期刊文献+
共找到1,146篇文章
< 1 2 58 >
每页显示 20 50 100
Evaluation of spatial variability characteristics based on anisotropic modes of random fields
1
作者 Kejing Chen Qinghui Jiang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期494-508,共15页
This paper introduces a framework for modeling random fields,with a particular emphasis on analyzing anisotropic spatial variability.It establishes a clear connection between the correlation function and the Kriging v... This paper introduces a framework for modeling random fields,with a particular emphasis on analyzing anisotropic spatial variability.It establishes a clear connection between the correlation function and the Kriging variogram across various anisotropic modes,providing mathematical models to enhance our understanding of random fields.A new anisotropy index,called LSAI,is introduced to quantify anisotropy based on the autocorrelation length and the orientation of the principal axes within the variogram.An LSAI value closer to one indicates a lower degree of anisotropy.The present study examines how the degree of anisotropy varies with different autocorrelation lengths and angles between the principal axes,providing valuable insights into these relationships.To improve the accuracy of parameter probability distribution estimations,this study integrates limited field test data using a Bayesian inference approach.Additionally,the Markov chain Monte Carlo simulation method is employed to develop a conditional random field(CRF)for the deformation modulus.By incorporating data from field bearing plate tests,the posterior variance data for the deformation modulus are derived.This process facilitates the construction of a detailed and reliable CRF for the deformation modulus. 展开更多
关键词 conditional random field(crf) Anisotropic mode KRIGING Bayesian method VARIOGRAM
在线阅读 下载PDF
Semantic role labeling based on conditional random fields 被引量:9
2
作者 于江德 樊孝忠 +1 位作者 庞文博 余正涛 《Journal of Southeast University(English Edition)》 EI CAS 2007年第3期361-364,共4页
Due to the fact that semantic role labeling (SRL) is very necessary for deep natural language processing, a method based on conditional random fields (CRFs) is proposed for the SRL task. This method takes shallow ... Due to the fact that semantic role labeling (SRL) is very necessary for deep natural language processing, a method based on conditional random fields (CRFs) is proposed for the SRL task. This method takes shallow syntactic parsing as the foundation, phrases or named entities as the labeled units, and the CRFs model is trained to label the predicates' semantic roles in a sentence. The key of the method is parameter estimation and feature selection for the CRFs model. The L-BFGS algorithm was employed for parameter estimation, and three category features: features based on sentence constituents, features based on predicate, and predicate-constituent features as a set of features for the model were selected. Evaluation on the datasets of CoNLL-2005 SRL shared task shows that the method can obtain better performance than the maximum entropy model, and can achieve 80. 43 % precision and 63. 55 % recall for semantic role labeling. 展开更多
关键词 semantic role labeling conditional random fields parameter estimation feature selection
在线阅读 下载PDF
TONE MODELING BASED ON HIDDEN CONDITIONAL RANDOM FIELDS AND DISCRIMINATIVE MODEL WEIGHT TRAINING 被引量:1
3
作者 黄浩 朱杰 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2008年第1期43-50,共8页
The use of hidden conditional random fields (HCRFs) for tone modeling is explored. The tone recognition performance is improved using HCRFs by taking advantage of intra-syllable dynamic, inter-syllable dynamic and d... The use of hidden conditional random fields (HCRFs) for tone modeling is explored. The tone recognition performance is improved using HCRFs by taking advantage of intra-syllable dynamic, inter-syllable dynamic and duration features. When the tone model is integrated into continuous speech recognition, the discriminative model weight training (DMWT) is proposed. Acoustic and tone scores are scaled by model weights discriminatively trained by the minimum phone error (MPE) criterion. Two schemes of weight training are evaluated and a smoothing technique is used to make training robust to overtraining problem. Experiments show that the accuracies of tone recognition and large vocabulary continuous speech recognition (LVCSR) can be improved by the HCRFs based tone model. Compared with the global weight scheme, continuous speech recognition can be improved by the discriminative trained weight combinations. 展开更多
