 《Applied Geophysics》 SCIE CSCD 2011年第4期311-318,371,共9页
The three parameters of P-wave velocity, S-wave velocity, and density have remarkable differences in conventional prestack inversion accuracy, so study of the consistency inversion of the "three parameters" is very ... The three parameters of P-wave velocity, S-wave velocity, and density have remarkable differences in conventional prestack inversion accuracy, so study of the consistency inversion of the "three parameters" is very important. In this paper, we present a new inversion algorithm and approach based on the in-depth analysis of the causes in their accuracy differences. With this new method, the inversion accuracy of the three parameters is improved synchronously by reasonable approximations and mutual constraint among the parameters. Theoretical model calculations and actual data applications with this method indicate that the three elastic parameters all have high inversion accuracy and maintain consistency, which also coincides with the theoretical model and actual data. This method has good application prospects. 展开更多
关键词 Prestack seismic inversion elastic parameter consistency inversion prior constraint
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Rheological properties of low consistency TMP from thinning wood of Chinese Fir 被引量:2
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作者 邱仁辉 王克奇 黄祖泰 《Journal of Forestry Research》 SCIE CAS CSCD 2006年第2期145-149,共5页
The rheological behavior of low consistency thermomechanical pulp of Chinese fir harvested by intermediate thinning was analyzed. The results show that the apparent viscosity of pulp changed along with the beating deg... The rheological behavior of low consistency thermomechanical pulp of Chinese fir harvested by intermediate thinning was analyzed. The results show that the apparent viscosity of pulp changed along with the beating degree, pulp consistency and shearing velocity. With the increasing of pulp consistency, the apparent viscosity of pulp increased gradually. Beating degree of pulp had an effect on microstructure of pulp. The apparent viscosity of pulp declined as beating degree of pulp increased, and the apparent viscosity of pulp fell along with the shearing velocity increasing. Based on the results, the rheological models are set up. The models showed that the fluid types of the low consistency pulp could be described as pseudoplastics fluids (non-Newtonian fluids). 展开更多
关键词 Thermomechanical pulp Chinese Fir Thinning wood Low consistency pulp Rheological properties Pseudoplastics fluid
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基于VSG的交流微电网自触发功率经济分配隐私保护策略
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作者 杨珺 范晏通 秦杰 《电力系统自动化》 北大核心 2026年第1期118-129,共12页
针对高比例可再生能源并网导致的微电网惯性下降问题,聚焦于虚拟同步发电机控制交流微电网的功率经济分配与数据安全协同优化问题展开研究。首先,提出了一种融合模型预测控制的改进增量成本一致性算法,对功率不平衡值进行计算,打破了传... 针对高比例可再生能源并网导致的微电网惯性下降问题,聚焦于虚拟同步发电机控制交流微电网的功率经济分配与数据安全协同优化问题展开研究。首先,提出了一种融合模型预测控制的改进增量成本一致性算法,对功率不平衡值进行计算,打破了传统一致性算法中领导节点需要计算全局信息的限制。其次,提出了一种双维度协同的自触发隐私保护策略,并采用差分隐私机制对交互信息进行噪声注入以解决数据泄露问题。同时,结合事件驱动的自触发机制以减少计算负担并降低通信和加密成本。最后,通过4机7节点系统进行仿真验证。结果表明,所提自触发隐私保护策略显著减少了通信资源与计算资源,提升了微电网控制的鲁棒性与隐私安全性。 展开更多
关键词 微电网 虚拟同步发电机 隐私保护 功率经济分配 模型预测控制 一致性算法
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CONSISTENCY OF MLE OF THE PARAMETER OF EXPONENTIAL LIFETIME DISTRIBUTION FOR RANDOM CENSORING MODEL WITH INCOMPLETE INFORMATION 被引量:18
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作者 YE ERHUA 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 1995年第4期379-386,共8页
In this paper, we have discussed a random censoring test with incomplete information, and proved that the maximum likelihood estimator(MLE) of the parameter based on the randomly censored data with incomplete informat... In this paper, we have discussed a random censoring test with incomplete information, and proved that the maximum likelihood estimator(MLE) of the parameter based on the randomly censored data with incomplete information in the case of the exponential distribution has the strong consistency. 展开更多
关键词 Random censoring test with incomplete information exponential distribution maximum likelihood estimator consistency.
