This research paper evaluated and investigated the effectiveness of the comprehensible technique (CT) introduced by the researcher as an alternative solution to Algebra’s linear equations in solving consecutive numbe...This research paper evaluated and investigated the effectiveness of the comprehensible technique (CT) introduced by the researcher as an alternative solution to Algebra’s linear equations in solving consecutive number problems. The CT is a proposed easy and efficient way of solving number problems which aimed to help the learners reduce their difficulties in using variables since the technique only uses basic arithmetic and mental Mathematics. Evaluation research was utilized in this study where 20 people, from various ages and professions, were chosen purposively as respondents of the study. The study found out that CT was very effective for the respondents especially in unlocking difficulties in solving consecutive number problems. Moreover, according to them, the CT is easy to use, it is engaging and enjoyable, direct and simple and can be utilized as shortcut way of solving consecutive number problems when competing in Math quiz bees or taking board examinations where time is of the essence.展开更多
This paper mainly focus on the literature concerning comprehensible input so as to find the arguments from the researchers,as well as its implication for teaching.
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar...This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.展开更多
采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry...采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry,GC×GC-TOF-MS)以及香气活度值(odour active value,OAV),对红星二锅头白酒的挥发性成分进行全面解析。研究发现,HS-SPME、LLE分别定性出928、802种挥发性化合物,共计定性出1304种挥发性化合物,共同定性出426种挥发性化合物。基于HS-SPME数据,通过香气数据库筛选出具有香气特征的382种香气化合物,其中酯类相对百分含量占比最高,其次是醇类、酸类和醛类。计算得到了49种香气化合物OAV>1,其中酯类(辛酸乙酯、异戊酸乙酯等)和萜烯类(β-大马酮)对白酒风味的贡献最大,醛类(异戊醛、己醛等)和含硫类(二甲基三硫)其次,醇类(1-辛烯-3-醇)和含氮类(2,3,5-三甲基吡嗪)也有一定风味贡献。该研究丰富了红星二锅头白酒的风味研究,也为下一步生产研究及调控提供了理论和数据支撑。展开更多
Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic ...Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic traits in tomato hybrid seed production,as it can reduce the cost of artificial emasculation and ensure high varietal purity.Abnormal pollen development is a critical factor for male sterility.To date,several genes have been identified to be involved in pollen development,in which EXCESS MICROSPOROCYTES1(EMS1)controls the formation of tapetum,which is necessary for pollen production(Chang et al.,2011).EMS1 encodes a leucine-rich repeat receptor-like kinase that is specifically expressed in the tapetum.In Arabidopsis,the anthers in the ems1mutant lack tapetal cells but can produce excess microsporocytes,which do not undergo cytokinesis,leading to microsporogenesis failure and male sterility(Zhao et al.,2002).However,there is no evidence of the role of EMS1 in tomato pollen development,which limits a comprehensive understanding of the molecular mechanism underlying tomato male fertility.展开更多
Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detectio...Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.展开更多
Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly c...Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People,s Republic of Chi...“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People,s Republic of China.The journal started publication in 1955.The original name at starting publication was“Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958owing to the name change of the university.展开更多
“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People s Republic of Chi...“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People s Republic of China.The journal started publication in 1955.The original name at starting publication was“Journal of Natural Science of Northeast People University”,which was changed into“Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958 owing to the name change of the university.展开更多
Currently,the International Maritime Organization(IMO)has approved and implemented the assessment requirement for Minimum Propulsion Power(MPP)of ships in adverse sea conditions.The assessment method and relevant infl...Currently,the International Maritime Organization(IMO)has approved and implemented the assessment requirement for Minimum Propulsion Power(MPP)of ships in adverse sea conditions.The assessment method and relevant influence factors will have a vital impact on ship's design and operation.On the other hand,MPP is essentially a criterion for manoeuvring safety at actual seas.However,the practical assessment methods adopted in IMO guidelines do not directly and accurately account for ship's coursekeeping ability in severe seas.A time-domain comprehensive method with supplementary course-keeping ability criteria has been proposed in the authors'preliminary research.Based on an updated mathematical model and criteria,this paper presents more detailed elaborations,results and discussions on the time-domain method,including the comparative analyses with a power line method and two steady-state equilibrium methods based on IMO guidelines and draft.Discussions on the influences of key factors,involving criterion conditions and calculation parameters,are also presented.The results indicate that different methods exhibit varying advantages and complexity in MPP assessment,thus constituting a multi-level assessment framework for MPP.In particular,the time-domain comprehensive assessment has a higher accuracy with more realistic description of manoeuvre behaviors,capable of offering a solution for the ships that cannot meet other assessments,or for the assessment requiring additional course-keeping ability.Furthermore,an expanded range of wave direction sets a stricter but potentially necessary requirement,while using the self-propulsion factors at low speeds can eliminate the unnecessary conservation of assessment result caused by those at design speed.展开更多
