The Third Plenary Session of the 18th CPC Central Committee ushered in a new chapter of China＇s comprehensive deepening of reform. The basic objective of comprehensively deepening reform of the state sector of econom...The Third Plenary Session of the 18th CPC Central Committee ushered in a new chapter of China＇s comprehensive deepening of reform. The basic objective of comprehensively deepening reform of the state sector of economy in the new chapter is to fully integrate this sector with a sophisticated market economic system with the market playing the decisive role in resource allocation. In order to achieve this objective, China is confronted with the four major priorities of adjusting the functions and layout of the state sector of economy according to national mandates, expediting the mixed ownership reform, creating a classified and multi- tiered new system for the administration of the sector, and developing a modern corporate system for SOEs to ensure an efficient micro-level governance mechanism for the sector. （1） The functions of the different types of SOEs should be accurately defined and SOEs should be divided into the three types of public policy SOEs, functional SOEs, and commercial SOEs. This classification forms the premises for reforming the state sector of economy. Based on the functions of the three types of SOEs, the directions and emphases for strategic adjustment should differ as well. （2） The mixed ownership reform should adhere to the methodological principles of combining top-down and bottom-up approaches, implementing pilot programs, and promoting coordinated progress. Practical implementation should ensure fair and standard reform procedures, reform programs consistent with laws and regulations, open and fair equity transfers, as well as fair and transparent internal distributions. The mixed ownership reform of SOEs should introduce the employee stock ownership system and adhere to the principles of compatible incentives, shared growth, and long-term development. Monopolistic sectors should be transformed into competitive market structures to create conditions for the implementation of mixed ownership for SOEs. （3） The new system for the administration of the state sector of economy should comprise three hierarchies： the Commission for the Administration of State Economy at the top level, state capital operation companies or state capital investment companies at the intermediate level and general for-profit enterprises at the bottom level, which administer public policy, functional SOEs, and commercial SOEs respectively. （4） Under the new system for the administration of the state sector of economy characterized by the three hierarchies and categories, the key for perfecting the modern corporate system of SOEs is to establish a differentiated, classified governance mechanism, i.e., different corporate governance mechanisms should be created for SOEs of different functions and roles.展开更多
Since the Eighteenth National Congress of CPC,the Central Committee of CPC with Comrade Xi Jinping at the core,with great political courage and shouldering spirit,targeting at the prominent problems with Party buildin...Since the Eighteenth National Congress of CPC,the Central Committee of CPC with Comrade Xi Jinping at the core,with great political courage and shouldering spirit,targeting at the prominent problems with Party building,made a series of major deployments,and led the whole Party in opening new prospects of Party building.展开更多
The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing...The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing Forward the Rule of Law （hereafter, ＂Decision＂）. The plenary session was convened at a pivotal stage in comprehensively building a well-off society and comprehen- sively deepening reform. It was the first of its kind with the theme of the rule of law and was a landmark event in China＇s legal construction. The Journal interviewed Professor Luo Haocai, who is also president of the China Society for Human Rights Studies （CSHRS）.展开更多
Faults and fractures of multiple scales are frequently induced and generated in compressional structural system. Comprehensive identification of these potential faults and fractures that cannot be distinguished direct...Faults and fractures of multiple scales are frequently induced and generated in compressional structural system. Comprehensive identification of these potential faults and fractures that cannot be distinguished directly from seismic profile of the complex structures is still an unanswered problem. Based on the compressional structural geometry and kinematics theories as well as the structural interpretation from seismic data, a set of techniques is established for the identification of potential faults and fractures in compressional structures. Firstly, three-dimensional(3D) patterns and characteristics of the faults directly interpreted from seismic profile were illustrated by 3D structural model. Then, the unfolding index maps, the principal structural curvature maps, and tectonic stress field maps were obtained from structural restoration. Moreover, potential faults and fractures in compressional structures were quantitatively identified relying on comprehensive analysis of these three maps. Successful identification of the potential faults and fractures in Mishrif limestone formation and in Asmari dolomite formation of Buzurgan anticline in Iraq demonstrates the applicability and reliability of these techniques.展开更多
This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of bi...This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf.展开更多
