Dear Editor,This letter studies output consensus problem of heterogeneous linear multiagent systems over directed graphs. A novel adaptive dynamic event-triggered controller is presented based only on the feedback com...Dear Editor,This letter studies output consensus problem of heterogeneous linear multiagent systems over directed graphs. A novel adaptive dynamic event-triggered controller is presented based only on the feedback combination of the agent's own state and neighbors' output,which can achieve exponential output consensus through intermittent communication. The controller is obtained by solving two linear matrix equations, and Zeno behavior is excluded.展开更多
Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the ...Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.展开更多
Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination...Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.展开更多
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
The Internet of Things(IoT)has gained substantial attention in both academic research and real-world applications.The proliferation of interconnected devices across various domains promises to deliver intelligent and ...The Internet of Things(IoT)has gained substantial attention in both academic research and real-world applications.The proliferation of interconnected devices across various domains promises to deliver intelligent and advanced services.However,this rapid expansion also heightens the vulnerability of the IoT ecosystem to security threats.Consequently,innovative solutions capable of effectively mitigating risks while accommodating the unique constraints of IoT environments are urgently needed.Recently,the convergence of Blockchain technology and IoT has introduced a decentralized and robust framework for securing data and interactions,commonly referred to as the Internet of Blockchained Things(IoBT).Extensive research efforts have been devoted to adapting Blockchain technology to meet the specific requirements of IoT deployments.Within this context,consensus algorithms play a critical role in assessing the feasibility of integrating Blockchain into IoT ecosystems.The adoption of efficient and lightweight consensus mechanisms for block validation has become increasingly essential.This paper presents a comprehensive examination of lightweight,constraint-aware consensus algorithms tailored for IoBT.The study categorizes these consensus mechanisms based on their core operations,the security of the block validation process,the incorporation of AI techniques,and the specific applications they are designed to support.展开更多
Traditional Internet of Things(IoT)architectures that rely on centralized servers for data management and decision-making are vulnerable to security threats and privacy leakage.To address this issue,blockchain has bee...Traditional Internet of Things(IoT)architectures that rely on centralized servers for data management and decision-making are vulnerable to security threats and privacy leakage.To address this issue,blockchain has been advocated for decentralized data management in a tamper-resistance,traceable,and transparent manner.However,a major issue that hinders the integration of blockchain and IoT lies in that,it is rather challenging for resource-constrained IoT devices to perform computation-intensive blockchain consensuses such as Proof-of-Work(PoW).Furthermore,the incentive mechanism of PoW pushes lightweight IoT nodes to aggregate their computing power to increase the possibility of successful block generation.Nevertheless,this eventually leads to the formation of computing power alliances,and significantly compromises the decentralization and security of BlockChain-aided IoT(BC-IoT)networks.To cope with these issues,we propose a lightweight consensus protocol for BC-IoT,called Proof-of-Trusted-Work(PoTW).The goal of the proposed consensus is to disincentivize the centralization of computing power and encourage the independent participation of lightweight IoT nodes in blockchain consensus.First,we put forth an on-chain reputation evaluation rule and a reputation chain for PoTW to enable the verifiability and traceability of nodes’reputations based on their contributions of computing power to the blockchain consensus,and we incorporate the multi-level block generation difficulty as a rewards for nodes to accumulate reputations.Second,we model the block generation process of PoTW and analyze the block throughput using the continuous time Markov chain.Additionally,we define and optimize the relative throughput gain to quantify and maximize the capability of PoTW that suppresses the computing power centralization(i.e.,centralization suppression).Furthermore,we investigate the impact of the computing power of the computing power alliance and the levels of block generation difficulty on the centralization suppression capability of PoTW.Finally,simulation results demonstrate the consistency of the analytical results in terms of block throughput.In particular,the results show that PoTW effectively reduces the block generation proportion of the computing power alliance compared with PoW,while simultaneously improving that of individual lightweight nodes.This indicates that PoTW is capable of suppressing the centralization of computing power to a certain degree.Moreover,as the levels of block generation difficulty in PoTW increase,its centralization suppression capability strengthens.展开更多
