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血清CCL2、VEGFA与非酒精性脂肪性肝病患者肝纤维化和代谢综合征的关系研究
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作者 郭瑞丹 刘倩 杨洁 《中西医结合肝病杂志》 2026年第1期32-36,共5页
目的:探究血清CC趋化因子配体2(CCL2)、血管内皮生长因子(VEGFA)与非酒精性脂肪性肝病(NAFLD)患者肝纤维化和代谢综合征(MS)的关系。方法:选取2022年1月至2024年1月在本院就诊的NAFLD患者116例(NAFLD组)作为研究对象,根据患者否并发MS分... 目的:探究血清CC趋化因子配体2(CCL2)、血管内皮生长因子(VEGFA)与非酒精性脂肪性肝病(NAFLD)患者肝纤维化和代谢综合征(MS)的关系。方法:选取2022年1月至2024年1月在本院就诊的NAFLD患者116例(NAFLD组)作为研究对象,根据患者否并发MS分为MS组(42例)和非MS组(74例),另取同期体检健康者66例作为对照组。收集所有受试者的临床资料;采用ELISA法检测血清中CCL2和VEGFA表达量;Pearson法分析血清CCL2、VEGFA水平与肝纤维化及MS相关指标的相关性;Logistic多因素分析影响NAFLD患者并发MS的因素;受试者工作特征曲线分析血清CCL2和VEGFA水平对NAFLD患者并发MS的预测价值。结果:NAFLD患者血清CCL2、VEGFA水平以及肝纤维化指标层黏连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(ⅣC)均显著高于对照组(P<0.05)。MS组的收缩压、舒张压、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、甘油三椡(TG)、CCL2、VEGFA水平显著高于非MS组,丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平显著低于非MS组(P<0.05)。血清中CCL2和VEGFA水平与LN、HA、PCⅢ、ⅣC、收缩压、舒张压、FPG、2 h PG、TG呈正相关,与ALT、AST呈负相关(P<0.05)。收缩压、舒张压、FPG、2 h PG、TG、CCL2、VEGFA是影响NAFLD患者并发MS的危险因素,ALT、AST是影响NAFLD患者并发MS的保护因素(P<0.05)。血清CCL2和VEGFA水平以及联合预测NAFLD患者并发MS情况的曲线下面积分别为0.842、0.884和0.938,联合预测优于各自单独预测(Z_(联合-CCL2)=2.959、Z_(联合-VEGFA)=2.731,P=0.003、0.006)。结论:NAFLD患者血清CCL2和VEGFA水平升高,且二者与NAFLD患者肝纤维化和MS密切相关,二者联合对NAFLD患者并发MS具有较高的预测价值。 展开更多
关键词 cc趋化因子配体2 血管内皮生长因子 非酒精性脂肪性肝病 肝纤维化 代谢综合征
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Accelerating Hartree-Fock Self-consistent Field Calculation on C86/DCU Heterogenous Computing Platform
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作者 Ji Qi Huimin Zhang +1 位作者 Dezun Shan Minghui Yang 《Chinese Journal of Chemical Physics》 2025年第1期81-94,I0056,共15页
In this study,we investigate the ef-ficacy of a hybrid parallel algo-rithm aiming at enhancing the speed of evaluation of two-electron repulsion integrals(ERI)and Fock matrix generation on the Hygon C86/DCU(deep compu... In this study,we investigate the ef-ficacy of a hybrid parallel algo-rithm aiming at enhancing the speed of evaluation of two-electron repulsion integrals(ERI)and Fock matrix generation on the Hygon C86/DCU(deep computing unit)heterogeneous computing platform.Multiple hybrid parallel schemes are assessed using a range of model systems,including those with up to 1200 atoms and 10000 basis func-tions.The findings of our research reveal that,during Hartree-Fock(HF)calculations,a single DCU ex-hibits 33.6 speedups over 32 C86 CPU cores.Compared with the efficiency of Wuhan Electronic Structure Package on Intel X86 and NVIDIA A100 computing platform,the Hygon platform exhibits good cost-effective-ness,showing great potential in quantum chemistry calculation and other high-performance scientific computations. 展开更多
关键词 Quantum chemistry Self-consistent field HARTREE-FOCK Electron repulsion inte-grals Heterogenous parallel computing C86/deep computing unit
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FedCLCC:A personalized federated learning algorithm for edge cloud collaboration based on contrastive learning and conditional computing
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作者 Kangning Yin Xinhui Ji +1 位作者 Yan Wang Zhiguo Wang 《Defence Technology(防务技术)》 2025年第1期80-93,共14页
