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Explicit ARL Computational for a Modified EWMA Control Chart in Autocorrelated Statistical Process Control Models
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作者 Yadpirun Supharakonsakun Yupaporn Areepong Korakoch Silpakob 《Computer Modeling in Engineering & Sciences》 2025年第10期699-720,共22页
This study presents an innovative development of the exponentially weighted moving average(EWMA)control chart,explicitly adapted for the examination of time series data distinguished by seasonal autoregressive moving ... This study presents an innovative development of the exponentially weighted moving average(EWMA)control chart,explicitly adapted for the examination of time series data distinguished by seasonal autoregressive moving average behavior—SARMA(1,1)L under exponential white noise.Unlike previous works that rely on simplified models such as AR(1)or assume independence,this research derives for the first time an exact two-sided Average Run Length(ARL)formula for theModified EWMAchart under SARMA(1,1)L conditions,using a mathematically rigorous Fredholm integral approach.The derived formulas are validated against numerical integral equation(NIE)solutions,showing strong agreement and significantly reduced computational burden.Additionally,a performance comparison index(PCI)is introduced to assess the chart’s detection capability.Results demonstrate that the proposed method exhibits superior sensitivity to mean shifts in autocorrelated environments,outperforming existing approaches.The findings offer a new,efficient framework for real-time quality control in complex seasonal processes,with potential applications in environmental monitoring and intelligent manufacturing systems. 展开更多
关键词 Statistical process control average run length modified EWMA control chart autocorrelated data SARMA process computational modeling real-time monitoring
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Computational Design of Interval Type-2 Fuzzy Control for Formation and Containment of Multi-Agent Systems with Collision Avoidance Capability
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作者 Yann-Horng Lin Wen-Jer Chang +2 位作者 Yi-Chen Lee Muhammad Shamrooz Aslam Cheung-Chieh Ku 《Computer Modeling in Engineering & Sciences》 2025年第8期2231-2262,共32页
An Interval Type-2(IT-2)fuzzy controller design approach is proposed in this research to simultaneously achievemultiple control objectives inNonlinearMulti-Agent Systems(NMASs),including formation,containment,and coll... An Interval Type-2(IT-2)fuzzy controller design approach is proposed in this research to simultaneously achievemultiple control objectives inNonlinearMulti-Agent Systems(NMASs),including formation,containment,and collision avoidance.However,inherent nonlinearities and uncertainties present in practical control systems contribute to the challenge of achieving precise control performance.Based on the IT-2 Takagi-Sugeno Fuzzy Model(T-SFM),the fuzzy control approach can offer a more effective solution for NMASs facing uncertainties.Unlike existing control methods for NMASs,the Formation and Containment(F-and-C)control problem with collision avoidance capability under uncertainties based on the IT-2 T-SFM is discussed for the first time.Moreover,an IT-2 fuzzy tracking control approach is proposed to solve the formation task for leaders in NMASs without requiring communication.This control scheme makes the design process of the IT-2 fuzzy Formation Controller(FC)more straightforward and effective.According to the communication interaction protocol,the IT-2 Containment Controller(CC)design approach is proposed for followers to ensure convergence into the region defined by the leaders.Leveraging the IT-2 T-SFM representation,the analysis methods developed for linear Multi-Agent Systems(MASs)are successfully extended to perform containment analysis without requiring the additional assumptions imposed in existing research.Notably,the IT-2 fuzzy tracking controller can also be applied in collision avoidance situations to track the desired trajectories calculated by the avoidance algorithm under the Artificial Potential Field(APF).Benefiting from the combination of vortex and source APFs,the leaders can properly adjust the system dynamics to prevent potential collision risk.Integrating the fuzzy theory and APFs avoidance algorithm,an IT-2 fuzzy controller design approach is proposed to achieve the F-and-C purposewhile ensuring collision avoidance capability.Finally,amulti-ship simulation is conducted to validate the feasibility and effectiveness of the designed IT-2 fuzzy controller. 展开更多
关键词 Interval type-2 Takagi-Sugeno fuzzy model multi-agent systems formation and containment control fuzzy collision avoidance artificial potential field
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Data-Driven Healthcare:The Role of Computational Methods in Medical Innovation 被引量:1
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作者 Hariharasakthisudhan Ponnarengan Sivakumar Rajendran +2 位作者 Vikas Khalkar Gunapriya Devarajan Logesh Kamaraj 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期1-48,共48页
