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Identification of key brain networks and functional connectivities of successful aging:A surface-based resting-state functional magnetic resonance study
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作者 Jiao-Jiao Sun Li Zhang +3 位作者 Ru-Hong Sun Xue-Zheng Gao Chun-Xia Fang Zhen-He Zhou 《World Journal of Psychiatry》 2025年第3期216-226,共11页
BACKGROUND Successful aging(SA)refers to the ability to maintain high levels of physical,cognitive,psychological,and social engagement in old age,with high cognitive function being the key to achieving SA.AIM To explo... BACKGROUND Successful aging(SA)refers to the ability to maintain high levels of physical,cognitive,psychological,and social engagement in old age,with high cognitive function being the key to achieving SA.AIM To explore the potential characteristics of the brain network and functional connectivity(FC)of SA.METHODS Twenty-six SA individuals and 47 usual aging individuals were recruited from community-dwelling elderly,which were taken the magnetic resonance imaging scan and the global cognitive function assessment by Mini Mental State Examination(MMSE).The resting state-functional magnetic resonance imaging data were preprocessed by DPABISurf,and the brain functional network was conducted by DPABINet.The support vector machine model was constructed with altered functional connectivities to evaluate the identification value of SA.RESULTS The results found that the 6 inter-network FCs of 5 brain networks were significantly altered and related to MMSE performance.The FC of the right orbital part of the middle frontal gyrus and right angular gyrus was mostly increased and positively related to MMSE score,and the FC of the right supramarginal gyrus and right temporal pole:Middle temporal gyrus was the only one decreased and negatively related to MMSE score.All 17 significantly altered FCs of SA were taken into the support vector machine model,and the area under the curve was 0.895.CONCLUSION The identification of key brain networks and FC of SA could help us better understand the brain mechanism and further explore neuroimaging biomarkers of SA. 展开更多
关键词 Successful aging Resting-state functional magnetic resonance imaging Surface-based brain network analysis Functional connectivity Support vector machine algorithm
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Changing Connectivities of Chinese Cities in the World City Network,2010–2016 被引量:19
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作者 Ben DERUDDER CAO Zhan +6 位作者 LIU Xingjian SHEN Wei DAI Liang ZHANG Weiyang Freke CASET Frank WITLOX Peter J.TAYLOR 《Chinese Geographical Science》 SCIE CSCD 2018年第2期183-201,共19页
Against the backdrop of the sizable economic growth of China in recent years, this paper uses the most recent data gathering of the Globalization and World Cities(Ga WC) research network to update and supplement earli... Against the backdrop of the sizable economic growth of China in recent years, this paper uses the most recent data gathering of the Globalization and World Cities(Ga WC) research network to update and supplement earlier research on the shifting global connectivity of Chinese cities. The update consists of an evaluation of the connectivity of Chinese cities in 2016, the supplement of an analysis of the changing position of Chinese cities in the world city network between 2010 and 2016. To this end, we build on a specification of the world city network as an ‘interlocking network' in which producer services firms play the crucial role in city network formation. Information about the presence of leading producer services firms in cities in 2010 and 2016 is used as the input to a bipartite network projection algorithm in order to measure cities' network connectivity. The first set of results discusses the geographies of urban connectivity in the world city network in 2016. The second set of results discusses standardized measures of change to reveal the major dimensions of the transformations between 2010 and 2016. We find that, with the exception of Hong Kong, Macao and Kaohsiung of Taiwan, all Chinese cities record connectivity gains. This wholesale rise in connectivity is nonetheless geographically uneven, with above all Beijing, Chengdu/Chongqing and Changsha/Wuhan becoming more connected. We conclude that the wholesale rise of Chinese cities in the world city network and their changing trajectories in the post-crisis era are embedded in shifting external and internal political economies. 展开更多
关键词 world city network producer services changing connectivities CITY China
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Connectivities of Minimal Cayley Coset Digraphs 被引量:2
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作者 MENG JIXIANG 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 1996年第4期497-500,共4页