Being an important part of the"four comprehensives"strategic thinking in an all-round way,the comprehensive and strict governance on the paxty has promoted the position of the construction of the party in co...Being an important part of the"four comprehensives"strategic thinking in an all-round way,the comprehensive and strict governance on the paxty has promoted the position of the construction of the party in constructing the socialism with Chinese characteristics.From the"strict governance on the pasty"to the"comprehensive and strict governance on the party,"it doesn't only mean that the"comprehensive"word is added in literal,but the content of innovation and requirements should be improved,and it has the following rules:Our country should adhere to combine the establishment of the ideological paxty and the governance of the institutional pasty,and our country should adhere to combine the comprehensive and strict governance on the pasty and the control of the"key minority."Our country should adhere to the combination of strengthening the main responsibility and playing the role of people's supervision and also should adhere to combine the strict punishment with the effective prevention.展开更多
The symposium on "Comprehensively Advancing Rule of Law and China's Human Rights New Development" was successfully held on April 11,2017 at Southwest University of Political Science and Law The symposium...The symposium on "Comprehensively Advancing Rule of Law and China's Human Rights New Development" was successfully held on April 11,2017 at Southwest University of Political Science and Law The symposium was organized by the China Society for Human Rights Studies and hosted by the Institute of Human Rights at Southwest University of Political Science and Law Representatives from the Commission of Legislative Affairs of the NPC Standing Committee,the Legislative Affairs Office of the State Council,the Ministry of Public Security,the Ministry of Justice,the Supreme People's Court,the Supreme People's Procuratorate and other relevant departments,and experts and scholars from human rights research institutes and colleges and universities conducted in-depth discussions and exchanged views on topics such as the "general theory of rule of law and human rights","scientific legislation and the progress of China's human rights cause","administration by law and the progress of China's human rights cause","judicial justice and the progress of China's human rights cause","concept of rule of law and the progress of China's human rights cause" among other issues展开更多
Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.Th...Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.The published version showed“Hongzhen Chen”,whereas the correct spelling should be“Hongzheng Chen”.The correct author name has been provided in this Correction,and the original article[1]has been corrected.展开更多
To serve the cause of building a great modern socialist country in all respects and achieving national rejuvenation through the Chinese path to modernization is a glorious mission of major-country diplomacy with Chine...To serve the cause of building a great modern socialist country in all respects and achieving national rejuvenation through the Chinese path to modernization is a glorious mission of major-country diplomacy with Chinese characteristics.The Resolution of the Central Committee of the Communist Party of China on Further Deepening Reform Comprehensively to Advance Chinese Modernization(hereinafter referred to as the Resolution)adopted at the Third Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)emphasizes that in the external work,we must“foster a favorable external environment for further deepening reform comprehensively to advance Chinese modernization.”展开更多
Dear Editor,Since the first plant receptor-like kinase(RLK)gene ZmPK1 was cloned from Zea mays in 1990(Walker and Zhang,1990),this large gene family has been extensively studied and shown to play crucial roles in grow...Dear Editor,Since the first plant receptor-like kinase(RLK)gene ZmPK1 was cloned from Zea mays in 1990(Walker and Zhang,1990),this large gene family has been extensively studied and shown to play crucial roles in growth,development,and immunity(Tang et al.,2017).RLKs are widespread in the plant kingdom.However,biological functions of most RLKs remain largely elusive(Dievart et al.,2020).Given RLKs share a conserved monophyletic RLK/Pelle kinase domain,RLKs in several model plants are classified into distinct families by extracellular domains(Shiu and Bleecker,2001).However,independent domain shuffling in specific lineages drives the origin of novel families,which raises a question what is the landscape of RLKs across the entire plant kingdom?Previously,sequence-homology-based methods have been widely used for RLK identification and classification,which might miss distantly related proteins with similar structures and potential novel families not mentioned in the literature.The academic community urgently requires a dedicated database for a systematic overview of the RLK gene family,providing data support for in-depth research on RLK genes.Here,we used a topology-based method to accurately isolate the RLKomes from proteomes.The obtained RLKomes were further classified into(sub)families based on extracellular domains.We con-structed a comprehensively curated plant RLK database(https://biotec.njau.edu.cn/rlkdb),which contains valuable re-sources for investigating the origin and evolution of the RLK fam-ily and multiple online tools for personalized analysis.展开更多
