The past 40 years has seen the remarkable history of the building of not only socialism with Chinese characteristics but also a moderately prosperous society by the Chinese people led by the Communist Party of China.B...The past 40 years has seen the remarkable history of the building of not only socialism with Chinese characteristics but also a moderately prosperous society by the Chinese people led by the Communist Party of China.By 2020,China will have finished building a moderately prosperous society in all respects and realized the second strategic objective of the rejuvenation of the Chinese nation.展开更多
As we review the historical process of completing the building a moderately prosperous society in all respects,the rule of law through the right to education,which has played a leading and guaranteeing role in this pr...As we review the historical process of completing the building a moderately prosperous society in all respects,the rule of law through the right to education,which has played a leading and guaranteeing role in this process,has not only made great achievements,but also set the direction and path for the development of the education system and unleashed education’s momentum in driving social development.The rule of law through the right to education has been established and developed during the great practice of reform and opening-up.After we achieve the goal of realizing all-round moderate prosperity,it is necessary to straighten out the internal mechanisms concerning its next-step development and codify educational laws in order to further promote human rights progress in China.展开更多
Technological developments that specifically address automation,compliance with environmental regulations,and hazard avoidance have accelerated more quickly than other drilling and completion technologies in the Unite...Technological developments that specifically address automation,compliance with environmental regulations,and hazard avoidance have accelerated more quickly than other drilling and completion technologies in the United States.This brief article provides a review of areas experiencing some of the most dramatic advances,while describing the need and addressing the solutions as they are now,and how they can be developed in the future.One aspect that all the new technologies have in common is an enhanced use of data analytics and in many cases,cloud-based solutions.A challenge that all have is a need to be able to quickly accommodate rapidly evolving requirements for emissions detection,hazard monitoring,and a reduced carbon footprint.Many solutions to the challenges require the ability to repurpose existing databases and use them for new purposes.展开更多
We present a new method for estimating missing values or correcting unreliable observed values of time dependent physical fields. This method, is based on Hidden Markov Models and Self-Organizing Maps, and is named PR...We present a new method for estimating missing values or correcting unreliable observed values of time dependent physical fields. This method, is based on Hidden Markov Models and Self-Organizing Maps, and is named PROFHMM_UNC. PROFHMM_UNC combines the knowledge of the physical process under study provided by an already known dynamic model and the truncated time series of observations of the phenomenon. In order to generate the states of the Hidden Markov Model, Self-Organizing Maps are used to discretize the available data. We make a modification to the Viterbi algorithm that forces the algorithm to take into account a priori information on the quality of the observed data when selecting the optimum reconstruction. The validity of PROFHMM_UNC was endorsed by performing a twin experiment with the outputs of the ocean biogeochemical NEMO-PISCES model.展开更多
Moderate prosperity is a social ideal for which the Chinese people have been striving for thousands of years.After the founding of the People's Republic of China,and especially since the reform and opening-up poli...Moderate prosperity is a social ideal for which the Chinese people have been striving for thousands of years.After the founding of the People's Republic of China,and especially since the reform and opening-up policy was implemented in the late 1970s,the Communist Party of China deepened its understanding of the laws governing the building a moderate prosperous society in practice and wrought brilliant achievements in completing a moderate prosperous society in all respects.Completing such a society is a key step in realizing the Chinese dream of national rejuvenation,making scientific socialism radiate strong vitality in the 21st century and greatly expanding the way developing countries modernize.The great practice of completing a moderately prosperous society in all respects has accumulated precious experience for building a modern socialist country in all respects.展开更多
International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and ...International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.展开更多
BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary app...BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.展开更多
When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can off...When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.展开更多