The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical r... The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical research.The review covers key topics such as computational modelling,bioinformatics,machine learning in medical diagnostics,and the integration of wearable technology for real-time health monitoring.Major findings indicate that computational models have significantly enhanced the understanding of complex biological systems,while machine learning algorithms have improved the accuracy of disease prediction and diagnosis.The synergy between bioinformatics and computational techniques has led to breakthroughs in personalized medicine,enabling more precise treatment strategies.Additionally,the integration of wearable devices with advanced computational methods has opened new avenues for continuous health monitoring and early disease detection.The review emphasizes the need for interdisciplinary collaboration to further advance this field.Future research should focus on developing more robust and scalable computational models,enhancing data integration techniques,and addressing ethical considerations related to data privacy and security.By fostering innovation at the intersection of these disciplines,the potential to revolutionize healthcare delivery and outcomes becomes increasingly attainable. 展开更多
关键词 computational models biomedical engineering BIOINFORMATICS machine learning wearable technology
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A Computationally Efficient Aggregation Optimization Strategy of Model Predictive Control 被引量:4
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作者 杜晓宁 Xi +2 位作者 Yugeng Li Shaoyuan 《High Technology Letters》 EI CAS 2002年第2期68-71,共4页
Model Predictive Control (MPC) is a popular technique and has been successfully used in various industrial applications. However, the big drawback of MPC involved in the formidable on line computational effort limits ... Model Predictive Control (MPC) is a popular technique and has been successfully used in various industrial applications. However, the big drawback of MPC involved in the formidable on line computational effort limits its applicability to relatively slow and/or small processes with a moderate number of inputs. This paper develops an aggregation optimization strategy for MPC that can improve the computational efficiency of MPC. For the regulation problem, an input decaying aggregation optimization algorithm is presented by aggregating all the original optimized variables on control horizon with the decaying sequence in respect of the current control action. 展开更多
关键词 Model Predictive control (MPC) on line computational effor
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COMPUTATIONAL FLOW RATE FEEDBACK AND CONTROL METHOD IN HYDRAULIC ELEVATORS 被引量:6
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作者 Xu Bing Ma Jien Lin Jianjie 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2005年第4期490-493,共4页
The computational flow rate feedback and control method, which can be used in proportional valve controlled hydraulic elevators, is discussed and analyzed. In a hydraulic elevator with this method, microprocessor rece... The computational flow rate feedback and control method, which can be used in proportional valve controlled hydraulic elevators, is discussed and analyzed. In a hydraulic elevator with this method, microprocessor receives pressure information from the pressure transducers and computes the flow rate through the proportional valve based on pressure-flow conversion real time algorithm. This hydraulic elevator is of lower cost and energy consumption than the conventional closed loop control hydraulic elevator whose flow rate is measured by a flow meter. Experiments arc carried out on a test rig which could simulate the load of hydraulic elevator. According to the experiment results, the means to modify the pressure-flow conversion algorithm are pointed out. 展开更多
关键词 Hydraulic elevator computational flow rate Proportional valve
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Artificial intelligence assisted light control and computational imaging through scattering media 被引量:10
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作者 Shengfu Cheng Huanhao Li +2 位作者 Yunqi Luo Yuanjin Zheng Puxiang Lai 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2019年第4期32-45,共14页