Federated learning(FL)is a distributed machine learning paradigm for edge cloud computing.FL can facilitate data-driven decision-making in tactical scenarios,effectively addressing both data volume and infrastructure ... Federated learning(FL)is a distributed machine learning paradigm for edge cloud computing.FL can facilitate data-driven decision-making in tactical scenarios,effectively addressing both data volume and infrastructure challenges in edge environments.However,the diversity of clients in edge cloud computing presents significant challenges for FL.Personalized federated learning(pFL)received considerable attention in recent years.One example of pFL involves exploiting the global and local information in the local model.Current pFL algorithms experience limitations such as slow convergence speed,catastrophic forgetting,and poor performance in complex tasks,which still have significant shortcomings compared to the centralized learning.To achieve high pFL performance,we propose FedCLCC:Federated Contrastive Learning and Conditional Computing.The core of FedCLCC is the use of contrastive learning and conditional computing.Contrastive learning determines the feature representation similarity to adjust the local model.Conditional computing separates the global and local information and feeds it to their corresponding heads for global and local handling.Our comprehensive experiments demonstrate that FedCLCC outperforms other state-of-the-art FL algorithms. 展开更多
关键词 Federated learning Statistical heterogeneity Personalized model Conditional computing Contrastive learning
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ParaGraph:a parallel graph computing accelerator based on software-hardware collaboration
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作者 DENG Junyong KANG Yuchun +2 位作者 YE Zekun ZHU Yun JIA Yanting 《High Technology Letters》 2025年第2期105-117,共13页
Graph computing has become pervasive in many applications due to its capacity to represent complex relationships among different objects in the big data era.However,general-purpose architectures are computationally in... Graph computing has become pervasive in many applications due to its capacity to represent complex relationships among different objects in the big data era.However,general-purpose architectures are computationally inefficient for graph algorithms,and dedicated architectures can provide high efficiency,but lack flexibility.To address these challenges,this paper proposes ParaGraph,a reduced instruction set computing-five(RISC-V)-based software-hardware co-designed graph computing accelerator that can process graph algorithms in parallel,and also establishes a performance evaluation model to assess the efficiency of co-acceleration.ParaGraph handles parallel processing of typical graph algorithms on the hardware side,while performing overall functional control on the software side with custom designed instructions.ParaGraph is verified on the XCVU440 field-programmable gate array(FPGA)board with E203,a RISC-V processor.Compared with current mainstream graph computing accelerators,ParaGraph consumes 7.94%less block RAM(BRAM)resources than ThunderGP.Its power consumption is reduced by 86.90%,24.90%,and 76.38%compared with ThunderGP,HitGraph,and GraphS,respectively.The power efficiency of connected components(CC)and degree centrality(DC)algorithms is improved by an average of 6.50 times over ThunderGP,2.51 times over HitGraph,and 3.99 times over GraphS.The software-hardware co-design acceleration performance indicators H/W.Cap for CC and DC are 13.02 and 14.02,respectively. 展开更多
关键词 graph computing software-hardware co-design reduced instruction set computing-five(RISC-V) parallel accelerator
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溃疡性结肠炎患者血清PRDX1、CCL-25水平及其与病情严重程度、临床转归的关系
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作者 周鑫 周丽峰 +2 位作者 杜行极 范军 杨惟明 《检验医学与临床》 2026年第1期32-37,共6页