Intelligent blockchain is an emerging field that integrates Artificial Intelligence(AI)techniques with blockchain networks,with a particular emphasis on improving the performance of blockchain,especially in cryptocurr...Intelligent blockchain is an emerging field that integrates Artificial Intelligence(AI)techniques with blockchain networks,with a particular emphasis on improving the performance of blockchain,especially in cryptocurrencies exchanges.Meanwhile,arbitrage bots are widely deployed and increasing in intelligent blockchain.These bots exploit the characteristics of cryptocurrencies exchanges to engage in frontrunning,generating substantial profits at the expense of ordinary users.In this paper,we address this issue by proposing a more efficient asynchronous Byzantine ordered consensus protocol,which can be used to prevent arbitrage bots from changing the order of the transactions for profits in intelligent blockchain-based cryptocurrencies.Specifically,we present two signal asynchronous common subset protocols,the more optimal one with only constant time complexity.We implement both our protocol and the optimal existing solution Chronos with Go language in the same environment.The experiment results indicate that our protocols achieve a threefold improvement over Chronos in consensus latency and nearly a tenfold increase in throughput.展开更多
Hemoptysis is defined as bleeding originating from the respiratory tract distal to the larynx and is associated with a wide spectrum of underlying conditions,including bronchiectasis,pulmonary malignancies,tuberculosi...Hemoptysis is defined as bleeding originating from the respiratory tract distal to the larynx and is associated with a wide spectrum of underlying conditions,including bronchiectasis,pulmonary malignancies,tuberculosis,aspergillosis,and vascular malformations.^([1-3]) A metaanalysis involving patients with massive hemoptysis reported a mortality rate of 3.5%.^([4])This underscores the critical importance of prompt and eff ective embolization of the responsible artery to improve outcomes,particularly in patients presenting with life-threatening hemoptysis.展开更多
Through three millennia of practice,Traditional Chinese Medicine(TCM)has evolved by integrating knowledge from diverse disciplines,forging a distinct developmental path that respects its ancient foundations while inco...Through three millennia of practice,Traditional Chinese Medicine(TCM)has evolved by integrating knowledge from diverse disciplines,forging a distinct developmental path that respects its ancient foundations while incorporating innovation.TCM has achieved significant breakthroughs in elucidating its theoretical foundations using contemporary scientific methodologies,through the implementation of modernization initiatives over the past three decades.The TCM modernization program has yielded continuous innovations,propelling TCM into a high-quality development stage across both clinical practice and industrial applications.Notably,these advances have enhanced global recognition and adoption of TCM.展开更多
This paper mainly focuses on the velocity-constrained consensus problem of discrete-time heterogeneous multi-agent systems with nonconvex constraints and arbitrarily switching topologies,where each agent has first-ord...This paper mainly focuses on the velocity-constrained consensus problem of discrete-time heterogeneous multi-agent systems with nonconvex constraints and arbitrarily switching topologies,where each agent has first-order or second-order dynamics.To solve this problem,a distributed algorithm is proposed based on a contraction operator.By employing the properties of the stochastic matrix,it is shown that all agents’position states could converge to a common point and second-order agents’velocity states could remain in corresponding nonconvex constraint sets and converge to zero as long as the joint communication topology has one directed spanning tree.Finally,the numerical simulation results are provided to verify the effectiveness of the proposed algorithms.展开更多
Helicobacter pylori(H.pylori),a widespread gram-negative bacterium that colonizes the stomach,causes chronic gastritis,which may progress to peptic ulcer,mucosa-associated lymphoid tissue lymphoma,and gastric cancer.H...Helicobacter pylori(H.pylori),a widespread gram-negative bacterium that colonizes the stomach,causes chronic gastritis,which may progress to peptic ulcer,mucosa-associated lymphoid tissue lymphoma,and gastric cancer.H.pylori infection affects over 50%of people in developing countries and 10%-20%in developed countries.The Kyoto consensus classifies H.pylori gastritis as an infectious disease in the International Classification of Disease 11th Revision.The Maastricht/Florence consensus recommends treatment for all infected individuals,introducing a shift in the management strategies.The prevalence of H.pylori infection is high in the Middle East,with infection rates of 40%-70%and 85%-90%being reported among children and adults,respectively.The increasing resistance to antibiotics,including macrolides and fluoroquinolones,is a major challenge in the management of H.pylori.Clarithromycin resistance,which is associated with reduced effectiveness of standard triple therapy regimens,leading to higher rates of treatment failure,impacts the eradication rates.This emphasizes the need for routine antibiotic susceptibility testing at the national level,the use of alternative therapies,including new molecular methods,and antibiotic stewardship.An online panel of experts from the Middle East,along with an international expert,developed this consensus to provide comprehensive guidelines on the diagnosis,treatment,prevention,and role of gut microbiota in H.pylori infection,with the goal of improving clinical decision-making and reducing the impact of antibiotic resistance in the region.These guidelines are intended to support healthcare professionals involved in the diagnosis and management of H.pylori,including primary care physicians,gastroenterologists,and other specialists.They may also inform future clinical research aimed at optimizing treatment strategies and addressing regional challenges.展开更多
This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-orde...This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-order error subsystems.A distributed consensus analysis for the corresponding error systems is conducted by employing recursive methods and virtual controllers,accompanied by a series of Lyapunov functions devised throughout the iterative process,which solves the leaderfollowing consensus problem of a class of nonlinear cascaded multi-agent systems.Specific simulation examples illustrate the effectiveness of the proposed control algorithm.展开更多