we prove that the Connectivities of Minimal Cayley Coset Digraphs are their regular degrees. Connectivity of transitive digraphs and a combinatorial propertyof finite groups Ann., Discrete Math., 8 1980 61--64 ... we prove that the Connectivities of Minimal Cayley Coset Digraphs are their regular degrees. Connectivity of transitive digraphs and a combinatorial propertyof finite groups Ann., Discrete Math., 8 1980 61--64 Meng Jixiang and Huang Qiongxiang On the connectivity of Cayley digraphs, to appear Sabidussi, G. Vertex transitive graphs Monatsh. Math., 68 1969 426--438 Watkins, M. E. Connectivity of transitive graphs J. Combin. Theory, 8 1970 23--29 Zemor, G. On positive and negative atoms of Cayley digraphs Discrete Applied Math., 23 1989 193--195 Department of Mathematics,Xinjiang University,Urumpi 830046.APPLIED MATHEMATICS 3. Statement of Inexact Method Here we assume F to be continuousely differentiable. Inexact Newton method was first studied in the solution of smooth equations (see ). Now, such a technique has been widely used in optimizations, nonlinear complementarity problems and nonsmooth equations (see, and , etc.) In order to establish the related inexact methods,we introduce a nonlinear operator T(x): R n R n . Its components are defined as follows: (T(x)p) i=[HL(2:1,Z;2,Z] (x k+p k) i, if i∈(x k), H i(x k)+ min {(p k) i,F i(x k) Tp k}, if i∈(x k), F i(x k)+F i(x k) Tp k, i∈(x k).(3.1) Then, it is clear that the subproblem (2.5) turns to T(x k)p k=0.(3.2) In inexact algorithm, we determine p k in the followinginexact way ( see ). ‖T(x k)p k‖ υ k‖H(x k)‖,(3.3) where υ k is a given positive sequence. It is then obviously that (3.2),or equivalently (2.5), is a special case of (3.3) corresponding to υ k=0 . In particular, (3.3) can be used as a termination rule of the iterative process for solving (2.5). The following proposition shows the existence of λ k satisfying (2.4). Proposition 3.1. Let F be continuously differe ntiable. υ k is chosen so that υ k for some constant ∈(0,1). Then p k generated by (3.3) is a descent direction of θ at x k, and for some constant σ∈(0, min (1/2,1- holds θ(x k)-θ(x k+λ kp k) 2σλ kθ(x k)(3.4) for all sufficiently small λ k>0. Proof For simplification, we omit the lower subscripts k and denote (x k) i , H i(x k) , (BH(x k)p k) i , etc.by x i , H i , (BHp) i , etc. respectively. To estimate the directional derivative of θ at x k along p k , we divide it into three parts: D p k θ(x k)=H T(x k)BH(x k)p k=T 1+T 2+T 3,(3.5) where T 1=Σ i∈α k H i(BHp) i , T 2=Σ i∈β k H i(BHp) i , T 3=Σ i∈γ k H i(BHp) i . Consider i∈α k= k∪α -(x k) . In this case, we always have H i(BH(x)p) i=H i 2+H i(x i+p i) . If i∈ k , then H i(BHp) i -H i 2+|H i‖(T(x)p) i|. If i∈α -(x k) , then x i<0 . We have either x i+p i 0 , or x i+p i<0 . When x i+p i 0 , we get H i(BH(x)p) i -H i 2 .In the later case, x i+p i<0 , so H i(BH(x)p) i=-H i 2+|H i‖x i+p i|. Then, by elementary computation, we deduce that T 1 -Σi∈α kH i 2+Σ i∈α k|H i‖(T(x)p) i|.(3.6) Received March 1, 1995. 1991 MR Subject Classification: 05C25 展开更多
关键词 Connectivity Cayley coset digraph
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Input signal design to estimate interwell connectivities in mature fields from the capacitance-resistance model 被引量:1
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作者 Gustavo A.Moreno Larry W.Lake 《Petroleum Science》 SCIE CAS CSCD 2014年第4期563-568,共6页
Interwell connectivities are fundamental parameters required to manage waterfloods in oil reservoirs. Data-driven models, such as the capacitance-resistance model (CRM), are fast tools to estimate these parameters f... Interwell connectivities are fundamental parameters required to manage waterfloods in oil reservoirs. Data-driven models, such as the capacitance-resistance model (CRM), are fast tools to estimate these parameters from time-correlations of input (injection rates) and output (production rates) signals. Noise and structure of the input time-series impose limits on the information that can be extracted from a given data-set. This work uses the CRM to study general prescriptions for the design of input signals that enhance the information content of injection/production data in the estimation of well-to-well interactions. Numerical schemes and general features of the optimal input signal strategy are derived for this problem. 展开更多
关键词 Intervell connectivity capacitance-resistance model mature field experiment design
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The Edge Connectivities of Total P_(k)-graphs
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作者 HAO Chen TAN Li ZHUANG Wei 《广西师范学院学报(自然科学版)》 2013年第3期8-12,共5页