目的探讨溃疡性结肠炎(UC)患者血清过氧化物还原酶1(PRDX1)、CC基序趋化因子配体-25(CCL-25)水平及其与病情严重程度、临床转归的关系。方法选取2021年3月至2024年6月克孜勒苏柯尔克孜自治州人民医院收治的218例UC患者作为UC组,根据病... 目的探讨溃疡性结肠炎(UC)患者血清过氧化物还原酶1(PRDX1)、CC基序趋化因子配体-25(CCL-25)水平及其与病情严重程度、临床转归的关系。方法选取2021年3月至2024年6月克孜勒苏柯尔克孜自治州人民医院收治的218例UC患者作为UC组,根据病情严重程度分度分为轻度组、中度组和重度组,根据6个月临床转归分为转归不良组和转归良好组。另选取同期在克孜勒苏柯尔克孜自治州人民医院体检的109例健康体检者作为对照组。采用酶联免疫吸附试验检测所有研究对象血清PRDX1、CCL-25水平。采用多因素Logistic回归分析UC患者临床转归不良的影响因素。绘制受试者工作特征(ROC)曲线分析血清PRDX1、CCL-25对UC患者临床转归不良的预测价值。结果UC组血清PRDX1、CCL-25水平均高于对照组,差异均有统计学意义(P<0.05)。中度组和重度组血清PRDX1、CCL-25水平均高于轻度组,重度组血清PRDX1、CCL-25水平均高于中度组,差异均有统计学意义(P<0.05)。转归不良组病程长于转归良好组,重度患者占比,以及血清PRDX1、CCL-25水平均高于转归良好组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,病情严重程度为重度及血清PRDX1、CCL-25水平升高均为UC患者临床转归不良的独立危险因素(P<0.05)。ROC曲线分析结果显示,血清PRDX1、CCL-25联合预测UC患者临床转归不良的曲线下面积(AUC)为0.888,大于二者单独预测的AUC(0.782、0.794),差异均有统计学意义(Z=4.316、3.814,P<0.001)。结论UC患者血清PRDX1、CCL-25水平均升高,与病情严重程度加重及临床转归不良均密切相关。血清PRDX1、CCL-25联合对UC患者临床转归不良的预测价值较高。 展开更多
关键词 溃疡性结肠炎 过氧化物还原酶1 cc基序趋化因子配体-25 病情严重程度 临床转归
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Back-gate-tuned organic electrochemical transistor with temporal dynamic modulation for reservoir computing
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作者 Qian Xu Jie Qiu +6 位作者 Mengyang Liu Dongzi Yang Tingpan Lan Jie Cao Yingfen Wei Hao Jiang Ming Wang 《Journal of Semiconductors》 2026年第1期118-123,共6页
Organic electrochemical transistor(OECT)devices demonstrate great promising potential for reservoir computing(RC)systems,but their lack of tunable dynamic characteristics limits their application in multi-temporal sca... Organic electrochemical transistor(OECT)devices demonstrate great promising potential for reservoir computing(RC)systems,but their lack of tunable dynamic characteristics limits their application in multi-temporal scale tasks.In this study,we report an OECT-based neuromorphic device with tunable relaxation time(τ)by introducing an additional vertical back-gate electrode into a planar structure.The dual-gate design enablesτreconfiguration from 93 to 541 ms.The tunable relaxation behaviors can be attributed to the combined effects of planar-gate induced electrochemical doping and back-gateinduced electrostatic coupling,as verified by electrochemical impedance spectroscopy analysis.Furthermore,we used theτ-tunable OECT devices as physical reservoirs in the RC system for intelligent driving trajectory prediction,achieving a significant improvement in prediction accuracy from below 69%to 99%.The results demonstrate that theτ-tunable OECT shows a promising candidate for multi-temporal scale neuromorphic computing applications. 展开更多
关键词 neuromorphic computing reservoir computing OECT tunable dynamics trajectory prediction
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血清YKL-40、CCL11、kisspeptin水平与先兆流产患者阴道微生态及其保胎后妊娠结局的相关性
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作者 王云玲 周娟 +1 位作者 马园园 高阿妮 《国际检验医学杂志》 2026年第1期114-119,共6页
目的 探讨血清甲壳质酶蛋白40(YKL-40)、CC趋化因子配体11(CCL11)、人吻素-1(kisspeptin)水平与先兆流产(TA)患者阴道微生态及其保胎后妊娠结局的相关性。方法 选取2022年1月至2024年10月该院收治的102例TA患者作为TA组。另选取同期来... 目的 探讨血清甲壳质酶蛋白40(YKL-40)、CC趋化因子配体11(CCL11)、人吻素-1(kisspeptin)水平与先兆流产(TA)患者阴道微生态及其保胎后妊娠结局的相关性。方法 选取2022年1月至2024年10月该院收治的102例TA患者作为TA组。另选取同期来该院进行产前检查的健康孕妇110例作为对照组。根据TA组保胎后妊娠结局分为妊娠失败组(37例)、妊娠良好组(65例)。采用酶联免疫吸附试验(ELISA)检测血清YKL-40、CCL11、kisspeptin水平。采用Pearson相关性分析阴道微生物菌群相对丰度与血清YKL-40、CCL11、kisspeptin水平的相关性。采用多因素Logistic回归分析影响保胎后不良妊娠结局的风险因素。采用受试者工作特征(ROC)曲线评估血清YKL-40、CCL11、kisspeptin水平对保胎后妊娠失败的预测价值。结果 TA组放线菌门、变形菌门、拟杆菌门、普氏菌属、加德纳菌属相对丰度高于对照组(P<0.05),厚壁菌门、梭杆菌门、乳酸杆菌属相对丰度低于对照组(P<0.05)。与对照组相比,TA组血清YKL-40、CCL11水平升高(P<0.05),kisspeptin水平降低(P<0.05)。Pearson相关性分析显示,血清YKL-40、CCL11水平与放线菌门、变形菌门、拟杆菌门、普氏菌属、加德纳菌属呈正相关(P<0.05),与厚壁菌门、梭杆菌门、乳酸杆菌属呈负相关(P<0.05);kisspeptin水平与放线菌门、变形菌门、拟杆菌门、普氏菌属、加德纳菌属呈负相关(P<0.05),与厚壁菌门、梭杆菌门、乳酸杆菌属呈正相关(P<0.05)。与妊娠良好组相比,妊娠失败组血清YKL-40、CCL11水平升高(P<0.05),孕酮、kisspeptin水平降低(P<0.05)。妊娠失败组放线菌门、变形菌门、拟杆菌门及链球菌属、普氏菌属、加德纳菌属相对丰度高于妊娠良好组(P<0.05),厚壁菌门、梭杆菌门及乳酸杆菌属相对丰度低于妊娠良好组(P<0.05)。多因素Logistic回归分析显示,YKL-40、CCL11是保胎后妊娠失败的危险因素(P<0.05),孕酮、kisspeptin是保胎后妊娠失败的保护因素(P<0.05)。ROC曲线显示,血清YKL-40、CCL11、kisspeptin单独及联合预测保胎后妊娠失败的曲线下面积分别为0.780、0.801、0.832、0.915,单独或联合均具有预测价值,且联合预测效能更高(Z_(YKL-40-三者联合)=3.014,Z_(CCL11-三者联合)=3.090,Z_(kisspeptin-三者联合)=2.576,P<0.05)。结论 TA患者血清YKL-40、CCL11水平升高,kisspeptin水平下降,且与阴道微生态失衡、保胎后不良妊娠结局有关,有望成为预测TA患者保胎后不良妊娠结局的有效指标。 展开更多
