目的:探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者CT平扫(non-contrast computed tomography,NCCT)Alberta卒中项目早期CT评分(Alberta stroke program early computed tomography score,ASPECTS)与CT灌注成像(CT perfusion,C...目的:探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者CT平扫(non-contrast computed tomography,NCCT)Alberta卒中项目早期CT评分(Alberta stroke program early computed tomography score,ASPECTS)与CT灌注成像(CT perfusion,CTP)梗死核心体积不匹配的影响因素及预后特征。方法:回顾性分析2019年10月—2023年8月449例行NCCT及CTP评估的前循环大血管闭塞型AIS患者的临床及影像资料。采用RAPID软件自动计算NCCT-ASPECTS和CTP梗死核心体积。“NCCT-CTP不匹配”定义为低NCCT-ASPECTS、小梗死核心体积(low ASPECTS and small ischemic core volume,LASC)(NCCT-ASPECTS<6分,CTP梗死核心体积<70 mL)以及高NCCT-ASPECTS、大梗死核心体积(high ASPECTS and large ischemic core volume,HALC)(NCCT-ASPECTS≥6分,CTP梗死核心体积≥70 m L)。采用血管内取栓治疗(endovascular thrombectomy,EVT)后90 d随访基线改良Rankin量表(mRS)评分0~2分定义预后良好。采用多因素逻辑回归分析NCCT-CTP不匹配的独立影响因素。结果:449例AIS患者中有145例出现NCCT-CTP不匹配,其中52例(35.9%)患者血管内取栓治疗(endovascular thrombectomy,EVT)后获得良好预后。多因素逻辑回归分析结果提示,影像评估前接受静脉溶栓(intravenous thrombolysis,IVT)(OR=1.833;95%CI:1.205~2.790,P=0.005)、更高的基线NIHSS评分(OR=1.055;95%CI:1.028~1.083,P<0.001)是AIS患者出现NCCT-CTP不匹配的独立影响因素。NCCT-CTP不匹配亚组分析提示,LASC患者卒中发病至基线影像检查的时间间隔大于HALC患者[306(219,482)min vs.125(63,307)min;P=0.004]。LASC患者EVT术后出血性脑梗死发生率高于HALC患者(66.9%vs.33.3%;P=0.021)。结论:约35%的NCCT-CTP不匹配患者可从EVT中获益。影像评估前接受IVT以及更高的基线NIHSS评分是出现NCCT-CTP不匹配的独立影响因素。展开更多
Computer science concept and ability is crucial to modern information technology.As a basic computer science education,computational thinking has become one of the first courses for college students and the foundation...Computer science concept and ability is crucial to modern information technology.As a basic computer science education,computational thinking has become one of the first courses for college students and the foundation for training for non-computer professionals.Computational thinking is a way of thinking that students in all majors should master.In the process of teaching,students learn to use computational thinking to solve professional and technical problems and make good use of computer’s powerful tools.It is one of the major themes of recent teaching research.We set course objectives from issues-driven and correspond each class to the module objectives,so that the focus of course content is clear.The learning clues for the students are clear,which is conducive to the cultivation and improvement of computational thinking.展开更多
目的:本研究利用CT三维重建技术重建颅骨,对广西壮族成年人眶区骨组织随年龄增长发生改变的特征进行量化分析,以期发现广西壮族人骨性眼眶老化的规律,为眶区年轻化治疗提供数据参考。方法:随机抽取广西医科大学第一附属医院及第二附属医...目的:本研究利用CT三维重建技术重建颅骨,对广西壮族成年人眶区骨组织随年龄增长发生改变的特征进行量化分析,以期发现广西壮族人骨性眼眶老化的规律,为眶区年轻化治疗提供数据参考。方法:随机抽取广西医科大学第一附属医院及第二附属医院100例颅骨发育正常的广西壮族成年人的头颅CT扫描资料作为研究样本,按年龄分为三组:年轻组37例(19~41岁)、中年组27例(48~59岁)、老年组36例(≥60岁)。利用GE AW 4.7工作台对每名受检者左眼眶的眶口宽度、眶口高度及两条斜径进行定量测量,以SPSS软件对采集数据进行统计学分析。结果:根据受试对象的眼眶宽度、眼眶高度、内上-外下径、内下-外上径的测量结果得出,在每个年龄分组中,男性研究对象的各项测量平均值均大于女性研究对象。男性研究对象的眼眶宽度(P=0.436)、眼眶高度(P=0.065)、内上-外下径(P=0.683)、内下-外上径(P=0.580)与年龄的增长无显著相关性。女性研究对象的眼眶宽度(P=0.674)、眼眶高度(P=0.502)、内上-外下径(P=0.966)、内下-外上径(P=0.290)与年龄的增长无显著相关性。眶缘在各个方向的变化是不规则的。结论:在本研究中,男性或女性广西壮族人的眶缘并未随年龄改变发生明显的变化。展开更多