The P_(k)-path graph P_(k)(G)corresponding to a graph G has for vertices the set of all paths of length k in G.Two vertices are joined by an edge if and only if the intersection of the corresponding paths forms a path... The P_(k)-path graph P_(k)(G)corresponding to a graph G has for vertices the set of all paths of length k in G.Two vertices are joined by an edge if and only if the intersection of the corresponding paths forms a path of length k-1 in G,and their union forms either a cycle or a path of length k+1.Let Ek={(v,p),p E V(P_(k)(G)),v is an end vertex of p in G},we define total P_(k)-graphs T_(k)(G)as Yk(G)=(V(G)UV(P_(k)(G)),E(G)U E(PI(G))U Ek).In this note,we introduce total P,-graphs Th(G)and study their edge connectivity,as the generaliza-tion of total graphs. 展开更多
关键词 edge connectivity total graph path graphl total P_(k)-graph
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An Optimal Right-Turn Coordination System for Connected and Automated Vehicles at Urban Intersections
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作者 Mahmudul Hasan Shuji Doman +2 位作者 A.S.M.Bakibillah Md Abdus Samad Kamal Kou Yamada 《Computers, Materials & Continua》 2026年第1期430-446,共17页
Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination syst... Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination system for Connected and Automated Vehicles(CAVs)at single-lane intersections,particularly in the context of left-hand side driving on roads.The goal is to facilitate smooth right turns for certain vehicles without creating bottlenecks.We consider that all approaching vehicles share relevant information through vehicular communications.The Intersection Coordination Unit(ICU)processes this information and communicates the optimal crossing or turning times to the vehicles.The primary objective of this coordination is to minimize overall traffic delays,which also helps improve the fuel consumption of vehicles.By considering information from upcoming vehicles at the intersection,the coordination system solves an optimization problem to determine the best timing for executing right turns,ultimately minimizing the total delay for all vehicles.The proposed coordination system is evaluated at a typical urban intersection,and its performance is compared to traditional traffic systems.Numerical simulation results indicate that the proposed coordination system significantly enhances the average traffic speed and fuel consumption compared to the traditional traffic system in various scenarios. 展开更多
关键词 Right-turn coordination connected and automated vehicles vehicular communication edge processing urban intersection
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Noradrenergic excitation of astrocytes supports cognitive reserve
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作者 Robert Zorec Alexei Verkhratsky 《Neural Regeneration Research》 2026年第4期1546-1547,共2页
The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It ha... The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024). 展开更多
关键词 ASTROCYTES brain reserve cognitive reserve clinical symptoms noradrenergic excitation neural reserve neural connections brain cognitive reserve
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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Sesquiterpene lactones as potential drugs treating nerve injury
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作者 Philipp Gobrecht Marco Leibinger Dietmar Fischer 《Neural Regeneration Research》 2026年第2期671-672,共2页
Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,... Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,this may lead to permanent impairements resulting in a loss of quality of life and a high socioeconomic burden. 展开更多
关键词 traumatic axonal lesions peripheral nervous system s axonal regrowththis permanent impairements nerve injury peripheral nerves disrupt neuronal connections sesquiterpene lactones
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基于H1 Connect的多元化评价标签相关分析及综合评价指标体系建立研究 被引量:1
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作者 许丹 罗祥东 +1 位作者 王雯霞 徐爽 《江苏科技信息》 2025年第5期93-98,共6页
文章基于H1 Connect对生物医学科技论文各类同行评议标签进行相关性分析研究,结合多元化指标尝试构建更为全面、科学的论文评价指标体系。从H1 Connect、Altmetric、WoS(Web of Science)平台获取同行评议、社会影响力、学术影响力代表... 文章基于H1 Connect对生物医学科技论文各类同行评议标签进行相关性分析研究,结合多元化指标尝试构建更为全面、科学的论文评价指标体系。从H1 Connect、Altmetric、WoS(Web of Science)平台获取同行评议、社会影响力、学术影响力代表性指标和评价标签,根据规则计算出综合评分,运用SPSS软件进行斯皮尔曼相关性比较分析。H1 Connect中同行评议各指标与不同评价标签之间大多呈低相关或不相关关系。相对引用率与同行评级之间也呈低相关或不相关关系,而星级权重与同行评级“Very Good”和“Exceptional”呈中度相关。文章提出综合评分指标CS,该指标与同行评议结果呈中度相关性,与社会影响力和学术影响力评价结果也高度一致,可为生物医学领域的学术评价提供新视角。 展开更多
关键词 H1 Connect 综合评分 评价标签 对比分析
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Unseen streams tracing emerging contaminants from stormwater to surface water:A brief review 被引量:1
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作者 Wenyuan Yang Minghao Shi +2 位作者 Tiantao Zhao Zuxin Xu Wenhai Chu 《Journal of Environmental Sciences》 2025年第9期96-110,共15页