Coherent optical control within or through scattering media via wavefront shaping has seen broad applications since its invention around 2007.Wavefront shaping is aimed at overcoming the strong scattering,featured by ... Coherent optical control within or through scattering media via wavefront shaping has seen broad applications since its invention around 2007.Wavefront shaping is aimed at overcoming the strong scattering,featured by random interference,namely speckle patterns.This randomness occurs due to the refractive index inhomogeneity in complex media like biological tissue or the modal dispersion in multimode fiber,yet this randomness is actually deterministic and potentially can be time reversal or precompensated.Various wavefront shaping approaches,such as optical phase conjugation,iterative optimization,and transmission matrix measurement,have been developed to generate tight and intense optical delivery or high-resolution image of an optical object behind or within a scattering medium.The performance of these modula-tions,however,is far from satisfaction.Most recently,artifcial intelligence has brought new inspirations to this field,providing exciting hopes to tackle the challenges by mapping the input and output optical patterns and building a neuron network that inherently links them.In this paper,we survey the developments to date on this topic and briefly discuss our views on how to harness machine learning(deep learning in particular)for further advancements in the field. 展开更多
关键词 Optical scattering deep learning wavefront shaping adaptive optics computational imaging
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Priority-Based Scheduling and Orchestration in Edge-Cloud Computing:A Deep Reinforcement Learning-Enhanced Concurrency Control Approach
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作者 Mohammad A Al Khaldy Ahmad Nabot +4 位作者 Ahmad Al-Qerem Mohammad Alauthman Amina Salhi Suhaila Abuowaida Naceur Chihaoui 《Computer Modeling in Engineering & Sciences》 2025年第10期673-697,共25页
The exponential growth of Internet ofThings(IoT)devices has created unprecedented challenges in data processing and resource management for time-critical applications.Traditional cloud computing paradigms cannot meet ... The exponential growth of Internet ofThings(IoT)devices has created unprecedented challenges in data processing and resource management for time-critical applications.Traditional cloud computing paradigms cannot meet the stringent latency requirements of modern IoT systems,while pure edge computing faces resource constraints that limit processing capabilities.This paper addresses these challenges by proposing a novel Deep Reinforcement Learning(DRL)-enhanced priority-based scheduling framework for hybrid edge-cloud computing environments.Our approach integrates adaptive priority assignment with a two-level concurrency control protocol that ensures both optimal performance and data consistency.The framework introduces three key innovations:(1)a DRL-based dynamic priority assignmentmechanism that learns fromsystem behavior,(2)a hybrid concurrency control protocol combining local edge validation with global cloud coordination,and(3)an integrated mathematical model that formalizes sensor-driven transactions across edge-cloud architectures.Extensive simulations across diverse workload scenarios demonstrate significant quantitative improvements:40%latency reduction,25%throughput increase,85%resource utilization(compared to 60%for heuristicmethods),40%reduction in energy consumption(300 vs.500 J per task),and 50%improvement in scalability factor(1.8 vs.1.2 for EDF)compared to state-of-the-art heuristic and meta-heuristic approaches.These results establish the framework as a robust solution for large-scale IoT and autonomous applications requiring real-time processing with consistency guarantees. 展开更多
关键词 Edge computing cloud computing scheduling algorithms orchestration strategies deep reinforcement learning concurrency control real-time systems IoT
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Digital Humanities,Computational Criticism and the Stanford Literary Lab:An Interviewwith Mark Algee-Hewittr
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作者 Hui Haifeng Mark Algee-Hewitt 《外国文学研究》 北大核心 2025年第4期1-10,共10页
The Literary Lab at Stanford University is one of the birthplaces of digital humanities and has maintained significant influence in this field over the years.Professor Hui Haifeng has been engaged in research on digit... The Literary Lab at Stanford University is one of the birthplaces of digital humanities and has maintained significant influence in this field over the years.Professor Hui Haifeng has been engaged in research on digital humanities and computational criticism in recent years.During his visiting scholarship at Stanford University,he participated in the activities of the Literary Lab.Taking this opportunity,he interviewed Professor Mark Algee-Hewitt,the director of the Literary Lab,discussing important topics such as the current state and reception of DH(digital humanities)in the English Department,the operations of the Literary Lab,and the landscape of computational criticism.Mark Algee-Hewitt's research focuses on the eighteenth and early nineteenth centuries in England and Germany and seeks to combine literary criticism with digital and quantitative analyses of literary texts.In particular,he is interested in the history of aesthetic theory and the development and transmission of aesthetic and philosophical concepts during the Enlightenment and Romantic periods.He is also interested in the relationship between aesthetic theory and the poetry of the long eighteenth century.Although his primary background is English literature,he also has a degree in computer science.He believes that the influence of digital humanities within the humanities disciplines is growing increasingly significant.This impact is evident in both the attraction and assistance it offers to students,as well as in the new interpretations it brings to traditional literary studies.He argues that the key to effectively integrating digital humanities into the English Department is to focus on literary research questions,exploring how digital tools can raise new questions or provide new insights into traditional research. 展开更多