Blockchain-based spectrum sharing with consensus is the key technology for sixth-generation mobile communication to realize dynamic spectrum management.In order to avoid the waste of computing and communication resour...Blockchain-based spectrum sharing with consensus is the key technology for sixth-generation mobile communication to realize dynamic spectrum management.In order to avoid the waste of computing and communication resources,a spectrum sharing policy-based consensus mechanism is proposed in this paper.Firstly,a spectrum sharing algorithm based on graph neural network is designed in the satelliteterrestrial spectrum sharing networks under the underlay model.It avoids high computational overhead of the traditional iterative optimization algorithm when the wireless channel condition and network topology are highly dynamic.Secondly,a consensus mechanism based on spectrum sharing strategy is designed,which converts the traditional meaningless hash problem into the graph neural network training.Miners compete for accounting rights by training a graph neutral network model that meets the spectrum sharing requirement.Finally,the consensus delay,communication and storage overhead of the proposed consensus mechanism are analyzed theoretically.The simulation results show that the proposed consensus mechanism can effectively improve spectrum efficiency with excellent scalability and generalization performance.展开更多
Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associa...Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associated with standard PCNL(sPCNL).However,despite this growing acceptance and recognition of its benefits,unresolved controversies and acknowledged limitations continue to impede widespread adoption due to a lack of consensus on optimal perioperative management strategies and procedural tips and tricks.In response to these challenges,an international panel comprising experts from the International Alliance of Urolithiasis(IAU)took on the task of compiling an expert consensus document on mPCNL procedures aimed at providing urologists with a comprehensive clinical framework for practice.This endeavor involved conducting a systematic literature review to identify research gaps(RGs),which formed the foundation for developing a structured questionnaire survey.Subsequently,a two-round modified Delphi survey was implemented,culminating in a group meeting to generate final evidence-based comments.All 64 experts completed the second-round survey,resulting in a response rate of 100.0%.Fifty-eight key questions were raised focusing on mPCNLs within 4 main domains,including general information(13 questions),preoperative work-up(13 questions),procedural tips and tricks(19 questions),and postoperative evaluation and follow-up(13 questions).Additionally,9 questions evaluated the experts’experience with PCNLs.Consensus was reached on 30 questions after the second-round survey,while professional statements for the remaining 28 key questions were provided after discussion in an online panel meeting.mPCNL,characterized by a tract smaller than 18 Fr and an innovative lithotripsy technique,has firmly established itself as a viable and effective approach for managing upper urinary tract stones in both adults and pediatrics.It offers several advantages over sPCNL including reduced bleeding,fewer requirements for nephrostomy tubes,decreased pain,and shorter hospital stays.The series of detailed techniques presented here serve as a comprehensive guide for urologists,aiming to improve their procedural understanding and optimize patient outcomes.展开更多
Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To de...Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To decrease the control cost,based on ISC,several LFC problems are investigated for second-order MASs without and with time delay,respectively.Firstly,an intermittent sampled controller is designed,and a sufficient and necessary condition is derived,under which state errors between the leader and all the followers approach zero asymptotically.Considering that time delay is inevitable,a new protocol is proposed to deal with the time-delay situation.The error system’s stability is analyzed using the Schur stability theorem,and sufficient and necessary conditions for LFC are obtained,which are closely associated with the coupling gain,the system parameters,and the network structure.Furthermore,for the case where the current position and velocity information are not available,a distributed protocol is designed that depends only on the sampled position information.The sufficient and necessary conditions for LFC are also given.The results show that second-order MASs can achieve the LFC if and only if the system parameters satisfy the inequalities proposed in the paper.Finally,the correctness of the obtained results is verified by numerical simulations.展开更多
In this paper, the multi-agent systems(MASs) typically with heterogeneous unknown nonlinearities and nonidentical unknown control coefficients are studied. Although the model information of MASs is coarse, the leader-...In this paper, the multi-agent systems(MASs) typically with heterogeneous unknown nonlinearities and nonidentical unknown control coefficients are studied. Although the model information of MASs is coarse, the leader-following consensus is still pursued, with a prescribed performance and zero consensus errors. Leveraging a powerful funnel control strategy, a fully distributed and completely relative-state-dependent protocol is designed. Distinctively, the time-varying function characterizing the performance boundary is introduced, not only to construct the funnel gains but also as an indispensable part of the protocol,enhancing the control ability and enabling the consensus errors to converge to zero(rather than a residual set). Remark that when control directions are unknown, coexisting with inherent system nonlinearities, it is essential to incorporate an additional compensation mechanism while imposing a hierarchical structure of communication topology for the control design and analysis. Simulation examples are given to illustrate the effectiveness of the theoretical results.展开更多