Emerging contaminants(ECs)have raised global concern due to their adverse effect on ecosystems and human health.However,the occurrence and transport of ECs in stormwater remain unclear.The impact of ECs from stormwate... Emerging contaminants(ECs)have raised global concern due to their adverse effect on ecosystems and human health.However,the occurrence and transport of ECs in stormwater remain unclear.The impact of ECs from stormwater on surface water quality and ecosystem health is also poorly documented.In this review,we examined the variations in EC concentrations in surface water resulting from stormwater.During the wet weather,the concentrations of most investigated ECs,e.g.,microplastics,per-and polyfluoroalkyl substances,and vehicle-related compounds,significantly increase in surface water,indicating that stormwater may be a critical source of these contaminants.Furthermore,the potential pathways of ECs from stormwater enter surface water are outlined.Studies demonstrate that surface runoff and combined sewer overflows are important pathways for ECs,with discharges comparable to or exceeding those from wastewater treatment plants.Illicit connection also plays an important part in elevated EC concentrations in surface water.Overall,our findings underscore the importance of stormwater as a source for ECs in surface waters,and urge for increased emphasis on,and reinforcement of,stormwater monitoring and control measures to minimize the transport of ECs into receiving water bodies. 展开更多
关键词 Emerging contaminants STORMWATER Surface runoff Combined sewer overflow Illicit connection
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高水平论文开放同行评议意见分析及启示——以H1Connect为例 被引量:1
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作者 刘晓娟 于姚 沈嘉宁 《数字图书馆论坛》 2025年第1期55-66,共12页
开放同行评议为论文评价提供了新的视角,分析高水平论文的评议意见特征,有利于评判优质论文、优化学术评价体系。以被全球生物医学领域权威开放同行评议平台H1 Connect专家推荐的、发表在顶级期刊上有关COVID-19的论文为高水平论文的典... 开放同行评议为论文评价提供了新的视角,分析高水平论文的评议意见特征,有利于评判优质论文、优化学术评价体系。以被全球生物医学领域权威开放同行评议平台H1 Connect专家推荐的、发表在顶级期刊上有关COVID-19的论文为高水平论文的典型案例,爬取这些论文在H1 Connect中的开放同行评议意见,从指标和文本两个层面分析专家评议意见所体现的对高水平论文的关注和认可程度、情感特征以及价值特征。研究发现,高水平论文能快速吸引专家的关注,但仅有少数引发热议。开放同行评议文本中存在一定数量的情感句,明确体现了专家的观点态度:正向评价居多,主要针对论文的总体表现;负向评价较少,主要针对论文采用的研究方法。开放同行评议意见认为论文的价值体现在学术领域和实践应用的多个维度,应用贡献更为突出。通过对高水平论文开放同行评议意见的分析,建议在学术评价体系中引入开放同行评议数据源,以提升学术评价的科学性和有效性。实际应用中,仍需进一步完善同行评议指标,深入挖掘评议文本中的关键要素,加强资源建设与技术融合,利用前沿技术智能解析评议文本的深层价值。 展开更多
关键词 开放同行评议 高水平论文 学术评价 H1 Connect
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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits
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作者 Yuehua Cui Xiaokuang Ma +7 位作者 Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1431-1444,共14页
Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse functi... Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions. 展开更多
关键词 aging circuit connectivity cortical circuits molecular mechanisms neural regeneration NEURODEGENERATION synapses
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Effects of Changes in Hydrological Connectivity Induced by Spartina alterniflora Invasions on Suaeda salsa Community Evolution in Yellow River Estuary Wetland, China 被引量:1
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作者 ZHANG Xin LI Yunzhao +6 位作者 YU Junbao GUAN Bo YANG Jisong ZHOU Di WANG Xuehong LI Xue ZHOU Jie 《Chinese Geographical Science》 2025年第3期423-437,共15页
Spartina alterniflora invasions seriously threaten the structure and functions of coastal wetlands in China.In this study,the Suaeda salsa community in the Yellow River Estuary wetland was monitored using long-term La... Spartina alterniflora invasions seriously threaten the structure and functions of coastal wetlands in China.In this study,the Suaeda salsa community in the Yellow River Estuary wetland was monitored using long-term Landsat satellite images acquired from 1997 to 2020 to quantify the impact of changes in hydrological connectivity induced by S.alterniflora on neighboring vegetation com-munities.The results showed that S.alterniflora rapidly expanded in the estuary area at a rate of 4.91 km^(2)/yr from 2010 to 2020.At the same time,the hydrological connectivity of the area and the distribution of S.salsa changed significantly.Small tidal creeks dominated the S.alterniflora landscape.The number of tidal creeks increased significantly,but their average length decreased and they tended to develop in a horizontal tree-like pattern.Affected by the changes in hydrological connectivity due to the S.alterniflora invasion,the area of S.salsa decreased by 41.1%,and the degree of landscape fragmentation increased from 1997 to 2020.Variations in the Largest Patch Index(LPI)indicated that the S.alterniflora landscape had become the dominant landscape type in the Yellow River Estuary.The res-ults of standard deviation ellipse(SDE)and Pearson’s correlation analyses indicated that a well-developed hydrological connectivity could promote the maintenance of the S.salsa landscape.The degradation of most S.salsa communities is caused by the influence of S.alterniflora on the morphological characteristics of the hydrological connectivity of tidal creek systems. 展开更多