During deep coal mining,an instability failure of coal usually occurs under the combined effect of initial damage and triaxial cyclic loading and unloading(TCLU).Therefore,this study investigated the impact of initial...During deep coal mining,an instability failure of coal usually occurs under the combined effect of initial damage and triaxial cyclic loading and unloading(TCLU).Therefore,this study investigated the impact of initial damage on mechanical behavior and acoustic emission(AE)characteristics of coal under TCLU.Initial damage variables(IDVs)of coal specimens were quantified using preloading,followed by TCLU experiments to assess the deformation,energy distribution,and fracture development.The results revealed that the increase in IDVs significantly reduced the structural integrity of coal specimens,increased the cumulative irreversible strain,and enhanced the dissipated energy owing to microfracture expansion.Moreover,AE monitoring showed earlier activation of fractures and a higher occurrence of large-scale rupture events of coal specimens with high IDVs,which correlated with decreasing AE b values(reflecting the different scales of fracture within specimens)and increasing S values(reflecting the AE activity within specimens).Additionally,computed tomography analysis revealed intensified fracture networks and increasing three-dimensional fractal dimensions of coal specimens with higher IDVs.Finally,the coupling effect of TCLU and initial damage on the weakening mechanism of coal was investigated.Initial damage significantly reduced the structural integrity of coal by increasing the number of weak planes within coal specimens,contributing to the earlier activation and rapid expansion of fractures at low stress levels under TCLU and eventually accelerating the weakening process of coal.This study provides a scientific basis and theoretical support for the prevention and control of dynamic disasters in deep coal mining.展开更多
Introduction to Computer Science,as one of the fundamental courses in computer-related majors,plays an important role in the cultivation of computer professionals.However,traditional teaching models and content can no...Introduction to Computer Science,as one of the fundamental courses in computer-related majors,plays an important role in the cultivation of computer professionals.However,traditional teaching models and content can no longer fully meet the needs of modern information technology development.In response to these issues,this article introduces the concept of computational creative thinking,optimizes course content,adopts exploratory teaching methods,and innovates course assessment methods,aiming to comprehensively enhance students’computational thinking and innovative abilities.By continuously improving and promoting this teaching model,it will undoubtedly promote computer education in universities to a new level.展开更多
文摘目的:探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者CT平扫(non-contrast computed tomography,NCCT)Alberta卒中项目早期CT评分(Alberta stroke program early computed tomography score,ASPECTS)与CT灌注成像(CT perfusion,CTP)梗死核心体积不匹配的影响因素及预后特征。方法:回顾性分析2019年10月—2023年8月449例行NCCT及CTP评估的前循环大血管闭塞型AIS患者的临床及影像资料。采用RAPID软件自动计算NCCT-ASPECTS和CTP梗死核心体积。“NCCT-CTP不匹配”定义为低NCCT-ASPECTS、小梗死核心体积(low ASPECTS and small ischemic core volume,LASC)(NCCT-ASPECTS<6分,CTP梗死核心体积<70 mL)以及高NCCT-ASPECTS、大梗死核心体积(high ASPECTS and large ischemic core volume,HALC)(NCCT-ASPECTS≥6分,CTP梗死核心体积≥70 m L)。采用血管内取栓治疗(endovascular thrombectomy,EVT)后90 d随访基线改良Rankin量表(mRS)评分0~2分定义预后良好。采用多因素逻辑回归分析NCCT-CTP不匹配的独立影响因素。结果:449例AIS患者中有145例出现NCCT-CTP不匹配,其中52例(35.9%)患者血管内取栓治疗(endovascular thrombectomy,EVT)后获得良好预后。多因素逻辑回归分析结果提示,影像评估前接受静脉溶栓(intravenous thrombolysis,IVT)(OR=1.833;95%CI:1.205~2.790,P=0.005)、更高的基线NIHSS评分(OR=1.055;95%CI:1.028~1.083,P<0.001)是AIS患者出现NCCT-CTP不匹配的独立影响因素。NCCT-CTP不匹配亚组分析提示,LASC患者卒中发病至基线影像检查的时间间隔大于HALC患者[306(219,482)min vs.125(63,307)min;P=0.004]。LASC患者EVT术后出血性脑梗死发生率高于HALC患者(66.9%vs.33.3%;P=0.021)。结论:约35%的NCCT-CTP不匹配患者可从EVT中获益。影像评估前接受IVT以及更高的基线NIHSS评分是出现NCCT-CTP不匹配的独立影响因素。
基金supported in part by the Production,Teaching and Research Project of the Ministry of Education in 2022.
