Cell competition is an evolutionarily ancient mechanism that functions to remove unfit or dangerous clonal cells in a multicellular community.A classical model is the removal of polarity-deficient clones,such as the p...Cell competition is an evolutionarily ancient mechanism that functions to remove unfit or dangerous clonal cells in a multicellular community.A classical model is the removal of polarity-deficient clones,such as the precancerous scribble(scrib)mutant clones,in Drosophila imaginal discs.The activation of Ras,Yki,or Notch signaling robustly reverses the scrib mutant clonal fate from elimination to tumorous growth.Whether these signals converge to adopt a common mechanism to overcome the elimination pressure posed by cell competition remains unclear.Using single-cell transcriptomics,we find that a critical converging point downstream of Ras,Yki,and Notch signals is the upregulation of Upd2,an IL-6 family cytokine.Overexpression of Upd2 is sufficient to rescue the scrib mutant clones from elimination.Depletion of Upd2 blocks the growth of the scrib mutant clones with active Ras,Yki,and Notch signals.Moreover,Upd2 overexpression promotes robust intestinal stem cell(ISC)proliferation,while Upd2 is intrinsically required in ISCs for the growth of the adult intestine.Together,these results identify Upd2 as a crucial cell fitness factor that sustains tissue growth but can potentiate tumorigenesis when deregulated.展开更多
Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness...Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness and mapped the effects of ecosystem services on agricultural competitiveness using multiple models.In this study,multi-source data from 2000 to 2020 were utilized to establish the indicator system of agricultural competitiveness;five ecosystem services were quantified using computation models;Geographic Information System(GIS)spatial analysis was used to explore the spatial patterns of agricultural competitiveness and ecosystem services;geographic detector models were applied to investigate the effects and driving mechanisms of ecosystem services on agricultural competitiveness.Shandong Province of China was selected as the case study area.The results demonstrated that:1)there was a significant increase in agricultural competitiveness during the study period,with high levels observed mainly in the east region of the study area.2)The spatial distribution patterns of ecosystem services and agricultural competitiveness primarily exhibited High-High and Low-Low Cluster types.3)Habitat quality emerged as the main driving factor of agricultural competitiveness in 2000 and 2020,while water yield played a substantial role in 2010.4)The coupling of two ecosystem services exerted a greater effect on agricultural competitiveness compared to individual ecosystem service.The innovations of this study are constructing an indicator system to quantify agricultural competitiveness,and exploring the effects of ecosystem services on agricultural competitiveness.This study proposed an indicator system to quantify agricultural competitiveness,which can be applied in other regions,and explored the effects of ecosystem services on agricultural competitiveness.The findings of this study can serve as valuable insights for policymakers to formulate tailored agricultural development policies that take into account the synergistic effects of ecosystem services on agricultural competitiveness.展开更多
Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital...Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital innovative technologies have rendered international competition and cooperation increasingly complex in both implications and forms.Beyond its role in accelerating technological progress,digital technology enhances state capability by adding a digital dimension to national power.It enables states that possess comparative advantages in digital R&D and deployment to gain greater influence in shaping international discourse,thereby widening the power gap among nations.展开更多
As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competit...As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competitiveness roadmap.According to India's Ministry of Textiles,the government has formulated a fourpoint action plan divided into short-term(two years),medium-term(five years),and two long-term stages.It aims to reduce production costs,enhance labor productivity,and strengthen export competitiveness in the textile sector.The plan seeks to increase India's textile and apparel exports to$100 billion by 2030,a significant leap from the$37.7 billion projected for the 2024-25 fiscal year.The trigger for this plan was the US imposition of 50%tariffs on Indian textiles earlier this year,raising concerns about India's competitiveness relative to Bangladesh,Vietnam,and China.展开更多