The 2Oth Central Committee of the Communist Party of China(CPC)adopted a resolution on further deepening reform comprehensively to advance Chinese modernization at its third plenary session held in Beijing from July 1...The 2Oth Central Committee of the Communist Party of China(CPC)adopted a resolution on further deepening reform comprehensively to advance Chinese modernization at its third plenary session held in Beijing from July 15 to 18.The Political Bureau of the CPC Central Committee presided over the meeting.General Secretary of the CPC Central Committee Xi Jinping delivered important addresses,according to a communique released on July 18.展开更多
A park and ride facility provides an option to car drivers to park their cars and switch to public transportation for the remaining portions of their trips.Although park and ride has been implemented in many cities in...A park and ride facility provides an option to car drivers to park their cars and switch to public transportation for the remaining portions of their trips.Although park and ride has been implemented in many cities in the United States and integrated with different modes of transportation,no comprehensive approach has been developed in published literature to assess the feasibility of a potential park and ride site.This research proposes a comprehensive approach,which consists of the following tasks,to evaluate potential park and ride facilities:1.Site location analysis 2.Bus system reliability analysis 3.Parking supply and usage analysis 4.Mode choice model 5.User demand and ridership estimation 6.Cost estimation and economic impacts analysis The application of the proposed tasks was demonstrated through a case study of a site in the City of El Paso,Texas.展开更多
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar...This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.展开更多
采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry...采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry,GC×GC-TOF-MS)以及香气活度值(odour active value,OAV),对红星二锅头白酒的挥发性成分进行全面解析。研究发现,HS-SPME、LLE分别定性出928、802种挥发性化合物,共计定性出1304种挥发性化合物,共同定性出426种挥发性化合物。基于HS-SPME数据,通过香气数据库筛选出具有香气特征的382种香气化合物,其中酯类相对百分含量占比最高,其次是醇类、酸类和醛类。计算得到了49种香气化合物OAV>1,其中酯类(辛酸乙酯、异戊酸乙酯等)和萜烯类(β-大马酮)对白酒风味的贡献最大,醛类(异戊醛、己醛等)和含硫类(二甲基三硫)其次,醇类(1-辛烯-3-醇)和含氮类(2,3,5-三甲基吡嗪)也有一定风味贡献。该研究丰富了红星二锅头白酒的风味研究,也为下一步生产研究及调控提供了理论和数据支撑。展开更多
Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic ...Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic traits in tomato hybrid seed production,as it can reduce the cost of artificial emasculation and ensure high varietal purity.Abnormal pollen development is a critical factor for male sterility.To date,several genes have been identified to be involved in pollen development,in which EXCESS MICROSPOROCYTES1(EMS1)controls the formation of tapetum,which is necessary for pollen production(Chang et al.,2011).EMS1 encodes a leucine-rich repeat receptor-like kinase that is specifically expressed in the tapetum.In Arabidopsis,the anthers in the ems1mutant lack tapetal cells but can produce excess microsporocytes,which do not undergo cytokinesis,leading to microsporogenesis failure and male sterility(Zhao et al.,2002).However,there is no evidence of the role of EMS1 in tomato pollen development,which limits a comprehensive understanding of the molecular mechanism underlying tomato male fertility.展开更多
Natural gas hydrates(hereinafter referred to as hydrates)are a promising clean energy source.However,their current development is far from reaching commercial exploitation.Reservoir stimulation tech-nology provides ne...Natural gas hydrates(hereinafter referred to as hydrates)are a promising clean energy source.However,their current development is far from reaching commercial exploitation.Reservoir stimulation tech-nology provides new approaches to enhance hydrate development effectiveness.Addressing the current lack of quantitative and objective methods for evaluating the fracability of hydrate reservoirs,this study clarifies the relationship between geological and engineering fracability and proposes a comprehensive evaluation model for hydrate reservoir fracability based on grey relational analysis and the criteria importance through intercriteria correlation method.By integrating results from hydraulic fracturing experiments on hydrate sediments,the fracability of hydrate reservoirs is assessed.The concept of critical construction parameter curves for hydrate reservoirs is introduced for the first time.Additionally,two-dimensional fracability index evaluation charts and three-dimensional fracability construction condition discrimination charts are established.The results indicate that as the comprehensive fracability index increases,the feasibility of forming fractures in hydrate reservoirs improves,and the required normalized fracturing construction parameters gradually decrease.The accuracy rate of the charts in judging experimental results reached 89.74%,enabling quick evaluations of whether hydrate reservoirs are worth fracturing,easy to fracture,and capable of being fractured.This has significant engineering implications forthehydraulicfracturingof hydratereservoirs.展开更多
Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detectio...Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.展开更多
Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly c...Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.展开更多