关键词 speech recognition MODELS hidden conditional random fields minimum phone error
在线阅读 下载PDF
Power entity recognition based on bidirectional long short-term memory and conditional random fields 被引量:9
4
作者 Zhixiang Ji Xiaohui Wang +1 位作者 Changyu Cai Hongjian Sun 《Global Energy Interconnection》 2020年第2期186-192,共7页
With the application of artificial intelligence technology in the power industry,the knowledge graph is expected to play a key role in power grid dispatch processes,intelligent maintenance,and customer service respons... With the application of artificial intelligence technology in the power industry,the knowledge graph is expected to play a key role in power grid dispatch processes,intelligent maintenance,and customer service response provision.Knowledge graphs are usually constructed based on entity recognition.Specifically,based on the mining of entity attributes and relationships,domain knowledge graphs can be constructed through knowledge fusion.In this work,the entities and characteristics of power entity recognition are analyzed,the mechanism of entity recognition is clarified,and entity recognition techniques are analyzed in the context of the power domain.Power entity recognition based on the conditional random fields (CRF) and bidirectional long short-term memory (BLSTM) models is investigated,and the two methods are comparatively analyzed.The results indicated that the CRF model,with an accuracy of 83%,can better identify the power entities compared to the BLSTM.The CRF approach can thus be applied to the entity extraction for knowledge graph construction in the power field. 展开更多
关键词 Knowledge graph Entity recognition conditional random fields(crf) Bidirectional Long Short-Term Memory(BLSTM)
在线阅读 下载PDF
Iterated Conditional Modes to Solve Simultaneous Localization and Mapping in Markov Random Fields Context 被引量:3
5
作者 J.Gimenez A.Amicarelli +2 位作者 J.M.Toibero F.di Sciascio R.Carelli 《International Journal of Automation and computing》 EI CSCD 2018年第3期310-324,共15页
This paper models the complex simultaneous localization and mapping(SLAM) problem through a very flexible Markov random field and then solves it by using the iterated conditional modes algorithm. Markovian models al... This paper models the complex simultaneous localization and mapping(SLAM) problem through a very flexible Markov random field and then solves it by using the iterated conditional modes algorithm. Markovian models allow to incorporate: any motion model; any observation model regardless of the type of sensor being chosen; prior information of the map through a map model; maps of diverse natures; sensor fusion weighted according to the accuracy. On the other hand, the iterated conditional modes algorithm is a probabilistic optimizer widely used for image processing which has not yet been used to solve the SLAM problem. This iterative solver has theoretical convergence regardless of the Markov random field chosen to model. Its initialization can be performed on-line and improved by parallel iterations whenever deemed appropriate. It can be used as a post-processing methodology if it is initialized with estimates obtained from another SLAM solver. The applied methodology can be easily implemented in other versions of the SLAM problem, such as the multi-robot version or the SLAM with dynamic environment. Simulations and real experiments show the flexibility and the excellent results of this proposal. 展开更多
关键词 Simultaneous localization and mapping Markov random fields iterated conditional modes modelling on-line solver.