文摘Computer science concept and ability is crucial to modern information technology.As a basic computer science education,computational thinking has become one of the first courses for college students and the foundation for training for non-computer professionals.Computational thinking is a way of thinking that students in all majors should master.In the process of teaching,students learn to use computational thinking to solve professional and technical problems and make good use of computer’s powerful tools.It is one of the major themes of recent teaching research.We set course objectives from issues-driven and correspond each class to the module objectives,so that the focus of course content is clear.The learning clues for the students are clear,which is conducive to the cultivation and improvement of computational thinking.
文摘目的:本研究利用CT三维重建技术重建颅骨,对广西壮族成年人眶区骨组织随年龄增长发生改变的特征进行量化分析,以期发现广西壮族人骨性眼眶老化的规律,为眶区年轻化治疗提供数据参考。方法:随机抽取广西医科大学第一附属医院及第二附属医院100例颅骨发育正常的广西壮族成年人的头颅CT扫描资料作为研究样本,按年龄分为三组:年轻组37例(19~41岁)、中年组27例(48~59岁)、老年组36例(≥60岁)。利用GE AW 4.7工作台对每名受检者左眼眶的眶口宽度、眶口高度及两条斜径进行定量测量,以SPSS软件对采集数据进行统计学分析。结果:根据受试对象的眼眶宽度、眼眶高度、内上-外下径、内下-外上径的测量结果得出,在每个年龄分组中,男性研究对象的各项测量平均值均大于女性研究对象。男性研究对象的眼眶宽度(P=0.436)、眼眶高度(P=0.065)、内上-外下径(P=0.683)、内下-外上径(P=0.580)与年龄的增长无显著相关性。女性研究对象的眼眶宽度(P=0.674)、眼眶高度(P=0.502)、内上-外下径(P=0.966)、内下-外上径(P=0.290)与年龄的增长无显著相关性。眶缘在各个方向的变化是不规则的。结论:在本研究中,男性或女性广西壮族人的眶缘并未随年龄改变发生明显的变化。
基金supported by the National Key R&D Program of China(Grant No.2022YFC3004704)the National Natural Science Foundation of China(Grant No.52174166)Graduate Research and Innovation Foundation of Chongqing,China(Grant No.CYB23031),which were gratefully acknowledged.
文摘During deep coal mining,an instability failure of coal usually occurs under the combined effect of initial damage and triaxial cyclic loading and unloading(TCLU).Therefore,this study investigated the impact of initial damage on mechanical behavior and acoustic emission(AE)characteristics of coal under TCLU.Initial damage variables(IDVs)of coal specimens were quantified using preloading,followed by TCLU experiments to assess the deformation,energy distribution,and fracture development.The results revealed that the increase in IDVs significantly reduced the structural integrity of coal specimens,increased the cumulative irreversible strain,and enhanced the dissipated energy owing to microfracture expansion.Moreover,AE monitoring showed earlier activation of fractures and a higher occurrence of large-scale rupture events of coal specimens with high IDVs,which correlated with decreasing AE b values(reflecting the different scales of fracture within specimens)and increasing S values(reflecting the AE activity within specimens).Additionally,computed tomography analysis revealed intensified fracture networks and increasing three-dimensional fractal dimensions of coal specimens with higher IDVs.Finally,the coupling effect of TCLU and initial damage on the weakening mechanism of coal was investigated.Initial damage significantly reduced the structural integrity of coal by increasing the number of weak planes within coal specimens,contributing to the earlier activation and rapid expansion of fractures at low stress levels under TCLU and eventually accelerating the weakening process of coal.This study provides a scientific basis and theoretical support for the prevention and control of dynamic disasters in deep coal mining.
基金2024 Education and Teaching Reform Research Project of Hainan Normal University(hsjg2024-04)。
文摘Introduction to Computer Science,as one of the fundamental courses in computer-related majors,plays an important role in the cultivation of computer professionals.However,traditional teaching models and content can no longer fully meet the needs of modern information technology development.In response to these issues,this article introduces the concept of computational creative thinking,optimizes course content,adopts exploratory teaching methods,and innovates course assessment methods,aiming to comprehensively enhance students’computational thinking and innovative abilities.By continuously improving and promoting this teaching model,it will undoubtedly promote computer education in universities to a new level.