With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient pur...With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.展开更多
The biased allocation of emission reduction target constraints quantifies emission reduction responsibilities and reflects differences in pollutant reductions both across and within cities.This approach represents a s...The biased allocation of emission reduction target constraints quantifies emission reduction responsibilities and reflects differences in pollutant reductions both across and within cities.This approach represents a systematic innovation aims to enhance China’s green competitiveness and facilitate its economic transformation through localized and precise policymaking.Using panel data from 275 Chinese cities spanning 2000-2022,this study applies the difference-in-differences method to estimate the impact of biased allocation of emission reduction target constraints on urban green competitiveness.The findings indicate that such constraints-whether based on chemical oxygen demand or sulfur dioxide targets-significantly improve urban green competitiveness,with both pollutant-specific constraints producing comparable effects.Furthermore,these constraints exhibit significant spatial spillover effects within a 200-km geographical radius.Heterogeneity analysis reveals stronger policy impacts in resource-based cities,eastern regions,and cities designated as key areas for pollution prevention and control.Mechanism analysis demonstrates that the constraints enhance green competitiveness primarily by fostering green technological innovation and optimizing industrial structures.These conclusions provide a practical foundation for addressing China’s enduring conflict between environmental protection and economic development.展开更多
This paper takes global manufacturing listed companies from 2010 to 2022 as samples and uses the difference-in-differences(DID)method to empirically examine the impact of the internationalization of ESG standards on t...This paper takes global manufacturing listed companies from 2010 to 2022 as samples and uses the difference-in-differences(DID)method to empirically examine the impact of the internationalization of ESG standards on the trade competitiveness of multinational enterprises and their mechanisms.The research finds that the internationalization of ESG standards significantly enhances the trade competitiveness of multinational manufacturing enterprises,and this effect is dynamic and sustainable.The mechanism analysis indicates that the internationalization of ESG standards exerts its influence through three pathways:reducing enterprise financing costs,promoting technological innovation,and enhancing brand reputation.The heterogeneity analysis shows that this effect is more significant in enterprises from developed countries,high-pollution industries,and larger enterprises.This paper provides micro-level evidence for understanding the economic consequences of the internationalization of ESG standards and offers policy implications for multinational enterprises to cope with the global ESG rule changes and enhance their trade competitiveness.展开更多
Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first co...Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first commercialization in the 1990s,and the three pioneers(John B.Goodenough,M.Stanley Whittingham,and Akira Yoshino)in the historical development of LIBs were awarded the Novel Prize in chemistry in 2019[4].However,the imbalance between supply and demand during the past few years induced extremely huge fluctuations in lithium resources.The misgivings of lithium resources have promoted the quick development of potential alternative battery technologies.展开更多
In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China...In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China's digital service trade is of significant importance.This article will analyze the current state of China's digital service trade development based on relevant theoretical concepts and provide a discussion on proposals for improving the international competitiveness of China's digital service trade,to offer a reference for the development of digital service trade in China.展开更多