关键词 先兆流产 甲壳质酶蛋白40 cc趋化因子配体11 人吻素-1 妊娠结局 阴道微生态
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Highly stable self-rectifying memristor integrated arrays for simulated annealing neuromorphic computing
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作者 Jiang Bian Yingfang Zhu +13 位作者 Shaoan Yan Yin Tang Jiayue Guo Gang Li Jiang Zhao Qing Zhong Qingjiang Li Sen Liu Rui Liu Qilai Chen Yongguang Xiao Xiaojian Zhu Qinghua Li Minghua Tang 《Nano Research》 2026年第1期1089-1101,共13页
This work presents a high-stability self-rectifying memristor(SRM)array based on the Pt/TaO_(x)/Ti structure,with an indepth investigation of the performance and potential applications of the device.The device demonst... This work presents a high-stability self-rectifying memristor(SRM)array based on the Pt/TaO_(x)/Ti structure,with an indepth investigation of the performance and potential applications of the device.The device demonstrates excellent rectification and on/off ratios,along with low-power readout,multi-state storage,and multi-level switching capabilities,highlighting its practicality and adaptability.Notably,the device exhibits outstanding fluctuation suppression and exceptional uniformity.The coefficient of variation(CV)of the rectification ratio,calculated as 0.11497 at 3 V,indicates its high stability under multiple cycles and low-voltage operation,making it well-suited for large-scale integration and operational applications.Moreover,the stability of the rectification ratio further reinforces its potential as a hardware foundation for large-scale inmemory computing systems.By combining the neuromorphic characteristics of the device with a simulated annealing algorithm and optimizing the annealing temperature function,the system emulates biological neuron behavior,enabling fast and efficient image restoration tasks.Experimental results demonstrate that this approach significantly outperforms traditional algorithms in both optimization speed and repair accuracy.The present study offers a novel perspective for the design of in-memory computing hardware and showcases promising applications in neuromorphic computing and image processing. 展开更多
关键词 self-rectifying memristor in-memory computing simulated annealing algorithm neuromorphic computing
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Two-Dimensional MXene-Based Advanced Sensors for Neuromorphic Computing Intelligent Application
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作者 Lin Lu Bo Sun +2 位作者 Zheng Wang Jialin Meng Tianyu Wang 《Nano-Micro Letters》 2026年第2期664-691,共28页
As emerging two-dimensional(2D)materials,carbides and nitrides(MXenes)could be solid solutions or organized structures made up of multi-atomic layers.With remarkable and adjustable electrical,optical,mechanical,and el... As emerging two-dimensional(2D)materials,carbides and nitrides(MXenes)could be solid solutions or organized structures made up of multi-atomic layers.With remarkable and adjustable electrical,optical,mechanical,and electrochemical characteristics,MXenes have shown great potential in brain-inspired neuromorphic computing electronics,including neuromorphic gas sensors,pressure sensors and photodetectors.This paper provides a forward-looking review of the research progress regarding MXenes in the neuromorphic sensing domain and discussed the critical challenges that need to be resolved.Key bottlenecks such as insufficient long-term stability under environmental exposure,high costs,scalability limitations in large-scale production,and mechanical mismatch in wearable integration hinder their practical deployment.Furthermore,unresolved issues like interfacial compatibility in heterostructures and energy inefficiency in neu-romorphic signal conversion demand urgent attention.The review offers insights into future research directions enhance the fundamental understanding of MXene properties and promote further integration into neuromorphic computing applications through the convergence with various emerging technologies. 展开更多