This paper highlights the utilization of parallel control and adaptive dynamic programming(ADP) for event-triggered robust parallel optimal consensus control(ETRPOC) of uncertain nonlinear continuous-time multiagent s...This paper highlights the utilization of parallel control and adaptive dynamic programming(ADP) for event-triggered robust parallel optimal consensus control(ETRPOC) of uncertain nonlinear continuous-time multiagent systems(MASs).First, the parallel control system, which consists of a virtual control variable and a specific auxiliary variable obtained from the coupled Hamiltonian, allows general systems to be transformed into affine systems. Of interest is the fact that the parallel control technique's introduction provides an unprecedented perspective on eliminating the negative effects of disturbance. Then, an eventtriggered mechanism is adopted to save communication resources while ensuring the system's stability. The coupled HamiltonJacobi(HJ) equation's solution is approximated using a critic neural network(NN), whose weights are updated in response to events. Furthermore, theoretical analysis reveals that the weight estimation error is uniformly ultimately bounded(UUB). Finally,numerical simulations demonstrate the effectiveness of the developed ETRPOC method.展开更多
Cloud environments are essential for modern computing,but are increasingly vulnerable to Side-Channel Attacks(SCAs),which exploit indirect information to compromise sensitive data.To address this critical challenge,we...Cloud environments are essential for modern computing,but are increasingly vulnerable to Side-Channel Attacks(SCAs),which exploit indirect information to compromise sensitive data.To address this critical challenge,we propose SecureCons Framework(SCF),a novel consensus-based cryptographic framework designed to enhance resilience against SCAs in cloud environments.SCF integrates a dual-layer approach combining lightweight cryptographic algorithms with a blockchain-inspired consensus mechanism to secure data exchanges and thwart potential side-channel exploits.The framework includes adaptive anomaly detection models,cryptographic obfuscation techniques,and real-time monitoring to identify and mitigate vulnerabilities proactively.Experimental evaluations demonstrate the framework's robustness,achieving over 95%resilience against advanced SCAs with minimal computational overhead.SCF provides a scalable,secure,and efficient solution,setting a new benchmark for side-channel attack mitigation in cloud ecosystems.展开更多
This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates senso...This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates sensor and actuator disturbances within the dynamics of follower robots.Each follower robot has unknown dynamics and control inputs,which expose it to the risks of both sensor and actuator attacks.The leader robot,described by a secondorder,time-varying nonlinear model,transmits its position,velocity,and acceleration information to follower robots through a wireless connection.To handle the complex setup and communication among robots in the network,we design a robust hybrid distributed adaptive control strategy combining the effect of sensor and actuator attack,which ensures asymptotic consensus,extending beyond conventional bounded consensus results.The proposed framework employs fuzzy logic systems(FLSs)as proactive controllers to estimate unknown nonlinear behaviors,while also effectively managing sensor and actuator attacks,ensuring stable consensus among all agents.To counter the impact of the combined signal attack on follower dynamics,a specialized robust control mechanism is designed,sustaining system stability and performance under adversarial conditions.The efficiency of this control strategy is demonstrated through simulations conducted across two different directed communication topologies,underscoring the protocol’s adaptability,resilience,and effectiveness in maintaining global consensus under complex attack scenarios.展开更多
This paper investigates the secure impulsive consensus of Lipschitz-type nonlinear multi-agent systems(MASs) with input saturation. According to the coupling of input saturation and denial of service(DoS) attacks, imp...This paper investigates the secure impulsive consensus of Lipschitz-type nonlinear multi-agent systems(MASs) with input saturation. According to the coupling of input saturation and denial of service(DoS) attacks, impulsive control for MASs becomes extremely challenging. Considering general DoS attacks,this paper provides the sufficient conditions for the almost sure consensus of the MASs with input saturation, where the error system can achieve almost sure local exponential stability.Through linear matrix inequalities(LMIs), the relation between the trajectory boundary and DoS attacks is characterized, and the trajectory boundary is estimated. Furthermore, an optimization method of the domain of attraction is proposed to maximize the size. And a non-conservative and practical boundary is proposed to characterize the effect of DoS attacks on MASs. Finally, considering a multi-agent system with typical Chua's circuit dynamic model, an example is provided to illustrate the theorems' correctness.展开更多
基金supported by the National Science and Technology Innovation 2030-Major Program(2022ZD 0115403)the National Natural Science Foundation of China(61991414)+1 种基金Chongqing Natural Science Foundation(CSTB2023NSCQJQX0018)Beijing Natural Science Foundation(L221005)
文摘Dear Editor,This letter studies output consensus problem of heterogeneous linear multiagent systems over directed graphs. A novel adaptive dynamic event-triggered controller is presented based only on the feedback combination of the agent's own state and neighbors' output,which can achieve exponential output consensus through intermittent communication. The controller is obtained by solving two linear matrix equations, and Zeno behavior is excluded.