关键词 hydrological connectivity tidal creek Spartina alterniflora Suaeda salsa Yellow River Estuary wetland China
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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control
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作者 Fernando Jose Bustos 《Neural Regeneration Research》 SCIE CAS 2025年第1期186-187,共2页
Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully a... Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas alone.Instead,they involve connectivity among brain areas,whether close or distant.At that time,this approach was considered the optimal way to dissect brain circuitry and function.These pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain function.However,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely elusive.Utilizing animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established. 展开更多
关键词 behavior CONNECTIVITY NEURAL
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The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning:A TMS and TMS-EEG Study 被引量:1
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作者 Jing Chen Yanzi Fan +6 位作者 Xize Jia Fengmei Fan Jinhui Wang Qihong Zou Bing Chen Xianwei Che Yating Lv 《Neuroscience Bulletin》 2025年第5期837-852,共16页
Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modula... Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified.This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper(SMAp)in modulating MSL across different complexity levels and for both hands,as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation.Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL,which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions,particularly in interhemispheric connections.These findings may have important clinical implications,particularly for motor rehabilitation in populations such as post-stroke patients. 展开更多
关键词 Motor sequence learning Intermittent theta burst stimulation Concurrent transcranial magnetic stimulation and electroencephalogram NEUROPLASTICITY Functional connectivity
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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats
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作者 Yunting Xiang Xiangxin Xing +6 位作者 Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu 《Neural Regeneration Research》 SCIE CAS 2025年第5期1495-1504,共10页
Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network lev... Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery. 展开更多
关键词 brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity
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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats
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作者 Pengfei Wang Yuewei Bi +6 位作者 Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang 《Neural Regeneration Research》 SCIE CAS 2025年第4期1164-1177,共14页
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu... Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia. 展开更多
关键词 aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials NEUROMODULATION Parkinson’s disease primary motor cortex
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Vertical gradients of neutral winds observed by ICON and estimated by the Horizontal Wind Model during the geomagnetic storm on August 26−28,2021
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作者 JiaWei Wu Chao Xiong +1 位作者 YuYang Huang YunLiang Zhou 《Earth and Planetary Physics》 EI CAS 2025年第1期69-80,共12页
The Michelson Interferometer for Global High-resolution Thermospheric Imaging(MIGHTI)onboard the Ionospheric Connection Explorer(ICON)satellite offers the opportunity to investigate the altitude profile of thermospher... The Michelson Interferometer for Global High-resolution Thermospheric Imaging(MIGHTI)onboard the Ionospheric Connection Explorer(ICON)satellite offers the opportunity to investigate the altitude profile of thermospheric winds.In this study,we used the red-line measurements of MIGHTI to compare with the results estimated by Horizontal Wind Model 14(HWM14).The data selected included both the geomagnetic quiet period(December 2019 to August 2022)and the geomagnetic storm on August 26-28,2021.During the geomagnetic quiet period,the estimations of neutral winds from HWM14 showed relatively good agreement with the observations from ICON.According to the ICON observations,near the equator,zonal winds reverse from westward to eastward at around 06:00 local time(LT)at higher altitudes,and the stronger westward winds appear at later LTs at lower altitudes.At around 16:00 LT,eastward