关键词 digital humanities computational criticism literary research Literary Lab
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Intelligent Control of Cabin Environment Using Computational Fluid Dynamics for Intelligent Manufacturing
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作者 Xi Wang Guangping Zeng 《Fluid Dynamics & Materials Processing》 EI 2022年第3期563-576,共14页
An efficient and versatile intelligent algorithm is developed for the control of the cabin environment of wind power generators.The method can be used to monitor and solve wind power generation problems at the same ti... An efficient and versatile intelligent algorithm is developed for the control of the cabin environment of wind power generators.The method can be used to monitor and solve wind power generation problems at the same time.It also provides several advantages with respect to other traditional methods which imply significant workload and maintenance personnel.The functional requirements of the intelligent control system are analyzed,and a control algorithm for the stepping motor is selected and evaluated.Through the comparative analysis of the active power and internal temperature curve for three kinds of output power of the prototype,it is proved that the environmental intelligent control system greatly improves the operation efficiency,solves typical problems in the ventilator room environment,and provides a solid theoretical basis for further research in this field. 展开更多
关键词 Wind turbine cabin environment control system computational fluid dynamics
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Computational Offloading and Resource Allocation for Internet of Vehicles Based on UAV-Assisted Mobile Edge Computing System
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作者 Fang Yujie Li Meng +3 位作者 Si Pengbo Yang Ruizhe Sun Enchang Zhang Yanhua 《China Communications》 2025年第9期333-351,共19页
As an essential element of intelligent trans-port systems,Internet of vehicles(IoV)has brought an immersive user experience recently.Meanwhile,the emergence of mobile edge computing(MEC)has enhanced the computational ... As an essential element of intelligent trans-port systems,Internet of vehicles(IoV)has brought an immersive user experience recently.Meanwhile,the emergence of mobile edge computing(MEC)has enhanced the computational capability of the vehicle which reduces task processing latency and power con-sumption effectively and meets the quality of service requirements of vehicle users.However,there are still some problems in the MEC-assisted IoV system such as poor connectivity and high cost.Unmanned aerial vehicles(UAVs)equipped with MEC servers have become a promising approach for providing com-munication and computing services to mobile vehi-cles.Hence,in this article,an optimal framework for the UAV-assisted MEC system for IoV to minimize the average system cost is presented.Through joint consideration of computational offloading decisions and computational resource allocation,the optimiza-tion problem of our proposed architecture is presented to reduce system energy consumption and delay.For purpose of tackling this issue,the original non-convex issue is converted into a convex issue and the alternat-ing direction method of multipliers-based distributed optimal scheme is developed.The simulation results illustrate that the presented scheme can enhance the system performance dramatically with regard to other schemes,and the convergence of the proposed scheme is also significant. 展开更多
关键词 computational offloading Internet of Vehicles mobile edge computing resource optimization unmanned aerial vehicle
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A Stable Fuzzy-Based Computational Model and Control for Inductions Motors 被引量:1
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作者 Yongqiu Liu Shaohui Zhong +3 位作者 Nasreen Kausar Chunwei Zhang Ardashir Mohammadzadeh Dragan Pamucar 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期793-812,共20页