基金supported by the National Natural Science Foundation of China(62325304,U22B2046,62073079,62376029)the Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)the China Postdoctoral Science Foundation(2023M730255,2024T171123)
文摘Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.
基金supports by the National Natural Science Foundation of China(Nos.82201135)"2015"Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School,Medical School of Nanjing University(No.0223A204).
文摘Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
文摘The Internet of Things(IoT)has gained substantial attention in both academic research and real-world applications.The proliferation of interconnected devices across various domains promises to deliver intelligent and advanced services.However,this rapid expansion also heightens the vulnerability of the IoT ecosystem to security threats.Consequently,innovative solutions capable of effectively mitigating risks while accommodating the unique constraints of IoT environments are urgently needed.Recently,the convergence of Blockchain technology and IoT has introduced a decentralized and robust framework for securing data and interactions,commonly referred to as the Internet of Blockchained Things(IoBT).Extensive research efforts have been devoted to adapting Blockchain technology to meet the specific requirements of IoT deployments.Within this context,consensus algorithms play a critical role in assessing the feasibility of integrating Blockchain into IoT ecosystems.The adoption of efficient and lightweight consensus mechanisms for block validation has become increasingly essential.This paper presents a comprehensive examination of lightweight,constraint-aware consensus algorithms tailored for IoBT.The study categorizes these consensus mechanisms based on their core operations,the security of the block validation process,the incorporation of AI techniques,and the specific applications they are designed to support.
基金supported in part by National Key R&D Program of China(Grant No.2021YFB1714100)in part by the National Natural Science Foundation of China(NSFC)under Grant 62371239+5 种基金in part by the the Program of Science and Technology Cooperation of Nanjing with International/Hong Kong,Macao and Taiwan(Grant No.202401019)in part by the Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515012407)in part by the the Research Center for FinTech and Digital-Intelligent Management at Shenzhen University,in part by the National Natural Science Foundation of China under Grant 62271192in part by the Equipment Pre-Research Joint Research Program of Ministry of Education under Grant 8091B032129in part by the Major Science and Technology Projects of Longmen Laboratory under Grant 231100220300 and 231100220200in part by the Central Plains Leading Talent in Scientific and Technological Innovation Program under Grant 244200510048.
文摘Traditional Internet of Things(IoT)architectures that rely on centralized servers for data management and decision-making are vulnerable to security threats and privacy leakage.To address this issue,blockchain has been advocated for decentralized data management in a tamper-resistance,traceable,and transparent manner.However,a major issue that hinders the integration of blockchain and IoT lies in that,it is rather challenging for resource-constrained IoT devices to perform computation-intensive blockchain consensuses such as Proof-of-Work(PoW).Furthermore,the incentive mechanism of PoW pushes lightweight IoT nodes to aggregate their computing power to increase the possibility of successful block generation.Nevertheless,this eventually leads to the formation of computing power alliances,and significantly compromises the decentralization and security of BlockChain-aided IoT(BC-IoT)networks.To cope with these issues,we propose a lightweight consensus protocol for BC-IoT,called Proof-of-Trusted-Work(PoTW).The goal of the proposed consensus is to disincentivize the centralization of computing power and encourage the independent participation of lightweight IoT nodes in blockchain consensus.First,we put forth an on-chain reputation evaluation rule and a reputation chain for PoTW to enable the verifiability and traceability of nodes’reputations based on their contributions of computing power to the blockchain consensus,and we incorporate the multi-level block generation difficulty as a rewards for nodes to accumulate reputations.Second,we model the block generation process of PoTW and analyze the block throughput using the continuous time Markov chain.Additionally,we define and optimize the relative throughput gain to quantify and maximize the capability of PoTW that suppresses the computing power centralization(i.e.,centralization suppression).Furthermore,we investigate the impact of the computing power of the computing power alliance and the levels of block generation difficulty on the centralization suppression capability of PoTW.Finally,simulation results demonstrate the consistency of the analytical results in terms of block throughput.In particular,the results show that PoTW effectively reduces the block generation proportion of the computing power alliance compared with PoW,while simultaneously improving that of individual lightweight nodes.This indicates that PoTW is capable of suppressing the centralization of computing power to a certain degree.Moreover,as the levels of block generation difficulty in PoTW increase,its centralization suppression capability strengthens.