In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-pin...In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.展开更多
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.展开更多
Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an es...Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an essential reference for comparative analysis.However,their application in pathology represents a challenge because of deficiency or contamination of maternal-origin tissues.This study aimed to develop a novel STR genotyping method for identifying CHM genotypes without a maternal component.Methods Samples with the pathologic description of molar pregnancy were collected.Routine hematoxylin–eosin(HE)staining and p57 immunohistochemistry staining were conducted in accordance with standard guidelines.A novel 26-plex system was explored to classify CHM and diploid pregnancies.The system combined 22 STRs on chromosomes 21/18/13/X,3 sex loci,and 1 quality control marker(TAF9L),enabling molecular diagnosis in the absence of maternal tissue.At last,traditional DNA typing based on villi and decidua(maternal component)of each case was used for result consistency analysis.Results CHM and nonmolar abortus could not be distinguished by the basic HE staining with no fetal evidence or other prominent features.DNA typing was successfully processed for all cases according to the novel 26-plex and traditional system.CHM(46XX)diagnosis required single A-STR/X-STR peaks and absent Y-chromosome markers,excluding chromosomal abnormalities via TAF9L analysis.When the villous tissue analysis revealed single peaks at X-STR/SRY loci,a 1:1 amelogenin ratio,and a 2:1 TAF9L peak ratio,these results overlapped with those of 46XY hydropic abortus or CHM.Notably,p57 immunohistochemical staining resolved the ambiguity.Consistency with traditional DNA genotyping confirmed system accuracy.This multiplex assay enhanced reliability in mole diagnosis,supporting clinical differentiation and genetic counseling.Conclusion This study presents a rapid and cost-effective assay for the genotypic identification of CHM without the need for a maternal component.The method combined the characteristics of STR loci distributed across different chromosomes and developed the clinic application of forensic biomarkers.展开更多
Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are...Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are scarce.Therefore,we conducted a randomized controlled trial investigating the effects of aerobic or resistance exercise concomitant to neoadjuvant chemotherapy(NACT)on tumor size.Methods In the BENEFIT study(German title:Bewegung bei neoadjuvanter chemotherapie zur verbesserung der fitness),patients with breast cancer scheduled for NACT were randomly assigned to supervised resistance training(RT,n=60)or aerobic training(AT,n=60)twice weekly during NACT or to a waitlist control group(WCG,n=60).The primary outcome,“change in tumor size”,as well as the secondary clinical outcomes pathologic complete response(pCR),type of surgery(breast conserving/mastectomy),axillary lymph node dissection(ALND,yes/no),premature discontinuation of chemotherapy(yes/no),and relative dose intensity(RDI)were derived from clinical records.Due to the highly skewed distribution,the primary outcome was categorized.Multiple(ordinal)logistic regression analyses were performed.Results Overall,there was no significant difference in post-intervention tumor size between RT or AT and WCG.However,there was a significant effect modification by hormone receptor(HR)status(P_(interaction)=0.030).Among patients with HR+tumors,results suggest a beneficial effect of AT on tumor shrinkage(odds ratio(OR)=2.37,95%confidence interval(95%CI):0.97‒5.78),on pCR(OR=3.21,95%CI:0.97‒10.61);and on ALND(OR=3.76,95%CI:0.78‒18.06)compared to WCG.The effects of RT were slightly less pronounced.For HR−subtypes,beneficial effects on RDI were found for AT(OR=3.71,95%CI:1.20‒11.50)and similarly for RT(OR=2.58,95%CI:0.88‒7.59).Both AT and RT had favorable effects on premature discontinuation of chemotherapy(OR(no vs.yes)=2.34,95%CI:1.10‒5.06),irrespective of tumor receptor status.Conclusion While there was no significant effect on the primary outcome in the overall group,aerobic and resistance exercise concomitant to NACT seem to beneficially affect tumor shrinkage and pCR,reduce the need for ALND among patients with HR+breast cancers,and prevent low RDI among patients with HR–breast cancers.These results warrant confirmation in further trials.展开更多
BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particu...BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particularly in the vertical direction.Endoscopic full-thickness resection(EFTR)has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.AIM To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.METHODS This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs,including 132 who underwent endoscopic submucosal dissection(ESD)and 28 who underwent EFTR.Lesions were categorized as<1 cm,1-2 cm,and>2 cm in size.CR rate,en bloc resection rate,operation time,and complications were evaluated.Subgroup analyses and follow-up were also performed.RESULTS EFTR achieved 100%CR rates for lesions<1 cm and 1-2 cm,compared with 67.0%and 50.0%,respectively,in the ESD group.En bloc resection and successful removal of the R-NENs were achieved in all patients.Meanwhile,EFTR showed performance comparable to ESD in terms of operation time,hospitalization cost,and postoperative adverse events,except for a one-day longer hospital stay.We also analyzed the invasion depth of R-NENs based on full-thickness specimens.The data showed that 80%of lesions(<1 cm)and 85.7%of lesions(1-2 cm)had invaded the SM3 level or deeper at the time of resection.For ESD specimens,46.6%(<1 cm)and 89.3%(1-2 cm)of lesions had infiltrated more than 2000μm beneath the muscularis mucosae.CONCLUSION EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.展开更多