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Consistency of Water Production Function Models of Two Crops 被引量:1
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作者 樊鹏 王莹 +1 位作者 杨青伟 杨喜会 《Agricultural Science & Technology》 CAS 2016年第1期12-14,共3页
On basis of test information, the research performed analysis on water production function models of two crops, which indicated that water model of crops in whole growth stage and water model of crops indifferent grow... On basis of test information, the research performed analysis on water production function models of two crops, which indicated that water model of crops in whole growth stage and water model of crops indifferent growth stages have consistency as well as differences, providing references for optimization of irrigation water. Meanwhile, the research analyzed the deficiency of optimization on irrigation water for crops just by Jensen model. 展开更多
关键词 Water production function Parabolic model Jensen model consistency
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The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome
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作者 聂小燕 胥洋 +6 位作者 扶宇 李俊蕾 梁广楷 张涌 陆芸 刘健 史录文 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2016年第11期838-845,共8页
Various platelet function tests are currently used to identify responsiveness to antiplatelet therapy. 176 ACS patients were enrolled and Linear regression and Kappa consistency analysis showed there was a significant... Various platelet function tests are currently used to identify responsiveness to antiplatelet therapy. 176 ACS patients were enrolled and Linear regression and Kappa consistency analysis showed there was a significant but moderate correlation between platelet inhibition rate and a significant but fair agreement between high clopidogrel on-treatment platelet reactivity tested by light transmission aggregometry and thrombelastography. 展开更多
关键词 Light transmission aggregometry THROMBELASTOGRAPHY CLOPIDOGREL High platelet reactivity consistency
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大语言模型幻觉检测方法综述
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作者 李自拓 孙建彬 +5 位作者 陈广州 方馨悦 崔瑞靖 田植良 黄震 杨克巍 《计算机研究与发展》 北大核心 2026年第1期123-146,共24页
近年来,大语言模型(large language models,LLMs)在自然语言处理(natural language processing,NLP)等领域取得了显著进展,展现出强大的语言理解与生成能力。然而,在实际应用过程中,大语言模型仍然面临诸多挑战。其中,幻觉(hallucinati... 近年来,大语言模型(large language models,LLMs)在自然语言处理(natural language processing,NLP)等领域取得了显著进展,展现出强大的语言理解与生成能力。然而,在实际应用过程中,大语言模型仍然面临诸多挑战。其中,幻觉(hallucination)问题引起了学术界和工业界的广泛关注。如何有效检测大语言模型幻觉,成为确保其在文本生成等下游任务可靠、安全、可信应用的关键挑战。该研究着重对大语言模型幻觉检测方法进行综述:首先,介绍了大语言模型概念,进一步明确了幻觉的定义与分类,系统梳理了大语言模型从构建到部署应用全生命周期各环节的特点,并深入分析了幻觉的产生机制与诱因;其次,立足于实际应用需求,考虑到在不同任务场景下模型透明度的差异等因素,将幻觉检测方法划分为针对白盒模型和黑盒模型2类,并进行了重点梳理和深入对比;而后,分析总结了现阶段主流的幻觉检测基准,为后续开展幻觉检测奠定基础;最后,指出了大语言模型幻觉检测的各种潜在研究方法和新的挑战。 展开更多
关键词 幻觉检测 大语言模型 事实一致性 文本生成 自然语言处理
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扩散池法考察不同生产厂家糠酸莫米松乳膏的体外释放度
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作者 王经纬 鲍实 +3 位作者 陈晓颙 尚悦 刘晨曦 胡敏 《医药导报》 北大核心 2026年第1期109-115,共7页
目的建立测定糠酸莫米松乳膏体外释放度的实验方法,对参比制剂和国内8种糠酸莫米松乳膏仿制药的体外释放一致性进行评价。方法采用立式扩散池法测定糠酸莫米松乳膏的释放度,考察释放接收介质、滤膜、搅拌速率、温度等因素对糠酸莫米松... 目的建立测定糠酸莫米松乳膏体外释放度的实验方法,对参比制剂和国内8种糠酸莫米松乳膏仿制药的体外释放一致性进行评价。方法采用立式扩散池法测定糠酸莫米松乳膏的释放度,考察释放接收介质、滤膜、搅拌速率、温度等因素对糠酸莫米松乳膏体外释放行为的影响,比较国内8种糠酸莫米松乳膏仿制药与参比制剂体外释放行为之间的差异。采用释放介质为0.9%氯化钠溶液-乙醇(1:1),滤膜为孔径0.45μm的聚醚砜膜(PES膜),分别于1、3、5、7、12、24 h各取样1次,取样体积1 mL。以高效液相色谱法测定糠酸莫米松的浓度,采用C 16色谱柱(250 mm×4.6 mm,5μm),流动相为甲醇-水(70:30),检测波长254 nm,柱温40℃,流速1.0 mL·min^(-1),进样量20μL。结果方法学验证表明,体外释放方法的滤膜惰性、专属性、灵敏度、选择性均符合要求。糠酸莫米松的定量限为0.2μg·mL^(-1),在0.2~20.0μg·mL^(-1)范围内线性良好(r^(2)=0.99999),回收率为97.1%,稳定性和重复性均良好。参比制剂24 h的释放百分比为1.41%,8种仿制药的释放度为1.93%~62.26%。结论建立的体外释放实验方法准确度好、灵敏度高,可为糠酸莫米松乳膏优化处方、生产工艺及一致性评价提供参考。 展开更多
关键词 糠酸莫米松乳膏 立式扩散池法 体外释放 参比制剂 一致性评价
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面向使用需求的舰船气流场模糊综合评价方法
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作者 陈成 张修远 +3 位作者 张祥瑞 常选明 何秦 王勤 《哈尔滨工程大学学报》 北大核心 2026年第1期182-192,共11页
当前舰船气流场特性评价方法存在系统性和合理性不足问题,无法为复杂舰船装备气流场方案评估决策提供可靠支撑。本文构建面向使用需求的舰船气流场特性评价指标体系,将经典层次分析法及逼近理想解法拓展到区间二型模糊群决策情境,并提... 当前舰船气流场特性评价方法存在系统性和合理性不足问题,无法为复杂舰船装备气流场方案评估决策提供可靠支撑。本文构建面向使用需求的舰船气流场特性评价指标体系,将经典层次分析法及逼近理想解法拓展到区间二型模糊群决策情境,并提出几何一致性改进算法及模糊包络体性能评估方法。通过“美国”级两栖攻击舰气流场方案综合评价实例,验证所提方法的可行性及有效性。研究结果为舰船气流场特性评价提供思路和方法。 展开更多
关键词 舰船设计 气流场 综合评价 多属性群决策 区间二型模糊集 使用需求 一致性验证 模糊包络体
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