In the ten years since the publication of Krashen’s theory on second language acquisition (SLA), the role of comprehensible input (CI) in the learning/acquiring of a language has received considerable attention (Kras...In the ten years since the publication of Krashen’s theory on second language acquisition (SLA), the role of comprehensible input (CI) in the learning/acquiring of a language has received considerable attention (Krashen, 1982, 1985; Ellis, 1991, 1992; Long, 1983, 1985). As a result of these studies researchers now agree on the following points. Exposure to a language does not lead to acquisition; the personal accounts of so many language learners who have spent many years in a country or who have listened to endless hours of radio and television without being able to understand or speak the language attest to this fact.展开更多
During the 14th Five-Year Plan period,China has further strengthened its industrial system,making it more complete,efficient,and resilient.Today,China has solidified its position as the world’s largest manufacturer,d...During the 14th Five-Year Plan period,China has further strengthened its industrial system,making it more complete,efficient,and resilient.Today,China has solidified its position as the world’s largest manufacturer,distinguished by its uniquely comprehensive industrial system.展开更多
[Objectives]To identify the drought resistance of main wheat varieties in Shandong Province and screen suitable cultivars for dryland cultivation.[Methods]Employing eight varieties including Jimai 60 as test materials...[Objectives]To identify the drought resistance of main wheat varieties in Shandong Province and screen suitable cultivars for dryland cultivation.[Methods]Employing eight varieties including Jimai 60 as test materials,this study simulated drought stress using 20%PEG-6000 and measured changes in germination-stage indicators.A comprehensive evaluation was conducted using the membership function method,incorporating relative coleoptile length,relative germ length,relative radicle length,relative germination rate,relative germination potential,and stress germination index.[Results]Drought stress not only reduced wheat seed germination rate but also inhibited the growth of the germ,coleoptile,and radicle.The D values of the eight varieties were ranked as follows:Jimai 60>Linmai 9>Yannong 999>Shannong 30>Shannong 28>Luyuan 502>Yannong 1212>Jimai 22.Based on D values,the eight dominant wheat varieties were classified into three categories:highly drought-resistant varieties(Linmai 9 and Jimai 60),moderately drought-resistant varieties(Yannong 999 and Shannong 30),and sensitive varieties(the others).Linmai 9 and Jimai 60 are recommended as suitable wheat varieties for dryland cultivation in Shandong Province.[Conclusions]Drought stress induced by 20%PEG-6000 reduced germination rate,germination potential,and germination index of wheat varieties while inhibiting the growth of coleoptiles and radicles.These indicators can provide a preliminary assessment of drought resistance in wheat cultivars.However,since filter paper was selected as the growth medium,root length measurement errors were introduced during root washing,leading to variations in final experimental results.Futuer studies could attempt using sterilized sand as an alternative growth medium.展开更多
Both China and Indonesia are influential maritime powers in the Asia-Pacific region.Strengthening practical maritime cooperation is highly significant to both sides as an important component of comprehensive strategic...Both China and Indonesia are influential maritime powers in the Asia-Pacific region.Strengthening practical maritime cooperation is highly significant to both sides as an important component of comprehensive strategic cooperation.Maritime cooperation has become a prominent part of the“five pillar”cooperation framework between the two countries alongside political,economic,people-to-people exchange,and security,playing a positive role in elevating the China-Indonesia comprehensive strategic partnership to a higher level.展开更多
Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received d...Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received diagnosis and treatment in our hospital from January 2024 to December 2024 were randomly divided into control and observation groups.The control group received routine nursing,while the observation group received comprehensive nursing.The Self-Rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate the patients’psychological states before and after nursing.Patient satisfaction with nursing was analyzed using a nursing satisfaction survey scale.Results:After nursing,the SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.05).The nursing satisfaction rates of the observation and control groups were 98.33%and 83.33%,respectively,with statistically significant differences(P<0.05).Conclusion:Comprehensive nursing intervention for patients with pulmonary micro-nodules can effectively relieve their psychological pressure and improve nursing satisfaction,demonstrating clinical value.展开更多