The global rise in CO_(2)concentration is having a profound impact on the structure and function of aquatic ecosystems.However,little information is available on the responses of odorproducing cyanobacteria to the inc...The global rise in CO_(2)concentration is having a profound impact on the structure and function of aquatic ecosystems.However,little information is available on the responses of odorproducing cyanobacteria to the increase in CO_(2)concentration.In this study,the effects of different CO_(2)concentrations on 2-methylisoborneol(MIB)-producing Pseudanabaena and non-2-MIB-producing Pseudanabaena under monoculture and co-culture conditions were investigated.Results show that the specific growth rate of Pseudanabaena gradually increased with the rise in CO_(2)concentration,and for the 2-MIB-producing strain,this increase was significantly higher than the non-2-MIB-producing strain.Under co-culture conditions,the proportion of non-2-MIB-producing Pseudanabaena was significantly higher than that of 2-MIB-producing Pseudanabaena,suggesting a superior competitive ability of non-2-MIB-producing Pseudanabaena over 2-MIB-producing Pseudanabaena.Under monoculture conditions,the total 2-MIB production at the 300-μg/g CO_(2)concentration was significantly higher than that at 600-and 1200-μg/g CO_(2)concentrations.The 2-MIB concentration produced by Pseudanabaena decreased with the increasing in CO_(2)concentration.Therefore,we believe that with the future increase in CO_(2)concentration,2-MIB concentration would be decreased and so would the risk of 2-MIB outbreaks.展开更多
This study observes the process of strategy building and capability accumulation of companies in the currently booming Chinese electric vehicles(EV)1 market from the perspective of business ecosystems.While examining ...This study observes the process of strategy building and capability accumulation of companies in the currently booming Chinese electric vehicles(EV)1 market from the perspective of business ecosystems.While examining the internal and external factors of the formation about the Chinese EV industry business ecosystem,such as industrial structure transformation,technology transfer,government policies,and corporate competition,with the platform theory,I analyze the growth strategies and competitiveness of Chinese companies,particularly BYD Co.,Ltd.(BYD),which has risen to the top of the world in EV completed vehicles,and Contemporary Amperex Technology Co.,Ltd.(CATL),which has risen to the top of the world in electric vehicle batteries(EVB)2.BYD and CATL have gained competitive advantages by utilizing the distinctive management resources,which have accumulated over the years to build platforms for EVBs and EVs in response to changes in the external environment,and have actively developed their platform strategies.展开更多
This paper deals with the competitiveness of Chinese agricultural products, base on the index of revealed comparative advantage (RCA) using lots of data for the period of 1980 to 2003. The index is useful in identifyi...This paper deals with the competitiveness of Chinese agricultural products, base on the index of revealed comparative advantage (RCA) using lots of data for the period of 1980 to 2003. The index is useful in identifying the demarcation between comparative advantage and comparative disadvantage. The research indicates that some agro-products in China such as edible vegetables and tea have a comparative advantage, but the RCA values have been declining over the 24-year period, which has vast impacts on future reform in China’s agricultural structure.展开更多
基金supported by grants to Yan Yan from the Research Grants Council of the Hong Kong Special Administrative Region(GRF16103620,GRF16104324,T13-602/21N)from Shenzhen Science and Technology Innovation Commission(JCYJ20200109140201722)+1 种基金to Toyotaka Ishibashi from the National Natural Science Foundation of China(32170548)to Zongzhao Zhai from the National Natural Science Foundation of China(32170509 and 31871469).
文摘Cell competition is an evolutionarily ancient mechanism that functions to remove unfit or dangerous clonal cells in a multicellular community.A classical model is the removal of polarity-deficient clones,such as the precancerous scribble(scrib)mutant clones,in Drosophila imaginal discs.The activation of Ras,Yki,or Notch signaling robustly reverses the scrib mutant clonal fate from elimination to tumorous growth.Whether these signals converge to adopt a common mechanism to overcome the elimination pressure posed by cell competition remains unclear.Using single-cell transcriptomics,we find that a critical converging point downstream of Ras,Yki,and Notch signals is the upregulation of Upd2,an IL-6 family cytokine.Overexpression of Upd2 is sufficient to rescue the scrib mutant clones from elimination.Depletion of Upd2 blocks the growth of the scrib mutant clones with active Ras,Yki,and Notch signals.Moreover,Upd2 overexpression promotes robust intestinal stem cell(ISC)proliferation,while Upd2 is intrinsically required in ISCs for the growth of the adult intestine.Together,these results identify Upd2 as a crucial cell fitness factor that sustains tissue growth but can potentiate tumorigenesis when deregulated.