The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique natu...The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.展开更多
Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance co...Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance compared with Lactiplantibacillus rhamnosus GG(LGG).L.plantarum MWFLp-182 was further examined for its antioxidant and anti-inflammatory activity in ABAP-treated HT-29 cells.Importantly,it enhanced the expression of anti-inflammatory factor(interleukin-10(IL-10)),antioxidant cytokines(superoxide dismutase(SOD),glutathione peroxidase(GPx),nuclear factor erythroid 2-related factor(Nrf2),and hemeoxygenase 1(HO-1)),B-cell lymphoma-2(Bcl-2),and tight junction(Zonula occludens protein 1(ZO-1),Claudin-1,and Occludin)proteins and genes,and reduced reactive oxygen species(ROS).The complete genome of L.plantarum MWFLp-182 contained a single circular chromosome that was 3257196 bp long,with a G+C content of 44.49%,and a single circular plasmid that was 53560 bp long.The genes tpx,trx A,trx B,npr,nrd H,dps,rec A,gpx,gsh A and ars C in this strain were related to antioxidant function;the key genes involved in antioxidant function were further investigated.In this study,we identified a probiotic candidate with antioxidant properties.展开更多
The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for ...The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for constructing Ramanujan-type series of level 3.Chan and Liaw introduced an alternating analogue of the Borwein brothers’identity for Ramanujan-type series of level 3;subsequently,Chan,Liaw,and Tian formulated another proof of the Chan–Liaw identity,via the use of Ramanujan’s class invariant.Using the elliptic lambda function and the elliptic alpha function,we prove,via a limiting case of the Kummer–Goursat transformation,a new identity for evaluating the summands for alternating Ramanujan-type series of level 3,and we apply this new identity to prove three conjectured formulas for quadratic-irrational,Ramanujan-type series that had been discovered via numerical experiments with Maple in 2012 by Aldawoud.We also apply our identity to prove a new Ramanujan-type series of level 3 with a quartic convergence rate and quartic coefficients.展开更多
Tracking and analyzing data from research projects is critical for understanding research trends and supporting the development of science and technology strategies.However,the data from these projects is often comple...Tracking and analyzing data from research projects is critical for understanding research trends and supporting the development of science and technology strategies.However,the data from these projects is often complex and inadequate,making it challenging for researchers to conduct in-depth data mining to improve policies or management.To address this problem,this paper adopts a top-down approach to construct a knowledge graph(KG)for research projects.Firstly,we construct an integrated ontology by referring to the metamodel of various architectures,which is called the meta-model integration conceptual reference model.Subsequently,we use the dependency parsing method to extract knowledge from unstructured textual data and use the entity alignment method based on weakly supervised learning to classify the extracted entities,completing the construction of the KG for the research projects.In addition,a knowledge inference model based on representation learning is employed to achieve knowledge completion and improve the KG.Finally,experiments are conducted on the KG for research projects and the results demonstrate the effectiveness of the proposed method in enriching incomplete data within the KG.展开更多
Rectal neuroendocrine tumor(rNET)is an indolent malignancy often detected during colonoscopy screening.The incidence of rNET has increased approximately 10-fold over the past 30 years.Most rNETs detected during screen...Rectal neuroendocrine tumor(rNET)is an indolent malignancy often detected during colonoscopy screening.The incidence of rNET has increased approximately 10-fold over the past 30 years.Most rNETs detected during screening endoscopy are small,measuring<10 mm.Current guidelines recommend endoscopic resection for small,well-differentiated rNET using modified endoscopic submucosal resection(mEMR)or endoscopic submucosal dissection.However,the optimal endoscopic treatment method remains uncertain.This paper summarizes the evidence on mEMR with submucosal stretching,mEMR without submucosal stretching,endoscopic submucosal dissection and endoscopic full-thickness resection.Given that rNETs often exhibit submucosal invasion,achieving adequate resection depth is crucial to ensure histological complete resection.mEMR with submucosal stretching appears favorable due to its high rate of histological complete resection,safety and convenience.Risk factors associated with lymph node and distant metastases are also discussed.A treatment algorithm is proposed to facilitate clinical decision-making.展开更多
BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the ...BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced BTC.However,the efficacy of this treatment for GBC remains unclear.CASE SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative surgery.Following three cycles of therapy,a partial response was observed.After one year of combined therapy,a clinical complete response was successfully achieved.Subsequent maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the patient.The patient experienced tolerable toxicities of reversible grade 2 nausea and fatigue.Tolerable adverse events were observed in the patient throughout the entirety of the treatment.CONCLUSION The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse events.Further research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.展开更多
In this paper,we established a class of parallel algorithm for solving low-rank tensor completion problem.The main idea is that N singular value decompositions are implemented in N different processors for each slice ...In this paper,we established a class of parallel algorithm for solving low-rank tensor completion problem.The main idea is that N singular value decompositions are implemented in N different processors for each slice matrix under unfold operator,and then the fold operator is used to form the next iteration tensor such that the computing time can be decreased.In theory,we analyze the global convergence of the algorithm.In numerical experiment,the simulation data and real image inpainting are carried out.Experiment results show the parallel algorithm outperform its original algorithm in CPU times under the same precision.展开更多
文摘The past 40 years has seen the remarkable history of the building of not only socialism with Chinese characteristics but also a moderately prosperous society by the Chinese people led by the Communist Party of China.By 2020,China will have finished building a moderately prosperous society in all respects and realized the second strategic objective of the rejuvenation of the Chinese nation.
基金a phased result of the“Institute for Education Law of the Ministry of Education”,a first-class liberal arts development program(think tank development and social service capability improvement program)of the universitythe“study on the refinement of socialist core values and legal system for education”,a major project of the National Social Science Fund of China(project number:19VHJ010)
文摘As we review the historical process of completing the building a moderately prosperous society in all respects,the rule of law through the right to education,which has played a leading and guaranteeing role in this process,has not only made great achievements,but also set the direction and path for the development of the education system and unleashed education’s momentum in driving social development.The rule of law through the right to education has been established and developed during the great practice of reform and opening-up.After we achieve the goal of realizing all-round moderate prosperity,it is necessary to straighten out the internal mechanisms concerning its next-step development and codify educational laws in order to further promote human rights progress in China.
文摘Technological developments that specifically address automation,compliance with environmental regulations,and hazard avoidance have accelerated more quickly than other drilling and completion technologies in the United States.This brief article provides a review of areas experiencing some of the most dramatic advances,while describing the need and addressing the solutions as they are now,and how they can be developed in the future.One aspect that all the new technologies have in common is an enhanced use of data analytics and in many cases,cloud-based solutions.A challenge that all have is a need to be able to quickly accommodate rapidly evolving requirements for emissions detection,hazard monitoring,and a reduced carbon footprint.Many solutions to the challenges require the ability to repurpose existing databases and use them for new purposes.
文摘We present a new method for estimating missing values or correcting unreliable observed values of time dependent physical fields. This method, is based on Hidden Markov Models and Self-Organizing Maps, and is named PROFHMM_UNC. PROFHMM_UNC combines the knowledge of the physical process under study provided by an already known dynamic model and the truncated time series of observations of the phenomenon. In order to generate the states of the Hidden Markov Model, Self-Organizing Maps are used to discretize the available data. We make a modification to the Viterbi algorithm that forces the algorithm to take into account a priori information on the quality of the observed data when selecting the optimum reconstruction. The validity of PROFHMM_UNC was endorsed by performing a twin experiment with the outputs of the ocean biogeochemical NEMO-PISCES model.