Comprehensively revealing the intensity of drought propagation from meteorological to hydrological drought is crucial for effective drought monitoring and management.However,existing assessments often fail to integrat...Comprehensively revealing the intensity of drought propagation from meteorological to hydrological drought is crucial for effective drought monitoring and management.However,existing assessments often fail to integrate multiple drought characteristics,resulting in incomplete evaluations.To address this limitation,this study introduced the drought comprehensive propagation intensity(DCPI)index,a systematic tool that quantifies propagation intensity and incorporates five drought characteristic indicators(drought frequency,total duration,maximum duration,coverage,and degree)to assess the comprehensive drought intensity in the upper Shiyang River Basin,China from 1961 to 2023.The results indicated that pre-1980s drought propagation was relatively weak(DCPI<0.964),reflecting stable hydrological homeostasis.After the 1980s,the intensity significantly increased,peaking at 5.530(rather strong drought)in the 2000s due to human-induced alterations in surface runoff and ecological changes.Spatially,the western tributaries(e.g.,the Xida River Watershed)presented stronger hydrological drought intensity,whereas the eastern tributaries(e.g.,the Huangyang,Gulang,and Dajing river watersheds)presented higher meteorological drought intensity.The DCPI values decreased from west to east,with near peer-to-peer propagation observed in the Dongda,Huangyang,and Jinta river watersheds,suggesting minimal human interference.A nonlinear relationship between meteorological and hydrological droughts was identified,with severe drought frequency and duration emerging as critical drivers of propagation intensity.Notably,trends of meteorological humidification coexist with hydrological aridification,highlighting systemic challenges for water resource management.The DCPI framework enhances the understanding of drought mechanisms by enabling a structured evaluation of drought impacts,which is essential for developing effective water resource strategies and ecological restoration efforts in arid areas.This study underscores the importance of integrating multi-dimensional drought characteristics to improve prediction accuracy and inform policy decisions.展开更多
This year marks the 20th anniversary of the Comprehensive Strategic Partnership between China and Spain.Over these two decades,this relationship has matured into a model of mutual respect,strategic foresight,and vibra...This year marks the 20th anniversary of the Comprehensive Strategic Partnership between China and Spain.Over these two decades,this relationship has matured into a model of mutual respect,strategic foresight,and vibrant cooperation,serving as a cornerstone for stability and growth in both nations and offering a reference for productive China-EU engagement.展开更多
The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,d...The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,designers need to explore,research and design with a more comprehensive and longer-term planning perspective,and a more comprehensive professional strength.Taking the comprehensive regulation and landscape design of Mayuanxi River in Chongqing as an example,this paper integrated the regulation,ecological restoration,landscape construction,project planning and cultural display of the river,and systematically put forward ideas and strategies for the comprehensive regulation and landscape design of the river,with a view to making a beneficial exploration for the research in this field.Notably,the paper highlighted innovative techniques such as vegetation concrete for revetment and rainwater gardens for ecological rainwater management.展开更多
文摘This research paper evaluated and investigated the effectiveness of the comprehensible technique (CT) introduced by the researcher as an alternative solution to Algebra’s linear equations in solving consecutive number problems. The CT is a proposed easy and efficient way of solving number problems which aimed to help the learners reduce their difficulties in using variables since the technique only uses basic arithmetic and mental Mathematics. Evaluation research was utilized in this study where 20 people, from various ages and professions, were chosen purposively as respondents of the study. The study found out that CT was very effective for the respondents especially in unlocking difficulties in solving consecutive number problems. Moreover, according to them, the CT is easy to use, it is engaging and enjoyable, direct and simple and can be utilized as shortcut way of solving consecutive number problems when competing in Math quiz bees or taking board examinations where time is of the essence.
文摘This paper mainly focus on the literature concerning comprehensible input so as to find the arguments from the researchers,as well as its implication for teaching.
文摘This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu.