原文传递
A CONDITIONAL RANDOM FIELDS APPROACH TO BIOMEDICAL NAMED ENTITY RECOGNITION 被引量:4
6
作者 Wang Haochang Zhao Tiejun Li Sheng Yu Hao 《Journal of Electronics(China)》 2007年第6期838-844,共7页
Named entity recognition is a fundamental task in biomedical data mining. In this letter, a named entity recognition system based on CRFs (Conditional Random Fields) for biomedical texts is presented. The system mak... Named entity recognition is a fundamental task in biomedical data mining. In this letter, a named entity recognition system based on CRFs (Conditional Random Fields) for biomedical texts is presented. The system makes extensive use of a diverse set of features, including local features, full text features and external resource features. All features incorporated in this system are described in detail, and the impacts of different feature sets on the performance of the system are evaluated. In order to improve the performance of system, post-processing modules are exploited to deal with the abbreviation phenomena, cascaded named entity and boundary errors identification. Evaluation on this system proved that the feature selection has important impact on the system performance, and the post-processing explored has an important contribution on system performance to achieve better resuits. 展开更多
关键词 conditional random fields crfs) Named entity recognition Feature selection Post-processing
在线阅读 下载PDF
Adaptive foreground and shadow segmentation using hidden conditional random fields 被引量:1
7
作者 CHU Yi-ping YE Xiu-zi +2 位作者 QIAN Jiang ZHANG Yin ZHANG San-yuan 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第4期586-592,共7页
Video object segmentation is important for video surveillance, object tracking, video object recognition and video editing. An adaptive video segmentation algorithm based on hidden conditional random fields (HCRFs) is... Video object segmentation is important for video surveillance, object tracking, video object recognition and video editing. An adaptive video segmentation algorithm based on hidden conditional random fields (HCRFs) is proposed, which models spatio-temporal constraints of video sequence. In order to improve the segmentation quality, the weights of spatio-temporal con- straints are adaptively updated by on-line learning for HCRFs. Shadows are the factors affecting segmentation quality. To separate foreground objects from the shadows they cast, linear transform for Gaussian distribution of the background is adopted to model the shadow. The experimental results demonstrated that the error ratio of our algorithm is reduced by 23% and 19% respectively, compared with the Gaussian mixture model (GMM) and spatio-temporal Markov random fields (MRFs). 展开更多
关键词 Video segmentation Shadow elimination Hidden conditional random fields (Hcrfs) On-line learning
在线阅读 下载PDF
A Remote Sensing Image Semantic Segmentation Method by Combining Deformable Convolution with Conditional Random Fields 被引量:13
8
作者 Zongcheng ZUO Wen ZHANG Dongying ZHANG 《Journal of Geodesy and Geoinformation Science》 2020年第3期39-49,共11页
Currently,deep convolutional neural networks have made great progress in the field of semantic segmentation.Because of the fixed convolution kernel geometry,standard convolution neural networks have been limited the a... Currently,deep convolutional neural networks have made great progress in the field of semantic segmentation.Because of the fixed convolution kernel geometry,standard convolution neural networks have been limited the ability to simulate geometric transformations.Therefore,a deformable convolution is introduced to enhance the adaptability of convolutional networks to spatial transformation.Considering that the deep convolutional neural networks cannot adequately segment the local objects at the output layer due to using the pooling layers in neural network architecture.To overcome this shortcoming,the rough prediction segmentation results of the neural network output layer will be processed by fully connected conditional random fields to improve the ability of image segmentation.The proposed method can easily be trained by end-to-end using standard backpropagation algorithms.Finally,the proposed method is tested on the ISPRS dataset.The results show that the proposed method can effectively overcome the influence of the complex structure of the segmentation object and obtain state-of-the-art accuracy on the ISPRS Vaihingen 2D semantic labeling dataset. 展开更多