1.Introduction The strength of metallic materials can be ameliorated by introducing boundaries,precipitates,or defects as obstacles to dislocation movement[1].However,high strength is generally obtained at the sacrifi...1.Introduction The strength of metallic materials can be ameliorated by introducing boundaries,precipitates,or defects as obstacles to dislocation movement[1].However,high strength is generally obtained at the sacrifice of plastic deformation capability[2].Lately,many strategies have been proposed to improve the comprehensive properties of materials,among which manipulating stacking fault energy(SFE)is effective[3–5].展开更多
文摘The Third Plenary Session of the 18th CPC Central Committee ushered in a new chapter of China＇s comprehensive deepening of reform. The basic objective of comprehensively deepening reform of the state sector of economy in the new chapter is to fully integrate this sector with a sophisticated market economic system with the market playing the decisive role in resource allocation. In order to achieve this objective, China is confronted with the four major priorities of adjusting the functions and layout of the state sector of economy according to national mandates, expediting the mixed ownership reform, creating a classified and multi- tiered new system for the administration of the sector, and developing a modern corporate system for SOEs to ensure an efficient micro-level governance mechanism for the sector. （1） The functions of the different types of SOEs should be accurately defined and SOEs should be divided into the three types of public policy SOEs, functional SOEs, and commercial SOEs. This classification forms the premises for reforming the state sector of economy. Based on the functions of the three types of SOEs, the directions and emphases for strategic adjustment should differ as well. （2） The mixed ownership reform should adhere to the methodological principles of combining top-down and bottom-up approaches, implementing pilot programs, and promoting coordinated progress. Practical implementation should ensure fair and standard reform procedures, reform programs consistent with laws and regulations, open and fair equity transfers, as well as fair and transparent internal distributions. The mixed ownership reform of SOEs should introduce the employee stock ownership system and adhere to the principles of compatible incentives, shared growth, and long-term development. Monopolistic sectors should be transformed into competitive market structures to create conditions for the implementation of mixed ownership for SOEs. （3） The new system for the administration of the state sector of economy should comprise three hierarchies： the Commission for the Administration of State Economy at the top level, state capital operation companies or state capital investment companies at the intermediate level and general for-profit enterprises at the bottom level, which administer public policy, functional SOEs, and commercial SOEs respectively. （4） Under the new system for the administration of the state sector of economy characterized by the three hierarchies and categories, the key for perfecting the modern corporate system of SOEs is to establish a differentiated, classified governance mechanism, i.e., different corporate governance mechanisms should be created for SOEs of different functions and roles.
文摘Since the Eighteenth National Congress of CPC,the Central Committee of CPC with Comrade Xi Jinping at the core,with great political courage and shouldering spirit,targeting at the prominent problems with Party building,made a series of major deployments,and led the whole Party in opening new prospects of Party building.
文摘The Fourth Plenary Session of the 18th Central Committee of the Communist Party of China （CPC） reviewed and approved the Decision of the CPC Central Committee on Certain Key Issues Concerning Comprehensively Pushing Forward the Rule of Law （hereafter, ＂Decision＂）. The plenary session was convened at a pivotal stage in comprehensively building a well-off society and comprehen- sively deepening reform. It was the first of its kind with the theme of the rule of law and was a landmark event in China＇s legal construction. The Journal interviewed Professor Luo Haocai, who is also president of the China Society for Human Rights Studies （CSHRS）.
基金Project(2014CB239205)supported by the National Basic Research Program of ChinaProject(20011ZX05030-005-003)supported by the National Science and Technology Major Project of China
文摘Faults and fractures of multiple scales are frequently induced and generated in compressional structural system. Comprehensive identification of these potential faults and fractures that cannot be distinguished directly from seismic profile of the complex structures is still an unanswered problem. Based on the compressional structural geometry and kinematics theories as well as the structural interpretation from seismic data, a set of techniques is established for the identification of potential faults and fractures in compressional structures. Firstly, three-dimensional(3D) patterns and characteristics of the faults directly interpreted from seismic profile were illustrated by 3D structural model. Then, the unfolding index maps, the principal structural curvature maps, and tectonic stress field maps were obtained from structural restoration. Moreover, potential faults and fractures in compressional structures were quantitatively identified relying on comprehensive analysis of these three maps. Successful identification of the potential faults and fractures in Mishrif limestone formation and in Asmari dolomite formation of Buzurgan anticline in Iraq demonstrates the applicability and reliability of these techniques.
文摘This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf.