关键词 TWO-DIMENSIONAL MXenes SENSOR Neuromorphic computing Multimodal intelligent system Wearable electronics
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Mechanical Properties Analysis of Flexible Memristors for Neuromorphic Computing
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作者 Zhenqian Zhu Jiheng Shui +1 位作者 Tianyu Wang Jialin Meng 《Nano-Micro Letters》 2026年第1期53-79,共27页
The advancement of flexible memristors has significantly promoted the development of wearable electronic for emerging neuromorphic computing applications.Inspired by in-memory computing architecture of human brain,fle... The advancement of flexible memristors has significantly promoted the development of wearable electronic for emerging neuromorphic computing applications.Inspired by in-memory computing architecture of human brain,flexible memristors exhibit great application potential in emulating artificial synapses for highefficiency and low power consumption neuromorphic computing.This paper provides comprehensive overview of flexible memristors from perspectives of development history,material system,device structure,mechanical deformation method,device performance analysis,stress simulation during deformation,and neuromorphic computing applications.The recent advances in flexible electronics are summarized,including single device,device array and integration.The challenges and future perspectives of flexible memristor for neuromorphic computing are discussed deeply,paving the way for constructing wearable smart electronics and applications in large-scale neuromorphic computing and high-order intelligent robotics. 展开更多
关键词 Flexible memristor Neuromorphic computing Mechanical property Wearable electronics
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High-Entropy Oxide Memristors for Neuromorphic Computing:From Material Engineering to Functional Integration
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作者 Jia‑Li Yang Xin‑Gui Tang +4 位作者 Xuan Gu Qi‑Jun Sun Zhen‑Hua Tang Wen‑Hua Li Yan-Ping Jiang 《Nano-Micro Letters》 2026年第2期138-169,共32页
High-entropy oxides(HEOs)have emerged as a promising class of memristive materials,characterized by entropy-stabilized crystal structures,multivalent cation coordination,and tunable defect landscapes.These intrinsic f... High-entropy oxides(HEOs)have emerged as a promising class of memristive materials,characterized by entropy-stabilized crystal structures,multivalent cation coordination,and tunable defect landscapes.These intrinsic features enable forming-free resistive switching,multilevel conductance modulation,and synaptic plasticity,making HEOs attractive for neuromorphic computing.This review outlines recent progress in HEO-based memristors across materials engineering,switching mechanisms,and synaptic emulation.Particular attention is given to vacancy migration,phase transitions,and valence-state dynamics—mechanisms that underlie the switching behaviors observed in both amorphous and crystalline systems.Their relevance to neuromorphic functions such as short-term plasticity and spike-timing-dependent learning is also examined.While encouraging results have been achieved at the device level,challenges remain in conductance precision,variability control,and scalable integration.Addressing these demands a concerted effort across materials design,interface optimization,and task-aware modeling.With such integration,HEO memristors offer a compelling pathway toward energy-efficient and adaptable brain-inspired electronics. 展开更多
