This article explores the design of a wireless fire alarm system supported by advanced data fusion technology.It includes discussions on the basic design ideas of the wireless fire alarm system,hardware design analysi...This article explores the design of a wireless fire alarm system supported by advanced data fusion technology.It includes discussions on the basic design ideas of the wireless fire alarm system,hardware design analysis,software design analysis,and simulation analysis,all supported by data fusion technology.Hopefully,this analysis can provide some reference for the rational application of data fusion technology to meet the actual design and application requirements of the system.展开更多
This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compa...This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compared to conventional design methodologies.Subsequently,it examines the specific implementations of BIM technology in architectural design,highlighting its substantial contributions to improving design precision,operational efficiency,and collaborative processes.Lastly,the paper anticipates the evolutionary trends of BIM technology.Looking ahead,as artificial intelligence,blockchain,and big data technologies continue to advance,BIM technology is poised to experience further innovations and breakthroughs,thereby presenting novel opportunities and challenges for the construction sector.展开更多
BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge c...BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge construction materials,construction techniques,and construction processes,a comprehensive analysis can be conducted to achieve visualization of the design and improve the efficiency of bridge design.This article mainly analyzes the advantages of BIM technology in bridge design,explores the application forms in bridge design,and proposes strategies to optimize bridge design,providing a certain reference for the improvement and optimization of bridge design work.展开更多
To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current...To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.展开更多
This paper mainly discusses the perioperative nursing course teaching model suitable for higher vocational education.The core content of“perioperative nursing”course is set according to surgical nursing posts,and ga...This paper mainly discusses the perioperative nursing course teaching model suitable for higher vocational education.The core content of“perioperative nursing”course is set according to surgical nursing posts,and gamified course objectives are designed according to learners’cognitive rules.Typical nursing tasks are used as the carrier,teaching case base is formed based on the concept of medical and educational collaboration,and gamified teaching situations are created based on VR technology to optimize the teaching process and enable students to experience the learning process immersive.Enhance students’job competency and professional competence.In the course design,modular teaching,project teaching,team cooperation teaching,gamification teaching,VR immersive teaching,medical teaching collaborative evaluation and other modes are aggregated,and the course design of perioperative nursing is re-carried out.展开更多
In response to the problem of improving practical abilities of students in the process of cultivating innovative talents in the field of financial technology in the specialized software college,this paper analyzes the...In response to the problem of improving practical abilities of students in the process of cultivating innovative talents in the field of financial technology in the specialized software college,this paper analyzes the characteristics and applicability of problem-based learning(PBL)method,proposes a PBL course integration design scheme for the integration of business and technology in the field of financial technology,and provides corresponding course cases.The plan described in this article has been jointly demonstrated by experts from schools and enterprises and has received good feedback.展开更多
As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support o...As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support of artificial intelligence,mechanical design and manufacturing can not only reduce input costs but also significantly reduce the demand for labor,playing a positive role in improving the design efficiency and quality of mechanical manufacturing[1].This paper studies how to apply artificial intelligence technology to the mechanical design and production process to achieve greater application and development.展开更多
The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a gard...The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a garden roaming demonstration system with the gardening design of a classical courtyard as an example. Besides, the advantages and disadvantages of applying Quest3D technology in garden landscape design are elaborated from the perspective of the selection of Quest3D technology, basic procedures for the selection and establishment of software and hardware.展开更多
Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle...Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.展开更多
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine...The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.展开更多
The metallurgy industry consumes a considerable amount of coal and fossil fuels,and its carbon dioxide emissions are increasing every year.Replacing coal with renewable,carbon-neutral biomass for metallurgical product...The metallurgy industry consumes a considerable amount of coal and fossil fuels,and its carbon dioxide emissions are increasing every year.Replacing coal with renewable,carbon-neutral biomass for metallurgical production is of great significance in reducing global carbon consumption.This study describes the current state of research in biomass metallurgy in recent years and analyzes the concept and scientific principles of biomass metallurgy.The fundamentals of biomass pretreatment technology and biomass metallurgy technology were discussed,and the industrial application framework of biomass metallurgy was proposed.Furthermore,the economic and social advantages of biomass metallurgy were analyzed to serve as a reference for the advancement of fundamental theory and industrial application of biomass metallurgy.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo...Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.展开更多