文摘Being an important part of the"four comprehensives"strategic thinking in an all-round way,the comprehensive and strict governance on the paxty has promoted the position of the construction of the party in constructing the socialism with Chinese characteristics.From the"strict governance on the pasty"to the"comprehensive and strict governance on the party,"it doesn't only mean that the"comprehensive"word is added in literal,but the content of innovation and requirements should be improved,and it has the following rules:Our country should adhere to combine the establishment of the ideological paxty and the governance of the institutional pasty,and our country should adhere to combine the comprehensive and strict governance on the pasty and the control of the"key minority."Our country should adhere to the combination of strengthening the main responsibility and playing the role of people's supervision and also should adhere to combine the strict punishment with the effective prevention.
文摘The symposium on "Comprehensively Advancing Rule of Law and China's Human Rights New Development" was successfully held on April 11,2017 at Southwest University of Political Science and Law The symposium was organized by the China Society for Human Rights Studies and hosted by the Institute of Human Rights at Southwest University of Political Science and Law Representatives from the Commission of Legislative Affairs of the NPC Standing Committee,the Legislative Affairs Office of the State Council,the Ministry of Public Security,the Ministry of Justice,the Supreme People's Court,the Supreme People's Procuratorate and other relevant departments,and experts and scholars from human rights research institutes and colleges and universities conducted in-depth discussions and exchanged views on topics such as the "general theory of rule of law and human rights","scientific legislation and the progress of China's human rights cause","administration by law and the progress of China's human rights cause","judicial justice and the progress of China's human rights cause","concept of rule of law and the progress of China's human rights cause" among other issues
文摘Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.The published version showed“Hongzhen Chen”,whereas the correct spelling should be“Hongzheng Chen”.The correct author name has been provided in this Correction,and the original article[1]has been corrected.
文摘To serve the cause of building a great modern socialist country in all respects and achieving national rejuvenation through the Chinese path to modernization is a glorious mission of major-country diplomacy with Chinese characteristics.The Resolution of the Central Committee of the Communist Party of China on Further Deepening Reform Comprehensively to Advance Chinese Modernization(hereinafter referred to as the Resolution)adopted at the Third Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)emphasizes that in the external work,we must“foster a favorable external environment for further deepening reform comprehensively to advance Chinese modernization.”
基金supported by grants from the National Natural Science Foundation of China(32270208,32202251,and 32230089)the Fundamental Research Funds for the Central Universities(KYCXJC2023001 and KYQN2023039)+1 种基金the Natural Science Foundation of Jiangsu Province(BK20221000)the China Agricultural Research System(CARS-21).
文摘Dear Editor,Since the first plant receptor-like kinase(RLK)gene ZmPK1 was cloned from Zea mays in 1990(Walker and Zhang,1990),this large gene family has been extensively studied and shown to play crucial roles in growth,development,and immunity(Tang et al.,2017).RLKs are widespread in the plant kingdom.However,biological functions of most RLKs remain largely elusive(Dievart et al.,2020).Given RLKs share a conserved monophyletic RLK/Pelle kinase domain,RLKs in several model plants are classified into distinct families by extracellular domains(Shiu and Bleecker,2001).However,independent domain shuffling in specific lineages drives the origin of novel families,which raises a question what is the landscape of RLKs across the entire plant kingdom?Previously,sequence-homology-based methods have been widely used for RLK identification and classification,which might miss distantly related proteins with similar structures and potential novel families not mentioned in the literature.The academic community urgently requires a dedicated database for a systematic overview of the RLK gene family,providing data support for in-depth research on RLK genes.Here,we used a topology-based method to accurately isolate the RLKomes from proteomes.The obtained RLKomes were further classified into(sub)families based on extracellular domains.We con-structed a comprehensively curated plant RLK database(https://biotec.njau.edu.cn/rlkdb),which contains valuable re-sources for investigating the origin and evolution of the RLK fam-ily and multiple online tools for personalized analysis.
文摘The 2Oth Central Committee of the Communist Party of China(CPC)adopted a resolution on further deepening reform comprehensively to advance Chinese modernization at its third plenary session held in Beijing from July 15 to 18.The Political Bureau of the CPC Central Committee presided over the meeting.General Secretary of the CPC Central Committee Xi Jinping delivered important addresses,according to a communique released on July 18.
文摘A park and ride facility provides an option to car drivers to park their cars and switch to public transportation for the remaining portions of their trips.Although park and ride has been implemented in many cities in the United States and integrated with different modes of transportation,no comprehensive approach has been developed in published literature to assess the feasibility of a potential park and ride site.This research proposes a comprehensive approach,which consists of the following tasks,to evaluate potential park and ride facilities:1.Site location analysis 2.Bus system reliability analysis 3.Parking supply and usage analysis 4.Mode choice model 5.User demand and ridership estimation 6.Cost estimation and economic impacts analysis The application of the proposed tasks was demonstrated through a case study of a site in the City of El Paso,Texas.
