This article aims to explore the teaching mode of using MWorks simulation software to promote teaching in circuit fundamentals courses in vocational colleges through competitions.By analyzing the limitations of tradit...This article aims to explore the teaching mode of using MWorks simulation software to promote teaching in circuit fundamentals courses in vocational colleges through competitions.By analyzing the limitations of traditional teaching,this article elaborates on the functional advantages of MWorks software and its specific application methods in promoting teaching through competitions,including how to combine skill competitions for teaching design,organizing internal selection and training,and other aspects.Practice has shown that this model effectively enhances students’professional skills,innovation ability,and teamwork spirit,while also promoting the improvement of teachers’teaching level.Finally,the problems encountered during the application process were reflected upon,and improvement suggestions were proposed,providing a reference for relevant teaching reforms in vocational colleges.展开更多
Hydrogen evolution reaction(HER)is unavoidable in many electrochemical synthesis systems,such as CO_(2)reduction,N2reduction,and H_(2)O_(2)synthesis.It makes those electrochemical reactions with multiple electron-prot...Hydrogen evolution reaction(HER)is unavoidable in many electrochemical synthesis systems,such as CO_(2)reduction,N2reduction,and H_(2)O_(2)synthesis.It makes those electrochemical reactions with multiple electron-proton transfers more complex when determining kinetics and mass transfer information.Understanding how HER competes with other electrochemical reduction reactions is crucial for both fundamental studies and system performance improvements.In this study,we employed the oxygen reduction reaction(ORR)as a model reaction to investigate HER competition on a polycrystalline-Au surface,using a rotating ring and disk electrode.It’s proved that water molecules serve as the proton source for ORR in alkaline,neutral,and even acidic electrolytes,and a 4-electron process can be achieved when the overpotential is sufficiently high.The competition from H⁺reduction becomes noticeable at the H⁺concentration higher than 2 mmol L^(–1)and intensi-fies as the H^(+)concentration increases.Based on the electrochemical results,we obtained an equivalent circuit diagram for the ORR system with competition from the H+reduction reaction,showing that these reactions occur in parallel and compete with each other.Electrochemical impedance spectroscopy measurements further confirm this argument.Additionally,we discover that the contribution of H+mass transfer to the total H^(+)reduction current is significant and comparable to the kinetic current.We believe this work will deepen our understanding of HER and its competition in electrochemical reduction systems.展开更多
The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the ...The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.展开更多
This paper analyzes the key challenges faced by vocational college students when participating in national skills competitions.It identifies problems such as limited resources,insufficient training,lack of mentorship,...This paper analyzes the key challenges faced by vocational college students when participating in national skills competitions.It identifies problems such as limited resources,insufficient training,lack of mentorship,academic workload constraints,and inadequate equipment.Targeted solutions are proposed,including improving resource access,providing structured skill training,implementing expert mentorship programs,offering flexible schedules,and upgrading experimental equipment.Implementing these recommendations through a collaborative effort among stakeholders can significantly empower vocational students to excel in skills competitions by enabling access to resources,building practical skills,obtaining guidance,managing time effectively,and gaining hands-on experience.展开更多
This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,l...This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,limited financial resources and hardware,teacher capacity limitations,inadequate reward systems,and curriculum misalignment.Through meticulous research and analysis,this paper presents practical recommendations to mitigate these challenges.Suggestions encompass strategies to enhance students’motivation,increase financial support,provide professional development opportunities for teachers,revamp the reward system,and align the curriculum with competition requirements.By implementing these measures,vocational colleges can cultivate active student participation,elevate teaching quality,bridge the gap between education and industry demands,and equip students for success in innovative skills competitions.展开更多
The main way they have of improving overall system reliability is to concentrate on human reliability if organizations are not installing new plant. Previous research by the author has shown that the main cause of sys...The main way they have of improving overall system reliability is to concentrate on human reliability if organizations are not installing new plant. Previous research by the author has shown that the main cause of system unreliability is operator unreliability. There are three main ways to deal with operator unreliability viz improve the environment, enhance the operator′s skill and increase his motivation. Of these, the last is the final untapped area for achieving significant gains in system reliability. Moves to do this by means of competitions for operators at both a local and international level are discussed, with a description of the successes so far.展开更多
