BACKGROUND Ulcerative colitis(UC)is a chronic relapsing inflammatory bowel disease with rising global incidence.Current therapies for UC often provide incomplete relief and are associated with adverse side effects,hig...BACKGROUND Ulcerative colitis(UC)is a chronic relapsing inflammatory bowel disease with rising global incidence.Current therapies for UC often provide incomplete relief and are associated with adverse side effects,highlighting the need for alternatives with increased safety and effectiveness.Compound spleen-tonifying composition(CSTC)contains ingredients,such as Pulsatilla chinensis(Bunge)Regel and Glycyrrhiza uralensis Fisch,that have been shown to be efficacious in the treatment of UC.Its mechanism needs to be investigated further.AIM To study the therapeutic effect and mechanism of CSTC in dextran sulfate sodium(DSS)-induced UC in rats.METHODS Sprague-Dawley rats were freely given 4%DSS solution for seven days to establish the UC model.After intervention with CSTC and its different solvent extracts,body weight changes,the disease activity index(DAI),and colon histopathology were assessed to evaluate therapeutic outcomes.The contents of superoxide dismutase(SOD),malondialdehyde(MDA),myeloperoxidase(MPO),glutathione peroxidase(GSH-px),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)in colon tissue were determined to investigate changes in biochemical indicators.RESULTS DSS administration triggered severe UC symptoms,including weight loss,colon shortening,elevated DAI scores,and histological damage.These symptoms were accompanied with oxidative stress(reduced SOD and GSH-px levels and increased MDA and MPO levels),inflammation(elevated TNF-α,IL-1β,and IL-6 levels),and a reduction in the expression levels of tight junction proteins[zonula occludens-1(ZO-1)and occluding].High-and mediumdose CSTC treatment significantly alleviated clinical symptoms,restored colon morphology,normalized oxidative stress markers,suppressed proinflammatory cytokines,and enhanced ZO-1 and occludin levels,demonstrating dose-dependent efficacy.Notably,solvent extraction critically influenced bioactivity:Nonpolar extracts(chloroform and petroleum ether)showed minimal effects,whereas polar extracts(ethyl acetate and n-butanol)remarkably improved clinical symptoms.CONCLUSION The above findings highlight CSTC’s multifaceted anti-UC effects,which are mediated through oxidative stress mitigation and cytokine modulation,while emphasizing the polarity-dependent efficacy of its extracts.展开更多
The Zn2＋, Ni2＋ and Co3＋ doped Sr14Cu24041 compounds were synthesized by standard solid state method. X-ray diffraction results show that the changes in lattice parameters are very small. Selected area electron diff...The Zn2＋, Ni2＋ and Co3＋ doped Sr14Cu24041 compounds were synthesized by standard solid state method. X-ray diffraction results show that the changes in lattice parameters are very small. Selected area electron diffraction patterns （EDPs） show that the diffraction spots corresponding to the CuO2 chain substructure are extended to streaks along a＊ and b＊ directions for all the samples, while the diffraction spots produced merely by the Cu203 ladder substructure are still very sharp. This means that the periodicities of chains in a＊ and b＊ directions are partially destroyed upon doping ofZn, Ni and Co due to that the initial phase of each chain becomes a random variable. The temperature dependence of magnetic properties was measured for every sample. And the number of dimers in CuO2 chain per formula unit （f.u.） and dimer coupling constant are obtained by fitting the temperature dependence of the magnetic susceptibility. It is found that the degree of initial phase disorder is related to the order degree of magnetic sequence in CuO2 chain. For the un-doped sample, the decoupling of dimers is weak, the magnetic sequence is slightly destroyed, and the streaks in EDP are also very weak, which implies the degree of initial phase disorder in CuO2 chain is very low. When Zn2~ and Ni2＋ ions are doped, the number of dimers per f.u. decreases, and the intensity of diffraction streaks increases in comparison with the corresponding spots. Furthermore, when the high spin magnetic ions Co3＋ are doped, the number of holes in Sr14Cu24041 decreases, the magnetic sequence is destroyed very seriously, and the spots in EDP are extended to streaks almost completely. The phenomenon that the diffraction spots ofCuO2 chain extend to streaks in EDP appears as evidence that the magnetic sequence in the CuO2 chain is destroyed by doping of Zn, Ni, Co.展开更多
