Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In v...Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and pro- duced highly contrasted visualization of the brain.展开更多
Objective：Contrast-enhanced ultrasound （CEUS） is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices...Objective：Contrast-enhanced ultrasound （CEUS） is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices,and its applications in the assessment of inflammatory arthritis,such as rheumatoid arthritis,psoriatic arthritis,and ankylosing spondylitis,have provoked abundant discussion and researches among radiologists and rheumatologists.To summarize the achievements of clinical studies on CEUS in the application of arthritis,and to keep up with the latest progresses of the imaging technique,we reviewed the literature in recent years,hoping to establish the role of CEUS in joint diseases.Data Sources：PubMed and EMBASE.Study Selection：We searched the database with the conditions ＂contrast-enhanced ultrasound AND arthritis＂ with the time limitation of recent 10 years.Clinical studies applying CEUS in inflammatory arthritis and review articles about development of CEUS in joint diseases in English were selected.Results：As it is proved by most studies in recent years,by delineating microvasculature within the inflamed joints,CEUS can indicate early arthritis with high sensitivity and specificity.Moreover,the imaging of CEUS has been proved to be consistent with histopathological changes of inflammatory arthritis.Quantitative analysis of CEUS permits further evaluation of disease activity.CEUS also plays a significant role in the therapeutic monitoring of the disease,which has been backed up by a number of studies.Conclusions：CEUS may be a new choice for the rheumatologists to evaluate inflammatory arthritis,because of its low price,ability to provide dynamic pictures,and high sensitivity to angiogenesis.It can also be applied in disease classification and therapeutic monitoring.More studies about CEUS need to be done to set up the diagnostic standards.展开更多
基金Project supported by National Natural Science Foundation of China (51173140)Key Natural Science Foundation of Hubei Province (2009CDA052)Wuhan Scientific and Technological Research and Development Program, Hubei Province (201060623274)
文摘Gadolinium diethylenetriamine-pentaacetic bisdopamide （Gd-DTPA-2DA） was synthesized by the incorporation of dopamine to diethylenetriaminepentaacetic acid （DTPA） and further reaction with gadolinium chloride. In vitro and in vivo properties were also evaluated. Gadolinium complex Gd-DTPA-2DA possessed higher relaxation effectiveness and less cytotoxicity to HeLa cells than that of Gd-DTPA. Moreover, Gd-DTPA-2DA greatly enhanced the contrast of MR images of the brains, provided prolonged intravascular duration, and pro- duced highly contrasted visualization of the brain.
基金This study was supported by grants from the International S and T Cooperation Program of China （No. 2015 DFA30440）, the Natural Science Foundation of China （No. 81301268）, and Beijing Nova Plan （No. Z 131 107000413063）.
文摘Objective：Contrast-enhanced ultrasound （CEUS） is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices,and its applications in the assessment of inflammatory arthritis,such as rheumatoid arthritis,psoriatic arthritis,and ankylosing spondylitis,have provoked abundant discussion and researches among radiologists and rheumatologists.To summarize the achievements of clinical studies on CEUS in the application of arthritis,and to keep up with the latest progresses of the imaging technique,we reviewed the literature in recent years,hoping to establish the role of CEUS in joint diseases.Data Sources：PubMed and EMBASE.Study Selection：We searched the database with the conditions ＂contrast-enhanced ultrasound AND arthritis＂ with the time limitation of recent 10 years.Clinical studies applying CEUS in inflammatory arthritis and review articles about development of CEUS in joint diseases in English were selected.Results：As it is proved by most studies in recent years,by delineating microvasculature within the inflamed joints,CEUS can indicate early arthritis with high sensitivity and specificity.Moreover,the imaging of CEUS has been proved to be consistent with histopathological changes of inflammatory arthritis.Quantitative analysis of CEUS permits further evaluation of disease activity.CEUS also plays a significant role in the therapeutic monitoring of the disease,which has been backed up by a number of studies.Conclusions：CEUS may be a new choice for the rheumatologists to evaluate inflammatory arthritis,because of its low price,ability to provide dynamic pictures,and high sensitivity to angiogenesis.It can also be applied in disease classification and therapeutic monitoring.More studies about CEUS need to be done to set up the diagnostic standards.