With the increasingly fierce athletic competition, some of the negative phenomena that appear in sports competitions are al-so increasing. In order to solve this problem, through literature and logical analysis, this ...With the increasingly fierce athletic competition, some of the negative phenomena that appear in sports competitions are al-so increasing. In order to solve this problem, through literature and logical analysis, this article attempts to analyze the reasons for the sub- jective and objective aspects of athletic competition arising from the crisis, and put forward the reasonable proposals in order to provide a reference for related research.展开更多
This paper explores the role of guiding students to participate in skills competitions on the development of young teachers in vocational colleges.We investigate the impact of skills competitions on the consolidation ...This paper explores the role of guiding students to participate in skills competitions on the development of young teachers in vocational colleges.We investigate the impact of skills competitions on the consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills with students.The results of this research demonstrate that skills competitions have a positive influence on the professional growth of young teachers.The consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills collectively contribute to the effectiveness of young teachers in vocational colleges.It is recommended that vocational colleges prioritize and support the participation of young teachers in skills competitions to foster their professional development.展开更多
Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society....Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society.The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts.The various types of skills competitions provide a“stage”for students to showcase their abilities.First,this paper explores students’problem-solving ability while preparing for these competitions,expounding the importance of vocational education and skills competitions.Second,this paper summarizes the views of different scholars.Third,based on a specific case,this paper describes the improvement in students’ability while preparing for these competitions.Fourth,this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ability.Lastly,this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.展开更多
The competition of waves has remained a hot topic in physics over the past few decades,especially the area of pattern control.Because of improved understanding of various dynamic behaviors,many practical applications ...The competition of waves has remained a hot topic in physics over the past few decades,especially the area of pattern control.Because of improved understanding of various dynamic behaviors,many practical applications have sprung up recently.The prediction of wave competitions is also very important and quite useful in these fields.This paper considers the behaviors of wave competitions in simple,inhomogeneous media which is modeled by Brusselator equations.We present a simple rule to judge the results of wave competitions utilizing the dispersion relation curves and the waves coming from different wave sources.Moreover,this rule can also be used to predict the results of wave propagation.It provides methods of obtaining the desired waves with given frequencies in inhomogeneous media.All our results are concluded and verified by computer simulations.展开更多
In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sport...In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sports, where victory is imperative, often treated as just another object and an obstacle to be overcome. Violence in sports performed primarily athletes themselves. In sports games can be applied aggressive tactics, but the use of violence is considered to be beyond the scope of what is considered to be the good behavior of an athlete. Athletes decide on violence sometimes with a clear goal of hurting the opposing player, and sometimes only for intimidation, in order to win. Extreme exercise, accompanied by great hardships and frequent injuries, are not always sufficient to achieve the required and expected results, and more and more athletes turning to the use of prohibited doping substances, thus trying to improve their own capabilities.展开更多
This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of te...This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of technical and tactical skills in mixed martial arts competitions,and its primary application strategies.It is hoped that this analysis can provide some guidelines for the appropriate application of mixed martial arts athletes’technical and tactical skills to improve their winning rate in mixed martial arts competitions.展开更多