关键词 high-resolution remote sensing image semantic segmentation deformable convolution network conditions random fields
在线阅读 下载PDF
Probabilistic Site Investigation Optimization of Gassy Soils Based on Conditional Random Field and Monte Carlo Simulation
9
作者 Shaolin Ding 《World Journal of Engineering and Technology》 2025年第1期1-11,共11页
Gassy soils are distributed in relatively shallow layers the Quaternary deposit in Hangzhou Bay area. The shallow gassy soils significantly affect the construction of underground projects. Proper characterization of s... Gassy soils are distributed in relatively shallow layers the Quaternary deposit in Hangzhou Bay area. The shallow gassy soils significantly affect the construction of underground projects. Proper characterization of spatial distribution of shallow gassy soils is indispensable prior to construction of underground projects in the area. Due to the costly conditions required in the site investigation for gassy soils, only a limited number of gas pressure data can be obtained in engineering practice, which leads to the uncertainty in characterizing spatial distribution of gassy soils. Determining the number of boreholes for investigating gassy soils and their corresponding locations is pivotal to reducing construction risk induced by gassy soils. However, this primarily relies on the engineering experience in the current site investigation practice. This study develops a probabilistic site investigation optimization method for planning investigation schemes (including the number and locations of boreholes) of gassy soils based on the conditional random field and Monte Carlo simulation. The proposed method aims to provide an optimal investigation scheme before the site investigation based on prior knowledge. Finally, the proposed approach is illustrated using a case study. 展开更多
关键词 Gassy Soils Site Investigation UNCERTAINTY conditional random Field Monte Carlo Simulation
在线阅读 下载PDF
Fast Chinese syntactic parsing method based on conditional random fields
10
作者 韩磊 罗森林 +1 位作者 陈倩柔 潘丽敏 《Journal of Beijing Institute of Technology》 EI CAS 2015年第4期519-525,共7页
A fast method for phrase structure grammar analysis is proposed based on conditional ran- dom fields (CRF). The method trains several CRF classifiers for recognizing the phrase nodes at dif- ferent levels, and uses ... A fast method for phrase structure grammar analysis is proposed based on conditional ran- dom fields (CRF). The method trains several CRF classifiers for recognizing the phrase nodes at dif- ferent levels, and uses the bottom-up to connect the recognized phrase nodes to construct the syn- tactic tree. On the basis of Beijing forest studio Chinese tagged corpus, two experiments are de- signed to select the training parameters and verify the validity of the method. The result shows that the method costs 78. 98 ms and 4. 63 ms to train and test a Chinese sentence of 17. 9 words. The method is a new way to parse the phrase structure grammar for Chinese, and has good generalization ability and fast speed. 展开更多
关键词 phrase structure grammar syntactic tree syntactic parsing conditional random field
在线阅读 下载PDF
Standardization of Robot Instruction Elements Based on Conditional Random Fields and Word Embeddin
11
作者 Hengsheng Wang Zhengang Zhang +1 位作者 Jin Ren Tong Liu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2019年第5期32-40,共9页
Natural language processing has got great progress recently. Controlling robots with spoken natural language has become expectable. With the reliability problem of this kind of control in mind a confirmation process o... Natural language processing has got great progress recently. Controlling robots with spoken natural language has become expectable. With the reliability problem of this kind of control in mind a confirmation process of natural language instruction should be included before carried out by the robot autonomously and the prototype dialog system was designed thus the standardization problem was raised for the natural and understandable language interaction. In the application background of remotely navigating a mobile robot inside a building with Chinese natural spoken language