Delayed coking is an important petroleum resid conversion process.The processability of coking liquids is known to be dependent on the heteroatom compounds present in the coking liquids.Eight commercial delayed coking...Delayed coking is an important petroleum resid conversion process.The processability of coking liquids is known to be dependent on the heteroatom compounds present in the coking liquids.Eight commercial delayed coking liquids were characterized by electrospray ionization(ESI)Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS)and gas chromatographic techniques.High relatively abundant heteroatom compounds in the coking liquids were 1-4 aromatic-ring pyridinic nitrogen compounds,carbazoles,benzocarbazoles,phenols,mercaptans,benzothiophenes,dibenzothiophenes,and naphthobenzothiophenes.Coking liquids derived from various feeds had similar compound class types,molecular weight distribution ranges,and double bond equivalents(DBE).However,the concentration of individual compounds and the distribution of DBE versus carbon number of heteroatom compounds varied.A comparison of heteroatom compounds in coker feeds and products revealed the various reaction mechanism of heteroatom compounds occurred during the coking process.The results suggested that molecular-level process models can be developed for optimization of unit operation to obtain desirable products that meet the environmental specifications and quality requirements.展开更多
Thin films of five vanadium compounds/composite： （1） VO2（3-fl） （3-fl = 3-Hydroxyflavone）, （2） VO（pbd）： （pbd = 1-Phenyl-l, 3-butadione）, （3） VO（dbm）2 （dbm = Dibenzoylmethane）, （4） VPc （Vanadyl Ph...Thin films of five vanadium compounds/composite： （1） VO2（3-fl） （3-fl = 3-Hydroxyflavone）, （2） VO（pbd）： （pbd = 1-Phenyl-l, 3-butadione）, （3） VO（dbm）2 （dbm = Dibenzoylmethane）, （4） VPc （Vanadyl Phthalocyanine） and （5） V2O5-PEPC （V2O5- poly-N-epoxypropylcarbazole composite）, were deposited by the dropcasting method from the solution in benzene. The transmittance-irradiance relationships were investigated and the transmission in the visible spectrum and optical images were obtained as well. It was found that the transmittance of the VO2（3-fl）, VO（pbd）2, VO（dbm）2 and VPc, was practically independent of the irradiance; whereas the transmittance of V2O5-PEPC decreased by 4% for thin and 9% for thick films with an increase of the irradiance.展开更多
基金Supported by Jilin Province Science and Technology Development Plan Project,No.20210204012YY.
文摘BACKGROUND Ulcerative colitis(UC)is a chronic relapsing inflammatory bowel disease with rising global incidence.Current therapies for UC often provide incomplete relief and are associated with adverse side effects,highlighting the need for alternatives with increased safety and effectiveness.Compound spleen-tonifying composition(CSTC)contains ingredients,such as Pulsatilla chinensis(Bunge)Regel and Glycyrrhiza uralensis Fisch,that have been shown to be efficacious in the treatment of UC.Its mechanism needs to be investigated further.AIM To study the therapeutic effect and mechanism of CSTC in dextran sulfate sodium(DSS)-induced UC in rats.METHODS Sprague-Dawley rats were freely given 4%DSS solution for seven days to establish the UC model.After intervention with CSTC and its different solvent extracts,body weight changes,the disease activity index(DAI),and colon histopathology were assessed to evaluate therapeutic outcomes.The contents of superoxide dismutase(SOD),malondialdehyde(MDA),myeloperoxidase(MPO),glutathione peroxidase(GSH-px),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)in colon tissue were determined to investigate changes in biochemical indicators.RESULTS DSS administration triggered severe UC symptoms,including weight loss,colon shortening,elevated DAI scores,and histological damage.These symptoms were accompanied with oxidative stress(reduced SOD and GSH-px levels and increased MDA and MPO levels),inflammation(elevated TNF-α,IL-1β,and IL-6 levels),and a reduction in the expression levels of tight junction proteins[zonula occludens-1(ZO-1)and occluding].High-and mediumdose CSTC treatment significantly alleviated clinical symptoms,restored colon morphology,normalized oxidative stress markers,suppressed proinflammatory cytokines,and enhanced ZO-1 and occludin levels,demonstrating dose-dependent efficacy.Notably,solvent extraction critically influenced bioactivity:Nonpolar extracts(chloroform and petroleum ether)showed minimal effects,whereas polar extracts(ethyl acetate and n-butanol)remarkably improved clinical symptoms.CONCLUSION The above findings highlight CSTC’s multifaceted anti-UC effects,which are mediated through oxidative stress mitigation and cytokine modulation,while emphasizing the polarity-dependent efficacy of its extracts.