文摘Moderate prosperity is a social ideal for which the Chinese people have been striving for thousands of years.After the founding of the People's Republic of China,and especially since the reform and opening-up policy was implemented in the late 1970s,the Communist Party of China deepened its understanding of the laws governing the building a moderate prosperous society in practice and wrought brilliant achievements in completing a moderate prosperous society in all respects.Completing such a society is a key step in realizing the Chinese dream of national rejuvenation,making scientific socialism radiate strong vitality in the 21st century and greatly expanding the way developing countries modernize.The great practice of completing a moderately prosperous society in all respects has accumulated precious experience for building a modern socialist country in all respects.
文摘International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.
文摘BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.
基金Military Healthcare Special Scientific Research Project(25BJZ31, awarded to SHI XM)。
文摘When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.
基金funded by the National Natural Science Foundation of China,grant number U24A20135Inner Mongolia Natural Science Foundation major project,grant number 2023ZD12+7 种基金Inner Mongolia Autonomous Region key research and development and achievement transformation plan project,grant number 2023YFHH0090Natural Science Foundation of Inner Mongolia,grant number 2022MS05006Inner Mongolia Autonomous Region Talent Development FundUniversity basic research business expenses,grant number 2023RCTD012University basic research business expenses,grant number 2023QNJS075Postgraduate Research Innovation Program and of Inner Mongolia Autonomous Region,grant number KC2024053BUniversity basic research business expenses,grant number 2024YXXS012National Key Laboratory of Special Vehicle Design and Manufacturing Integration Technology,grant number GZ2023KF012.
文摘In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS)the National Natural Science Foundation of China,No.31970970(to JSR)Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
文摘Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
基金supported by the Key Research and Development Program of Shaanxi(No.S2024-YF-YB-SF-1359).
文摘Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an essential reference for comparative analysis.However,their application in pathology represents a challenge because of deficiency or contamination of maternal-origin tissues.This study aimed to develop a novel STR genotyping method for identifying CHM genotypes without a maternal component.Methods Samples with the pathologic description of molar pregnancy were collected.Routine hematoxylin–eosin(HE)staining and p57 immunohistochemistry staining were conducted in accordance with standard guidelines.A novel 26-plex system was explored to classify CHM and diploid pregnancies.The system combined 22 STRs on chromosomes 21/18/13/X,3 sex loci,and 1 quality control marker(TAF9L),enabling molecular diagnosis in the absence of maternal tissue.At last,traditional DNA typing based on villi and decidua(maternal component)of each case was used for result consistency analysis.Results CHM and nonmolar abortus could not be distinguished by the basic HE staining with no fetal evidence or other prominent features.DNA typing was successfully processed for all cases according to the novel 26-plex and traditional system.CHM(46XX)diagnosis required single A-STR/X-STR peaks and absent Y-chromosome markers,excluding chromosomal abnormalities via TAF9L analysis.When the villous tissue analysis revealed single peaks at X-STR/SRY loci,a 1:1 amelogenin ratio,and a 2:1 TAF9L peak ratio,these results overlapped with those of 46XY hydropic abortus or CHM.Notably,p57 immunohistochemical staining resolved the ambiguity.Consistency with traditional DNA genotyping confirmed system accuracy.This multiplex assay enhanced reliability in mole diagnosis,supporting clinical differentiation and genetic counseling.Conclusion This study presents a rapid and cost-effective assay for the genotypic identification of CHM without the need for a maternal component.The method combined the characteristics of STR loci distributed across different chromosomes and developed the clinic application of forensic biomarkers.
基金supported by an intramural proof of concept grant of the NCT Heidelberg.