Purpose China Adolescents Science and Technology Innovation Contest(CASTIC)has created a better experimental environment for science education than that provided by formal schooling.In order to assess its educational ...Purpose China Adolescents Science and Technology Innovation Contest(CASTIC)has created a better experimental environment for science education than that provided by formal schooling.In order to assess its educational effect,this study examines different talent development models resulting from CASTIC,as well as learning environment and processes it fosters.Design/Approach/Methods This multi-case study sampled teachers and students from different schools that participated in the Shanghai division of CASTIC,and then analyzed the implementation process of CASTIC as well as various models it formed for talent development.Findings This study argues that,by constructing multiple settings for learning involving schools,science clubs,and competitions,CASTIC enables schools to establish diversified talent development models based on process motivation.As structural problems arising from the inadequacy of educational resources for science and technology innovation continue to limit the educational effectiveness of these competitions,a series of curriculum reforms and institutional designs are necessary to fully harness the educational power of science and technology innovation competitions.Originality/Value This study provides an important reference for understanding the talent training mechanism of science competition and exploring its future development.展开更多
We study in this paper a mathematical programming model for the coexistence of competitions and cooperations problems. We introduce a new solution concept, s-optimal solution for the problem, which always exists under...We study in this paper a mathematical programming model for the coexistence of competitions and cooperations problems. We introduce a new solution concept, s-optimal solution for the problem, which always exists under compact and continuous conditions. It is shown that an s-optimal solution can be obtained by solving a nonlinear programming problem. Some examples are given to explain how to compute an s-optimal solution.展开更多
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The...Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The long noncoding RNA growth arrest-specific 5(GAS5) is a member of the 5′-terminal oligopyrimidine gene family that may be involved in neurological disorders, but its role in Alzheimer's disease remains unclear. This study aimed to investigate the function of GAS5 and construct a GAS5-associated competitive endogenous RNA network comprising potential targets. RNA sequencing results showed that GAS5 was upregulated in five familial Alzheimer's disease(5×FAD) mice, APPswe/PSEN1dE9(APP/PS1) mice, Alzheimer's disease-related APPswe cells, and serum from patients with Alzheimer's disease. Functional experiments with targeted overexpression and silencing demonstrated that GAS5 played a role in cognitive dysfunction and multiple Alzheimer's disease-associated pathologies, including tau hyperphosphorylation, amyloid-beta accumulation, and neuronal apoptosis. Mechanistic studies indicated that GAS5 acted as an endogenous sponge by competing for microRNA-23b-3p(miR-23b-3p) binding to regulate its targets glycogen synthase kinase 3beta(GSK-3β) and phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in an Argonaute 2-induced RNA silencing complex(RISC)-dependent manner. GAS5 inhibited miR-23b-3p-mediated GSK-3β and PTEN cascades with a feedforward PTEN/protein kinase B(Akt)/GSK-3β linkage. Furthermore, recovery of GAS5/miR-23b-3p/GSK-3β/PTEN pathways relieved Alzheimer's disease-like symptoms in vivo, indicated by the amelioration of spatial cognition, neuronal degeneration, amyloid-beta load, and tau phosphorylation. Together, these findings suggest that GAS5 promotes Alzheimer's disease pathogenesis. This study establishes the functional convergence of the GAS5/miR-23b-3p/GSK-3β/PTEN pathway on multiple pathologies, suggesting a candidate therapeutic target in Alzheimer's disease.展开更多
The architectural design competition remains a widely accepted method to advance design innovation, creativity, theoretical discourse, and the profession. In the rearm of healthcare facility design, by contrast, clien...The architectural design competition remains a widely accepted method to advance design innovation, creativity, theoretical discourse, and the profession. In the rearm of healthcare facility design, by contrast, clients and their sponsoring organizations seldom utilize this method. The reasons for this are many, and continue to stand in stark contrast to a growing body of evidence-based research and design （EBREtD）that is potentially of value in improving performance-based dimensions-esthetic and otherwise-of healthcare facilities globally. A comparative analysis of the entrants to a recent U.S. completion was conducted. Based on the results of this anatysis, a two-phased healthcare facility design competition paradigm is put forth that is premised on the assumption that the intuitive dimensions of design creativity can be further advanced by means of a weft timed and thoughlfur injection of quantitatively based knowtedge pertaining to patient, family, staff, and organizational concerns and priorities. This proposal＇s limitations, and future opportunities, are discussed.展开更多
Football is a popular sport all over the world,and it also has a large number of fans in China.However,in many international competitions,the Chinese team often fails to achieve the expected results.This situation mak...Football is a popular sport all over the world,and it also has a large number of fans in China.However,in many international competitions,the Chinese team often fails to achieve the expected results.This situation makes its fans very disappointed.But we should also see that the Chinese football community is making efforts to improve the situation.展开更多
基金MWORKS University Application Verification Project(BX2024C081).
