BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylen...BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.展开更多
The lateral distributions of depth-averaged velocity in open compound channels with emerged and submerged vegetated floodplains were analyzed based on the analytical solution of the depth-integrated Reynolds-Averaged ...The lateral distributions of depth-averaged velocity in open compound channels with emerged and submerged vegetated floodplains were analyzed based on the analytical solution of the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term to account for the effects of vegetation.The three cases considered for open channels were two-stage rectangular channel with emerged vegetated floodplain,rectangular channel with submerged vegetated corner,and two-stage rectangular channel with submerged vegetated floodplain,respectively.To predict the depth-averaged velocity with submerged vegetated floodplains,we proposed a new method based on a two-layer approach where flow above and through the vegetation layer was described separately.Moreover,further experiments in the two-stage rectangular channel with submerged vegetated floodplain were carried out to verify the results.The analytical solutions of the cases indicated that the corresponding analytical depth-averaged velocity distributions agree well with the simulated and experimental prediction.The analytical solutions of the cases with theoretical foundation and without programming calculation were reasonable and applicable,which were more convenient than numerical simulations.The analytical solutions provided a way for future researches to solve the problems of submerged vegetation and discontinuous phenomenon of depth-averaged velocity at the stage point for compound channels.Understanding the hydraulics of flow in compound channels with vegetated floodplains is very important for supporting the management of fluvial processes.展开更多
基金Supported by the Science and Technology Program of Rui’an,No.MS2023030.
文摘BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.
基金Under the auspices of National Basic Research Program of China(No.2011CB403303)National Key Research and Development Program of China(No.2016YFC0402408-5)National Natural Science Foundation of China(No.51179181,40788001)
文摘The lateral distributions of depth-averaged velocity in open compound channels with emerged and submerged vegetated floodplains were analyzed based on the analytical solution of the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term to account for the effects of vegetation.The three cases considered for open channels were two-stage rectangular channel with emerged vegetated floodplain,rectangular channel with submerged vegetated corner,and two-stage rectangular channel with submerged vegetated floodplain,respectively.To predict the depth-averaged velocity with submerged vegetated floodplains,we proposed a new method based on a two-layer approach where flow above and through the vegetation layer was described separately.Moreover,further experiments in the two-stage rectangular channel with submerged vegetated floodplain were carried out to verify the results.The analytical solutions of the cases indicated that the corresponding analytical depth-averaged velocity distributions agree well with the simulated and experimental prediction.The analytical solutions of the cases with theoretical foundation and without programming calculation were reasonable and applicable,which were more convenient than numerical simulations.The analytical solutions provided a way for future researches to solve the problems of submerged vegetation and discontinuous phenomenon of depth-averaged velocity at the stage point for compound channels.Understanding the hydraulics of flow in compound channels with vegetated floodplains is very important for supporting the management of fluvial processes.