文摘Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are scarce.Therefore,we conducted a randomized controlled trial investigating the effects of aerobic or resistance exercise concomitant to neoadjuvant chemotherapy(NACT)on tumor size.Methods In the BENEFIT study(German title:Bewegung bei neoadjuvanter chemotherapie zur verbesserung der fitness),patients with breast cancer scheduled for NACT were randomly assigned to supervised resistance training(RT,n=60)or aerobic training(AT,n=60)twice weekly during NACT or to a waitlist control group(WCG,n=60).The primary outcome,“change in tumor size”,as well as the secondary clinical outcomes pathologic complete response(pCR),type of surgery(breast conserving/mastectomy),axillary lymph node dissection(ALND,yes/no),premature discontinuation of chemotherapy(yes/no),and relative dose intensity(RDI)were derived from clinical records.Due to the highly skewed distribution,the primary outcome was categorized.Multiple(ordinal)logistic regression analyses were performed.Results Overall,there was no significant difference in post-intervention tumor size between RT or AT and WCG.However,there was a significant effect modification by hormone receptor(HR)status(P_(interaction)=0.030).Among patients with HR+tumors,results suggest a beneficial effect of AT on tumor shrinkage(odds ratio(OR)=2.37,95%confidence interval(95%CI):0.97‒5.78),on pCR(OR=3.21,95%CI:0.97‒10.61);and on ALND(OR=3.76,95%CI:0.78‒18.06)compared to WCG.The effects of RT were slightly less pronounced.For HR−subtypes,beneficial effects on RDI were found for AT(OR=3.71,95%CI:1.20‒11.50)and similarly for RT(OR=2.58,95%CI:0.88‒7.59).Both AT and RT had favorable effects on premature discontinuation of chemotherapy(OR(no vs.yes)=2.34,95%CI:1.10‒5.06),irrespective of tumor receptor status.Conclusion While there was no significant effect on the primary outcome in the overall group,aerobic and resistance exercise concomitant to NACT seem to beneficially affect tumor shrinkage and pCR,reduce the need for ALND among patients with HR+breast cancers,and prevent low RDI among patients with HR–breast cancers.These results warrant confirmation in further trials.
基金Supported by National Natural Science Foundation of China,No.82004298Jiangsu Graduate Research and Practice Innovation Program,China,No.KYCX23_2090.
文摘BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particularly in the vertical direction.Endoscopic full-thickness resection(EFTR)has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.AIM To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.METHODS This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs,including 132 who underwent endoscopic submucosal dissection(ESD)and 28 who underwent EFTR.Lesions were categorized as<1 cm,1-2 cm,and>2 cm in size.CR rate,en bloc resection rate,operation time,and complications were evaluated.Subgroup analyses and follow-up were also performed.RESULTS EFTR achieved 100%CR rates for lesions<1 cm and 1-2 cm,compared with 67.0%and 50.0%,respectively,in the ESD group.En bloc resection and successful removal of the R-NENs were achieved in all patients.Meanwhile,EFTR showed performance comparable to ESD in terms of operation time,hospitalization cost,and postoperative adverse events,except for a one-day longer hospital stay.We also analyzed the invasion depth of R-NENs based on full-thickness specimens.The data showed that 80%of lesions(<1 cm)and 85.7%of lesions(1-2 cm)had invaded the SM3 level or deeper at the time of resection.For ESD specimens,46.6%(<1 cm)and 89.3%(1-2 cm)of lesions had infiltrated more than 2000μm beneath the muscularis mucosae.CONCLUSION EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.
基金Project(42202318)supported by the National Natural Science Foundation of ChinaProject(252300421199)supported by the Natural Science Foundation of Henan Province,ChinaProject(2024JJ6219)supported by the Hunan Provincial Natural Science Foundation of China。
文摘The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.
基金supported by the Natural Science Foundation of Guangxi,China(2020GXNSFBA297083)the National Natural Science Foundation of China(32072193)。
文摘Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance compared with Lactiplantibacillus rhamnosus GG(LGG).L.plantarum MWFLp-182 was further examined for its antioxidant and anti-inflammatory activity in ABAP-treated HT-29 cells.Importantly,it enhanced the expression of anti-inflammatory factor(interleukin-10(IL-10)),antioxidant cytokines(superoxide dismutase(SOD),glutathione peroxidase(GPx),nuclear factor erythroid 2-related factor(Nrf2),and hemeoxygenase 1(HO-1)),B-cell lymphoma-2(Bcl-2),and tight junction(Zonula occludens protein 1(ZO-1),Claudin-1,and Occludin)proteins and genes,and reduced reactive oxygen species(ROS).The complete genome of L.plantarum MWFLp-182 contained a single circular chromosome that was 3257196 bp long,with a G+C content of 44.49%,and a single circular plasmid that was 53560 bp long.The genes tpx,trx A,trx B,npr,nrd H,dps,rec A,gpx,gsh A and ars C in this strain were related to antioxidant function;the key genes involved in antioxidant function were further investigated.In this study,we identified a probiotic candidate with antioxidant properties.