文摘采用顶空固相微萃取(headspace solid-phase microextraction,HS-SPME)和液液萃取(liquid-liquid extraction,LLE)结合全二维气相色谱飞行时间质谱(comprehensive two-dimensional gas chromatography time of flight mass spectrometry,GC×GC-TOF-MS)以及香气活度值(odour active value,OAV),对红星二锅头白酒的挥发性成分进行全面解析。研究发现,HS-SPME、LLE分别定性出928、802种挥发性化合物,共计定性出1304种挥发性化合物,共同定性出426种挥发性化合物。基于HS-SPME数据,通过香气数据库筛选出具有香气特征的382种香气化合物,其中酯类相对百分含量占比最高,其次是醇类、酸类和醛类。计算得到了49种香气化合物OAV>1,其中酯类(辛酸乙酯、异戊酸乙酯等)和萜烯类(β-大马酮)对白酒风味的贡献最大,醛类(异戊醛、己醛等)和含硫类(二甲基三硫)其次,醇类(1-辛烯-3-醇)和含氮类(2,3,5-三甲基吡嗪)也有一定风味贡献。该研究丰富了红星二锅头白酒的风味研究,也为下一步生产研究及调控提供了理论和数据支撑。
基金supported by the National Natural Science Foundation of China(Grant No.32372723,U1906205)Key Research and Development Program of Shandong Province(Grant No.2023CXPT018,2022TZXD0025)+1 种基金Natural Science Foundation of Shandong Province(Grant No.ZR2023MC206)Key Research and Development Task Special Project of Xinjiang(Grant No.2022B02002)。
文摘Tomato(Solanum lycopersicum)is one of the most consumed vegetable crops around the world,and its breeding is performed by exploiting heterosis in F1hybrid crosses.Male sterility is one of the most desirable agronomic traits in tomato hybrid seed production,as it can reduce the cost of artificial emasculation and ensure high varietal purity.Abnormal pollen development is a critical factor for male sterility.To date,several genes have been identified to be involved in pollen development,in which EXCESS MICROSPOROCYTES1(EMS1)controls the formation of tapetum,which is necessary for pollen production(Chang et al.,2011).EMS1 encodes a leucine-rich repeat receptor-like kinase that is specifically expressed in the tapetum.In Arabidopsis,the anthers in the ems1mutant lack tapetal cells but can produce excess microsporocytes,which do not undergo cytokinesis,leading to microsporogenesis failure and male sterility(Zhao et al.,2002).However,there is no evidence of the role of EMS1 in tomato pollen development,which limits a comprehensive understanding of the molecular mechanism underlying tomato male fertility.
基金National Natural Science Foundation of China(grant numbers 42293351,41877239,51422904 and 51379112).
文摘Advanced geological prediction is a crucial means to ensure safety and efficiency in tunnel construction.However,diff erent advanced geological forecasting methods have their own limitations,resulting in poor detection accuracy.Using multiple methods to carry out a comprehensive evaluation can eff ectively improve the accuracy of advanced geological prediction results.In this study,geological information is combined with the detection results of geophysical methods,including transient electromagnetic,induced polarization,and tunnel seismic prediction,to establish a comprehensive analysis method of adverse geology.First,the possible main adverse geological problems are determined according to the geological information.Subsequently,various physical parameters of the rock mass in front of the tunnel face can then be derived on the basis of multisource geophysical data.Finally,based on the analysis results of geological information,the multisource data fusion algorithm is used to determine the type,location,and scale of adverse geology.The advanced geological prediction results that can provide eff ective guidance for tunnel construction can then be obtained.
基金supported by the Research Project of Maternal and Child Health Hospital of Hubei Province(No.2023SFYM008)Key Project of Hubei Provincial Natural Science Foundation(No.JCZRLH202500304).
文摘Objective ZW10 interacting kinetochore protein(ZWINT)has been demonstrated to play a pivotal role in the growth,invasion,and migration of cancers.Nevertheless,whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive.This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.Methods We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis.The approach included the Breast Cancer Gene-Expression Miner v5.1(bc-GenExMiner v5.1),TNMplot,MuTarget,PrognoScan database,and Database for Annotation,Visualization,and Integrated Discovery(DAVID).Results Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer.ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1(CDH1)and tumor protein p53(TP53),suggesting potential functional crosstalk in tumor progression pathways.The overexpression of ZWINT correlated with adverse clinical outcomes,showing 48%increased mortality risk(overall survival:HR 1.48,95%CI 1.23–1.79),66%higher recurrence probability(relapse-free survival:1.66,95%CI 1.50–1.84),and 63%elevated metastasis risk(distant metastasis-free survival:HR 1.63,95%CI 1.39–1.90).Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant(P<0.001,Harrell’s C-index=0.7827),which was validated through bootstrap resampling(1000 iterations).Conclusion ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
文摘“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People,s Republic of China.The journal started publication in 1955.The original name at starting publication was“Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958owing to the name change of the university.