considering that as an important navigation element in instructions a place name can be expressed with different lexical terms in spoken language this paper proposes a model for substituting different alternatives of a place name with a standard one (called standardization). First a CRF (Conditional Random Fields) model is trained to label the term required be standardized then a trained word embedding model is to represent lexical terms as digital vectors. In the vector space similarity of lexical terms is defined and used to find out the most similar one to the term picked out to be standardized. Experiments show that the method proposed works well and the dialog system responses to confirm the instructions are natural and understandable. 展开更多
关键词 WORD embedding conditional random fields ( crfs ) STANDARDIZATION interaction Chinese NATURAL Spoken LANGUAGE (CNSL) NATURAL LANGUAGE Processing (NLP) human-robot
在线阅读 下载PDF
基于XLM-RoBERTa-Large-Finetuned-Conll03-English模型结合CRF的中文命名实体识别微调优化方法
12
作者 廉雄杰 董振 《吉林大学学报(理学版)》 北大核心 2026年第2期370-376,共7页
针对中文中词与词之间无明显的空格分隔,导致词汇边界不明确,难以准确捕捉实体与周围词的关系,从而使中文命名实体识别准确率较低的问题,提出一种基于XLM-RoBERTa-Large-Finetuned-Conll03-English模型并结合条件随机场(CRF)的中文命名... 针对中文中词与词之间无明显的空格分隔,导致词汇边界不明确,难以准确捕捉实体与周围词的关系,从而使中文命名实体识别准确率较低的问题,提出一种基于XLM-RoBERTa-Large-Finetuned-Conll03-English模型并结合条件随机场(CRF)的中文命名实体识别微调优化方法.首先,建立中文命名实体指示词库,确定命名实体范围并对实体排序,利用概率计算获取命名实体的最优特征;其次,将CRF获取的特征引入到XLM-RoBERTa-Large-Finetune-Conll03-English模型中,捕捉命名实体特征序列及序列的依赖关系;最后,通过在多语言模型上添加CR F层实现对中文命名实体识别的微调优化.实验结果表明,该微调优化方法显著提升了中文命名实体识别性能,使模型有更高的准确率和更低的损失值,在中文命名实体识别任务中适用性更好. 展开更多
关键词 XLM-RoBERTa模型 命名实体识别 微调优化 条件随机场
在线阅读 下载PDF
基于BiLSTM+CRF融合的藏文文本共指消解研究
13
作者 索南旺姆 索南尖措 +2 位作者 扎西平措 高兴 万玛才旦 《高原科学研究》 2026年第1期129-140,共12页
等多个下游应用中发挥关键作用。然而,当前主流研究多集中于高资源语种,对于藏语等低资源语言的共指消解研究仍较为薄弱。为解决藏文自然语言处理领域相关数据集与应用研究不足问题,文章构建了涵盖新闻与文学体裁的藏文共指消解语料库Ti... 等多个下游应用中发挥关键作用。然而,当前主流研究多集中于高资源语种,对于藏语等低资源语言的共指消解研究仍较为薄弱。为解决藏文自然语言处理领域相关数据集与应用研究不足问题,文章构建了涵盖新闻与文学体裁的藏文共指消解语料库TiCoref-2025,并在此基础上提出了一种融合多种建模策略的神经网络模型TiCoref。该模型以BERT-base-Tibetan为基础编码器,结合BiLSTM增强长距离依存建模能力,并引入条件随机场(CRF)以提升提及边界识别精度。此外,针对文学体裁文本的特点,专门引入“词藻知识库”模块以提供外部先验知识,从而提升模型对复杂共指关系的识别能力,并验证了该策略在特定体裁下的有效性。实验结果表明,所提方法在MUC、B3、CEAFϕ4三个指标上的F1值分别达到了78.70%、71.08%和68.22%,验证了模型在低资源藏文文本上的适用性与鲁棒性。 展开更多
关键词 共指消解 藏文文本 BiLSTM 条件随机场 知识增强
在线阅读 下载PDF
A conditional random fields approach to Chinese pinyin-to-character conversion
14
作者 LI Lu WANG Xuan WANG Xiao-long YU Yan-bing 《通讯和计算机(中英文版)》 2009年第4期25-31,共7页
关键词 随机场 汉语拼音 字符转换 特征空间
在线阅读 下载PDF
Enhanced Identifying Gene Names from Biomedical Literature with Conditional Random Fields
15
作者 Wei-Zhong Qian Chong Fu +2 位作者 Hong-Rong Cheng Qiao Liu Zhi-Guang Qin 《Journal of Electronic Science and Technology of China》 2009年第3期227-231,共5页
Identifying gene names is an attractive research area of biology computing.However,accurate extraction of gene names is a challenging task with the lack of conventions for describing gene names.We devise a systematica... Identifying gene names is an attractive research area of biology computing.However,accurate extraction of gene names is a challenging task with the lack of conventions for describing gene names.We devise a systematical architecture and apply the model using conditional random fields(CRFs)for extracting gene names from Medline.In order to improve the performance,biomedical ontology features are inserted into the model and post processing including boundary adjusting and word filter is presented to solve name overlapping problem and remove false positive single words.Pure string match method,baseline CRFs,and CRFs with our methods are applied to human gene names and HIV gene names extraction respectively in 1100 abstracts of Medline and their performances are contrasted.Results show that CRFs are robust for unseen gene names.Furthermore,CRFs with our methods outperforms other methods with precision 0.818 and recall 0.812. 展开更多
关键词 conditional random fields gene nameextraction information extraction named entityrecognition
在线阅读 下载PDF
Rockhead profile simulation using an improved generation method of conditional random field 被引量:6
16
作者 Liang Han Lin Wang +2 位作者 Wengang Zhang Boming Geng Shang Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第3期896-908,共13页