文摘This article aims to explore the teaching mode of using MWorks simulation software to promote teaching in circuit fundamentals courses in vocational colleges through competitions.By analyzing the limitations of traditional teaching,this article elaborates on the functional advantages of MWorks software and its specific application methods in promoting teaching through competitions,including how to combine skill competitions for teaching design,organizing internal selection and training,and other aspects.Practice has shown that this model effectively enhances students’professional skills,innovation ability,and teamwork spirit,while also promoting the improvement of teachers’teaching level.Finally,the problems encountered during the application process were reflected upon,and improvement suggestions were proposed,providing a reference for relevant teaching reforms in vocational colleges.
文摘Hydrogen evolution reaction(HER)is unavoidable in many electrochemical synthesis systems,such as CO_(2)reduction,N2reduction,and H_(2)O_(2)synthesis.It makes those electrochemical reactions with multiple electron-proton transfers more complex when determining kinetics and mass transfer information.Understanding how HER competes with other electrochemical reduction reactions is crucial for both fundamental studies and system performance improvements.In this study,we employed the oxygen reduction reaction(ORR)as a model reaction to investigate HER competition on a polycrystalline-Au surface,using a rotating ring and disk electrode.It’s proved that water molecules serve as the proton source for ORR in alkaline,neutral,and even acidic electrolytes,and a 4-electron process can be achieved when the overpotential is sufficiently high.The competition from H⁺reduction becomes noticeable at the H⁺concentration higher than 2 mmol L^(–1)and intensi-fies as the H^(+)concentration increases.Based on the electrochemical results,we obtained an equivalent circuit diagram for the ORR system with competition from the H+reduction reaction,showing that these reactions occur in parallel and compete with each other.Electrochemical impedance spectroscopy measurements further confirm this argument.Additionally,we discover that the contribution of H+mass transfer to the total H^(+)reduction current is significant and comparable to the kinetic current.We believe this work will deepen our understanding of HER and its competition in electrochemical reduction systems.
文摘The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024).
文摘This paper analyzes the key challenges faced by vocational college students when participating in national skills competitions.It identifies problems such as limited resources,insufficient training,lack of mentorship,academic workload constraints,and inadequate equipment.Targeted solutions are proposed,including improving resource access,providing structured skill training,implementing expert mentorship programs,offering flexible schedules,and upgrading experimental equipment.Implementing these recommendations through a collaborative effort among stakeholders can significantly empower vocational students to excel in skills competitions by enabling access to resources,building practical skills,obtaining guidance,managing time effectively,and gaining hands-on experience.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project number:2022X305-SXZC).
文摘This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,limited financial resources and hardware,teacher capacity limitations,inadequate reward systems,and curriculum misalignment.Through meticulous research and analysis,this paper presents practical recommendations to mitigate these challenges.Suggestions encompass strategies to enhance students’motivation,increase financial support,provide professional development opportunities for teachers,revamp the reward system,and align the curriculum with competition requirements.By implementing these measures,vocational colleges can cultivate active student participation,elevate teaching quality,bridge the gap between education and industry demands,and equip students for success in innovative skills competitions.
文摘The main way they have of improving overall system reliability is to concentrate on human reliability if organizations are not installing new plant. Previous research by the author has shown that the main cause of system unreliability is operator unreliability. There are three main ways to deal with operator unreliability viz improve the environment, enhance the operator′s skill and increase his motivation. Of these, the last is the final untapped area for achieving significant gains in system reliability. Moves to do this by means of competitions for operators at both a local and international level are discussed, with a description of the successes so far.