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced...Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.展开更多
The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to...Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.展开更多
One of the major challenges in designing and fabricating Spintronic devices is the choice of both, Materials and the Technology, along with understanding the intricacies of the Designing aspects. In this communication...One of the major challenges in designing and fabricating Spintronic devices is the choice of both, Materials and the Technology, along with understanding the intricacies of the Designing aspects. In this communication, we have attempted to briefly discuss these factors, with an aim to draw the attention of the Materials Scientists and Technologists to this serious challenge, in the direction of which, though a lot of research and development work has been done, still needs more concerted efforts to be made in order to make the Spintronic devices that can offer good efficiency for maximizing their usefulness.展开更多
Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industria...Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industrial needs in pattern design and technology in China's Mainland. The data were collected from the employers and employees from the garment industry and students in the major of fashion and clothing studies. It indicated that there was a gap between the employer and employee, especially the requirements of the industrial needs and the course contents covered by the tertiary schools. The employers expected to recruit more experienced pattern designers, at the same time, they were not reluctant to hire fresh graduates and spent more resources on the training of employees. The students knew little about their employment situation of the garment industry, spent too little time on the course study and learned too little practical skills in pattern design. They could not make use of the knowledge which prevented them from being employed by the garment industry. Efforts should be taken by both the tertiary schools and the garment industry. The students should be aspirated towards the profession of pattern cutters and the syllabuses of pattern making should be more practical and industrial orientated. The solution might benefit the garment industry a lot in a long run.展开更多
基金Chongqing Engineering University Undergraduate Innovation and Entrepreneurship Training Program Project:Wireless Fire Automatic Alarm System(Project No.:CXCY2024017)Chongqing Municipal Education Commission Science and Technology Research Project:Development and Research of Chongqing Wireless Fire Automatic Alarm System(Project No.:KJQN202401906)。
文摘This article explores the design of a wireless fire alarm system supported by advanced data fusion technology.It includes discussions on the basic design ideas of the wireless fire alarm system,hardware design analysis,software design analysis,and simulation analysis,all supported by data fusion technology.Hopefully,this analysis can provide some reference for the rational application of data fusion technology to meet the actual design and application requirements of the system.
基金Scientific and Technological Research Program of Chongqing Municipal Education Commission(Project No.:KJQN202301907)。
文摘This paper investigates the application of Building Information Modeling(BIM)technology in architectural design and its future developmental trajectories.It begins by elucidating the advantages of BIM technology compared to conventional design methodologies.Subsequently,it examines the specific implementations of BIM technology in architectural design,highlighting its substantial contributions to improving design precision,operational efficiency,and collaborative processes.Lastly,the paper anticipates the evolutionary trends of BIM technology.Looking ahead,as artificial intelligence,blockchain,and big data technologies continue to advance,BIM technology is poised to experience further innovations and breakthroughs,thereby presenting novel opportunities and challenges for the construction sector.
文摘BIM technology has become an important tool in road and bridge design.Through the application of BIM technology,the entire bridge process can be modeled to form a virtual bridge form.Through the simulation of bridge construction materials,construction techniques,and construction processes,a comprehensive analysis can be conducted to achieve visualization of the design and improve the efficiency of bridge design.This article mainly analyzes the advantages of BIM technology in bridge design,explores the application forms in bridge design,and proposes strategies to optimize bridge design,providing a certain reference for the improvement and optimization of bridge design work.
基金Basic scientific research business expenses of universities directly under Inner Mongolia Autonomous Region,Key project of Philosophy and Social Science Foundation of Inner Mongolia Agricultural University(BR220603)Special project for improving scientific research ability of young teachers of Inner Mongolia Agricultural University(BR230218).
文摘To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.
基金Scientific Research Project of Hunan Provincial Department of Education“Design and Implementation of Vocational Nursing Talent Training Based on Virtual Reality Immersive Game Teaching”(Project No.:23C0938)Loudi Vocational and Technical College 2024 Education and Teaching Reform Research Project“Design and Implementation of Surgical Nursing Gamification Course Based on Immersive Virtual Reality Technology”(Project No.:LZJY24ZZC01)。
文摘This paper mainly discusses the perioperative nursing course teaching model suitable for higher vocational education.The core content of“perioperative nursing”course is set according to surgical nursing posts,and gamified course objectives are designed according to learners’cognitive rules.Typical nursing tasks are used as the carrier,teaching case base is formed based on the concept of medical and educational collaboration,and gamified teaching situations are created based on VR technology to optimize the teaching process and enable students to experience the learning process immersive.Enhance students’job competency and professional competence.In the course design,modular teaching,project teaching,team cooperation teaching,gamification teaching,VR immersive teaching,medical teaching collaborative evaluation and other modes are aggregated,and the course design of perioperative nursing is re-carried out.