文摘This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.
文摘采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry,GC×GC-TOF-MS)以及香气活度值(odour active value,OAV),对红星二锅头白酒的挥发性成分进行全面解析。研究发现,HS-SPME、LLE分别定性出928、802种挥发性化合物,共计定性出1304种挥发性化合物,共同定性出426种挥发性化合物。基于HS-SPME数据,通过香气数据库筛选出具有香气特征的382种香气化合物,其中酯类相对百分含量占比最高,其次是醇类、酸类和醛类。计算得到了49种香气化合物OAV>1,其中酯类(辛酸乙酯、异戊酸乙酯等)和萜烯类(β-大马酮)对白酒风味的贡献最大,醛类(异戊醛、己醛等)和含硫类(二甲基三硫)其次,醇类(1-辛烯-3-醇)和含氮类(2,3,5-三甲基吡嗪)也有一定风味贡献。该研究丰富了红星二锅头白酒的风味研究,也为下一步生产研究及调控提供了理论和数据支撑。
基金supported by the National Natural Science Foundation of China(Grant No.32372723,U1906205)Key Research and Development Program of Shandong Province(Grant No.2023CXPT018,2022TZXD0025)+1 种基金Natural Science Foundation of Shandong Province(Grant No.ZR2023MC206)Key Research and Development Task Special Project of Xinjiang(Grant No.2022B02002)。
文摘Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic traits in tomato hybrid seed production,as it can reduce the cost of artificial emasculation and ensure high varietal purity.Abnormal pollen development is a critical factor for male sterility.To date,several genes have been identified to be involved in pollen development,in which EXCESS MICROSPOROCYTES1(EMS1)controls the formation of tapetum,which is necessary for pollen production(Chang et al.,2011).EMS1 encodes a leucine-rich repeat receptor-like kinase that is specifically expressed in the tapetum.In Arabidopsis,the anthers in the ems1mutant lack tapetal cells but can produce excess microsporocytes,which do not undergo cytokinesis,leading to microsporogenesis failure and male sterility(Zhao et al.,2002).However,there is no evidence of the role of EMS1 in tomato pollen development,which limits a comprehensive understanding of the molecular mechanism underlying tomato male fertility.
基金support of the National Natural Science Foundation of China(Grant No.52074332).
文摘Natural gas hydrates(hereinafter referred to as hydrates)are a promising clean energy source.However,their current development is far from reaching commercial exploitation.Reservoir stimulation tech-nology provides new approaches to enhance hydrate development effectiveness.Addressing the current lack of quantitative and objective methods for evaluating the fracability of hydrate reservoirs,this study clarifies the relationship between geological and engineering fracability and proposes a comprehensive evaluation model for hydrate reservoir fracability based on grey relational analysis and the criteria importance through intercriteria correlation method.By integrating results from hydraulic fracturing experiments on hydrate sediments,the fracability of hydrate reservoirs is assessed.The concept of critical construction parameter curves for hydrate reservoirs is introduced for the first time.Additionally,two-dimensional fracability index evaluation charts and three-dimensional fracability construction condition discrimination charts are established.The results indicate that as the comprehensive fracability index increases,the feasibility of forming fractures in hydrate reservoirs improves,and the required normalized fracturing construction parameters gradually decrease.The accuracy rate of the charts in judging experimental results reached 89.74%,enabling quick evaluations of whether hydrate reservoirs are worth fracturing,easy to fracture,and capable of being fractured.This has significant engineering implications forthehydraulicfracturingof hydratereservoirs.
基金National Natural Science Foundation of China(grant numbers 42293351,41877239,51422904 and 51379112).
文摘Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.
基金supported by the Research Project of Maternal and Child Health Hospital of Hubei Province(No.2023SFYM008)Key Project of Hubei Provincial Natural Science Foundation(No.JCZRLH202500304).
文摘Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.
基金financially supported by the National Natural Science Foundation of China(NSFC)under grant No.52371100.
文摘1.Introduction The strength of metallic materials can be ameliorated by introducing boundaries,precipitates,or defects as obstacles to dislocation movement[1].However,high strength is generally obtained at the sacrifice of plastic deformation capability[2].Lately,many strategies have been proposed to improve the comprehensive properties of materials,among which manipulating stacking fault energy(SFE)is effective[3–5].