文摘With the increasingly fierce athletic competition, some of the negative phenomena that appear in sports competitions are al-so increasing. In order to solve this problem, through literature and logical analysis, this article attempts to analyze the reasons for the sub- jective and objective aspects of athletic competition arising from the crisis, and put forward the reasonable proposals in order to provide a reference for related research.
基金The Project of China Vocational Education Association(Project number:ZJS2022YB024)。
文摘This paper explores the role of guiding students to participate in skills competitions on the development of young teachers in vocational colleges.We investigate the impact of skills competitions on the consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills with students.The results of this research demonstrate that skills competitions have a positive influence on the professional growth of young teachers.The consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills collectively contribute to the effectiveness of young teachers in vocational colleges.It is recommended that vocational colleges prioritize and support the participation of young teachers in skills competitions to foster their professional development.
基金This work was supported by the Project of China Vocational Education Association(Project Number:ZJS2022YB024)the Project of Innovation and Development Center of Ideological and Political Work(Beijing Polytechnic),Ministry of Education(Project Number:2022X305-SXZC).
文摘Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society.The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts.The various types of skills competitions provide a“stage”for students to showcase their abilities.First,this paper explores students’problem-solving ability while preparing for these competitions,expounding the importance of vocational education and skills competitions.Second,this paper summarizes the views of different scholars.Third,based on a specific case,this paper describes the improvement in students’ability while preparing for these competitions.Fourth,this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ability.Lastly,this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.
基金Supported by National Natural Science Foundation of China under Grant Nos.11105051,11104071,11247272Fundamental Research Funds for Central Universities,Beijing Higher Education Elite Young Teacher ProjectYouth Scholars Program of Beijing Normal University
文摘The competition of waves has remained a hot topic in physics over the past few decades,especially the area of pattern control.Because of improved understanding of various dynamic behaviors,many practical applications have sprung up recently.The prediction of wave competitions is also very important and quite useful in these fields.This paper considers the behaviors of wave competitions in simple,inhomogeneous media which is modeled by Brusselator equations.We present a simple rule to judge the results of wave competitions utilizing the dispersion relation curves and the waves coming from different wave sources.Moreover,this rule can also be used to predict the results of wave propagation.It provides methods of obtaining the desired waves with given frequencies in inhomogeneous media.All our results are concluded and verified by computer simulations.
文摘In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sports, where victory is imperative, often treated as just another object and an obstacle to be overcome. Violence in sports performed primarily athletes themselves. In sports games can be applied aggressive tactics, but the use of violence is considered to be beyond the scope of what is considered to be the good behavior of an athlete. Athletes decide on violence sometimes with a clear goal of hurting the opposing player, and sometimes only for intimidation, in order to win. Extreme exercise, accompanied by great hardships and frequent injuries, are not always sufficient to achieve the required and expected results, and more and more athletes turning to the use of prohibited doping substances, thus trying to improve their own capabilities.
文摘This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of technical and tactical skills in mixed martial arts competitions,and its primary application strategies.It is hoped that this analysis can provide some guidelines for the appropriate application of mixed martial arts athletes’technical and tactical skills to improve their winning rate in mixed martial arts competitions.
基金part of the phased achievements of“Recommendations for Enhancing the Effectiveness of Science and Technology Innovation Competitions for Adolescents in Nurturing a Reserve of Young Talents in Science and Technology,”a project supported by the Shanghai Association for Science and Technology in 2019。
文摘Purpose China Adolescents Science and Technology Innovation Contest(CASTIC)has created a better experimental environment for science education than that provided by formal schooling.In order to assess its educational effect,this study examines different talent development models resulting from CASTIC,as well as learning environment and processes it fosters.Design/Approach/Methods This multi-case study sampled teachers and students from different schools that participated in the Shanghai division of CASTIC,and then analyzed the implementation process of CASTIC as well as various models it formed for talent development.Findings This study argues that,by constructing multiple settings for learning involving schools,science clubs,and competitions,CASTIC enables schools to establish diversified talent development models based on process motivation.As structural problems arising from the inadequacy of educational resources for science and technology innovation continue to limit the educational effectiveness of these competitions,a series of curriculum reforms and institutional designs are necessary to fully harness the educational power of science and technology innovation competitions.Originality/Value This study provides an important reference for understanding the talent training mechanism of science competition and exploring its future development.