关键词 High-entropy oxides MEMRISTORS Neuromorphic computing Configurational entropy Resistive switching
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A low-thermal-budget MOSFET-based reservoir computing for temporal data classification
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作者 Yanqing Li Feixiong Wang +5 位作者 Heyi Huang Yadong Zhang Xiangpeng Liang Shuang Liu Jianshi Tang Huaxiang Yin 《Journal of Semiconductors》 2026年第1期42-48,共7页
Neuromorphic devices have garnered significant attention as potential building blocks for energy-efficient hardware systems owing to their capacity to emulate the computational efficiency of the brain.In this regard,r... Neuromorphic devices have garnered significant attention as potential building blocks for energy-efficient hardware systems owing to their capacity to emulate the computational efficiency of the brain.In this regard,reservoir computing(RC)framework,which leverages straightforward training methods and efficient temporal signal processing,has emerged as a promising scheme.While various physical reservoir devices,including ferroelectric,optoelectronic,and memristor-based systems,have been demonstrated,many still face challenges related to compatibility with mainstream complementary metal oxide semiconductor(CMOS)integration processes.This study introduced a silicon-based schottky barrier metal-oxide-semiconductor field effect transistor(SB-MOSFET),which was fabricated under low thermal budget and compatible with back-end-of-line(BEOL).The device demonstrated short-term memory characteristics,facilitated by the modulation of schottky barriers and charge trapping.Utilizing these characteristics,a RC system for temporal data processing was constructed,and its performance was validated in a 5×4 digital classification task,achieving an accuracy exceeding 98%after 50 training epochs.Furthermore,the system successfully processed temporal signal in waveform classification and prediction tasks using time-division multiplexing.Overall,the SB-MOSFET's high compatibility with CMOS technology provides substantial advantages for large-scale integration,enabling the development of energy-efficient reservoir computing hardware. 展开更多
关键词 schottky barrier MOSFET back-end-of-line integration reservoir computing
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CCS助力香港地区垃圾运输发电项目首批5艘纯电船交付
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《中国船检》 2026年第1期83-83,共1页
近日,由中国船级社(CCS)承担建造检验的香港地区环保署垃圾运输发电项目首批5艘纯电池动力船交付,意味着CCS深度参与香港地区环保产业建设、助力粤港澳大湾区航运业绿色发展取得实质性成效。该批5艘纯电池动力船包括“新北嶼”“榕樹灣I... 近日,由中国船级社(CCS)承担建造检验的香港地区环保署垃圾运输发电项目首批5艘纯电池动力船交付,意味着CCS深度参与香港地区环保产业建设、助力粤港澳大湾区航运业绿色发展取得实质性成效。该批5艘纯电池动力船包括“新北嶼”“榕樹灣II”“梅窩II”“索罟灣II”“嶼連II”轮。 展开更多
关键词 垃圾运输 纯电船 发电项目 香港地区 ccS
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Lightweight YOLOv5 with ShuffleNetV2 for Rice Disease Detection in Edge Computing
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作者 Qingtao Meng Sang-Hyun Lee 《Computers, Materials & Continua》 2026年第1期1395-1409,共15页