基金supported by the National Key R&D Program of China under Grant(2022YFB2702702)in part by the National Natural Science Foundation of China under Grants(62372020,72031001)+1 种基金in part by the Beijing Natural Science Foundation under Grants(L222050)in part by the Fundamental Research Funds for the Central Universities under Grant(YWF-23-L-1032).
文摘Intelligent blockchain is an emerging field that integrates Artificial Intelligence(AI)techniques with blockchain networks,with a particular emphasis on improving the performance of blockchain,especially in cryptocurrencies exchanges.Meanwhile,arbitrage bots are widely deployed and increasing in intelligent blockchain.These bots exploit the characteristics of cryptocurrencies exchanges to engage in frontrunning,generating substantial profits at the expense of ordinary users.In this paper,we address this issue by proposing a more efficient asynchronous Byzantine ordered consensus protocol,which can be used to prevent arbitrage bots from changing the order of the transactions for profits in intelligent blockchain-based cryptocurrencies.Specifically,we present two signal asynchronous common subset protocols,the more optimal one with only constant time complexity.We implement both our protocol and the optimal existing solution Chronos with Go language in the same environment.The experiment results indicate that our protocols achieve a threefold improvement over Chronos in consensus latency and nearly a tenfold increase in throughput.
文摘Hemoptysis is defined as bleeding originating from the respiratory tract distal to the larynx and is associated with a wide spectrum of underlying conditions,including bronchiectasis,pulmonary malignancies,tuberculosis,aspergillosis,and vascular malformations.^([1-3]) A metaanalysis involving patients with massive hemoptysis reported a mortality rate of 3.5%.^([4])This underscores the critical importance of prompt and eff ective embolization of the responsible artery to improve outcomes,particularly in patients presenting with life-threatening hemoptysis.
文摘Through three millennia of practice,Traditional Chinese Medicine(TCM)has evolved by integrating knowledge from diverse disciplines,forging a distinct developmental path that respects its ancient foundations while incorporating innovation.TCM has achieved significant breakthroughs in elucidating its theoretical foundations using contemporary scientific methodologies,through the implementation of modernization initiatives over the past three decades.The TCM modernization program has yielded continuous innovations,propelling TCM into a high-quality development stage across both clinical practice and industrial applications.Notably,these advances have enhanced global recognition and adoption of TCM.
基金2024 Jiangsu Province Youth Science and Technology Talent Support Project2024 Yancheng Key Research and Development Plan(Social Development)projects,“Research and Application of Multi Agent Offline Distributed Trust Perception Virtual Wireless Sensor Network Algorithm”and“Research and Application of a New Type of Fishery Ship Safety Production Monitoring Equipment”。
文摘This paper mainly focuses on the velocity-constrained consensus problem of discrete-time heterogeneous multi-agent systems with nonconvex constraints and arbitrarily switching topologies,where each agent has first-order or second-order dynamics.To solve this problem,a distributed algorithm is proposed based on a contraction operator.By employing the properties of the stochastic matrix,it is shown that all agents’position states could converge to a common point and second-order agents’velocity states could remain in corresponding nonconvex constraint sets and converge to zero as long as the joint communication topology has one directed spanning tree.Finally,the numerical simulation results are provided to verify the effectiveness of the proposed algorithms.
文摘Helicobacter pylori(H.pylori),a widespread gram-negative bacterium that colonizes the stomach,causes chronic gastritis,which may progress to peptic ulcer,mucosa-associated lymphoid tissue lymphoma,and gastric cancer.H.pylori infection affects over 50%of people in developing countries and 10%-20%in developed countries.The Kyoto consensus classifies H.pylori gastritis as an infectious disease in the International Classification of Disease 11th Revision.The Maastricht/Florence consensus recommends treatment for all infected individuals,introducing a shift in the management strategies.The prevalence of H.pylori infection is high in the Middle East,with infection rates of 40%-70%and 85%-90%being reported among children and adults,respectively.The increasing resistance to antibiotics,including macrolides and fluoroquinolones,is a major challenge in the management of H.pylori.Clarithromycin resistance,which is associated with reduced effectiveness of standard triple therapy regimens,leading to higher rates of treatment failure,impacts the eradication rates.This emphasizes the need for routine antibiotic susceptibility testing at the national level,the use of alternative therapies,including new molecular methods,and antibiotic stewardship.An online panel of experts from the Middle East,along with an international expert,developed this consensus to provide comprehensive guidelines on the diagnosis,treatment,prevention,and role of gut microbiota in H.pylori infection,with the goal of improving clinical decision-making and reducing the impact of antibiotic resistance in the region.These guidelines are intended to support healthcare professionals involved in the diagnosis and management of H.pylori,including primary care physicians,gastroenterologists,and other specialists.They may also inform future clinical research aimed at optimizing treatment strategies and addressing regional challenges.