In this paper,a stable and adaptive sliding mode control(SMC)method for induction motors is introduced.Determining the parameters of this system has been one of the existing challenges.To solve this challenge,a new se... In this paper,a stable and adaptive sliding mode control(SMC)method for induction motors is introduced.Determining the parameters of this system has been one of the existing challenges.To solve this challenge,a new self-tuning type-2 fuzzy neural network calculates and updates the control system parameters with a fast mechanism.According to the dynamic changes of the system,in addition to the parameters of the SMC,the parameters of the type-2 fuzzy neural network are also updated online.The conditions for guaranteeing the convergence and stability of the control system are provided.In the simulation part,in order to test the proposed method,several uncertain models and load torque have been applied.Also,the results have been compared to the SMC based on the type-1 fuzzy system,the traditional SMC,and the PI controller.The average RMSE in different scenarios,for type-2 fuzzy SMC,is 0.0311,for type-1 fuzzy SMC is 0.0497,for traditional SMC is 0.0778,and finally for PI controller is 0.0997. 展开更多
关键词 Sliding mode control self-tuning type-2 fuzzy systems inductions motor parameters uncertainty
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Harnessing the Power of PM6:Y6 Semitransparent Photoanodes by Computational Balancement of Photon Absorption in Photoanode/Photovoltaic Organic Tandems:>7mA cm^(-2) Solar Synthetic Fuels Production at Bias-Free Potentials
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作者 Francisco Bernal-Texca Emmanouela Andrioti +1 位作者 Jordi Martorell Carles Ros 《Energy & Environmental Materials》 2025年第1期197-202,共6页
This study first demonstrates the potential of organic photoabsorbing blends in overcoming a critical limitation of metal oxide photoanodes in tandem modules:insufficient photogenerated current.Various organic blends,... This study first demonstrates the potential of organic photoabsorbing blends in overcoming a critical limitation of metal oxide photoanodes in tandem modules:insufficient photogenerated current.Various organic blends,including PTB7-Th:FOIC,PTB7-Th:O6T-4F,PM6:Y6,and PM6:FM,were systematically tested.When coupled with electron transport layer(ETL)contacts,these blends exhibit exceptional charge separation and extraction,with PM6:Y6 achieving saturation photocurrents up to 16.8 mA cm^(-2) at 1.23 VRHE(oxygen evolution thermodynamic potential).For the first time,a tandem structure utilizing organic photoanodes has been computationally designed and fabricated and the implementation of a double PM6:Y6 photoanode/photovoltaic structure resulted in photogenerated currents exceeding 7mA cm^(-2) at 0 VRHE(hydrogen evolution thermodynamic potential)and anodic current onset potentials as low as-0.5 VRHE.The herein-presented organic-based approach paves the way for further exploration of different blend combinations to target specific oxidative reactions by selecting precise donor/acceptor candidates among the multiple existing ones. 展开更多
关键词 computational hydrogen ORGANIC photoanodes photovoltaics tandem
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Task-and-role-based access-control model for computational grid
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作者 龙涛 《Journal of Chongqing University》 CAS 2007年第4期249-255,共7页
Access control in a grid environment is a challenging issue because the heterogeneous nature and independent administration of geographically dispersed resources in grid require access control to use fine-grained poli... Access control in a grid environment is a challenging issue because the heterogeneous nature and independent administration of geographically dispersed resources in grid require access control to use fine-grained policies. We established a task-and-role-based access-control model for computational grid (CG-TRBAC model), integrating the concepts of role-based access control (RBAC) and task-based access control (TBAC). In this model, condition restrictions are defined and concepts specifically tailored to Workflow Management System are simplified or omitted so that role assignment and security administration fit computational grid better than traditional models; permissions are mutable with the task status and system variables, and can be dynamically controlled. The CG-TRBAC model is proved flexible and extendible. It can implement different control policies. It embodies the security principle of least privilege and executes active dynamic authorization. A task attribute can be extended to satisfy different requirements in a real grid system. 展开更多
关键词 computational grid task-and-role-based access control grid security role assignment
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Quality Control and Optimization of Computed Tomography Dose Index Volume (CTDIvol) of LightSpeed RT16 Xtra CT Scanner
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作者 Umme Sadia Binte Kashem Shirin Akter +4 位作者 Afroza Shelley Rajada Khatun Ashrafun Nahar Monika Laila Sharmin Md. Anwarul Islam 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2025年第1期1-13,共13页
Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed To... Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit. 展开更多
关键词 Quality control CTDIvol LightSpeed RT16 Xtra CT Scanner PHANTOM
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Introduction to the Special Issue on Mathematical Aspects of Computational Biology and Bioinformatics-Ⅱ