文摘In response to the problem of improving practical abilities of students in the process of cultivating innovative talents in the field of financial technology in the specialized software college,this paper analyzes the characteristics and applicability of problem-based learning(PBL)method,proposes a PBL course integration design scheme for the integration of business and technology in the field of financial technology,and provides corresponding course cases.The plan described in this article has been jointly demonstrated by experts from schools and enterprises and has received good feedback.
文摘As a product of the new century,artificial intelligence has been continuously developed and advanced.It has been applied to many fields,especially in the field of mechanical design and manufacturing.With the support of artificial intelligence,mechanical design and manufacturing can not only reduce input costs but also significantly reduce the demand for labor,playing a positive role in improving the design efficiency and quality of mechanical manufacturing[1].This paper studies how to apply artificial intelligence technology to the mechanical design and production process to achieve greater application and development.
文摘The application of virtual reality technology has become more and more influential in garden design. Quest3D as a significant software to realize the virtual reality technology is utilized in this study to make a garden roaming demonstration system with the gardening design of a classical courtyard as an example. Besides, the advantages and disadvantages of applying Quest3D technology in garden landscape design are elaborated from the perspective of the selection of Quest3D technology, basic procedures for the selection and establishment of software and hardware.
基金The National Natural Science Foundation of China(No.71271053)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX13_082)
文摘Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.
文摘The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.
基金financially supported by the National Natural Science Foundation of China(No.51704216)the State Key Laboratory of Advanced Metallurgy,University of Science and Technology Beijing(Nos.41620025,41620026,and 41621009)+1 种基金the Interdisciplinary Research Project for Young Teachers of University of ScienceTechnology Beijing(Fundamental Research Funds f or the Central Universities)(No.FRF-IDRY-20-014)。
文摘The metallurgy industry consumes a considerable amount of coal and fossil fuels,and its carbon dioxide emissions are increasing every year.Replacing coal with renewable,carbon-neutral biomass for metallurgical production is of great significance in reducing global carbon consumption.This study describes the current state of research in biomass metallurgy in recent years and analyzes the concept and scientific principles of biomass metallurgy.The fundamentals of biomass pretreatment technology and biomass metallurgy technology were discussed,and the industrial application framework of biomass metallurgy was proposed.Furthermore,the economic and social advantages of biomass metallurgy were analyzed to serve as a reference for the advancement of fundamental theory and industrial application of biomass metallurgy.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.
基金The study was financially supported by the key project of Science and Technology Commission of Shanghai Local Gov-ernment (No. 015211010), the National Natural Science Foundation of China (No. 50171038) and the China-Belgium bi-lateral project (No. 2001-242).
文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.
文摘The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
文摘Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.
文摘One of the major challenges in designing and fabricating Spintronic devices is the choice of both, Materials and the Technology, along with understanding the intricacies of the Designing aspects. In this communication, we have attempted to briefly discuss these factors, with an aim to draw the attention of the Materials Scientists and Technologists to this serious challenge, in the direction of which, though a lot of research and development work has been done, still needs more concerted efforts to be made in order to make the Spintronic devices that can offer good efficiency for maximizing their usefulness.
文摘Pattern design and technology play a very important role in the garment industry. In order to improve the level of pattern making and design of the garment industry, a survey was conducted to investigate the industrial needs in pattern design and technology in China's Mainland. The data were collected from the employers and employees from the garment industry and students in the major of fashion and clothing studies. It indicated that there was a gap between the employer and employee, especially the requirements of the industrial needs and the course contents covered by the tertiary schools. The employers expected to recruit more experienced pattern designers, at the same time, they were not reluctant to hire fresh graduates and spent more resources on the training of employees. The students knew little about their employment situation of the garment industry, spent too little time on the course study and learned too little practical skills in pattern design. They could not make use of the knowledge which prevented them from being employed by the garment industry. Efforts should be taken by both the tertiary schools and the garment industry. The students should be aspirated towards the profession of pattern cutters and the syllabuses of pattern making should be more practical and industrial orientated. The solution might benefit the garment industry a lot in a long run.