基金This research is supported by the National Natural Science Foundation of China under grunt 70271021 and SRG7001150.
文摘We study in this paper a mathematical programming model for the coexistence of competitions and cooperations problems. We introduce a new solution concept, s-optimal solution for the problem, which always exists under compact and continuous conditions. It is shown that an s-optimal solution can be obtained by solving a nonlinear programming problem. Some examples are given to explain how to compute an s-optimal solution.
基金supported by the National Natural Science Foundation of China,Nos. 82173806 and U1803281Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science,Nos. 2021-I2M-1-030 and 2022-I2M-2-002Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No. 2022-JKCS-08 (all to RL)。
文摘Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The long noncoding RNA growth arrest-specific 5(GAS5) is a member of the 5′-terminal oligopyrimidine gene family that may be involved in neurological disorders, but its role in Alzheimer's disease remains unclear. This study aimed to investigate the function of GAS5 and construct a GAS5-associated competitive endogenous RNA network comprising potential targets. RNA sequencing results showed that GAS5 was upregulated in five familial Alzheimer's disease(5×FAD) mice, APPswe/PSEN1dE9(APP/PS1) mice, Alzheimer's disease-related APPswe cells, and serum from patients with Alzheimer's disease. Functional experiments with targeted overexpression and silencing demonstrated that GAS5 played a role in cognitive dysfunction and multiple Alzheimer's disease-associated pathologies, including tau hyperphosphorylation, amyloid-beta accumulation, and neuronal apoptosis. Mechanistic studies indicated that GAS5 acted as an endogenous sponge by competing for microRNA-23b-3p(miR-23b-3p) binding to regulate its targets glycogen synthase kinase 3beta(GSK-3β) and phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in an Argonaute 2-induced RNA silencing complex(RISC)-dependent manner. GAS5 inhibited miR-23b-3p-mediated GSK-3β and PTEN cascades with a feedforward PTEN/protein kinase B(Akt)/GSK-3β linkage. Furthermore, recovery of GAS5/miR-23b-3p/GSK-3β/PTEN pathways relieved Alzheimer's disease-like symptoms in vivo, indicated by the amelioration of spatial cognition, neuronal degeneration, amyloid-beta load, and tau phosphorylation. Together, these findings suggest that GAS5 promotes Alzheimer's disease pathogenesis. This study establishes the functional convergence of the GAS5/miR-23b-3p/GSK-3β/PTEN pathway on multiple pathologies, suggesting a candidate therapeutic target in Alzheimer's disease.
文摘The architectural design competition remains a widely accepted method to advance design innovation, creativity, theoretical discourse, and the profession. In the rearm of healthcare facility design, by contrast, clients and their sponsoring organizations seldom utilize this method. The reasons for this are many, and continue to stand in stark contrast to a growing body of evidence-based research and design （EBREtD）that is potentially of value in improving performance-based dimensions-esthetic and otherwise-of healthcare facilities globally. A comparative analysis of the entrants to a recent U.S. completion was conducted. Based on the results of this anatysis, a two-phased healthcare facility design competition paradigm is put forth that is premised on the assumption that the intuitive dimensions of design creativity can be further advanced by means of a weft timed and thoughlfur injection of quantitatively based knowtedge pertaining to patient, family, staff, and organizational concerns and priorities. This proposal＇s limitations, and future opportunities, are discussed.
文摘Football is a popular sport all over the world,and it also has a large number of fans in China.However,in many international competitions,the Chinese team often fails to achieve the expected results.This situation makes its fans very disappointed.But we should also see that the Chinese football community is making efforts to improve the situation.