基金National Natural Science Foundation of China(No.12071370)。
文摘This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-order error subsystems.A distributed consensus analysis for the corresponding error systems is conducted by employing recursive methods and virtual controllers,accompanied by a series of Lyapunov functions devised throughout the iterative process,which solves the leaderfollowing consensus problem of a class of nonlinear cascaded multi-agent systems.Specific simulation examples illustrate the effectiveness of the proposed control algorithm.
基金supported in part by the National Natural Science Foundation of China under Grant 62171020.
文摘Blockchain-based spectrum sharing with consensus is the key technology for sixth-generation mobile communication to realize dynamic spectrum management.In order to avoid the waste of computing and communication resources,a spectrum sharing policy-based consensus mechanism is proposed in this paper.Firstly,a spectrum sharing algorithm based on graph neural network is designed in the satelliteterrestrial spectrum sharing networks under the underlay model.It avoids high computational overhead of the traditional iterative optimization algorithm when the wireless channel condition and network topology are highly dynamic.Secondly,a consensus mechanism based on spectrum sharing strategy is designed,which converts the traditional meaningless hash problem into the graph neural network training.Miners compete for accounting rights by training a graph neutral network model that meets the spectrum sharing requirement.Finally,the consensus delay,communication and storage overhead of the proposed consensus mechanism are analyzed theoretically.The simulation results show that the proposed consensus mechanism can effectively improve spectrum efficiency with excellent scalability and generalization performance.
文摘Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associated with standard PCNL(sPCNL).However,despite this growing acceptance and recognition of its benefits,unresolved controversies and acknowledged limitations continue to impede widespread adoption due to a lack of consensus on optimal perioperative management strategies and procedural tips and tricks.In response to these challenges,an international panel comprising experts from the International Alliance of Urolithiasis(IAU)took on the task of compiling an expert consensus document on mPCNL procedures aimed at providing urologists with a comprehensive clinical framework for practice.This endeavor involved conducting a systematic literature review to identify research gaps(RGs),which formed the foundation for developing a structured questionnaire survey.Subsequently,a two-round modified Delphi survey was implemented,culminating in a group meeting to generate final evidence-based comments.All 64 experts completed the second-round survey,resulting in a response rate of 100.0%.Fifty-eight key questions were raised focusing on mPCNLs within 4 main domains,including general information(13 questions),preoperative work-up(13 questions),procedural tips and tricks(19 questions),and postoperative evaluation and follow-up(13 questions).Additionally,9 questions evaluated the experts’experience with PCNLs.Consensus was reached on 30 questions after the second-round survey,while professional statements for the remaining 28 key questions were provided after discussion in an online panel meeting.mPCNL,characterized by a tract smaller than 18 Fr and an innovative lithotripsy technique,has firmly established itself as a viable and effective approach for managing upper urinary tract stones in both adults and pediatrics.It offers several advantages over sPCNL including reduced bleeding,fewer requirements for nephrostomy tubes,decreased pain,and shorter hospital stays.The series of detailed techniques presented here serve as a comprehensive guide for urologists,aiming to improve their procedural understanding and optimize patient outcomes.
基金supported by the National Natural Science Foundation of China under Grants 62476138 and 42375016.
文摘Continuous control protocols are extensively utilized in traditional MASs,in which information needs to be transmitted among agents consecutively,therefore resulting in excessive consumption of limited resources.To decrease the control cost,based on ISC,several LFC problems are investigated for second-order MASs without and with time delay,respectively.Firstly,an intermittent sampled controller is designed,and a sufficient and necessary condition is derived,under which state errors between the leader and all the followers approach zero asymptotically.Considering that time delay is inevitable,a new protocol is proposed to deal with the time-delay situation.The error system’s stability is analyzed using the Schur stability theorem,and sufficient and necessary conditions for LFC are obtained,which are closely associated with the coupling gain,the system parameters,and the network structure.Furthermore,for the case where the current position and velocity information are not available,a distributed protocol is designed that depends only on the sampled position information.The sufficient and necessary conditions for LFC are also given.The results show that second-order MASs can achieve the LFC if and only if the system parameters satisfy the inequalities proposed in the paper.Finally,the correctness of the obtained results is verified by numerical simulations.
