Sepsis is a significant global health burden,with substantial morbidity and mortality.The host immune response to infection appears to be a double-edged sword in the development of septic complications.Although an app...Sepsis is a significant global health burden,with substantial morbidity and mortality.The host immune response to infection appears to be a double-edged sword in the development of septic complications.Although an appropriate immune response is essential for pathogen clearance,an excessive or dysregulated response can lead to immune dissonance and subsequent organ injury.The immune response may vary depending on individual patient characteristics,pathogen type,infection site,and co-existing factors.This heterogeneity presents a substantial challenge for clinical evaluation of immune status.展开更多
基金This study was supported by grants from the National Key Research and Development Program of China(No.2022YFA1104600)the General Program of National Natural Science Foundation of China(No.82472194)the Key Program of National Natural Science Foundation of China(No.82241062).
文摘Sepsis is a significant global health burden,with substantial morbidity and mortality.The host immune response to infection appears to be a double-edged sword in the development of septic complications.Although an appropriate immune response is essential for pathogen clearance,an excessive or dysregulated response can lead to immune dissonance and subsequent organ injury.The immune response may vary depending on individual patient characteristics,pathogen type,infection site,and co-existing factors.This heterogeneity presents a substantial challenge for clinical evaluation of immune status.