文摘“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People s Republic of China.The journal started publication in 1955.The original name at starting publication was“Journal of Natural Science of Northeast People University”,which was changed into“Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958 owing to the name change of the university.
文摘Currently,the International Maritime Organization(IMO)has approved and implemented the assessment requirement for Minimum Propulsion Power(MPP)of ships in adverse sea conditions.The assessment method and relevant influence factors will have a vital impact on ship's design and operation.On the other hand,MPP is essentially a criterion for manoeuvring safety at actual seas.However,the practical assessment methods adopted in IMO guidelines do not directly and accurately account for ship's coursekeeping ability in severe seas.A time-domain comprehensive method with supplementary course-keeping ability criteria has been proposed in the authors'preliminary research.Based on an updated mathematical model and criteria,this paper presents more detailed elaborations,results and discussions on the time-domain method,including the comparative analyses with a power line method and two steady-state equilibrium methods based on IMO guidelines and draft.Discussions on the influences of key factors,involving criterion conditions and calculation parameters,are also presented.The results indicate that different methods exhibit varying advantages and complexity in MPP assessment,thus constituting a multi-level assessment framework for MPP.In particular,the time-domain comprehensive assessment has a higher accuracy with more realistic description of manoeuvre behaviors,capable of offering a solution for the ships that cannot meet other assessments,or for the assessment requiring additional course-keeping ability.Furthermore,an expanded range of wave direction sets a stricter but potentially necessary requirement,while using the self-propulsion factors at low speeds can eliminate the unnecessary conservation of assessment result caused by those at design speed.
文摘In the ten years since the publication of Krashen’s theory on second language acquisition (SLA), the role of comprehensible input (CI) in the learning/acquiring of a language has received considerable attention (Krashen, 1982, 1985; Ellis, 1991, 1992; Long, 1983, 1985). As a result of these studies researchers now agree on the following points. Exposure to a language does not lead to acquisition; the personal accounts of so many language learners who have spent many years in a country or who have listened to endless hours of radio and television without being able to understand or speak the language attest to this fact.
文摘During the 14th Five-Year Plan period,China has further strengthened its industrial system,making it more complete,efficient,and resilient.Today,China has solidified its position as the world’s largest manufacturer,distinguished by its uniquely comprehensive industrial system.
基金Supported by National Wheat Industry Technology System"Linyi Integrated Experimental Station"(CARS-03-66)Shandong Provincial Modern Agricultural Industry Technology System"Linyi Integrated Experimental Station"(SDATT-01-18).
文摘[Objectives]To identify the drought resistance of main wheat varieties in Shandong Province and screen suitable cultivars for dryland cultivation.[Methods]Employing eight varieties including Jimai 60 as test materials,this study simulated drought stress using 20%PEG-6000 and measured changes in germination-stage indicators.A comprehensive evaluation was conducted using the membership function method,incorporating relative coleoptile length,relative germ length,relative radicle length,relative germination rate,relative germination potential,and stress germination index.[Results]Drought stress not only reduced wheat seed germination rate but also inhibited the growth of the germ,coleoptile,and radicle.The D values of the eight varieties were ranked as follows:Jimai 60>Linmai 9>Yannong 999>Shannong 30>Shannong 28>Luyuan 502>Yannong 1212>Jimai 22.Based on D values,the eight dominant wheat varieties were classified into three categories:highly drought-resistant varieties(Linmai 9 and Jimai 60),moderately drought-resistant varieties(Yannong 999 and Shannong 30),and sensitive varieties(the others).Linmai 9 and Jimai 60 are recommended as suitable wheat varieties for dryland cultivation in Shandong Province.[Conclusions]Drought stress induced by 20%PEG-6000 reduced germination rate,germination potential,and germination index of wheat varieties while inhibiting the growth of coleoptiles and radicles.These indicators can provide a preliminary assessment of drought resistance in wheat cultivars.However,since filter paper was selected as the growth medium,root length measurement errors were introduced during root washing,leading to variations in final experimental results.Futuer studies could attempt using sterilized sand as an alternative growth medium.