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作者 Dumitru Baleanu Carla M.A.Pinto Sunil Kumar 《Computer Modeling in Engineering & Sciences》 2025年第5期1297-1299,共3页
1 Summary Mathematical modeling has become a cornerstone in understanding the complex dynamics of infectious diseases and chronic health conditions.With the advent of more refined computational techniques,researchers ... 1 Summary Mathematical modeling has become a cornerstone in understanding the complex dynamics of infectious diseases and chronic health conditions.With the advent of more refined computational techniques,researchers are now able to incorporate intricate features such as delays,stochastic effects,fractional dynamics,variable-order systems,and uncertainty into epidemic models.These advancements not only improve predictive accuracy but also enable deeper insights into disease transmission,control,and policy-making.Tashfeen et al. 展开更多
关键词 computational techniquesresearchers effectsfractional dynamicsvariable order understanding complex dynamics infectious diseases chronic health conditionswith computational techniques mathematical modeling infectious diseases chronic health conditions DELAYS
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Merging computational intelligence and wearable technologies for adolescent idiopathic scoliosis: a quest for multiscale modelling, long-term monitoring and personalized treatment
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作者 Chun-Zhi Yi Xiao-Lei Sun 《Medical Data Mining》 2025年第2期21-30,共10页
Adolescent idiopathic scoliosis(AIS)is a dynamic progression during growth,which requires long-term collaborations and efforts from clinicians,patients and their families.It would be beneficial to have a precise inter... Adolescent idiopathic scoliosis(AIS)is a dynamic progression during growth,which requires long-term collaborations and efforts from clinicians,patients and their families.It would be beneficial to have a precise intervention based on cross-scale understandings of the etiology,real-time sensing and actuating to enable early detection,screening and personalized treatment.We argue that merging computational intelligence and wearable technologies can bridge the gap between the current trajectory of the techniques applied to AIS and this vision.Wearable technologies such as inertial measurement units(IMUs)and surface electromyography(sEMG)have shown great potential in monitoring spinal curvature and muscle activity in real-time.For instance,IMUs can track the kinematics of the spine during daily activities,while sEMG can detect asymmetric muscle activation patterns that may contribute to scoliosis progression.Computational intelligence,particularly deep learning algorithms,can process these multi-modal data streams to identify early signs of scoliosis and adapt treatment strategies dynamically.By using their combination,we can find potential solutions for a better understanding of the disease,a more effective and intelligent way for treatment and rehabilitation. 展开更多
关键词 adolescent idiopathic scoliosis computational intelligence wearable technologies
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Computational redesign of a thermostable MHET hydrolase and its role as an endo-PETase in promoting PET depolymerization
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作者 Xiaomeng Liu Zehua Chen +5 位作者 Xinyue Liu Tong Zhu Jinyuan Sun Chunli Li Yinglu Cui Bian Wu 《Chinese Journal of Catalysis》 2025年第11期182-191,共10页
Biotechnological strategies for plastic depolymerization and recycling have emerged as transformative approaches to combat the global plastic pollution crisis,aligning with the principles of a sustainable and circular... Biotechnological strategies for plastic depolymerization and recycling have emerged as transformative approaches to combat the global plastic pollution crisis,aligning with the principles of a sustainable and circular economy.Despite advances in engineering PET hydrolases,the degradation process is frequently compromised by product inhibition and the heterogeneity of final products,thereby obstructing subsequent PET recondensation and impeding the synthesis of high-value derivatives.In this work,we utilized previously devised computational strategies to redesign a thermostable DuraMHETase,achieving an apparent melting temperature of 72℃ in complex with MHET and a 6-fold higher in total turnover number(TTN)toward MHET than the wild-type enzyme at 60℃.The fused enzyme system composed of DuraMHETase and TurboPETase demonstrated higher efficiency than other PET hydrolases and the separated dual enzyme systems.Furthermore,we identified both exo-and endo-PETase activities in DuraMHETase,whereas the endo-activity was previously unobserved at ambient temperatures.These results expand the functional scope of MHETase beyond mere intermediate hydrolysis,and may provide guidance for the development of more synergistic approaches to plastic biodepolymerization and recycling. 展开更多