基金supported by a Killam Postdoctoral Fellowship from the Killam Trusts.
文摘The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for constructing Ramanujan-type series of level 3.Chan and Liaw introduced an alternating analogue of the Borwein brothers’identity for Ramanujan-type series of level 3;subsequently,Chan,Liaw,and Tian formulated another proof of the Chan–Liaw identity,via the use of Ramanujan’s class invariant.Using the elliptic lambda function and the elliptic alpha function,we prove,via a limiting case of the Kummer–Goursat transformation,a new identity for evaluating the summands for alternating Ramanujan-type series of level 3,and we apply this new identity to prove three conjectured formulas for quadratic-irrational,Ramanujan-type series that had been discovered via numerical experiments with Maple in 2012 by Aldawoud.We also apply our identity to prove a new Ramanujan-type series of level 3 with a quartic convergence rate and quartic coefficients.
基金supported by the National Natural Science Foundation of China(72101263).
文摘Tracking and analyzing data from research projects is critical for understanding research trends and supporting the development of science and technology strategies.However,the data from these projects is often complex and inadequate,making it challenging for researchers to conduct in-depth data mining to improve policies or management.To address this problem,this paper adopts a top-down approach to construct a knowledge graph(KG)for research projects.Firstly,we construct an integrated ontology by referring to the metamodel of various architectures,which is called the meta-model integration conceptual reference model.Subsequently,we use the dependency parsing method to extract knowledge from unstructured textual data and use the entity alignment method based on weakly supervised learning to classify the extracted entities,completing the construction of the KG for the research projects.In addition,a knowledge inference model based on representation learning is employed to achieve knowledge completion and improve the KG.Finally,experiments are conducted on the KG for research projects and the results demonstrate the effectiveness of the proposed method in enriching incomplete data within the KG.
基金Supported by Nanchang High-Level Scientific and Technological Innovation Talents‘Double Hundred Plan’Project,China,No.2022-312.
文摘Rectal neuroendocrine tumor(rNET)is an indolent malignancy often detected during colonoscopy screening.The incidence of rNET has increased approximately 10-fold over the past 30 years.Most rNETs detected during screening endoscopy are small,measuring<10 mm.Current guidelines recommend endoscopic resection for small,well-differentiated rNET using modified endoscopic submucosal resection(mEMR)or endoscopic submucosal dissection.However,the optimal endoscopic treatment method remains uncertain.This paper summarizes the evidence on mEMR with submucosal stretching,mEMR without submucosal stretching,endoscopic submucosal dissection and endoscopic full-thickness resection.Given that rNETs often exhibit submucosal invasion,achieving adequate resection depth is crucial to ensure histological complete resection.mEMR with submucosal stretching appears favorable due to its high rate of histological complete resection,safety and convenience.Risk factors associated with lymph node and distant metastases are also discussed.A treatment algorithm is proposed to facilitate clinical decision-making.
基金Supported by General Project of Natural Science Foundation of Chongqing,China,No.cstc2021jcyj-msxmX0604Chongqing Doctoral"Through Train"Research Program,China,No.CSTB2022BSXM-JCX0045.
文摘BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced BTC.However,the efficacy of this treatment for GBC remains unclear.CASE SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative surgery.Following three cycles of therapy,a partial response was observed.After one year of combined therapy,a clinical complete response was successfully achieved.Subsequent maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the patient.The patient experienced tolerable toxicities of reversible grade 2 nausea and fatigue.Tolerable adverse events were observed in the patient throughout the entirety of the treatment.CONCLUSION The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse events.Further research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.
基金Supported by National Nature Science Foundation(12371381)Nature Science Foundation of Shanxi(202403021222270)。
文摘In this paper,we established a class of parallel algorithm for solving low-rank tensor completion problem.The main idea is that N singular value decompositions are implemented in N different processors for each slice matrix under unfold operator,and then the fold operator is used to form the next iteration tensor such that the computing time can be decreased.In theory,we analyze the global convergence of the algorithm.In numerical experiment,the simulation data and real image inpainting are carried out.Experiment results show the parallel algorithm outperform its original algorithm in CPU times under the same precision.