文摘Both China and Indonesia are influential maritime powers in the Asia-Pacific region.Strengthening practical maritime cooperation is highly significant to both sides as an important component of comprehensive strategic cooperation.Maritime cooperation has become a prominent part of the“five pillar”cooperation framework between the two countries alongside political,economic,people-to-people exchange,and security,playing a positive role in elevating the China-Indonesia comprehensive strategic partnership to a higher level.
基金Science and Technology Support Program of Baoding City,Hebei Province(Project No.:2241ZF326)。
文摘Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received diagnosis and treatment in our hospital from January 2024 to December 2024 were randomly divided into control and observation groups.The control group received routine nursing,while the observation group received comprehensive nursing.The Self-Rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate the patients’psychological states before and after nursing.Patient satisfaction with nursing was analyzed using a nursing satisfaction survey scale.Results:After nursing,the SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.05).The nursing satisfaction rates of the observation and control groups were 98.33%and 83.33%,respectively,with statistically significant differences(P<0.05).Conclusion:Comprehensive nursing intervention for patients with pulmonary micro-nodules can effectively relieve their psychological pressure and improve nursing satisfaction,demonstrating clinical value.
基金supported by the National Natural Science Foundation of China(42475177,41877521)the National Key Research and Development Program of China(2023YFC3008505,2016YFA0602402).
文摘Comprehensively revealing the intensity of drought propagation from meteorological to hydrological drought is crucial for effective drought monitoring and management.However,existing assessments often fail to integrate multiple drought characteristics,resulting in incomplete evaluations.To address this limitation,this study introduced the drought comprehensive propagation intensity(DCPI)index,a systematic tool that quantifies propagation intensity and incorporates five drought characteristic indicators(drought frequency,total duration,maximum duration,coverage,and degree)to assess the comprehensive drought intensity in the upper Shiyang River Basin,China from 1961 to 2023.The results indicated that pre-1980s drought propagation was relatively weak(DCPI<0.964),reflecting stable hydrological homeostasis.After the 1980s,the intensity significantly increased,peaking at 5.530(rather strong drought)in the 2000s due to human-induced alterations in surface runoff and ecological changes.Spatially,the western tributaries(e.g.,the Xida River Watershed)presented stronger hydrological drought intensity,whereas the eastern tributaries(e.g.,the Huangyang,Gulang,and Dajing river watersheds)presented higher meteorological drought intensity.The DCPI values decreased from west to east,with near peer-to-peer propagation observed in the Dongda,Huangyang,and Jinta river watersheds,suggesting minimal human interference.A nonlinear relationship between meteorological and hydrological droughts was identified,with severe drought frequency and duration emerging as critical drivers of propagation intensity.Notably,trends of meteorological humidification coexist with hydrological aridification,highlighting systemic challenges for water resource management.The DCPI framework enhances the understanding of drought mechanisms by enabling a structured evaluation of drought impacts,which is essential for developing effective water resource strategies and ecological restoration efforts in arid areas.This study underscores the importance of integrating multi-dimensional drought characteristics to improve prediction accuracy and inform policy decisions.
文摘This year marks the 20th anniversary of the Comprehensive Strategic Partnership between China and Spain.Over these two decades,this relationship has matured into a model of mutual respect,strategic foresight,and vibrant cooperation,serving as a cornerstone for stability and growth in both nations and offering a reference for productive China-EU engagement.
基金Supported by General Project of Chongqing Natural Science Foundation(CSTB2024NSCQ-MSX1067)Key Project of Humanities and Social Sciences of Chongqing Municipal Education Commission(24SKGH346)Natural Science Project of Chongqing College of Humanities,Science and Technology(CRKZK2023010).
文摘The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,designers need to explore,research and design with a more comprehensive and longer-term planning perspective,and a more comprehensive professional strength.Taking the comprehensive regulation and landscape design of Mayuanxi River in Chongqing as an example,this paper integrated the regulation,ecological restoration,landscape construction,project planning and cultural display of the river,and systematically put forward ideas and strategies for the comprehensive regulation and landscape design of the river,with a view to making a beneficial exploration for the research in this field.Notably,the paper highlighted innovative techniques such as vegetation concrete for revetment and rainwater gardens for ecological rainwater management.
