Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminar...Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.展开更多
Macrocyclic compounds,with their unique ring structures and diverse functionalities,offer broad potential in fields such as molecular recognition,catalysis,drug design,optoelectronics,and supramolecular chemistry.Macr...Macrocyclic compounds,with their unique ring structures and diverse functionalities,offer broad potential in fields such as molecular recognition,catalysis,drug design,optoelectronics,and supramolecular chemistry.Macrocyclic compounds are endowed with specific binding sites and functions and exhibit remarkable expandability.The diversification of their functions and the broadening of their applications can be achieved through structural modifications or the introduction of various functional groups.Thiophene-containing molecular building units,including oligothiophenes,fused thiophenes,and their derivatives,are particularly advantageous in the construction of macrocycles due to their versatile structural characteristics.Introducing thiophene units into macrocycles and adjusting their structure,quantity,and positioning allows for the precise control of critical material properties,such as band gaps,optical absorption/emission characteristics,and redox potentials,thereby optimizing their photophysical properties,catalytic activity,and supramolecular interactions[1–3].展开更多
基金supported by the National Key Research and Develop-ment Program of China(2022YFF1100205)National Science Foundation of China for Young Scholars(32101879).
文摘Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.
基金supported by the National Key R&D Program of China(2024YFB3612600)the National Natural Science Foundation of China(22071112,22275098,62288102,and 22302097)+1 种基金the Project of State Key Laboratory of Organic Electronics and Information Displays(GDX2022010005 and GZR2023010001)Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(NY223180 and NY223068)。
文摘Macrocyclic compounds,with their unique ring structures and diverse functionalities,offer broad potential in fields such as molecular recognition,catalysis,drug design,optoelectronics,and supramolecular chemistry.Macrocyclic compounds are endowed with specific binding sites and functions and exhibit remarkable expandability.The diversification of their functions and the broadening of their applications can be achieved through structural modifications or the introduction of various functional groups.Thiophene-containing molecular building units,including oligothiophenes,fused thiophenes,and their derivatives,are particularly advantageous in the construction of macrocycles due to their versatile structural characteristics.Introducing thiophene units into macrocycles and adjusting their structure,quantity,and positioning allows for the precise control of critical material properties,such as band gaps,optical absorption/emission characteristics,and redox potentials,thereby optimizing their photophysical properties,catalytic activity,and supramolecular interactions[1–3].