关键词 computational enzyme redesign BIOCATALYSIS Plastic degradation Enzyme mechanism Thermostability
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Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment
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作者 Lei Zhang Jing Chen +7 位作者 Yu-Ying Zhang Lei Liu Han-Dan Wang Ya-Fei Zhang Jun Sheng Qiu-Shi Hu Ming-Liang Liu Yi-Lin Yuan 《World Journal of Gastrointestinal Endoscopy》 2025年第3期50-59,共10页
BACKGROUND Inguinal hernias are common after surgery.Tension-free repair is widely accepted as the main method for managing inguinal hernias.Adequate exposure,coverage,and repair of the myopectineal orifice(MPO)are ne... BACKGROUND Inguinal hernias are common after surgery.Tension-free repair is widely accepted as the main method for managing inguinal hernias.Adequate exposure,coverage,and repair of the myopectineal orifice(MPO)are necessary.However,due to differences in race and sex,people’s body shapes vary.According to European guidelines,the patch should measure 10 cm×15 cm.If any part of the MPO is dissected,injury to the nerves,vascular network,or organs may occur during surgery,thereby leading to inguinal discomfort,pain,and seroma formation after surgery.Therefore,accurate localization and measurement of the boundary of the MPO are crucial for selecting the optimal patch for inguinal hernia repair.AIM To compare the size of the MPO measured on three-dimensional multislice spiral computed tomography(CT)with that measured via laparoscopy and explore the relevant factors influencing the size of the MPO.METHODS Clinical data from 74 patients who underwent laparoscopic tension-free inguinal hernia repair at the General Surgery Department of the First Affiliated Hospital of Anhui University of Science and Technology between September 2022 and July 2024 were collected and analyzed retrospectively.Transabdominal preperitoneal was performed.Sixty-four males and 10 females,with an average age of 58.30±12.32 years,were included.The clinical data of the patients were collected.The boundary of the MPO was measured on three-dimensional CT images before surgery and then again during transabdominal preperitoneal.All the preoperative and intraoperative data were analyzed via paired t-tests.A t-test was used for comparisons of age,body mass index,and sex between the groups.In the comparative analysis,a P value less than 0.05 indicated a significant difference.RESULTS The boundaries of the MPO on 3-dimensional CT images measured 7.05±0.47 cm and 6.27±0.61 cm,and the area of the MPO was 19.54±3.33 cm^(2).The boundaries of the MPO during surgery were 7.18±0.51 cm and 6.17±0.40 cm.The errors were not statistically significant.However,the intraoperative BD(the width of the MPO,P=0.024,P<0.05)and preoperative AC(the length of the MPO,P=0.045,P<0.05)significantly differed according to sex.The AC and BD measurements before and during surgery were not significantly different according to age,body mass index,hernia side or hernia type(P>0.05).CONCLUSION The application of this technology can aid in determining the most appropriate dissection range and patch size. 展开更多
关键词 HERNIA INGUINAL Myopectineal orifice Three-dimensional reconstruction computed tomography Inguinal hernia
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Towards the future of physics-and data-guided AI frameworks in computational mechanics
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作者 Jinshuai Bai Yizheng Wang +8 位作者 Hyogu Jeong Shiyuan Chu Qingxia Wang Laith Alzubaidi Xiaoying Zhuang Timon Rabczuk Yi Min Xie Xi-Qiao Feng Yuantong Gu 《Acta Mechanica Sinica》 2025年第7期38-51,共14页
The integration of physics-based modelling and data-driven artificial intelligence(AI)has emerged as a transformative paradigm in computational mechanics.This perspective reviews the development and current status of ... The integration of physics-based modelling and data-driven artificial intelligence(AI)has emerged as a transformative paradigm in computational mechanics.This perspective reviews the development and current status of AI-empowered frameworks,including data-driven methods,physics-informed neural networks,and neural operators.While these approaches have demonstrated significant promise,challenges remain in terms of robustness,generalisation,and computational efficiency.We delineate four promising research directions:(1)Modular neural architectures inspired by traditional computational mechanics,(2)physics informed neural operators for resolution-invariant operator learning,(3)intelligent frameworks for multiphysics and multiscale biomechanics problems,and(4)structural optimisation strategies based on physics constraints and reinforcement learning.These directions represent a shift toward foundational frameworks that combine the strengths of physics and data,opening new avenues for the modelling,simulation,and optimisation of complex physical systems. 展开更多
关键词 computational mechanics Physics-informed neural network Operator learning BIOMECHANICS Topology optimisation
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