Rockhead profile is an important part of geological profiles and can have significant impacts on some geotechnical engineering practice,and thus,it is necessary to establish a useful method to reverse the rockhead pro... Rockhead profile is an important part of geological profiles and can have significant impacts on some geotechnical engineering practice,and thus,it is necessary to establish a useful method to reverse the rockhead profile using site investigation results.As a general method to reflect the spatial distribution of geo-material properties based on field measurements,the conditional random field(CRF)was improved in this paper to simulate rockhead profiles.Besides,in geotechnical engineering practice,measurements are generally limited due to the limitations of budget and time so that the estimation of the mean value can have uncertainty to some extent.As the Bayesian theory can effectively combine the measurements and prior information to deal with uncertainty,CRF was implemented with the aid of the Bayesian framework in this study.More importantly,this simulation procedure is achieved as an analytical solution to avoid the time-consuming sampling work.The results show that the proposed method can provide a reasonable estimation about the rockhead depth at various locations against measurement data and as a result,the subjectivity in determining prior mean can be minimized.Finally,both the measurement data and selection of hyper-parameters in the proposed method can affect the simulated rockhead profiles,while the influence of the latter is less significant than that of the former. 展开更多
关键词 Rockhead profile BOREHOLE conditional random field(crf) BAYESIAN Mean uncertainty
在线阅读 下载PDF
Conditional Random Field Tracking Model Based on a Visual Long Short Term Memory Network 被引量:3
17
作者 Pei-Xin Liu Zhao-Sheng Zhu +1 位作者 Xiao-Feng Ye Xiao-Feng Li 《Journal of Electronic Science and Technology》 CAS CSCD 2020年第4期308-319,共12页
In dense pedestrian tracking,frequent object occlusions and close distances between objects cause difficulty when accurately estimating object trajectories.In this study,a conditional random field tracking model is es... In dense pedestrian tracking,frequent object occlusions and close distances between objects cause difficulty when accurately estimating object trajectories.In this study,a conditional random field tracking model is established by using a visual long short term memory network in the three-dimensional(3D)space and the motion estimations jointly performed on object trajectory segments.Object visual field information is added to the long short term memory network to improve the accuracy of the motion related object pair selection and motion estimation.To address the uncertainty of the length and interval of trajectory segments,a multimode long short term memory network is proposed for the object motion estimation.The tracking performance is evaluated using the PETS2009 dataset.The experimental results show that the proposed method achieves better performance than the tracking methods based on the independent motion estimation. 展开更多
关键词 conditional random field(crf) long short term memory network(LSTM) motion estimation multiple object tracking(MOT)
在线阅读 下载PDF
STABC-IR:An air target intention recognition method based on bidirectional gated recurrent unit and conditional random field with space-time attention mechanism 被引量:17
18
作者 Siyuan WANG Gang WANG +3 位作者 Qiang FU Yafei SONG Jiayi LIU Sheng HE 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第3期316-334,共19页
The battlefield environment is changing rapidly,and fast and accurate identification of the tactical intention of enemy targets is an important condition for gaining a decision-making advantage.The current Intention R... The battlefield environment is changing rapidly,and fast and accurate identification of the tactical intention of enemy targets is an important condition for gaining a decision-making advantage.The current Intention Recognition(IR)method for air targets has shortcomings in temporality,interpretability and back-and-forth dependency of intentions.To address these problems,this paper designs a novel air target intention recognition method named STABC-IR,which is based on Bidirectional Gated Recurrent Unit(Bi GRU)and Conditional Random Field(CRF)with Space-Time Attention mechanism(STA).First,the problem of intention recognition of air targets is described and analyzed in