winds at 300 km reverse to westward,and vertical gradients of zonal winds similar to those at sunrise hours can be observed.In the middle latitudes,zonal winds reverse about 2-4 h earlier.Meridional winds vary more significantly than zonal winds with seasonal and latitudinal variations.According to the ICON observations,in the northern low latitudes,vertical reversals of meridional winds are found at 08:00-13:00 LT from 300 to 160 km and at around 18:00 LT from 300 to 200 km during the June solstice.Similar reversals of meridional winds are found at 04:00-07:00 LT from 300 to 160 km and at 22:00-02:00 LT from 270 to 200 km during the December solstice.In the southern low latitudes,meridional wind reversals occur at 08:00-11:00 LT from 200 to 160 km and at 21:00-02:00 LT from 300 to 200 km during the June solstice.During the December solstice,reversals of the meridional wind appear at 20:00-01:00 LT below 200 km and at 06:00-11:00 LT from 300 to 160 km.In the northern middle latitudes,the northward winds are dominant at 08:00-14:00 LT at 230 km during the June solstice.Northward winds persist until 16:00 LT at 160 and 300 km.During the December solstice,the northward winds are dominant from 06:00 to 21:00 LT.The vertical variations in neutral winds during the geomagnetic storm on August 26-28 were analyzed in detail.Both meridional and zonal winds during the active geomagnetic period observed by ICON show distinguishable vertical shear structures at different stages of the storm.On the dayside,during the main phase,the peak velocities of westward winds extend from a higher altitude to a lower altitude,whereas during the recovery phase,the peak velocities of the westward winds extend from lower altitudes to higher altitudes.The velocities of the southward winds are stronger at lower altitudes during the storm.These vertical structures of horizontal winds during the storm could not be reproduced by the HWM14 wind estimations,and the overall response to the storm of the horizontal winds in the low and middle latitudes is underestimated by HWM14.The ICON observations provide a good dataset for improving the HWM wind estimations in the middle and upper atmosphere,especially the vertical variations. 展开更多
关键词 horizontal neutral winds vertical gradients Ionospheric Connection Explorer satellite Horizontal Wind Model 14 geomagnetic storm
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Current status and diversity of fish resources in the Pinglu Canal Century Project
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作者 LU Jia TANG Wei +3 位作者 WANG Li XU Shengxian ZHANG Peng YANG Shengfa 《水利水电技术(中英文)》 北大核心 2025年第4期131-144,共14页
[Objective]The channel straightening project of the Pinglu Canal has fragmented the river course,compromising the integrity of original river course and causing ecosystem patchiness.Understanding the current status of... [Objective]The channel straightening project of the Pinglu Canal has fragmented the river course,compromising the integrity of original river course and causing ecosystem patchiness.Understanding the current status of fish resources and the characteristics of their diversity is crucial for the ecological management of the Pinglu Canal.[Methods]During the spring and autumn in 2021 and 2022,a survey of fish resources and species diversity in the Pinglu Canal was conducted using multi-mesh gill nets.A total of 125 fish species were collected,belonging to 10 orders,34 families,and 89 genera.[Results]The result showed that the Pinglu Canal contained three nationally protected Class II species,two endemic species of the Qinjiang River,three anadromous/migratory species,and eight invasive species,accounting for 2.4%,1.6%,2.4%,and 6.4%of the total species,respectively.The fish community primarily consisted of mid-and bottom-dwelling,adhesive-egg-laying,and omnivorous species.The Shannon-Wiener,Simpson,Margalef,and Pielou indices of the fish community in the Pinglu Canal ranged from 2.347 to 2.757,0.081 to 0.151,3.493 to 4.382,and 0.812 to 0.892,respectively.These indices showed relatively uniform distribution across different river reaches.[Conclusion]The result indicate that the fish community structure in the Pinglu Canal is relatively uniform.The reach from the Yujiang River to the Shaping River shows higher stability,while other river reaches experience moderate or severe disturbances.This study provides supplementary baseline data on the fish community structure in the Pinglu Canal and explores the potential impact of inter-basin connectivity on fish resources,aiming to provide a scientific basis for habitat restoration assessments after the channel straightening project. 展开更多
关键词 Pinglu Canal Project inter-basin connectivity fish resources community structure BIODIVERSITY influencing factors
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