基金Under the auspices of the National Key Research and Development Program of China(No.2022YFC3204404)。
文摘Quantifying and mapping how ecosystem services impact agricultural competitiveness is crucial for attaining the Sustainable Development Goals of United Nations.However,few study quantified agricultural competitiveness and mapped the effects of ecosystem services on agricultural competitiveness using multiple models.In this study,multi-source data from 2000 to 2020 were utilized to establish the indicator system of agricultural competitiveness;five ecosystem services were quantified using computation models;Geographic Information System(GIS)spatial analysis was used to explore the spatial patterns of agricultural competitiveness and ecosystem services;geographic detector models were applied to investigate the effects and driving mechanisms of ecosystem services on agricultural competitiveness.Shandong Province of China was selected as the case study area.The results demonstrated that:1)there was a significant increase in agricultural competitiveness during the study period,with high levels observed mainly in the east region of the study area.2)The spatial distribution patterns of ecosystem services and agricultural competitiveness primarily exhibited High-High and Low-Low Cluster types.3)Habitat quality emerged as the main driving factor of agricultural competitiveness in 2000 and 2020,while water yield played a substantial role in 2010.4)The coupling of two ecosystem services exerted a greater effect on agricultural competitiveness compared to individual ecosystem service.The innovations of this study are constructing an indicator system to quantify agricultural competitiveness,and exploring the effects of ecosystem services on agricultural competitiveness.This study proposed an indicator system to quantify agricultural competitiveness,which can be applied in other regions,and explored the effects of ecosystem services on agricultural competitiveness.The findings of this study can serve as valuable insights for policymakers to formulate tailored agricultural development policies that take into account the synergistic effects of ecosystem services on agricultural competitiveness.
文摘Digital technology is the most dynamic frontier of contemporary global scientific and technological advancements,serving as a central driver of today’s technological progress.Ongoing R&D and deployment of digital innovative technologies have rendered international competition and cooperation increasingly complex in both implications and forms.Beyond its role in accelerating technological progress,digital technology enhances state capability by adding a digital dimension to national power.It enables states that possess comparative advantages in digital R&D and deployment to gain greater influence in shaping international discourse,thereby widening the power gap among nations.
文摘As India vigorously reclaims its cost advantages in textiles,the apparel trade landscape in South Asia is set for a reshuffle,with Bangladesh,Vietnam,and China becoming key reference points in India's new competitiveness roadmap.According to India's Ministry of Textiles,the government has formulated a fourpoint action plan divided into short-term(two years),medium-term(five years),and two long-term stages.It aims to reduce production costs,enhance labor productivity,and strengthen export competitiveness in the textile sector.The plan seeks to increase India's textile and apparel exports to$100 billion by 2030,a significant leap from the$37.7 billion projected for the 2024-25 fiscal year.The trigger for this plan was the US imposition of 50%tariffs on Indian textiles earlier this year,raising concerns about India's competitiveness relative to Bangladesh,Vietnam,and China.
文摘With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.
基金The funding was provided by National Office for Philosophy and Social ScienceThe authors express their gratitude to the research project titled“Study on Synergistic Governance and Optimization Path of Urban Environment under the Constraint of Biased Emission Reduction Target”[Grant No.23BGL222]this research is also supported by the Hubei Market Entity Vitality Research Center,a Key Research Institute of Humanities and Social Sciences in Hubei Universities[Grant No.00120721].
文摘The biased allocation of emission reduction target constraints quantifies emission reduction responsibilities and reflects differences in pollutant reductions both across and within cities.This approach represents a systematic innovation aims to enhance China’s green competitiveness and facilitate its economic transformation through localized and precise policymaking.Using panel data from 275 Chinese cities spanning 2000-2022,this study applies the difference-in-differences method to estimate the impact of biased allocation of emission reduction target constraints on urban green competitiveness.The findings indicate that such constraints-whether based on chemical oxygen demand or sulfur dioxide targets-significantly improve urban green competitiveness,with both pollutant-specific constraints producing comparable effects.Furthermore,these constraints exhibit significant spatial spillover effects within a 200-km geographical radius.Heterogeneity analysis reveals stronger policy impacts in resource-based cities,eastern regions,and cities designated as key areas for pollution prevention and control.Mechanism analysis demonstrates that the constraints enhance green competitiveness primarily by fostering green technological innovation and optimizing industrial structures.These conclusions provide a practical foundation for addressing China’s enduring conflict between environmental protection and economic development.