detail.Then,a temporal network based on Bi GRU is constructed to achieve the temporal requirement.Subsequently,STA is proposed to focus on the key parts of the features and timing information to meet certain interpretability requirements while strengthening the timing requirements.Finally,an intention transformation network based on CRF is proposed to solve the back-and-forth dependency and transformation problem by jointly modeling the tactical intention of the target at each moment.The experimental results show that the recognition accuracy of the jointly trained STABC-IR model can reach 95.7%,which is higher than other latest intention recognition methods.STABC-IR solves the problem of intention transformation for the first time and considers both temporality and interpretability,which is important for improving the tactical intention recognition capability and has reference value for the construction of command and control auxiliary decision-making system. 展开更多
关键词 Bidirectional gated recurrent network conditional random field Intention recognition Intention transformation Situation cognition Space-time attention mechanism
原文传递
Detection and characterization of regulatory elements using probabilistic conditional random field and hidden Markov models 被引量:3
19
作者 Hongyan Wang Xiaobo Zhou 《Chinese Journal of Cancer》 SCIE CAS CSCD 2013年第4期186-194,共9页
By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers t... By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers to link these marks to cis-regulatory elements. With the help of next generation sequencing technologies, we can now correlate one specific chromatin mark with regulatory elements (e.g. enhancers or promoters) and also build tools, such as hidden Markov models, to gain insight into mark combinations. However, hidden Markov models have limitation for their character of generative models and assume that a current observation depends only on a current hidden state in the chain. Here, we employed two graphical probabilistic models, namely the linear conditional random field model and multivariate hidden Markov model, to mark gene regions with different states based on recurrent and spatially coherent character of these eight marks. Both models revealed chromatin states that may correspond to enhancers and promoters, transcribed regions, transcriptional elongation, and low-signal regions. We also found that the linear conditional random field model was more effective than the hidden Markov model in recognizing regulatory elements, such as promoter-, enhancer-, and transcriptional elongation-associated regions, which gives us a better choice. 展开更多
关键词 Epigenetics HISTONE modification conditional random field REGULATORY elements
暂未订购
Prediction of Potential Disease-Associated MicroRNAs Based on Hidden Conditional Random Field 被引量:1
20
作者 Maozu Guo Shuang Cheng +2 位作者 Chunyu Wang Xiaoyan Liu Yang Liu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2018年第1期57-66,共10页
MicroRNAs( miRNAs) are reported to be associated with various diseases. The identification of disease-related miRNAs would be beneficial to the disease diagnosis and prognosis. However,in contrast with the widely avai... MicroRNAs( miRNAs) are reported to be associated with various diseases. The identification of disease-related miRNAs would be beneficial to the disease diagnosis and prognosis. However,in contrast with the widely available expression profiling, the limited knowledge of molecular function restrict the development of previous methods based on network similarity measure. To construct reliable training data,the decision fusion method is used to prioritize the results of existing methods. After that,the performance of decision fusion method is validated. Furthermore,in consideration of the long range dependencies of successive expression values,Hidden Conditional Random Field model( HCRF) is selected and applied to miRNA expression profiling to infer disease-associated miRNAs. The results show that HCRF achieves superior performance and outperforms the previous methods. The results also demonstrate the power of using expression profiling for discovering disease-associated miRNAs. 展开更多
关键词 expression PROFILING hidden conditional random field miRNA-disease ASSOCIATION network
在线阅读 下载PDF
上一页 1 2 58 下一页 到第
使用帮助 返回顶部