A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
The random forest algorithm was applied to study the nuclear binding energy and charge radius.The regularized root-mean-square of error(RMSE)was proposed to avoid overfitting during the training of random forest.RMSE ...The random forest algorithm was applied to study the nuclear binding energy and charge radius.The regularized root-mean-square of error(RMSE)was proposed to avoid overfitting during the training of random forest.RMSE for nuclides with Z,N>7 is reduced to 0.816 MeV and 0.0200 fm compared with the six-term liquid drop model and a three-term nuclear charge radius formula,respectively.Specific interest is in the possible(sub)shells among the superheavy region,which is important for searching for new elements and the island of stability.The significance of shell features estimated by the so-called shapely additive explanation method suggests(Z,N)=(92,142)and(98,156)as possible subshells indicated by the binding energy.Because the present observed data is far from the N=184 shell,which is suggested by mean-field investigations,its shell effect is not predicted based on present training.The significance analysis of the nuclear charge radius suggests Z=92 and N=136 as possible subshells.The effect is verified by the shell-corrected nuclear charge radius model.展开更多
This paper discusses a distributed design for clustering based on the K-means algorithm in a switching multi-agent network, for the case when data are decentralized stored and unavailable to all agents. The authors pr...This paper discusses a distributed design for clustering based on the K-means algorithm in a switching multi-agent network, for the case when data are decentralized stored and unavailable to all agents. The authors propose a consensus-based algorithm in distributed case, that is, the double- clock consensus-based K-means algorithm （DCKA）. With mild connectivity conditions, the authors show convergence of DCKA to guarantee a distributed solution to the clustering problem, even though the network topology is time-varying. Moreover, the authors provide experimental results on vari- ous clustering datasets to illustrate the effectiveness of the fully distributed algorithm DCKA, whose performance may be better than that of the centralized K-means algorithm.展开更多
In this paper, we present a distributed consensus-based algorithm to solve the social welfare maximization problem. This is one of typical problems of distributed energy management in smart grid. In this problem, we c...In this paper, we present a distributed consensus-based algorithm to solve the social welfare maximization problem. This is one of typical problems of distributed energy management in smart grid. In this problem, we consider not only the generator and demand, but also the transmission losses which make the feasibility set of the formulated problem a non-convex set. In solving this issue, we find a noticeable result that the primal problem has the same solution with a new convex optimization problem by getting the utmost out of the implied term in practice. Considering the general communication topology among generators and demands, we first design a finite step algorithm to make each generator and demand know the information of parameters of others.Then, we design a distributed algorithm and also prove the optimality and convergence of the proposed algorithm. Finally, the convergence and optimality are examined through extensive simulations.展开更多
Nuclear mass is an important property in both nuclear and astrophysics.In this study,we explore an improved mass model that incorporates a higher-order term of symmetry energy using algorithms.The sequential least squ...Nuclear mass is an important property in both nuclear and astrophysics.In this study,we explore an improved mass model that incorporates a higher-order term of symmetry energy using algorithms.The sequential least squares programming(SLSQP)algorithm augments the precision of this multinomial mass model by reducing the error from 1.863 MeV to 1.631 MeV.These algorithms were further examined using 200 sample mass formulae derived from theδE term of the E_(isospin) mass model.The SLSQP method exhibited superior performance compared to the other algorithms in terms of errors and convergence speed.This algorithm is advantageous for handling large-scale multiparameter optimization tasks in nuclear physics.展开更多
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
基金Supported by Basic and Applied Basic Research Project of Guangdong Province(2021B0301030006)。
文摘The random forest algorithm was applied to study the nuclear binding energy and charge radius.The regularized root-mean-square of error(RMSE)was proposed to avoid overfitting during the training of random forest.RMSE for nuclides with Z,N>7 is reduced to 0.816 MeV and 0.0200 fm compared with the six-term liquid drop model and a three-term nuclear charge radius formula,respectively.Specific interest is in the possible(sub)shells among the superheavy region,which is important for searching for new elements and the island of stability.The significance of shell features estimated by the so-called shapely additive explanation method suggests(Z,N)=(92,142)and(98,156)as possible subshells indicated by the binding energy.Because the present observed data is far from the N=184 shell,which is suggested by mean-field investigations,its shell effect is not predicted based on present training.The significance analysis of the nuclear charge radius suggests Z=92 and N=136 as possible subshells.The effect is verified by the shell-corrected nuclear charge radius model.
基金supported by the National Key Research and Development Program of China under Grant No.2016YFB0901902the National Natural Science Foundation of China under Grant Nos.61573344,61333001,61733018,and 61374168
文摘This paper discusses a distributed design for clustering based on the K-means algorithm in a switching multi-agent network, for the case when data are decentralized stored and unavailable to all agents. The authors propose a consensus-based algorithm in distributed case, that is, the double- clock consensus-based K-means algorithm （DCKA）. With mild connectivity conditions, the authors show convergence of DCKA to guarantee a distributed solution to the clustering problem, even though the network topology is time-varying. Moreover, the authors provide experimental results on vari- ous clustering datasets to illustrate the effectiveness of the fully distributed algorithm DCKA, whose performance may be better than that of the centralized K-means algorithm.
基金supported by the Science and Technology Project of State Grid Zhejiang Electric Power Co.Ltd.(Grant No.5211JY17000P)the Fundamental Research Funds for the Central Universities(Grant No.2242019K40111)+1 种基金the National Natural Science Foundation of China(Grant No.61673107)the Jiangsu Provincial Key Laboratory of Networked Collective Intelligence(Grant No.BM2017002)
文摘In this paper, we present a distributed consensus-based algorithm to solve the social welfare maximization problem. This is one of typical problems of distributed energy management in smart grid. In this problem, we consider not only the generator and demand, but also the transmission losses which make the feasibility set of the formulated problem a non-convex set. In solving this issue, we find a noticeable result that the primal problem has the same solution with a new convex optimization problem by getting the utmost out of the implied term in practice. Considering the general communication topology among generators and demands, we first design a finite step algorithm to make each generator and demand know the information of parameters of others.Then, we design a distributed algorithm and also prove the optimality and convergence of the proposed algorithm. Finally, the convergence and optimality are examined through extensive simulations.
基金supported by the National Natural Science Foundation of China(Nos.U2267205 and 12475124)a ZSTU intramural grant(22062267-Y)Excellent Graduate Thesis Cultivation Fund(LW-YP2024011).
文摘Nuclear mass is an important property in both nuclear and astrophysics.In this study,we explore an improved mass model that incorporates a higher-order term of symmetry energy using algorithms.The sequential least squares programming(SLSQP)algorithm augments the precision of this multinomial mass model by reducing the error from 1.863 MeV to 1.631 MeV.These algorithms were further examined using 200 sample mass formulae derived from theδE term of the E_(isospin) mass model.The SLSQP method exhibited superior performance compared to the other algorithms in terms of errors and convergence speed.This algorithm is advantageous for handling large-scale multiparameter optimization tasks in nuclear physics.