文摘This paper takes global manufacturing listed companies from 2010 to 2022 as samples and uses the difference-in-differences(DID)method to empirically examine the impact of the internationalization of ESG standards on the trade competitiveness of multinational enterprises and their mechanisms.The research finds that the internationalization of ESG standards significantly enhances the trade competitiveness of multinational manufacturing enterprises,and this effect is dynamic and sustainable.The mechanism analysis indicates that the internationalization of ESG standards exerts its influence through three pathways:reducing enterprise financing costs,promoting technological innovation,and enhancing brand reputation.The heterogeneity analysis shows that this effect is more significant in enterprises from developed countries,high-pollution industries,and larger enterprises.This paper provides micro-level evidence for understanding the economic consequences of the internationalization of ESG standards and offers policy implications for multinational enterprises to cope with the global ESG rule changes and enhance their trade competitiveness.
文摘Rechargeable batteries have changed human daily life from electronic devices and electric transport to renewable energy systems[1-3].Especially,lithium-ion batteries(LIBs)have dominated the market since their first commercialization in the 1990s,and the three pioneers(John B.Goodenough,M.Stanley Whittingham,and Akira Yoshino)in the historical development of LIBs were awarded the Novel Prize in chemistry in 2019[4].However,the imbalance between supply and demand during the past few years induced extremely huge fluctuations in lithium resources.The misgivings of lithium resources have promoted the quick development of potential alternative battery technologies.
文摘In the context of accelerated globalization and the rapid development of the digital economy,the scale of China's import and export trade continues to expand.Enhancing the international competitiveness of China's digital service trade is of significant importance.This article will analyze the current state of China's digital service trade development based on relevant theoretical concepts and provide a discussion on proposals for improving the international competitiveness of China's digital service trade,to offer a reference for the development of digital service trade in China.
基金Supported by the National Key R&D Program of China(No.2021YFC3200900)the National Natural Science Foundation of China(No.31971477)。
文摘The global rise in CO_(2)concentration is having a profound impact on the structure and function of aquatic ecosystems.However,little information is available on the responses of odorproducing cyanobacteria to the increase in CO_(2)concentration.In this study,the effects of different CO_(2)concentrations on 2-methylisoborneol(MIB)-producing Pseudanabaena and non-2-MIB-producing Pseudanabaena under monoculture and co-culture conditions were investigated.Results show that the specific growth rate of Pseudanabaena gradually increased with the rise in CO_(2)concentration,and for the 2-MIB-producing strain,this increase was significantly higher than the non-2-MIB-producing strain.Under co-culture conditions,the proportion of non-2-MIB-producing Pseudanabaena was significantly higher than that of 2-MIB-producing Pseudanabaena,suggesting a superior competitive ability of non-2-MIB-producing Pseudanabaena over 2-MIB-producing Pseudanabaena.Under monoculture conditions,the total 2-MIB production at the 300-μg/g CO_(2)concentration was significantly higher than that at 600-and 1200-μg/g CO_(2)concentrations.The 2-MIB concentration produced by Pseudanabaena decreased with the increasing in CO_(2)concentration.Therefore,we believe that with the future increase in CO_(2)concentration,2-MIB concentration would be decreased and so would the risk of 2-MIB outbreaks.
文摘This study observes the process of strategy building and capability accumulation of companies in the currently booming Chinese electric vehicles(EV)1 market from the perspective of business ecosystems.While examining the internal and external factors of the formation about the Chinese EV industry business ecosystem,such as industrial structure transformation,technology transfer,government policies,and corporate competition,with the platform theory,I analyze the growth strategies and competitiveness of Chinese companies,particularly BYD Co.,Ltd.(BYD),which has risen to the top of the world in EV completed vehicles,and Contemporary Amperex Technology Co.,Ltd.(CATL),which has risen to the top of the world in electric vehicle batteries(EVB)2.BYD and CATL have gained competitive advantages by utilizing the distinctive management resources,which have accumulated over the years to build platforms for EVBs and EVs in response to changes in the external environment,and have actively developed their platform strategies.
文摘This paper deals with the competitiveness of Chinese agricultural products, base on the index of revealed comparative advantage (RCA) using lots of data for the period of 1980 to 2003. The index is useful in identifying the demarcation between comparative advantage and comparative disadvantage. The research indicates that some agro-products in China such as edible vegetables and tea have a comparative advantage, but the RCA values have been declining over the 24-year period, which has vast impacts on future reform in China’s agricultural structure.