基金Funded by the National Natural Science Foundation of China(Nos.10674105 and 50471028)
文摘The Zn2＋, Ni2＋ and Co3＋ doped Sr14Cu24041 compounds were synthesized by standard solid state method. X-ray diffraction results show that the changes in lattice parameters are very small. Selected area electron diffraction patterns （EDPs） show that the diffraction spots corresponding to the CuO2 chain substructure are extended to streaks along a＊ and b＊ directions for all the samples, while the diffraction spots produced merely by the Cu203 ladder substructure are still very sharp. This means that the periodicities of chains in a＊ and b＊ directions are partially destroyed upon doping ofZn, Ni and Co due to that the initial phase of each chain becomes a random variable. The temperature dependence of magnetic properties was measured for every sample. And the number of dimers in CuO2 chain per formula unit （f.u.） and dimer coupling constant are obtained by fitting the temperature dependence of the magnetic susceptibility. It is found that the degree of initial phase disorder is related to the order degree of magnetic sequence in CuO2 chain. For the un-doped sample, the decoupling of dimers is weak, the magnetic sequence is slightly destroyed, and the streaks in EDP are also very weak, which implies the degree of initial phase disorder in CuO2 chain is very low. When Zn2~ and Ni2＋ ions are doped, the number of dimers per f.u. decreases, and the intensity of diffraction streaks increases in comparison with the corresponding spots. Furthermore, when the high spin magnetic ions Co3＋ are doped, the number of holes in Sr14Cu24041 decreases, the magnetic sequence is destroyed very seriously, and the spots in EDP are extended to streaks almost completely. The phenomenon that the diffraction spots ofCuO2 chain extend to streaks in EDP appears as evidence that the magnetic sequence in the CuO2 chain is destroyed by doping of Zn, Ni, Co.
基金supported by the National Natural Science Foundation of China(U1162204,21236009,21376262)
文摘Delayed coking is an important petroleum resid conversion process.The processability of coking liquids is known to be dependent on the heteroatom compounds present in the coking liquids.Eight commercial delayed coking liquids were characterized by electrospray ionization(ESI)Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS)and gas chromatographic techniques.High relatively abundant heteroatom compounds in the coking liquids were 1-4 aromatic-ring pyridinic nitrogen compounds,carbazoles,benzocarbazoles,phenols,mercaptans,benzothiophenes,dibenzothiophenes,and naphthobenzothiophenes.Coking liquids derived from various feeds had similar compound class types,molecular weight distribution ranges,and double bond equivalents(DBE).However,the concentration of individual compounds and the distribution of DBE versus carbon number of heteroatom compounds varied.A comparison of heteroatom compounds in coker feeds and products revealed the various reaction mechanism of heteroatom compounds occurred during the coking process.The results suggested that molecular-level process models can be developed for optimization of unit operation to obtain desirable products that meet the environmental specifications and quality requirements.
文摘Thin films of five vanadium compounds/composite： （1） VO2（3-fl） （3-fl = 3-Hydroxyflavone）, （2） VO（pbd）： （pbd = 1-Phenyl-l, 3-butadione）, （3） VO（dbm）2 （dbm = Dibenzoylmethane）, （4） VPc （Vanadyl Phthalocyanine） and （5） V2O5-PEPC （V2O5- poly-N-epoxypropylcarbazole composite）, were deposited by the dropcasting method from the solution in benzene. The transmittance-irradiance relationships were investigated and the transmission in the visible spectrum and optical images were obtained as well. It was found that the transmittance of the VO2（3-fl）, VO（pbd）2, VO（dbm）2 and VPc, was practically independent of the irradiance; whereas the transmittance of V2O5-PEPC decreased by 4% for thin and 9% for thick films with an increase of the irradiance.