基金supported in part by the National Natural Science Foundation of China(61821004,62033007)Major Fundamental Research Program of Shandong Province(ZR2023ZD37)
文摘In this paper, the multi-agent systems(MASs) typically with heterogeneous unknown nonlinearities and nonidentical unknown control coefficients are studied. Although the model information of MASs is coarse, the leader-following consensus is still pursued, with a prescribed performance and zero consensus errors. Leveraging a powerful funnel control strategy, a fully distributed and completely relative-state-dependent protocol is designed. Distinctively, the time-varying function characterizing the performance boundary is introduced, not only to construct the funnel gains but also as an indispensable part of the protocol,enhancing the control ability and enabling the consensus errors to converge to zero(rather than a residual set). Remark that when control directions are unknown, coexisting with inherent system nonlinearities, it is essential to incorporate an additional compensation mechanism while imposing a hierarchical structure of communication topology for the control design and analysis. Simulation examples are given to illustrate the effectiveness of the theoretical results.
基金supported in part by the National Key Research and Development Program of China(2021YFE0206100)the National Natural Science Foundation of China(62425310,62073321)+2 种基金the National Defense Basic Scientific Research Program(JCKY2019203C029,JCKY2020130C025)the Science and Technology Development FundMacao SAR(FDCT-22-009-MISE,0060/2021/A2,0015/2020/AMJ)
文摘This paper highlights the utilization of parallel control and adaptive dynamic programming(ADP) for event-triggered robust parallel optimal consensus control(ETRPOC) of uncertain nonlinear continuous-time multiagent systems(MASs).First, the parallel control system, which consists of a virtual control variable and a specific auxiliary variable obtained from the coupled Hamiltonian, allows general systems to be transformed into affine systems. Of interest is the fact that the parallel control technique's introduction provides an unprecedented perspective on eliminating the negative effects of disturbance. Then, an eventtriggered mechanism is adopted to save communication resources while ensuring the system's stability. The coupled HamiltonJacobi(HJ) equation's solution is approximated using a critic neural network(NN), whose weights are updated in response to events. Furthermore, theoretical analysis reveals that the weight estimation error is uniformly ultimately bounded(UUB). Finally,numerical simulations demonstrate the effectiveness of the developed ETRPOC method.
文摘Cloud environments are essential for modern computing,but are increasingly vulnerable to Side-Channel Attacks(SCAs),which exploit indirect information to compromise sensitive data.To address this critical challenge,we propose SecureCons Framework(SCF),a novel consensus-based cryptographic framework designed to enhance resilience against SCAs in cloud environments.SCF integrates a dual-layer approach combining lightweight cryptographic algorithms with a blockchain-inspired consensus mechanism to secure data exchanges and thwart potential side-channel exploits.The framework includes adaptive anomaly detection models,cryptographic obfuscation techniques,and real-time monitoring to identify and mitigate vulnerabilities proactively.Experimental evaluations demonstrate the framework's robustness,achieving over 95%resilience against advanced SCAs with minimal computational overhead.SCF provides a scalable,secure,and efficient solution,setting a new benchmark for side-channel attack mitigation in cloud ecosystems.
文摘This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates sensor and actuator disturbances within the dynamics of follower robots.Each follower robot has unknown dynamics and control inputs,which expose it to the risks of both sensor and actuator attacks.The leader robot,described by a secondorder,time-varying nonlinear model,transmits its position,velocity,and acceleration information to follower robots through a wireless connection.To handle the complex setup and communication among robots in the network,we design a robust hybrid distributed adaptive control strategy combining the effect of sensor and actuator attack,which ensures asymptotic consensus,extending beyond conventional bounded consensus results.The proposed framework employs fuzzy logic systems(FLSs)as proactive controllers to estimate unknown nonlinear behaviors,while also effectively managing sensor and actuator attacks,ensuring stable consensus among all agents.To counter the impact of the combined signal attack on follower dynamics,a specialized robust control mechanism is designed,sustaining system stability and performance under adversarial conditions.The efficiency of this control strategy is demonstrated through simulations conducted across two different directed communication topologies,underscoring the protocol’s adaptability,resilience,and effectiveness in maintaining global consensus under complex attack scenarios.
基金supported by the National Natural Science Foundation of China(62373302,62333009)
文摘This paper investigates the secure impulsive consensus of Lipschitz-type nonlinear multi-agent systems(MASs) with input saturation. According to the coupling of input saturation and denial of service(DoS) attacks, impulsive control for MASs becomes extremely challenging. Considering general DoS attacks,this paper provides the sufficient conditions for the almost sure consensus of the MASs with input saturation, where the error system can achieve almost sure local exponential stability.Through linear matrix inequalities(LMIs), the relation between the trajectory boundary and DoS attacks is characterized, and the trajectory boundary is estimated. Furthermore, an optimization method of the domain of attraction is proposed to maximize the size. And a non-conservative and practical boundary is proposed to characterize the effect of DoS attacks on MASs. Finally, considering a multi-agent system with typical Chua's circuit dynamic model, an example is provided to illustrate the theorems' correctness.