This study proposes a lightweight rice disease detection model optimized for edge computing environments.The goal is to enhance the You Only Look Once(YOLO)v5 architecture to achieve a balance between real-time diagno... This study proposes a lightweight rice disease detection model optimized for edge computing environments.The goal is to enhance the You Only Look Once(YOLO)v5 architecture to achieve a balance between real-time diagnostic performance and computational efficiency.To this end,a total of 3234 high-resolution images(2400×1080)were collected from three major rice diseases Rice Blast,Bacterial Blight,and Brown Spot—frequently found in actual rice cultivation fields.These images served as the training dataset.The proposed YOLOv5-V2 model removes the Focus layer from the original YOLOv5s and integrates ShuffleNet V2 into the backbone,thereby resulting in both model compression and improved inference speed.Additionally,YOLOv5-P,based on PP-PicoDet,was configured as a comparative model to quantitatively evaluate performance.Experimental results demonstrated that YOLOv5-V2 achieved excellent detection performance,with an mAP 0.5 of 89.6%,mAP 0.5–0.95 of 66.7%,precision of 91.3%,and recall of 85.6%,while maintaining a lightweight model size of 6.45 MB.In contrast,YOLOv5-P exhibited a smaller model size of 4.03 MB,but showed lower performance with an mAP 0.5 of 70.3%,mAP 0.5–0.95 of 35.2%,precision of 62.3%,and recall of 74.1%.This study lays a technical foundation for the implementation of smart agriculture and real-time disease diagnosis systems by proposing a model that satisfies both accuracy and lightweight requirements. 展开更多
关键词 Lightweight object detection YOLOv5-V2 ShuffleNet V2 edge computing rice disease detection
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血清GDF9、BMP15及CCL18在子宫内膜异位症患者中的表达及其预测复发的价值
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作者 郭天宝 夏敏 张格霞 《临床医学研究与实践》 2026年第1期106-109,共4页
目的探究血清生长分化因子9(GDF9)、骨形态发生蛋白15(BMP15)及趋化因子配体18(CCL18)在子宫内膜异位症患者中的表达及其预测复发的价值。方法选取2020年3月至2022年1月在我院进行诊治的150例子宫内膜异位症患者作为病例组,根据不同痛... 目的探究血清生长分化因子9(GDF9)、骨形态发生蛋白15(BMP15)及趋化因子配体18(CCL18)在子宫内膜异位症患者中的表达及其预测复发的价值。方法选取2020年3月至2022年1月在我院进行诊治的150例子宫内膜异位症患者作为病例组,根据不同痛经程度将其分为轻度组、中度组、重度组;根据患者治疗2年后超声检测结果将其分为未复发组及复发组。同期选取135例健康体检者作为对照组。检测不同组间患者的血清GDF9、BMP15及CCL18水平;分析血清GDF9、BMP15与CCL18水平的相关性;建立受试者工作特征(ROC)曲线分析GDF9、BMP15、CCL18对子宫内膜异位症复发的预测价值。结果与对照组比较,病例组的血清GDF9和BMP15水平降低,CCL18水平升高(P<0.05)。与轻度组相比,中、重度组的血清GDF9、BMP15水平较低,CCL18水平较高(P<0.05);与中度组相比,重度组的血清GDF9、BMP15水平较低,CCL18水平较高(P<0.05)。与未复发组比较,复发组的血清GDF9和BMP15水平降低,CCL18水平升高(P<0.05)。Pearson相关性分析结果显示,血清GDF9、BMP15水平均与CCL18水平呈负相关(P<0.05)。ROC曲线分析结果显示,GDF9、BMP15、CCL18单独及联合预测子宫内膜异位症复发的曲线下面积(AUC)分别为0.779、0.793、0.864、0.942,联合检测的临床价值高于单一指标。结论GDF9、BMP15及CCL18在子宫内膜异位症患者中表达异常,与病情严重程度密切相关,可作为预测子宫内膜异位症复发的潜在生物标志物。 展开更多
关键词 生长分化因子9 骨形态发生蛋白15 趋化因子配体18 子宫内膜异位症 复发
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急性呼吸窘迫综合征患者血清STAT3、CCR7、HDAC6水平及与严重程度及预后的关系
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作者 魏丽 王秋波 +2 位作者 李筱妍 聂宜婷 王静 《分子诊断与治疗杂志》 2026年第1期19-22,共4页
目的探讨急性呼吸窘迫综合征(ARDS)患者血清信号转导与转录激活因子3(STAT3)、趋化因子受体7(CCR7)、组蛋白去乙酰化酶6(HDAC6)水平及与严重程度及预后的关系。方法选择2022年3月至2024年12月上海健康医学院附属周浦医院收治的208例ARD... 目的探讨急性呼吸窘迫综合征(ARDS)患者血清信号转导与转录激活因子3(STAT3)、趋化因子受体7(CCR7)、组蛋白去乙酰化酶6(HDAC6)水平及与严重程度及预后的关系。方法选择2022年3月至2024年12月上海健康医学院附属周浦医院收治的208例ARDS患者作为观察对象(ARDS组),根据ARDS病情严重程度分为轻度组(n=61)、中度组(n=65)和重度组(n=82);对ARDS患者进行28 d的随访,根据生存结局分为生存组(n=150)和死亡组(n=58);选择本院同期体检健康的志愿者214例作为对照组。比较对照组和ARDS组以及不同严重程度ARDS患者血清STAT3、CCR7、HDAC6水平;比较生存组和死亡组临床资料及血清STAT3、CCR7、HDAC6水平;采用多因素Logistic回归分析ARDS患者死亡的影响因素;采用ROC分析血清STAT3、CCR7、HDAC6对ARDS患者发生死亡的预测价值。结果ARDS组血清STAT3、CCR7、HDAC6水平均高于对照组,差异有统计学意义(P<0.05);血清STAT3、CCR7、HDAC6水平为:重度组>中度组>轻度组,差异有统计学意义(P<0.05);生存组和死亡组吸烟史、性别、高血压史、年龄、高血脂史、饮酒史、体重指数、糖尿病史、收缩压、冠心病史、舒张压水平比较,差异无统计学意义(P>0.05);死亡组血清STAT3、CCR7、HDAC6水平均高于生存组,差异有统计学意义(P<0.05);血清STAT3、CCR7、HDAC6水平升高是ARDS患者死亡的危险因素(P<0.05);血清STAT3、CCR7、HDAC6单独及联合预测ARDS患者死亡的AUC分别为0.830、0.836、0.733、0.919,三者联合优于各自单独预测(Z=3.606、2.756、4.481,P=0.000、0.006、0.000)。结论ARDS患者血清STAT3、CCR7、HDAC6水平升高,且与病情严重程度相关,三者联合检测可以作为预测ARDS患者预后的潜在生物标志物。 展开更多
关键词 急性呼吸窘迫综合征 信号转导与转录激活因子3 趋化因子受体7 组蛋白去乙酰化酶6
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流化床技术:CCS和脱碳应用中的挑战与前景 被引量:2
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作者 陆勇 李林 +1 位作者 孙镇坤 段伦博 《洁净煤技术》 北大核心 2025年第3期1-16,共16页
流化床反应器(FBR)作为碳捕集与封存(CCS)及工业脱碳的核心技术,凭借其高效传热传质、操作灵活及规模化潜力,已成为降低工业CO_(2)排放的关键路径。系统梳理了FBR在燃烧前、中、后三阶段的碳捕集技术进展:燃烧前阶段通过气化工艺将固体... 流化床反应器(FBR)作为碳捕集与封存(CCS)及工业脱碳的核心技术,凭借其高效传热传质、操作灵活及规模化潜力,已成为降低工业CO_(2)排放的关键路径。系统梳理了FBR在燃烧前、中、后三阶段的碳捕集技术进展:燃烧前阶段通过气化工艺将固体燃料转化为高纯度合成气,结合钙基吸附剂强化CO_(2)分离效率;燃烧中碳捕集技术聚焦富氧燃烧与化学链燃烧(CLC),利用流态化特性优化燃烧条件,实现烟气中CO_(2)体积分数提升至80%以上;燃烧后技术则依托钙循环(CaL)与碱基吸附剂循环,通过FBR的连续操作实现高效吸附−再生循环。此外,太阳能与电加热技术的创新融合进一步拓展了FBR的低碳应用场景——太阳能驱动的高温煅烧与钙循环耦合可减少化石燃料供热产生的CO_(2)排放并降低30%的能耗,而电加热流化床通过精准温控与快速响应特性,为生物质气化、吸附剂再生及水泥煅烧等过程提供零碳解决方案。然而,FBR的规模化推广仍面临多重瓶颈:吸附剂循环稳定性不足(如烧结导致的孔隙结构坍塌与表面钝化使得钙基材料经10次循环后活性下降40%)、设备磨损与高温腐蚀(SiC涂层可降低70%磨损率但仍需优化)、高能耗(煅烧需900~950℃)及工艺集成复杂性(如CLC需同步控制燃料反应器、空气反应器与载氧体循环倍率)。面向碳中和目标,未来研究需多维度突破:①开发高稳定性吸附材料(如纳米改性钙基吸附剂、金属有机框架(MOF)材料);②设计多级集成反应器(如鼓泡−输运耦合系统)以优化传质与热管理;③结合CFD多尺度建模与AI实时控制,提升系统动态响应能力;④推动跨领域协同创新,政策层面需完善碳定价机制、加大试点项目资助,并通过国际合作加速技术标准化进程。通过融合可再生能源、智能控制与材料创新,FBR技术有望在电力、水泥、钢铁等高碳行业实现深度脱碳,为全球能源结构转型提供兼具经济性与可持续性的技术支撑。 展开更多
关键词 流化床反应器 碳捕集与封存 脱碳技术 太阳能 电加热
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碳捕集与封存(CCS)项目关键风险识别与分析 被引量:2
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作者 陈媛 陈田丰 徐英华 《天津大学学报(社会科学版)》 2025年第3期222-230,共9页
在国家“双碳”目标的驱动下,将二氧化碳捕集、封存来缓解气候变化变得尤为重要。然而,碳捕集与封存(CCS)项目在实施过程中仍存在各种风险,且不同风险间会相互影响。文章运用文献分析法归纳CCS项目风险清单,进而构建出风险网络模型。同... 在国家“双碳”目标的驱动下,将二氧化碳捕集、封存来缓解气候变化变得尤为重要。然而,碳捕集与封存(CCS)项目在实施过程中仍存在各种风险,且不同风险间会相互影响。文章运用文献分析法归纳CCS项目风险清单,进而构建出风险网络模型。同时,从社会网络视角探究CCS项目风险网络特征并识别关键风险节点,进而提出风险防范和规避的对策建议。研究发现,CCS项目风险网络具有一定的连通性,技术成本风险、二氧化碳泄露风险、选址风险、政策法规风险是网络中的关键节点,需要给予重点关注。以期为相关决策者开展CCS项目风险管理提供理论依据,促进该类项目的可持续发展。 展开更多
关键词 ccS 风险识别 风险分析 社会网络
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IgA肾病患者血清CCR2、CCL2水平与病情、疾病转归的关系 被引量:1
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作者 杨小华 何绍沿 +2 位作者 罗富秀 全强 景海宁 《转化医学杂志》 2025年第4期92-96,共5页
目的探讨IgA肾病患者血清CC趋化因子受体2(CCR2)及趋化因子CC基序配体2(CCL2)水平与病情严重程度及疾病转归的关系。方法选取2020年1月至2022年12月广元市中心医院收治的106例Ig A肾病患者作为研究组及100例体检的健康体检者作为对照组... 目的探讨IgA肾病患者血清CC趋化因子受体2(CCR2)及趋化因子CC基序配体2(CCL2)水平与病情严重程度及疾病转归的关系。方法选取2020年1月至2022年12月广元市中心医院收治的106例Ig A肾病患者作为研究组及100例体检的健康体检者作为对照组。根据肾间质纤维化程度将患者分为轻度组(42例)、中度组(35例)和重度组(29例)。随访2年后,根据疾病转归情况分为转归良好组78例(73.58%)与转归不良组28例(26.42%)。收集所有IgA肾病患者的临床资料及入院时血清CCR2、CCL2水平,分析其与IgA肾病患者病情的相关性,采用多因素Logistic回归分析影响患者转归不良的危险因素。结果研究组患者血清CCR2、CCL2水平高于对照组(P<0.05)。且随着IgA肾病患者病情加重而逐渐升高(P<0.05)。Spearman相关分析显示,IgA肾病患者血清CCR2(r=0.613)和CCL2(r=0.684)水平与病情严重程度呈正相关(P<0.05)。在为期2年的随访中,转归不良组24 h尿蛋白定量、血清CCR2、血清CCL2、血尿素氮、血清肌酐、尿酸均高于转归良好组,eGFR低于转归良好组(P<0.05)。多因素Logistic回归分析显示,血清肌酐(OR=2.277,95%CI:1.048~4.949),24 h尿蛋白定量(OR=2.502,95%CI:1.226~5.106),血清CCR2(OR=3.093,95%CI:1.711~5.590),血清CCL2(OR=3.800,95%CI:2.066~6.991)是影响Ig A肾病患者疾病转归的独立危险因素(P<0.05)。结论Ig A肾病患者血清CCR2、CCL2水平与病情严重程度及预后密切相关,可能作为评估疾病进展和预后的潜在生物学标志物。 展开更多
关键词 IGA肾病 cc趋化因子受体2 趋化因子cc基序配体2 疾病转归
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东亚峰会国家CCS现状与合作展望
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作者 张鑫刚 刘佳 +2 位作者 方圆 黄文韬 徐晶晶 《中国矿业》 北大核心 2025年第9期65-73,共9页
东亚峰会参与国作为全球能源消费核心区与碳捕集与封存(CCS)技术发展前沿区域,在推进碳中和进程中具有重要战略地位。本文系统梳理东亚峰会成员国CCS技术发展现状与区域合作进展,通过国别案例分析、政策框架比较与跨国项目评估,揭示区... 东亚峰会参与国作为全球能源消费核心区与碳捕集与封存(CCS)技术发展前沿区域,在推进碳中和进程中具有重要战略地位。本文系统梳理东亚峰会成员国CCS技术发展现状与区域合作进展,通过国别案例分析、政策框架比较与跨国项目评估,揭示区域合作潜力与关键挑战。东亚峰会国家呈现出差异化发展格局,发达国家CCS战略目标明确,财政投入持续稳定,通过系统性开展地质封存潜力评估指导项目部署,注重基础研究到商业转化,并且政策法规体系日趋完善。美国在CCS技术研发与商业化部署方面占据绝对主导地位;澳大利亚建立了系统化的研发模式,形成了从基础研究、技术转化到商业化应用的完整路径;日本构建了技术研发、政策供给、企业协同的三位一体体系;韩国立法构建CCS全产业链。东盟国家CCS发展水平呈现显著分化,其中,印度尼西亚、越南引领区域进程,政策法规框架初建且不平衡,项目阶段差异大。区域合作聚焦跨境运输网络构建、监测技术联合研发、封存潜力协同评估、政策框架协调等,形成了新加坡-印度尼西亚、韩国-马来西亚等跨国合作模式。为实现《巴黎协定》目标,东亚峰会国家间需要深化CCS技术研发合作,完善政策协同机制,强化基础设施互联。东亚峰会国家有望通过深化技术协同、政策衔接与设施联通,建成全球领先的CCS技术应用示范区,为碳中和目标提供区域性实践参考。 展开更多
关键词 东亚峰会 碳捕集与封存(ccS) 能源 碳中和 碳减排
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